Detailed information for compound 34483

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 668.82 | Formula: C36H52N4O8
  • H donors: 5 H acceptors: 9 LogP: 4.15 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[C@H]([C@H](C(=O)N(c1ccccn1)C)NC(=O)[C@H](C(C)C)CC([C@H](NC(=O)C(C(C(=O)O)O)C(=O)Cc1ccccc1)CC(C)C)O)C
  • InChi: 1S/C36H52N4O8/c1-8-23(6)31(35(46)40(7)29-16-12-13-17-37-29)39-33(44)25(22(4)5)20-27(41)26(18-21(2)3)38-34(45)30(32(43)36(47)48)28(42)19-24-14-10-9-11-15-24/h9-17,21-23,25-27,30-32,41,43H,8,18-20H2,1-7H3,(H,38,45)(H,39,44)(H,47,48)/t23?,25-,26-,27?,30?,31-,32?/m0/s1
  • InChiKey: WVFVYHKXJBDHSE-CNUYSTGBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0119 0.1309 0.1275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0155 0.174 0.1322
Trypanosoma cruzi cysteine peptidase, putative 0.0839 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0561 0.6651 0.6482
Giardia lamblia Hypothetical protein 0.0155 0.174 0.2863
Giardia lamblia Cathepsin L precursor 0.0155 0.174 0.2863
Giardia lamblia Cathepsin B precursor 0.0155 0.174 0.2863
Brugia malayi cathepsin B-like cysteine proteinase 0.0155 0.174 0.1708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0839 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.174 0.1722
Echinococcus granulosus cathepsin L cysteine protease 0.0432 0.5089 0.5089
Entamoeba histolytica cysteine proteinase 1, putative 0.0432 0.5089 0.4923
Trypanosoma cruzi cysteine peptidase, putative 0.0839 1 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0155 0.174 0.1708
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0298 0.0277
Brugia malayi Cathepsin L-like cysteine proteinase 0.0561 0.6651 0.6638
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0583 0.0546
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.174 0.1722
Plasmodium falciparum methionine aminopeptidase 2 0.0051 0.0482 0.0445
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0618 0.0143
Giardia lamblia Hypothetical protein 0.0375 0.4394 0.8904
Loa Loa (eye worm) hypothetical protein 0.0155 0.174 0.174
Entamoeba histolytica cysteine proteinase, putative 0.0432 0.5089 0.4923
Brugia malayi transcriptional regulator, Sir2 family protein 0.0096 0.1034 0.0999
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0206 0.0168
Brugia malayi Cathepsin L-like precursor 0.0561 0.6651 0.6638
Giardia lamblia Cathepsin B precursor 0.0155 0.174 0.2863
Trypanosoma cruzi cysteine peptidase, putative 0.0432 0.5089 0.5047
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0039 0.0018
Loa Loa (eye worm) hypothetical protein 0.0062 0.0618 0.0618
Echinococcus granulosus cathepsin b 0.0155 0.174 0.174
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.174 0.1722
Plasmodium falciparum histone deacetylase 2 0.0018 0.0084 0.0045
Loa Loa (eye worm) histone deacetylase 3 0.0062 0.0618 0.0618
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0051 0.0482 0.0401
Echinococcus multilocularis lamin dm0 0.0059 0.0583 0.0583
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0326 0.0326
Echinococcus multilocularis histone deacetylase 1 0.0062 0.0618 0.0618
Schistosoma mansoni cathepsin F (C01 family) 0.0839 1 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0096 0.1034 0.0999
Plasmodium vivax aspartyl proteinase, putative 0.0059 0.0583 0.0546
Giardia lamblia Cysteine protease 0.0155 0.174 0.2863
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0839 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0201 0.0201
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0537 0.0517
Brugia malayi Pre-SET motif family protein 0.0243 0.2803 0.2775
Entamoeba histolytica cysteine proteinase, putative 0.0432 0.5089 0.4923
Brugia malayi Cathepsin L-like precursor 0.0277 0.3219 0.3193
Schistosoma mansoni cpg binding protein 0.0032 0.026 0.0239
Brugia malayi RNA binding protein 0.0064 0.0648 0.0611
Entamoeba histolytica hypothetical protein 0.0155 0.174 0.1461
Trypanosoma cruzi major cysteine proteinase, putative 0.0155 0.174 0.167
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0096 0.1034 0.0958
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.174 0.2863
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0482 0.0482
Trypanosoma cruzi cysteine peptidase, putative 0.0839 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.174 0.1322
Giardia lamblia Cathepsin B precursor 0.0155 0.174 0.2863
Giardia lamblia Cathepsin L-like protease 0.0155 0.174 0.2863
Loa Loa (eye worm) hypothetical protein 0.0155 0.174 0.174
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.2195 0.2178
Loa Loa (eye worm) hypothetical protein 0.0561 0.6651 0.6651
Plasmodium falciparum serine repeat antigen 6 0.0155 0.174 0.1708
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0206 0.0168
Echinococcus multilocularis histone deacetylase 7 0.0018 0.0084 0.0084
Onchocerca volvulus 0.0059 0.0583 0.0546
Giardia lamblia Histone deacetylase 0.0062 0.0618 0.031
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0432 0.5089 0.5047
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0648 0.0628
Plasmodium vivax vivapain-2 0.0839 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.174 0.1722
Schistosoma mansoni intermediate filament proteins 0.0059 0.0583 0.0563
Echinococcus granulosus cathepsin l cysteine peptidase 0.0839 1 1
Echinococcus multilocularis cathepsin b 0.0155 0.174 0.174
Echinococcus granulosus histone deacetylase 6 0.0018 0.0084 0.0084
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0155 0.174 0.174
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Plasmodium falciparum serine repeat antigen 4 0.0155 0.174 0.1708
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.174 0.1322
Brugia malayi Cathepsin L-like precursor 0.0561 0.6651 0.6638
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0155 0.174 0.1708
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0155 0.174 0.1461
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0096 0.1034 0.5
Plasmodium vivax serine-repeat antigen (SERA) 0.0155 0.174 0.1708
Loa Loa (eye worm) hypothetical protein 0.0155 0.174 0.174
Brugia malayi Histone deacetylase family protein 0.0018 0.0084 0.0045
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0084 0.0084
Schistosoma mansoni histone deacetylase 0.0062 0.0618 0.0598
Echinococcus multilocularis cathepsin L 0.0432 0.5089 0.5089
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Echinococcus granulosus histone deacetylase 6 0.0018 0.0084 0.0084
Schistosoma mansoni chromatin regulatory protein sir2 0.0414 0.4876 0.4865
Giardia lamblia Cathepsin L precursor 0.0155 0.174 0.2863
Echinococcus granulosus histone deacetylase 6 0.0018 0.0084 0.0084
Plasmodium falciparum histone deacetylase, putative 0.0018 0.0084 0.0045
Brugia malayi cathepsin L precursor 0.0155 0.174 0.1708
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0298 0.0277
Loa Loa (eye worm) hypothetical protein 0.0018 0.0084 0.0084
Entamoeba histolytica cysteine protease, putative 0.0155 0.174 0.1461
Brugia malayi Cathepsin L-like precursor 0.0839 1 1
Echinococcus granulosus dnaJ subfamily B 0.0434 0.5118 0.5118
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0648 0.0628
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.174 0.1322
Plasmodium vivax histone deacetylase 1, putative 0.0062 0.0618 0.0581
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0839 1 1
Onchocerca volvulus 0.0276 0.3207 0.3181
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0298 0.0277
Giardia lamblia Cysteine protease 0.0155 0.174 0.2863
Loa Loa (eye worm) hypothetical protein 0.0561 0.6651 0.6651
Trypanosoma cruzi cysteine proteinase, putative 0.0432 0.5089 0.5047
Onchocerca volvulus 0.0839 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0298 0.0298
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.2177 0.2177
Echinococcus granulosus cpg binding protein 0.0032 0.026 0.026
Giardia lamblia Cysteine protease 0.0155 0.174 0.2863
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0155 0.174 0.1708
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0155 0.174 0.1322
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.0583 0.0563
Leishmania major silent information regulator 2, putative 0.0375 0.4394 0.4347
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0277 0.3219 0.3193
Plasmodium vivax unspecified product 0.0277 0.3219 0.3193
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0039 0.0018
Brugia malayi Papain family cysteine protease containing protein 0.0839 1 1
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.0084 0.0063
Echinococcus multilocularis methionyl aminopeptidase 2 0.0051 0.0482 0.0482
Brugia malayi Cathepsin L-like precursor 0.0839 1 1
Trichomonas vaginalis set domain proteins, putative 0.0276 0.3207 0.2864
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0414 0.4876 0.4876
Trypanosoma cruzi cysteine peptidase, putative 0.0839 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.2177 0.2177
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0096 0.1034 0.0958
Schistosoma mansoni cpg binding protein 0.0032 0.026 0.0239
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.174 0.1322
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0155 0.174 0.1708
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Echinococcus granulosus cysteine protease 0.0432 0.5089 0.5089
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0084 0.0084
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0537 0.0537
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0206 0.0124
Giardia lamblia Cathepsin L precursor 0.0155 0.174 0.2863
Brugia malayi Histone deacetylase family protein 0.0018 0.0084 0.0045
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0252 0.0214
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.174 0.1708
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0298 0.0277
Onchocerca volvulus Histone deacetylase 10 homolog 0.0018 0.0084 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1309 0.1309
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.174 0.1322
Toxoplasma gondii histone deacetylase HDAC1 0.0018 0.0084 0.0045
Brugia malayi initiation factor 2-associated protein. 0.0051 0.0482 0.0445
Echinococcus granulosus GPCR family 2 0.0016 0.0064 0.0064
Mycobacterium ulcerans Sir2-like regulatory protein 0.0096 0.1034 0.5
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0456 0.0435
Echinococcus multilocularis cathepsin L cysteine protease 0.0839 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0839 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0096 0.1034 0.058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Toxoplasma gondii aspartyl protease ASP1 0.0059 0.0583 0.0546
Trypanosoma brucei cysteine peptidase C (CPC) 0.0155 0.174 0.167
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0064 0.0025
Loa Loa (eye worm) hypothetical protein 0.0048 0.0456 0.0456
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0375 0.4394 0.411
Loa Loa (eye worm) initiation factor 2-associated protein 0.0051 0.0482 0.0482
Entamoeba histolytica cysteine proteinase 2 0.0432 0.5089 0.4923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.174 0.1322
Leishmania major sir2-family protein-like protein 0.0096 0.1034 0.0958
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0414 0.4876 0.4616
Plasmodium falciparum plasmepsin VI 0.0059 0.0583 0.0546
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0375 0.4394 0.411
Plasmodium falciparum plasmepsin II 0.0059 0.0583 0.0546
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0584 0.0547
Plasmodium vivax NAD-dependent deacetylase, putative 0.0096 0.1034 0.0999
Schistosoma mansoni cathepsin B (C01 family) 0.0155 0.174 0.1722
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Brugia malayi Cathepsin L-like precursor 0.0839 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0561 0.6651 0.6482
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0051 0.0482 0.0445
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.174 0.1722
Brugia malayi TAR-binding protein 0.0064 0.0648 0.0611
Schistosoma mansoni hypothetical protein 0.0056 0.0548 0.0528
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.174 0.1722
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0618 0.0143
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0059 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0051 0.0482 0.0482
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0548 0.0511
Brugia malayi CXXC zinc finger family protein 0.0031 0.0239 0.0201
Onchocerca volvulus Cathepsin L homolog 0.0839 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0326 0.0326
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0096 0.1034 0.0999
Echinococcus granulosus lamin dm0 0.0059 0.0583 0.0583
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0839 1 1
Giardia lamblia Cathepsin B precursor 0.0155 0.174 0.2863
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.174 0.2863
Schistosoma mansoni chromatin regulatory protein sir2 0.0096 0.1034 0.1015
Trypanosoma cruzi cysteine proteinase, putative 0.0432 0.5089 0.5047
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0064 0.0064
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0375 0.4394 0.4394
Plasmodium vivax histone deacetylase 2, putative 0.0018 0.0084 0.0045
Loa Loa (eye worm) transcriptional regulator 0.0375 0.4394 0.4394
Schistosoma mansoni chromatin regulatory protein sir2 0.0096 0.1034 0.1015
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0214 0.0214
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0051 0.0482 0.0445
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0298
Echinococcus granulosus chromatin regulatory protein sir2 0.0375 0.4394 0.4394
Onchocerca volvulus 0.0048 0.0456 0.0418
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0456 0.0435
Giardia lamblia Cathepsin B precursor 0.0155 0.174 0.2863
Toxoplasma gondii cathepsin CPC2 0.0155 0.174 0.1708
Loa Loa (eye worm) histone deacetylase 7A 0.0018 0.0084 0.0084
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0155 0.174 0.1708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0839 1 1
Echinococcus granulosus histone deacetylase 8 0.0018 0.0084 0.0084
Giardia lamblia Encystation-specific protease 0.0155 0.174 0.2863
Schistosoma mansoni cathepsin S (C01 family) 0.0155 0.174 0.1722
Loa Loa (eye worm) MBCTL1 0.0055 0.0537 0.0537
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0096 0.1034 0.0731
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0648 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Plasmodium vivax vivapain-2 0.0839 1 1
Schistosoma mansoni cathepsin C 0.0155 0.174 0.1722
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0051 0.0482 0.0401
Schistosoma mansoni hypothetical protein 0.0295 0.3428 0.3414
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0583 0.0583
Schistosoma mansoni histone deacetylase 0.0062 0.0618 0.0598
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0155 0.174 0.1722
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.174 0.1322
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0456 0.0418
Schistosoma mansoni chromatin regulatory protein sir2 0.0375 0.4394 0.4382
Leishmania major histone deacetylase, putative 0.0062 0.0618 0.0539
Brugia malayi hypothetical protein 0.0038 0.0326 0.0289
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0482 0.0445
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.174 0.1322
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Schistosoma mansoni cpg binding protein 0.0031 0.0239 0.0218
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0537 0.05
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0298 0.0298
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0839 1 1
Loa Loa (eye worm) hypothetical protein 0.0277 0.3219 0.3219
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0064 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0648 0.0628
Toxoplasma gondii histone deacetylase HDAC5 0.0018 0.0084 0.0045
Plasmodium falciparum histone deacetylase 1 0.0062 0.0618 0.0581
Schistosoma mansoni chromatin regulatory protein sir2 0.0096 0.1034 0.1015
Echinococcus multilocularis lamin 0.0059 0.0583 0.0583
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.2195 0.2164
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.174 0.1708
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0059 0.0583 0.0583
Brugia malayi Papain family cysteine protease containing protein 0.0432 0.5089 0.5069
Echinococcus multilocularis neuropeptide receptor A26 0.0474 0.5592 0.5592
Loa Loa (eye worm) hypothetical protein 0.0059 0.0583 0.0583
Schistosoma mansoni survival motor neuron protein 0.0056 0.0548 0.0528
Plasmodium vivax hypothetical protein, conserved 0.0096 0.1034 0.0999
Entamoeba histolytica cysteine protease, putative 0.0155 0.174 0.1461
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0239 0.0239
Echinococcus multilocularis GPCR, family 2 0.0016 0.0064 0.0064
Leishmania major cathepsin L-like protease 0.0839 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0096 0.1034 0.0731
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0062 0.0618 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.174 0.1322
Schistosoma mansoni hypothetical protein 0.0016 0.0064 0.0043
Plasmodium vivax histone deacetylase, putative 0.0018 0.0084 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0277 0.3219 0.3162
Giardia lamblia Cathepsin B precursor 0.0155 0.174 0.2863
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0096 0.1034 0.058
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0155 0.174 0.174
Schistosoma mansoni histone deacetylase 1 2 3 0.0018 0.0084 0.0063
Echinococcus granulosus survival motor neuron protein 1 0.0275 0.3194 0.3194
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.174 0.1322
Loa Loa (eye worm) hypothetical protein 0.0155 0.174 0.174
Leishmania major cathepsin L-like protease 0.0839 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.5118 0.5118
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0155 0.174 0.1708
Leishmania major histone deacetylase, putative 0.0062 0.0618 0.0539
Echinococcus multilocularis histone deacetylase 8 0.0018 0.0084 0.0084
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0059 0.0583 0.0106
Echinococcus multilocularis cathepsin b 0.0155 0.174 0.174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.5089 0.484
Entamoeba histolytica cysteine protease, putative 0.0155 0.174 0.1461
Echinococcus granulosus neuropeptide s receptor 0.0474 0.5592 0.5592
Plasmodium vivax vivapain-3 0.0432 0.5089 0.5069
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0839 1 1
Brugia malayi Cathepsin L-like precursor 0.0839 1 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0155 0.174 0.1708
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0155 0.174 0.174
Loa Loa (eye worm) hypothetical protein 0.0155 0.174 0.174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Toxoplasma gondii cathepsin CPC1 0.0155 0.174 0.1708
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0214 0.0214
Plasmodium vivax unspecified product 0.0432 0.5089 0.5069
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0432 0.5089 0.5078
Trypanosoma cruzi major cysteine proteinase, putative 0.0155 0.174 0.167
Echinococcus multilocularis cysteine protease 0.0839 1 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0155 0.174 0.1708
Brugia malayi cathepsin F-like cysteine proteinase 0.0277 0.3219 0.3193
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0375 0.4394 0.4205
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0414 0.4876 0.4876
Toxoplasma gondii histone deacetylase HDAC2 0.0062 0.0618 0.0581
Plasmodium falciparum plasmepsin I 0.0059 0.0583 0.0546
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Toxoplasma gondii histone deacetylase SIR2-like 0.0096 0.1034 0.0999
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0375 0.4394 0.4205
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0839 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0096 0.1034 0.058
Plasmodium falciparum cysteine proteinase falcipain 3 0.0839 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0206 0.0124
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0096 0.1034 0.0958
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0648 0.0648
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0298 0.026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0839 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0021 0.0021
Entamoeba histolytica histone deacetylase, putative 0.0062 0.0618 0.0301
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.2803 0.2803
Plasmodium falciparum serine repeat antigen 5 0.0155 0.174 0.1708
Brugia malayi histone deacetylase 3 (HD3) 0.0062 0.0618 0.0581
Trypanosoma cruzi cruzipain precursor, putative 0.0277 0.3219 0.3162
Brugia malayi fibroinase precursor 0.0155 0.174 0.1708
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0561 0.6651 0.6623
Brugia malayi hypothetical protein 0.0028 0.0206 0.0168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.2195 0.2195
Loa Loa (eye worm) histone deacetylase 0.0018 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.5089 0.5047
Schistosoma mansoni cathepsin D (A01 family) 0.0174 0.1971 0.1954
Brugia malayi hypothetical protein 0.0018 0.0087 0.0049
Schistosoma mansoni hypothetical protein 0.0434 0.5118 0.5107
Leishmania major cathepsin L-like protease 0.0839 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0155 0.174 0.1708
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0618 0.0143
Brugia malayi Histone deacetylase 1 0.0062 0.0618 0.0581
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0051 0.0482 0.0401
Plasmodium falciparum serine repeat antigen 1 0.0155 0.174 0.1708
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0456 0.0456
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0432 0.5089 0.5078
Schistosoma mansoni chromatin regulatory protein sir2 0.0375 0.4394 0.4382
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0839 1 1
Loa Loa (eye worm) transcriptional regulator 0.0096 0.1034 0.1034
Toxoplasma gondii histone deacetylase HDAC4 0.0018 0.0084 0.0045
Schistosoma mansoni hypothetical protein 0.0038 0.0326 0.0306
Brugia malayi mbt repeat family protein 0.0048 0.0456 0.0418
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0059 0.0583 0.0546
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0096 0.1034 0.1034
Loa Loa (eye worm) histone deacetylase 1 0.0062 0.0618 0.0618
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0618 0.0143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0839 1 1
Brugia malayi intermediate filament protein 0.0059 0.0583 0.0546
Brugia malayi follicle stimulating hormone receptor 0.0238 0.2741 0.2713
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Loa Loa (eye worm) sirtuin 4 0.0096 0.1034 0.1034
Schistosoma mansoni cathepsin F (C01 family) 0.0839 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0206 0.0168
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0096 0.1034 0.0999
Leishmania major cathepsin L-like protease 0.0839 1 1
Leishmania major cathepsin L-like protease 0.0839 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.174 0.1722
Loa Loa (eye worm) hypothetical protein 0.0035 0.0289 0.0289
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0028 0.0214 0.0214
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0096 0.1034 0.1034
Giardia lamblia Cathepsin L precursor 0.0155 0.174 0.2863
Schistosoma mansoni eyes absent homolog 0.0087 0.0923 0.0904
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0456 0.0456
Entamoeba histolytica cysteine protease, putative 0.0155 0.174 0.1461
Echinococcus granulosus tar DNA binding protein 0.0064 0.0648 0.0648
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0155 0.174 0.167
Loa Loa (eye worm) histone deacetylase 11 0.0018 0.0084 0.0084
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0456 0.0456
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Loa Loa (eye worm) cysteine protease 0.0839 1 1
Loa Loa (eye worm) hypothetical protein 0.0275 0.3194 0.3194
Onchocerca volvulus 0.0839 1 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0648 0.0628
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0155 0.174 0.167
Onchocerca volvulus 0.0839 1 1
Onchocerca volvulus Cathepsin F homolog 0.0839 1 1
Brugia malayi mbt repeat family protein 0.0048 0.0456 0.0418
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0155 0.174 0.1708
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0051 0.0482 0.0401
Loa Loa (eye worm) hypothetical protein 0.0155 0.174 0.174
Plasmodium vivax plasmepsin IV, putative 0.0059 0.0583 0.0546
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0155 0.174 0.2863
Entamoeba histolytica methionine aminopeptidase, putative 0.0051 0.0482 0.0161
Entamoeba histolytica cysteine proteinase, putative 0.0432 0.5089 0.4923
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Loa Loa (eye worm) hypothetical protein 0.0277 0.3219 0.3219
Schistosoma mansoni lamin 0.0059 0.0583 0.0563
Mycobacterium ulcerans NAD-dependent deacetylase 0.0096 0.1034 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.174 0.1322
Plasmodium vivax SET domain protein, putative 0.0035 0.0298 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.2195 0.2178
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0206 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0839 1 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0375 0.4394 0.4347
Echinococcus granulosus histone deacetylase 7 0.0018 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0155 0.174 0.1322
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0155 0.174 0.2863
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0537 0.0537
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0059 0.0583 0.0583
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.0084 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0432 0.5089 0.5047
Echinococcus multilocularis cpg binding protein 0.0032 0.026 0.026
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0096 0.1034 0.0958
Giardia lamblia Cathepsin L precursor 0.0155 0.174 0.2863
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0155 0.174 0.1708
Loa Loa (eye worm) ctsf protein 0.0839 1 1
Plasmodium vivax methionine aminopeptidase 2, putative 0.0051 0.0482 0.0445
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0155 0.174 0.1708
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1309 0.1309
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.174 0.1722
Echinococcus granulosus cathepsin b 0.0155 0.174 0.174
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0155 0.174 0.167
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0155 0.174 0.1708
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0039 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0923 0.0923
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0155 0.174 0.1461
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0155 0.174 0.1722
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0252 0.0252
Echinococcus multilocularis cathepsin L 0.0155 0.174 0.174
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0456 0.0456
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0155 0.174 0.1708
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0206 0.0124
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0238 0.2741 0.2741
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0839 1 1
Brugia malayi Pre-SET motif family protein 0.0035 0.0298 0.026
Onchocerca volvulus 0.0839 1 1
Echinococcus granulosus histone deacetylase 1 0.0062 0.0618 0.0618
Giardia lamblia Cathepsin B precursor 0.0155 0.174 0.2863
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Schistosoma mansoni memapsin-2 (A01 family) 0.0014 0.0039 0.0018
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0618 0.0143
Brugia malayi Cathepsin L-like precursor 0.0839 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0028 0.0206 0.0206
Echinococcus multilocularis chromatin regulatory protein sir2 0.0375 0.4394 0.4394
Leishmania major cathepsin L-like protease 0.0839 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0039 0.0018
Echinococcus multilocularis histone deacetylase 3 0.0062 0.0618 0.0618
Schistosoma mansoni histone deacetylase hda2 0.0018 0.0084 0.0063
Schistosoma mansoni cathepsin F (C01 family) 0.0561 0.6651 0.6644
Leishmania major methionine aminopeptidase 2, putative 0.0051 0.0482 0.0401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.174 0.1322
Schistosoma mansoni hypothetical protein 0.0016 0.0064 0.0043
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0414 0.4876 0.4616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0839 1 1
Plasmodium falciparum serine repeat antigen 8 0.0155 0.174 0.1708
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Giardia lamblia Sirtuin type 2 0.0096 0.1034 0.1256
Echinococcus multilocularis cysteine protease 0.0839 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.174 0.1322
Onchocerca volvulus 0.0561 0.6651 0.6638
Loa Loa (eye worm) RNA binding protein 0.0064 0.0648 0.0648
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0618 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0155 0.174 0.1322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0155 0.174 0.1708
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0064 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.2195 0.2195
Echinococcus granulosus cathepsin L 0.0432 0.5089 0.5089
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0064 0.0064
Echinococcus granulosus histone deacetylase 0.0018 0.0084 0.0084
Onchocerca volvulus Cathepsin L homolog 0.0155 0.174 0.1708
Giardia lamblia Transcriptional regulator, Sir2 family 0.0096 0.1034 0.1256
Loa Loa (eye worm) cathepsin B 0.0155 0.174 0.174
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0667 0.0648
Brugia malayi histone deacetylase 11 0.0018 0.0084 0.0045
Brugia malayi cathepsin Z-like cysteine proteinase 0.0155 0.174 0.1708
Trypanosoma cruzi histone deacetylase 1, putative 0.0062 0.0618 0.0539
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0051 0.0482 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0289 0.0251
Trypanosoma brucei SIR2-like protein 4, putative 0.0096 0.1034 0.0958
Brugia malayi cathepsin F-like cysteine proteinase 0.0155 0.174 0.1708
Echinococcus granulosus methionyl aminopeptidase 2 0.0051 0.0482 0.0482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0155 0.174 0.1722
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0155 0.174 0.1322
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0648 0.0648
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0482 0.0445
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0537 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.174 0.1322
Loa Loa (eye worm) hypothetical protein 0.0561 0.6651 0.6651
Onchocerca volvulus 0.0839 1 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0432 0.5089 0.5069
Brugia malayi hypothetical protein 0.0275 0.3194 0.3167
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0064 0.0025
Schistosoma mansoni hypothetical protein 0.0016 0.0064 0.0043
Giardia lamblia Cathepsin L-like protease 0.0155 0.174 0.2863
Trypanosoma cruzi cruzipain precursor, putative 0.0839 1 1
Echinococcus granulosus histone deacetylase 3 0.0062 0.0618 0.0618
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.2195 0.2178
Plasmodium falciparum serine repeat antigen 9 0.0155 0.174 0.1708
Brugia malayi NAD-dependent deacetylase SIRT1 0.0414 0.4876 0.4855
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Entamoeba histolytica cysteine proteinase, putative 0.0839 1 1
Onchocerca volvulus 0.0059 0.0583 0.0546
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0096 0.1034 0.1034
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Schistosoma mansoni hypothetical protein 0.0016 0.0064 0.0043
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0039
Leishmania major cathepsin L-like protease 0.0839 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0561 0.6651 0.6538
Schistosoma mansoni lamin 0.0059 0.0583 0.0563
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.2195 0.2195
Toxoplasma gondii cathepsin B 0.0155 0.174 0.1708
Brugia malayi histone deacetylase 1 (HD1) 0.0062 0.0618 0.0581
Leishmania major cysteine peptidase A (CPA) 0.0839 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0648 0.0611
Loa Loa (eye worm) hypothetical protein 0.0155 0.174 0.174
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0839 1 1
Leishmania major hypothetical protein, conserved 0.0028 0.0206 0.0124
Schistosoma mansoni cathepsin D (A01 family) 0.0174 0.1971 0.1954
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0583 0.0583
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.2195 0.2195
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0432 0.5089 0.5078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0839 1 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0155 0.174 0.1708
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0155 0.174 0.1722
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0039 0.0018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0414 0.4876 0.4616
Onchocerca volvulus 0.0031 0.0239 0.0201
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.2195 0.2195
Loa Loa (eye worm) transcriptional regulator 0.0096 0.1034 0.1034
Schistosoma mansoni histone deacetylase hda2 0.0018 0.0084 0.0063
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0456 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.0289 0.0268
Loa Loa (eye worm) hypothetical protein 0.0318 0.3712 0.3712
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.174 0.1708
Giardia lamblia Cathepsin B precursor 0.0155 0.174 0.2863
Toxoplasma gondii cathepsin CPL 0.0839 1 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0096 0.1034 0.1034
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0155 0.174 0.1708
Loa Loa (eye worm) hypothetical protein 0.0059 0.0583 0.0583
Echinococcus granulosus lamin 0.0059 0.0583 0.0583
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0375 0.4394 0.4347
Onchocerca volvulus 0.0035 0.0298 0.026
Brugia malayi Papain family cysteine protease containing protein 0.0432 0.5089 0.5069
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0375 0.4394 0.4394
Echinococcus multilocularis cathepsin L cysteine protease 0.0839 1 1
Plasmodium falciparum plasmepsin IV 0.0059 0.0583 0.0546
Echinococcus multilocularis histone deacetylase 0.0018 0.0084 0.0084
Echinococcus granulosus neuropeptide receptor A26 0.0474 0.5592 0.5592
Toxoplasma gondii histone deacetylase HDAC3 0.0062 0.0618 0.0581
Entamoeba histolytica cysteine protease, putative 0.0432 0.5089 0.4923
Onchocerca volvulus 0.0839 1 1
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0096 0.1034 0.0731
Toxoplasma gondii histone deacetylase SIR2 0.0096 0.1034 0.0999
Echinococcus multilocularis musashi 0.0059 0.0583 0.0583
Trypanosoma cruzi histone deacetylase 1, putative 0.0062 0.0618 0.0539
Loa Loa (eye worm) fibroinase 0.0839 1 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0014 0.0039 0.0039
Echinococcus multilocularis neuropeptide s receptor 0.0474 0.5592 0.5592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0432 0.5089 0.484
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0039 0.0018
Onchocerca volvulus 0.0155 0.174 0.1708
Entamoeba histolytica cysteine protease, putative 0.0155 0.174 0.1461
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0039 0.0018
Plasmodium vivax serine-repeat antigen (SERA) 0.0155 0.174 0.1708
Plasmodium falciparum serine repeat antigen 3 0.0155 0.174 0.1708
Loa Loa (eye worm) hypothetical protein 0.0277 0.3219 0.3219
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0155 0.174 0.1722
Echinococcus granulosus cathepsin L 0.0155 0.174 0.174
Plasmodium falciparum serine repeat antigen 7 0.0155 0.174 0.1708
Trypanosoma cruzi cysteine protease, putative 0.0432 0.5089 0.5047
Brugia malayi hypothetical protein 0.0087 0.0923 0.0887
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0432 0.5089 0.4923
Echinococcus multilocularis survival motor neuron protein 1 0.0275 0.3194 0.3194
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0155 0.174 0.1322
Giardia lamblia Hypothetical protein 0.0155 0.174 0.2863
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0275 0.0275
Plasmodium vivax unspecified product 0.0155 0.174 0.1708
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0155 0.174 0.1722
Loa Loa (eye worm) hypothetical protein 0.0027 0.0201 0.0201
Echinococcus granulosus intermediate filament protein 0.0059 0.0583 0.0583
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0537 0.0537
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0414 0.4876 0.4876
Entamoeba histolytica cysteine protease, putative 0.0839 1 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0062 0.0618 0.0143
Entamoeba histolytica cysteine proteinase, putative 0.0839 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0414 0.4876 0.4616
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0277 0.3219 0.3219
Loa Loa (eye worm) hypothetical protein 0.0839 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0839 1 1
Schistosoma mansoni cathepsin s 0.0277 0.3219 0.3205
Echinococcus granulosus cathepsin l1 0.0839 1 1
Onchocerca volvulus Cathepsin L homolog 0.0839 1 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0014 0.0039 0.0018
Echinococcus granulosus cathepsin l1 0.0561 0.6651 0.6651
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0062 0.0618 0.0143
Loa Loa (eye worm) aspartyl protease 6 0.0014 0.0039 0.0039
Trypanosoma brucei histone deacetylase 1 0.0062 0.0618 0.0539
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0414 0.4876 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0648 0.0648
Entamoeba histolytica cysteine protease, putative 0.0155 0.174 0.1461
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0298 0.0298
Plasmodium vivax histone deacetylase, putative 0.0018 0.0084 0.0045
Onchocerca volvulus 0.0839 1 1
Giardia lamblia Cysteine protease 0.0155 0.174 0.2863
Leishmania major cathepsin L-like protease 0.0839 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0839 1 1
Plasmodium vivax vivapain-1 0.0432 0.5089 0.5069
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0096 0.1034 0.058
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0326 0.0306
Brugia malayi transcriptional regulator, Sir2 family protein 0.0375 0.4394 0.4372
Plasmodium falciparum serine repeat antigen 2 0.0155 0.174 0.1708
Brugia malayi cathepsin L-like precursor 0.0561 0.6651 0.6638
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0096 0.1034 0.058
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0084 0.0084
Schistosoma mansoni chromatin regulatory protein sir2 0.0375 0.4394 0.4382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0839 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0537 0.0537
Giardia lamblia Cathepsin L precursor 0.0155 0.174 0.2863
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0375 0.4394 0.4347
Onchocerca volvulus 0.0056 0.0548 0.0511
Loa Loa (eye worm) hypothetical protein 0.0058 0.057 0.057

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.2 nM Inhibition of human plasma renin at pH 6 ChEMBL. 2184238

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.