Detailed information for compound 34489

Basic information

Technical information
  • TDR Targets ID: 34489
  • Name: 2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propy l]isoindole-1,3-dione
  • MW: 379.452 | Formula: C22H25N3O3
  • H donors: 0 H acceptors: 2 LogP: 2.86 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)CCCN1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C22H25N3O3/c1-28-20-10-5-4-9-19(20)24-15-13-23(14-16-24)11-6-12-25-21(26)17-7-2-3-8-18(17)22(25)27/h2-5,7-10H,6,11-16H2,1H3
  • InChiKey: MDQWSMFPLDSLBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]isoindoline-1,3-dione
  • 2-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]isoindoline-1,3-dione
  • 2-[3-[4-(2-methoxyphenyl)piperazino]propyl]isoindoline-1,3-quinone
  • 2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]isoindoline-1,3-quinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL No references
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni regulator of G protein signaling 0.0066 0.0191 0.0409
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0057 0.0138
Echinococcus multilocularis g protein coupled receptor 0.0613 0.2224 0.2224
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0066 0.0191 0.0402
Onchocerca volvulus 0.0035 0.0076 0.0339
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0075 0.018
Brugia malayi GnHR receptor homolog 0.0613 0.2224 0.3693
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0044 0.0076
Giardia lamblia Grp94/Hsp90 0.0035 0.0074 0.0282
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0072 0.0211 0.0211
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0069 0.0145
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.1094 0.4015 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0096
Echinococcus multilocularis regulator of G protein signaling 3 0.0066 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0072 0.0211 0.0451
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.1094 0.4015 1
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0009 0.0016
Leishmania major C-8 sterol isomerase-like protein 0.043 0.1542 0.3821
Loa Loa (eye worm) AGC/PKN protein kinase 0.0072 0.0211 0.035
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0389 0.1392 0.2311
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0076 0.0228 0.0378
Echinococcus multilocularis neuropeptides capa receptor 0.0613 0.2224 0.2224
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0075 0.0121
Schistosoma mansoni intermediate filament proteins 0.003 0.0057 0.0122
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0054 0.0144 0.0239
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0049 0.0128 0.0287
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0613 0.2224 0.4761
Toxoplasma gondii heat shock protein HSP90 0.003 0.0057 0.0138
Schistosoma mansoni serine/threonine protein kinase 0.0476 0.1713 0.3667
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0054 0.0144 0.0355
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0476 0.1713 0.4264
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0022 0.0027 0.0027
Trypanosoma cruzi C-8 sterol isomerase, putative 0.043 0.1542 0.3838
Loa Loa (eye worm) hypothetical protein 0.0373 0.133 0.2208
Echinococcus multilocularis serotonin receptor 0.076 0.2771 0.2771
Brugia malayi Hsp90 protein 0.002 0.0019 0.0032
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0051 0.0133 0.0327
Brugia malayi Calcitonin receptor-like protein seb-1 0.0227 0.0787 0.1307
Brugia malayi SET domain containing protein 0.0017 0.0006 0.001
Entamoeba histolytica hypothetical protein 0.0042 0.0101 0.0253
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0476 0.1713 0.4265
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Echinococcus multilocularis N chimaerin 0.003 0.0055 0.0055
Schistosoma mansoni protein arginine N-methyltransferase 1 0.009 0.028 0.0599
Echinococcus granulosus axis inhibition protein axin 0.0066 0.0191 0.0402
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0035 0.0074 0.9824
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.0202 0.0425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0075 0.0181
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0022 0.0027 0.0045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0613 0.2224 0.2224
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0231 0.0804 0.1975
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0379 0.0938
Loa Loa (eye worm) hypothetical protein 0.0045 0.0111 0.0183
Treponema pallidum heat shock protein 90 0.0035 0.0074 0.9883
Brugia malayi hypothetical protein 0.0613 0.2224 0.3693
Echinococcus granulosus low density lipoprotein receptor ldl 0.0022 0.0027 0.0057
Loa Loa (eye worm) heterochromatin protein 1 0.0082 0.0249 0.0413
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Schistosoma mansoni opsin-like receptor 0.0613 0.2224 0.4761
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0103
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0613 0.2224 0.4677
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Entamoeba histolytica protein kinase, putative 0.0113 0.0364 0.0906
Echinococcus granulosus high affinity choline transporter 1 0.0405 0.1453 0.3054
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0054 0.0144 0.0144
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0057 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0613 0.2224 0.4761
Schistosoma mansoni chromobox protein 0.0082 0.0249 0.0532
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.003 0.0055 0.0055
Echinococcus granulosus adenosylhomocysteinase 0.1094 0.4015 0.844
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0054 0.0144 0.036
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0103
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0041 0.0097 0.0097
Onchocerca volvulus 0.0022 0.0027 0.0122
Loa Loa (eye worm) RNA binding protein 0.0189 0.0649 0.1077
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0094 0.0201
Echinococcus granulosus low density lipoprotein receptor ldl 0.0022 0.0027 0.0057
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0091 0.0195
Brugia malayi Bloom's syndrome protein homolog 0.0074 0.0219 0.0364
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0051 0.0133 0.0327
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0054 0.0144 0.0239
Brugia malayi PXA domain containing protein 0.0066 0.0191 0.0318
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0013 0.0033
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0094 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0094 0.0201
Brugia malayi Protein kinase domain containing protein 0.0039 0.0091 0.0151
Loa Loa (eye worm) latrophilin receptor protein 2 0.0072 0.0211 0.035
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0049 0.0128 0.0314
Loa Loa (eye worm) hypothetical protein 0.0036 0.0078 0.0129
Brugia malayi RNA binding protein 0.0189 0.0649 0.1077
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0094 0.0228
Brugia malayi Adenosylhomocysteinase 0.1094 0.4015 0.6665
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.002 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.043 0.1542 0.256
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0181 0.0447
Brugia malayi G-protein coupled receptor 0.0613 0.2224 0.3693
Brugia malayi hypothetical protein 0.0613 0.2224 0.3693
Brugia malayi Protein kinase c protein 2 0.0239 0.0834 0.1385
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0094 0.0201
Toxoplasma gondii exonuclease III APE 0.0022 0.0026 0.0061
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0062 0.0175 0.043
Trypanosoma brucei heat shock protein, putative 0.003 0.0057 0.011
Onchocerca volvulus 0.0022 0.0027 0.0122
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0613 0.2224 0.4761
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0075 0.0121
Brugia malayi glutathione reductase 0.0101 0.0321 0.0533
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0022 0.0027 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0379 0.0938
Echinococcus granulosus Protein kinase C brain isozyme 0.0301 0.1065 0.2238
Loa Loa (eye worm) RecQ helicase 0.0074 0.0219 0.0364
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0649 0.1389
Entamoeba histolytica hypothetical protein 0.003 0.0055 0.0136
Loa Loa (eye worm) hypothetical protein 0.0141 0.0469 0.0779
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Trypanosoma brucei heat shock protein 90, putative 0.003 0.0057 0.011
Entamoeba histolytica diacylglycerol kinase, putative 0.003 0.0055 0.0136
Echinococcus multilocularis axis inhibition protein axin 0.0066 0.0191 0.0191
Brugia malayi neuropeptide F receptor 0.0613 0.2224 0.3693
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0009 0.0016
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0076 0.0228 0.0378
Entamoeba histolytica hypothetical protein 0.0042 0.0101 0.0253
Onchocerca volvulus 0.0032 0.0064 0.0289
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0054 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0613 0.2224 0.4761
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0054 0.0144 0.0355
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0613 0.2224 0.4761
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Schistosoma mansoni protein arginine n-methyltransferase 0.0051 0.0133 0.0285
Brugia malayi MAP kinase sur-1 0.0128 0.042 0.0697
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0075 0.0287
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0091 0.0194
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0013
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0051 0.0133 0.0326
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0026 0.0061
Trypanosoma brucei rac serine-threonine kinase, putative 0.0117 0.0379 0.0913
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0091
Plasmodium vivax heat shock protein, putative 0.002 0.0019 0.0048
Trypanosoma brucei heat shock protein 90, putative 0.003 0.0057 0.011
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0031 0.0058 0.0138
Brugia malayi basement membrane proteoglycan precursor 0.0022 0.0027 0.0045
Brugia malayi Tachykinin-like peptides receptor 99D 0.0613 0.2224 0.3693
Schistosoma mansoni serine/threonine protein kinase 0.0301 0.1065 0.2279
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0027 0.0045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0227 0.0787 0.1307
Schistosoma mansoni regulator of G protein signaling 0.0066 0.0191 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0649 0.1389
Schistosoma mansoni alpha-1 adrenergic receptor 0.0613 0.2224 0.4761
Echinococcus multilocularis calcium dependent protein kinase 0.0044 0.0108 0.0108
Schistosoma mansoni atypical protein kinase C 0.0101 0.0321 0.0688
Brugia malayi CXXC zinc finger family protein 0.0032 0.0064 0.0107
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0476 0.1713 0.3602
Brugia malayi Protein kinase domain containing protein 0.143 0.5265 0.8741
Schistosoma mansoni rac gtpase activating protein 0.003 0.0055 0.0117
Trichomonas vaginalis DNA helicase recq1, putative 0.0074 0.0219 0.0541
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.0649 0.1077
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0039 0.0091 0.0151
Schistosoma mansoni smad 0.0034 0.0069 0.0148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0613 0.2224 0.4761
Onchocerca volvulus 0.0613 0.2224 1
Brugia malayi MH2 domain containing protein 0.0034 0.0069 0.0115
Schistosoma mansoni opsin-like receptor 0.0613 0.2224 0.4761
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0013 0.0013
Echinococcus granulosus dna polymerase kappa 0.004 0.0094 0.0197
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0072 0.0211 0.0443
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0035 0.0074 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.042 0.1041
Echinococcus multilocularis axis inhibition protein axin 0.0066 0.0191 0.0191
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.005 0.013 0.0325
Trypanosoma brucei heat shock protein, putative 0.003 0.0057 0.011
Echinococcus granulosus sodium:glucose cotransporter 2 0.0045 0.0111 0.0232
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0026 0.0044
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0318
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0045 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.003 0.0055 0.0117
Brugia malayi Carm1-pending protein 0.0051 0.0133 0.0221
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0101 0.0213
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0022 0.0027 0.0058
Toxoplasma gondii heat shock protein 75, putative 0.002 0.0019 0.0042
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0045 0.0111 0.0232
Entamoeba histolytica protein kinase, putative 0.0016 0.0003 0.0008
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.009 0.028 0.0698
Entamoeba histolytica adenosylhomocysteinase, putative 0.1094 0.4015 1
Schistosoma mansoni protein kinase 0.0054 0.0144 0.0309
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0476 0.1713 0.3602
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0613 0.2224 0.4761
Toxoplasma gondii hypothetical protein 0.0049 0.0128 0.0314
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Onchocerca volvulus 0.0545 0.1973 0.8869
Onchocerca volvulus Arrow homolog 0.0022 0.0027 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0613 0.2224 0.2224
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0094 0.0201
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0318
Echinococcus multilocularis g protein coupled receptor 0.0613 0.2224 0.2224
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0045 0.0111 0.0111
Trypanosoma brucei heat shock protein 84, putative 0.002 0.0019 0.0014
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0893 0.3266 0.6867
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0128 0.042 0.1042
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0094 0.0201
Echinococcus multilocularis protein kinase c epsilon type 0.0108 0.0344 0.0344
Brugia malayi Calcium binding EGF domain containing protein 0.0022 0.0027 0.0045
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.026 0.0911 0.2264
Schistosoma mansoni amine GPCR 0.0613 0.2224 0.4761
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.0202 0.0202
Schistosoma mansoni neuropeptide receptor 0.0613 0.2224 0.4761
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0049 0.0128 0.0314
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Echinococcus granulosus endoplasmin 0.0035 0.0074 0.0155
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0013 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.0613 0.2224 0.2224
Echinococcus multilocularis rhodopsin orphan GPCR 0.0613 0.2224 0.2224
Loa Loa (eye worm) hypothetical protein 0.0227 0.0787 0.1307
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0021 0.0047
Brugia malayi Melatonin receptor type 1A 0.0613 0.2224 0.3693
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0022 0.0027 0.0058
Schistosoma mansoni neuropeptide F-like receptor 0.0613 0.2224 0.4761
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0476 0.1713 0.1713
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0031 0.0058 0.0121
Echinococcus granulosus rhodopsin orphan GPCR 0.0613 0.2224 0.4677
Echinococcus multilocularis GPCR, family 2 0.0072 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Brugia malayi Pleckstrin Homology Domain 0.0034 0.007 0.0116
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0613 0.2224 0.2224
Echinococcus multilocularis nervana 2 0.0041 0.0097 0.0097
Brugia malayi ORL1-like opioid receptor 0.0613 0.2224 0.3693
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0064 0.0107
Trichomonas vaginalis adenosylhomocysteinase, putative 0.1094 0.4015 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0094 0.0201
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0057 0.0183
Echinococcus granulosus single minded 2 0.0035 0.0076 0.0159
Schistosoma mansoni serine/threonine-protein kinase 0.0055 0.0148 0.0317
Trypanosoma brucei unspecified product 0.004 0.0094 0.0201
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0058 0.0139
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Loa Loa (eye worm) hypothetical protein 0.016 0.054 0.0896
Brugia malayi Smad1 0.0034 0.0069 0.0115
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0613 0.2224 0.4761
Echinococcus granulosus mitogen activated protein kinase 0.0128 0.042 0.0883
Echinococcus granulosus basement membrane specific heparan sulfate 0.0022 0.0027 0.0057
Plasmodium vivax thioredoxin reductase, putative 0.0101 0.0321 0.08
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0613 0.2224 0.4761
Echinococcus multilocularis regulator of G protein signaling 3 0.0066 0.0191 0.0191
Echinococcus granulosus peptide allatostatin:somatostatin 0.0613 0.2224 0.4677
Echinococcus granulosus g protein coupled receptor 0.0613 0.2224 0.4677
Schistosoma mansoni hypothetical protein 0.0022 0.0027 0.0058
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0026 0.0066
Echinococcus granulosus nervana 2 0.0041 0.0097 0.0203
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0027 0.0045
Schistosoma mansoni hypothetical protein 0.1271 0.4673 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0128 0.042 0.1042
Plasmodium vivax endoplasmin, putative 0.003 0.0057 0.0143
Toxoplasma gondii Hsp90 domain-containing protein 0.002 0.0019 0.0042
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0013 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0613 0.2224 0.4761
Loa Loa (eye worm) G-protein coupled receptor 0.0613 0.2224 0.3693
Schistosoma mansoni protein arginine N-methyltransferase 1 0.009 0.028 0.0599
Schistosoma mansoni neuropeptide f receptor 76f 0.0613 0.2224 0.4761
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0534 0.1929 0.4056
Echinococcus multilocularis protein arginine methyltransferase 0.009 0.028 0.028
Schistosoma mansoni hypothetical protein 0.0155 0.0521 0.1114
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0613 0.2224 0.3693
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0128 0.0313
Echinococcus granulosus cpg binding protein 0.0034 0.0071 0.015
Brugia malayi larval opioid receptor 0.0613 0.2224 0.3693
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0075 0.0181
Echinococcus granulosus intermediate filament protein 0.003 0.0057 0.012
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0091
Schistosoma mansoni hypothetical protein 0.0072 0.0211 0.0451
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0057 0.0138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0075 0.0181
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0128 0.042 0.1042
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0091
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0022 0.0027 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0094 0.0201
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0021 0.0047
Schistosoma mansoni z-protein (S1r protein) 0.0066 0.0191 0.0409
Schistosoma mansoni amine GPCR 0.0613 0.2224 0.4761
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.0649 0.1077
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0142 0.0471 0.099
Schistosoma mansoni smad1 5 8 and 0.0034 0.0069 0.0148
Trypanosoma brucei unspecified product 0.0028 0.0047 0.0085
Echinococcus granulosus basement membrane specific heparan sulfate 0.0022 0.0027 0.0057
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0054 0.0144 0.0303
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0075 0.0154
Schistosoma mansoni myosin xvIII 0.0613 0.2224 0.4761
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0005 0.0008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0257 0.09 0.2215
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0026 0.0061
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0021 0.0047
Echinococcus multilocularis histone h3 methyltransferase 0.0389 0.1392 0.1392
Brugia malayi hypothetical protein 0.0613 0.2224 0.3693
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0026 0.0033
Echinococcus multilocularis regulator of G protein signaling 7 0.0066 0.0191 0.0191
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0072 0.0211 0.0211
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0054 0.0144 0.0303
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0072 0.0211 0.035
Onchocerca volvulus 0.0613 0.2224 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0066 0.0191 0.0409
Brugia malayi Variant SH3 domain containing protein 0.003 0.0055 0.0091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0613 0.2224 0.2224
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0051 0.0133 0.0327
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0013 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0069 0.0202 0.0202
Plasmodium falciparum protein arginine N-methyltransferase 1 0.009 0.028 0.0692
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0095
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0094 0.0201
Echinococcus granulosus expressed protein 0.1294 0.4757 1
Entamoeba histolytica hypothetical protein 0.0066 0.0191 0.0477
Schistosoma mansoni adenosylhomocysteinase 0.0677 0.2463 0.5271
Entamoeba histolytica PH domain containing protein kinase, putative 0.048 0.1729 0.4306
Echinococcus granulosus Rac GTPase activating protein 1 0.003 0.0055 0.0115
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0072 0.0211 0.0443
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0039 0.0091 0.0151
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0227 0.0787 0.1307
Loa Loa (eye worm) G-protein coupled receptor 0.0613 0.2224 0.3693
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0094 0.0156
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0101 0.0101
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0094 0.0229
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0466 0.1677 0.1677
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0022 0.0027 0.0027
Schistosoma mansoni diacylglycerol kinase theta 0.003 0.0055 0.0117
Echinococcus granulosus orexin receptor type 2 0.0613 0.2224 0.4677
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0065 0.0186 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0211 0.0451
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0075 0.016
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0022 0.0027 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0144 0.0309
Echinococcus granulosus unc 13 munc13 0.0036 0.0078 0.0163
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Trichomonas vaginalis adenosylhomocysteinase, putative 0.1094 0.4015 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0128 0.042 0.1017
Loa Loa (eye worm) hypothetical protein 0.0405 0.1453 0.2411
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0072 0.0211 0.0443
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0613 0.2224 0.2224
Onchocerca volvulus 0.0045 0.0111 0.0497
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0002 0.0004
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0045 0.0111 0.0111
Echinococcus multilocularis fmrfamide receptor 0.0613 0.2224 0.2224
Schistosoma mansoni regulator of G protein signaling 0.0066 0.0191 0.0409
Schistosoma mansoni thyroid hormone receptor 0.0153 0.0513 0.1098
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0022 0.0027 0.0027
Onchocerca volvulus 0.0613 0.2224 1
Leishmania major heat shock protein, putative 0.002 0.0019 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0022
Trypanosoma brucei heat shock protein, putative 0.003 0.0057 0.011
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0051 0.0133 0.0133
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0128 0.042 0.1042
Echinococcus granulosus g protein coupled receptor 0.0613 0.2224 0.4677
Schistosoma mansoni heat shock protein 0.003 0.0057 0.0123
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0026 0.006
Brugia malayi MH1 domain containing protein 0.0034 0.0069 0.0115
Brugia malayi intermediate filament protein 0.003 0.0057 0.0095
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0094 0.0094
Echinococcus multilocularis heat shock protein 0.003 0.0057 0.0057
Entamoeba histolytica hypothetical protein 0.0042 0.0101 0.0253
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0069 0.0202 0.0499
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0013 0.0028
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Onchocerca volvulus 0.0036 0.0078 0.0349
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0001 0.0002
Schistosoma mansoni unc-13 (munc13) 0.0036 0.0078 0.0166
Echinococcus multilocularis somatostatin receptor 0.0613 0.2224 0.2224
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0534 0.1929 0.4788
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0318
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0007 0.0011
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0054 0.0144 0.036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0021 0.0047
Toxoplasma gondii AGC kinase 0.0113 0.0364 0.0901
Loa Loa (eye worm) hypothetical protein 0.0069 0.0202 0.0336
Schistosoma mansoni single-minded 0.0048 0.0122 0.026
Brugia malayi MH2 domain containing protein 0.0493 0.1778 0.2951
Trichomonas vaginalis heat shock protein, putative 0.003 0.0057 0.0137
Trypanosoma cruzi trypanothione reductase, putative 0.0101 0.0321 0.0795
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0066 0.0191 0.0409
Loa Loa (eye worm) hypothetical protein 0.0072 0.0211 0.035
Schistosoma mansoni biogenic amine receptor 0.0613 0.2224 0.4761
Brugia malayi heat shock protein 90 0.003 0.0057 0.0095
Echinococcus granulosus 7TM GPCR rhodopsin 0.0613 0.2224 0.4677
Brugia malayi hypothetical protein 0.0143 0.0476 0.079
Trypanosoma brucei heat shock protein, putative 0.003 0.0057 0.011
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Loa Loa (eye worm) AGC/PKA protein kinase 0.0476 0.1713 0.2844
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0094 0.0201
Brugia malayi protein kinase C3,putative 0.0039 0.0091 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.0466 0.1679 0.3593
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0613 0.2224 0.2224
Echinococcus multilocularis neuropeptides capa receptor 0.0613 0.2224 0.2224
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0039 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0115 0.028
Entamoeba histolytica PH domain containing protein kinase, putative 0.048 0.1729 0.4306
Echinococcus granulosus smad 0.0034 0.0069 0.0145
Echinococcus multilocularis tar DNA binding protein 0.0189 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Loa Loa (eye worm) neuropeptide F receptor 0.0613 0.2224 0.3693
Echinococcus multilocularis thioredoxin glutathione reductase 0.0101 0.0321 0.0321
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0069 0.0115
Giardia lamblia DINP protein human, muc B family 0.004 0.0094 0.04
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Echinococcus multilocularis raf serine:threonine protein kinase 0.003 0.0055 0.0055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0026 0.0066
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0613 0.2224 0.3693
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0094 0.0169
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0076 0.0125
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0094 0.0229
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0072 0.0211 0.0211
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0113 0.0364 0.0603
Echinococcus granulosus protein kinase C gamma type 0.0272 0.0954 0.2006
Loa Loa (eye worm) Smad1 0.0034 0.0069 0.0115
Onchocerca volvulus 0.003 0.0055 0.0245
Schistosoma mansoni heat shock protein 0.003 0.0057 0.0123
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0091
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0249 0.0614
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0065 0.0156
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0076 0.0076
Brugia malayi Endoplasmin precursor 0.003 0.0057 0.0095
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0069 0.0069
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0141 0.0469 0.1169
Brugia malayi RhoGAP domain containing protein 0.003 0.0055 0.0091
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0035 0.0074 0.0152
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0075 0.0154
Schistosoma mansoni endoplasmin 0.003 0.0057 0.0123
Schistosoma mansoni smad1 5 8 and 0.0034 0.0069 0.0148
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0613 0.2224 0.4677
Entamoeba histolytica diacylglycerol kinase, putative 0.003 0.0055 0.0136
Schistosoma mansoni biogenic amine receptor 0.0613 0.2224 0.4761
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0091
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0476 0.1713 0.4249
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Schistosoma mansoni hypothetical protein 0.0142 0.0471 0.1008
Echinococcus multilocularis cpg binding protein 0.0034 0.0071 0.0071
Echinococcus multilocularis Regulator of G protein signaling 20 0.0066 0.0191 0.0191
Brugia malayi Hr1 repeat family protein 0.0072 0.0211 0.035
Schistosoma mansoni hypothetical protein 0.1271 0.4673 1
Echinococcus granulosus allatostatin A receptor 0.0613 0.2224 0.4677
Echinococcus granulosus low density lipoprotein receptor protein 0.0022 0.0027 0.0057
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0476 0.1713 0.4265
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0344 0.0737
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0057 0.0138
Onchocerca volvulus 0.0613 0.2224 1
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0091 0.0194
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0613 0.2224 0.3693
Brugia malayi RhoGEF domain containing protein 0.003 0.0055 0.0091
Loa Loa (eye worm) hypothetical protein 0.004 0.0094 0.0156
Brugia malayi putative neuropeptide receptor NPR1 0.0613 0.2224 0.3693
Brugia malayi G-protein coupled receptor 0.0613 0.2224 0.3693
Echinococcus multilocularis fmrfamide receptor 0.0613 0.2224 0.2224
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0094 0.0229
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0075 0.0187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0021 0.0047
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0075 0.0154
Schistosoma mansoni cpg binding protein 0.0034 0.0071 0.0152
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0022 0.0027 0.0027
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0054 0.0144 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0065 0.0156
Echinococcus granulosus protein arginine N methyltransferase 7 0.0051 0.0133 0.028
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0104
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0091
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Echinococcus granulosus hypothetical protein 0.0613 0.2224 0.4677
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Echinococcus granulosus heat shock protein 90 0.003 0.0057 0.012
Loa Loa (eye worm) MH2 domain-containing protein 0.0493 0.1778 0.2951
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0613 0.2224 0.4761
Loa Loa (eye worm) hypothetical protein 0.076 0.2771 0.4601
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0613 0.2224 0.4761
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0476 0.1713 0.1713
Trypanosoma brucei C-8 sterol isomerase, putative 0.043 0.1542 0.3821
Echinococcus granulosus tm gpcr rhodopsin 0.0613 0.2224 0.4677
Trypanosoma brucei heat shock protein, putative 0.003 0.0057 0.011
Echinococcus granulosus Glutaredoxin protein 5 0.0041 0.0097 0.0203
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0075 0.0157
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0075 0.0187
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0013
Schistosoma mansoni amine GPCR 0.0613 0.2224 0.4761
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0613 0.2224 0.4761
Schistosoma mansoni inositol transporter 0.0045 0.0111 0.0237
Toxoplasma gondii AGC kinase 0.0476 0.1713 0.4265
Loa Loa (eye worm) RasGEF domain-containing protein 0.003 0.0055 0.0091
Schistosoma mansoni ap endonuclease 0.0022 0.0026 0.0056
Onchocerca volvulus 0.0613 0.2224 1
Brugia malayi isocitrate dehydrogenase 0.0019 0.0013 0.0022
Leishmania major protein kinase A catalytic subunit 0.0476 0.1713 0.4249
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0075 0.018
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0022 0.0027 0.0045
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0094 0.0156
Echinococcus granulosus g protein coupled receptor 0.0613 0.2224 0.4677
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0076 0.0123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0021 0.0047
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.1094 0.4015 1
Echinococcus multilocularis lamin dm0 0.003 0.0057 0.0057
Echinococcus granulosus regulator of G protein signaling 3 0.0066 0.0191 0.0402
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0072 0.0211 0.035
Echinococcus multilocularis g protein coupled receptor 0.0613 0.2224 0.2224
Echinococcus granulosus sodium:glucose cotransporter 0.0045 0.0111 0.0232
Mycobacterium tuberculosis Probable oxidoreductase 0.0257 0.09 0.2215
Plasmodium falciparum calcium-dependent protein kinase 2 0.0054 0.0144 0.0354
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0191 0.0471
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0613 0.2224 0.4761
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0379 0.0938
Echinococcus granulosus 7tm_1 domain containing protein 0.0613 0.2224 0.4677
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0026 0.0055
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0094 0.0156
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0075 0.0154
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0051 0.0133 0.0133
Echinococcus granulosus heat shock protein 0.003 0.0057 0.012
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0211 0.0451
Toxoplasma gondii heat shock protein 90, putative 0.003 0.0057 0.0138
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.009 0.028 0.0692
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0128 0.042 0.0697
Brugia malayi latrophilin 2 splice variant baaae 0.0155 0.0521 0.0864
Loa Loa (eye worm) intermediate filament protein 0.003 0.0057 0.0095
Brugia malayi Regulator of G protein signaling domain containing protein 0.0066 0.0191 0.0318
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0108 0.0344 0.0572
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0026 0.006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0083 0.0252 0.0539
Echinococcus multilocularis bloom syndrome protein 0.0074 0.0219 0.0219
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0534 0.1929 0.4802
Brugia malayi chromobox protein homolog 3 0.0046 0.0115 0.0191
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0054 0.0144 0.0355
Echinococcus multilocularis rhodopsin orphan GPCR 0.0613 0.2224 0.2224
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0013 0.0028
Schistosoma mansoni DNA helicase recq5 0.0031 0.0058 0.0124
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.042 0.1041
Echinococcus multilocularis protein kinase c eta type 0.003 0.0055 0.0055
Brugia malayi MH1 domain containing protein 0.0019 0.0013 0.0022
Echinococcus multilocularis Glutaredoxin protein 5 0.0041 0.0097 0.0097
Leishmania major hypothetical protein, conserved 0.0027 0.0044 0.0076
Echinococcus granulosus rhodopsin orphan GPCR 0.0613 0.2224 0.4677
Schistosoma mansoni sodium/solute symporter 0.0045 0.0111 0.0237
Brugia malayi diacylglycerol kinase 0.003 0.0055 0.0091
Brugia malayi RhoGAP domain containing protein 0.003 0.0055 0.0091
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0075 1
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0051 0.0133 0.03
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0649 0.1389
Onchocerca volvulus 0.0022 0.0027 0.0122
Leishmania major arginine N-methyltransferase-like protein 0.009 0.028 0.0667
Brugia malayi hypothetical protein 0.0066 0.0191 0.0318
Brugia malayi diacylglycerol kinase 0.003 0.0055 0.0091
Onchocerca volvulus 0.0466 0.1679 0.7548
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0228 0.0487
Echinococcus granulosus neuropeptide receptor A26 0.0613 0.2224 0.4677
Onchocerca volvulus 0.0613 0.2224 1
Echinococcus multilocularis smad 0.0034 0.0069 0.0069
Schistosoma mansoni vav2 0.0034 0.007 0.015
Plasmodium falciparum glutathione reductase 0.0035 0.0075 0.018
Loa Loa (eye worm) hypothetical protein 0.0194 0.0665 0.1103
Brugia malayi Latrophilin receptor protein 2 0.0072 0.0211 0.035
Leishmania major protein kinase, putative 0.0022 0.0027 0.0033
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0075 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0613 0.2224 0.2224
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0094 0.0229
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0257 0.09 0.2215
Schistosoma mansoni axis inhibition protein axin 0.0066 0.0191 0.0409
Brugia malayi PAS domain containing protein 0.0048 0.0122 0.0202
Loa Loa (eye worm) melatonin receptor type 1A 0.0613 0.2224 0.3693
Trypanosoma brucei heat shock protein, putative 0.003 0.0057 0.011
Schistosoma mansoni smad1 5 8 and 0.0034 0.0069 0.0148
Brugia malayi RE15519p 0.0613 0.2224 0.3693
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0211 0.052
Onchocerca volvulus 0.0083 0.0252 0.1133
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0036 0.0078 0.0078
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0069 0.0069
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0022 0.0027 0.0027
Mycobacterium ulcerans heat shock protein 90 0.0035 0.0074 0.0119
Brugia malayi hypoxia-induced factor 1 0.0148 0.0494 0.0819
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0026 0.0033
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0027 0.0045
Plasmodium falciparum calcium-dependent protein kinase 1 0.0054 0.0144 0.0354
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.009 0.028 0.0692
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0128 0.042 0.1017
Brugia malayi C1-like domain containing protein 0.0039 0.0091 0.0151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Echinococcus granulosus fmrfamide receptor 0.0613 0.2224 0.4677
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0613 0.2224 0.2224
Schistosoma mansoni adenosylhomocysteinase 0.0677 0.2463 0.5271
Mycobacterium tuberculosis Probable dehydrogenase 0.0231 0.0804 0.1975
Leishmania major protein kinase, putative 0.0054 0.0144 0.0327
Plasmodium falciparum calcium-dependent protein kinase 5 0.0054 0.0144 0.0354
Entamoeba histolytica protein kinase, putative 0.0117 0.0379 0.0944
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Echinococcus granulosus tm gpcr rhodopsin 0.0613 0.2224 0.4677
Echinococcus granulosus protein arginine N methyltransferase 8 0.009 0.028 0.0588
Plasmodium falciparum heat shock protein 90 0.003 0.0057 0.0137
Plasmodium falciparum calcium-dependent protein kinase 3 0.0054 0.0144 0.0354
Schistosoma mansoni lamin 0.003 0.0057 0.0122
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0075 0.0181
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0021 0.0047
Echinococcus granulosus beta-adrenergic receptor kinase 0.0076 0.0228 0.0478
Leishmania major hypothetical protein, conserved 0.0049 0.0128 0.0287
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0613 0.2224 0.3693
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0051 0.0133 0.0326
Trypanosoma brucei unspecified product 0.0028 0.0047 0.0085
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.143 0.5265 0.8741
Echinococcus granulosus bloom syndrome protein 0.0074 0.0219 0.0461
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0231 0.0804 0.1975
Plasmodium vivax heat shock protein 86, putative 0.003 0.0057 0.0143
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0027 0.0045
Onchocerca volvulus 0.0022 0.0027 0.0122
Trypanosoma brucei Heat shock protein 83, putative 0.003 0.0057 0.011
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0091 0.0222
Echinococcus multilocularis protein arginine N methyltransferase 8 0.009 0.028 0.028
Echinococcus granulosus serine/threonine protein kinase 0.0055 0.0148 0.0311
Echinococcus granulosus lamin 0.003 0.0057 0.012
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0075 0.0124
Schistosoma mansoni neuropeptide receptor 0.0613 0.2224 0.4761
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0142 0.0471 0.0471
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.003 0.0057 0.012
Echinococcus granulosus somatostatin receptor 0.0613 0.2224 0.4677
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0649 0.1389
Schistosoma mansoni adenosylhomocysteinase 0.0677 0.2463 0.5271
Loa Loa (eye worm) RGS-3 protein 0.0066 0.0191 0.0318
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0057 0.0138
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0051 0.0133 0.0221
Echinococcus granulosus alpha 1A adrenergic receptor 0.0613 0.2224 0.4677
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Schistosoma mansoni Smad4 0.0034 0.0069 0.0148
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0051 0.0133 0.0326
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.042 0.1041
Echinococcus granulosus serotonin receptor 0.0613 0.2224 0.4677
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.1094 0.4015 1
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Loa Loa (eye worm) heat shock protein 75 0.002 0.0019 0.0032
Schistosoma mansoni protein kinase C 0.0036 0.0078 0.0166
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0128 0.042 0.1042
Brugia malayi hypothetical protein 0.0027 0.0044 0.0072
Entamoeba histolytica heat shock protein 90, putative 0.003 0.0057 0.0143
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0051 0.0133 0.03
Echinococcus multilocularis orexin receptor type 2 0.0613 0.2224 0.2224
Echinococcus granulosus NDR protein kinase 0.0072 0.0211 0.0443
Brugia malayi ERG2 and Sigma1 receptor like protein 0.043 0.1542 0.256
Brugia malayi Pre-SET motif family protein 0.0479 0.1727 0.2867
Leishmania major histone-lysine N-methyltransferase, putative 0.0049 0.0128 0.0287
Echinococcus multilocularis G-protein coupled receptor, putative 0.0613 0.2224 0.2224
Echinococcus granulosus tar DNA binding protein 0.0189 0.0649 0.1364
Echinococcus multilocularis regulator of G protein signaling 0.0066 0.0191 0.0191
Echinococcus multilocularis dna polymerase kappa 0.004 0.0094 0.0094
Brugia malayi hypothetical protein 0.0017 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0318
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0036 0.0078 0.0163
Echinococcus multilocularis dro:myosuppressin receptor 0.0613 0.2224 0.2224
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0094 0.0229
Schistosoma mansoni hypothetical protein 0.0022 0.0027 0.0058
Schistosoma mansoni protein arginine N-methyltransferase 1 0.009 0.028 0.0599
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0057 0.0183
Entamoeba histolytica protein kinase, putative 0.0072 0.0211 0.0526
Entamoeba histolytica recQ family DNA helicase 0.0016 0.0002 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0613 0.2224 0.4761
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0075 0.018
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0058 0.0096
Loa Loa (eye worm) hypothetical protein 0.0476 0.1713 0.2844
Echinococcus granulosus sodium:myo inositol cotransporter 0.0045 0.0111 0.0232
Trichomonas vaginalis heat shock protein, putative 0.003 0.0057 0.0137
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0101 0.0321 0.0769
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0057 0.0095
Brugia malayi hypothetical protein 0.0042 0.0101 0.0168
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0613 0.2224 0.2224
Schistosoma mansoni adenosylhomocysteinase 0.0677 0.2463 0.5271
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Echinococcus multilocularis serine:threonine protein kinase N2 0.0072 0.0211 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0094 0.0201
Echinococcus multilocularis rac serine:threonine kinase 0.0055 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0072 0.0211 0.0451
Loa Loa (eye worm) hypothetical protein 0.0034 0.007 0.0116
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0049 0.0128 0.0314
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0534 0.1929 0.1929
Echinococcus granulosus myotubularin protein 13 0.0034 0.007 0.0147
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0476 0.1713 0.1713
Echinococcus granulosus raf serine:threonine protein kinase 0.003 0.0055 0.0115
Brugia malayi G protein-coupled receptor 0.0613 0.2224 0.3693
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0228 0.0487
Brugia malayi Dopamine receptor protein 1 0.0613 0.2224 0.3693
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0031 0.0058 0.0121
Loa Loa (eye worm) hypothetical protein 0.0155 0.0521 0.0864
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0534 0.1929 0.3202
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0001 0.0001
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0054 0.0144 0.0303
Schistosoma mansoni adenoreceptor 0.0613 0.2224 0.4761
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0031 0.0058 0.0058
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0076 0.0228 0.0378
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0094 0.0201
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0026 0.3341
Echinococcus multilocularis allatostatin A receptor 0.0613 0.2224 0.2224
Echinococcus multilocularis heat shock protein 90 0.003 0.0057 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0189 0.0649 0.1389
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0479 0.1727 0.2867
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0072 0.0211 0.0443
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0191
Brugia malayi GH02984p 0.0405 0.1453 0.2411
Echinococcus granulosus serine threonine protein kinase nrc 0.0051 0.0133 0.0279
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0228 0.0487
Echinococcus granulosus Smad4 0.0034 0.0069 0.0145
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0301 0.1065 0.1065
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0091
Schistosoma mansoni amine GPCR 0.0613 0.2224 0.4761
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0094 0.0234
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0072 0.0211 0.0211
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1634 0.6024 1
Brugia malayi CUB domain containing protein 0.0022 0.0027 0.0045
Echinococcus multilocularis beta adrenergic receptor kinase 0.0076 0.0228 0.0227
Schistosoma mansoni axis inhibition protein axin 0.0066 0.0191 0.0409
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0141 0.0469 0.1164
Echinococcus granulosus methyltransferase protein 5 0.0051 0.0133 0.028
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0072
Schistosoma mansoni hypothetical protein 0.0613 0.2224 0.4761
Onchocerca volvulus Neuropeptide F receptor homolog 0.0613 0.2224 1
Echinococcus granulosus chromobox protein 1 0.0082 0.0249 0.0523
Brugia malayi Serotonin receptor 0.0613 0.2224 0.3693
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.042 0.0899
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0075 0.0181
Onchocerca volvulus 0.0613 0.2224 1
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0141 0.0469 0.1169
Schistosoma mansoni neuropeptide receptor 0.0613 0.2224 0.4761
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0049 0.0128 0.0287
Echinococcus granulosus Regulator of G protein signaling 20 0.0066 0.0191 0.0402
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Loa Loa (eye worm) hypothetical protein 0.0072 0.0211 0.035
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0613 0.2224 0.4761
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0202 0.0433
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0075 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0075 0.0181
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Plasmodium falciparum calcium-dependent protein kinase 4 0.0054 0.0144 0.0354
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0091
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0534 0.1929 0.4788
Onchocerca volvulus 0.0613 0.2224 1
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0066 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Brugia malayi hypothetical protein 0.016 0.054 0.0896
Echinococcus multilocularis solute carrier family 5 0.0045 0.0111 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0211 0.0451
Echinococcus multilocularis geminin 0.1271 0.4673 0.4672
Echinococcus granulosus dna polymerase eta 0.004 0.0094 0.0197
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0072 0.0211 0.035
Treponema pallidum NADH oxidase 0.0035 0.0075 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0041 0.0097 0.0203
Schistosoma mansoni inositol transporter 0.0045 0.0111 0.0237
Loa Loa (eye worm) thioredoxin reductase 0.0101 0.0321 0.0533
Echinococcus granulosus G protein coupled receptor 139 0.0613 0.2224 0.4677
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0013 0.0027
Echinococcus multilocularis protein kinase c iota type 0.0101 0.0321 0.0321
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0613 0.2224 0.3693
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0005 0.0008
Echinococcus multilocularis myotubularin protein 13 0.0034 0.007 0.007
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0022 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Trichomonas vaginalis set domain proteins, putative 0.0545 0.1973 0.4911
Echinococcus granulosus N chimaerin 0.003 0.0055 0.0115
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0054 0.0144 0.0144
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0613 0.2224 0.4761
Brugia malayi hypothetical protein 0.0613 0.2224 0.3693
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0039 0.0091 0.0191
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Echinococcus multilocularis thyroid hormone receptor alpha 0.0153 0.0513 0.0513
Brugia malayi regulator of G-protein signaling rgs-7 0.0066 0.0191 0.0318
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0613 0.2224 0.4677
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0613 0.2224 0.4761
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0075 0.0075
Trypanosoma brucei protein kinase, putative 0.0128 0.042 0.1017
Entamoeba histolytica protein kinase 2, putative 0.0051 0.0133 0.0331
Leishmania major S-adenosylhomocysteine hydrolase 0.1094 0.4015 1
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Echinococcus multilocularis expressed protein 0.1294 0.4757 0.4756
Brugia malayi AKH receptor 0.0613 0.2224 0.3693
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0091 0.0195
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Brugia malayi hypothetical protein 0.0613 0.2224 0.3693
Echinococcus granulosus neuropeptide receptor 0.0613 0.2224 0.4677
Brugia malayi Thioredoxin reductase 0.0101 0.0321 0.0533
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.004 0.0067
Echinococcus granulosus tm gpcr rhodopsin 0.0613 0.2224 0.4677
Giardia lamblia Kinase, AGC PKA 0.0051 0.0133 0.0631
Brugia malayi hypothetical protein 0.0613 0.2224 0.3693
Schistosoma mansoni DNA polymerase eta 0.004 0.0094 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0094 0.0201
Brugia malayi MH2 domain containing protein 0.0034 0.0069 0.0115
Plasmodium falciparum adenosylhomocysteinase 0.1094 0.4015 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0128 0.042 0.042
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0613 0.2224 0.2224
Echinococcus granulosus serine:threonine protein kinase N2 0.0072 0.0211 0.0443
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Brugia malayi follicle stimulating hormone receptor 0.1634 0.6024 1
Loa Loa (eye worm) TAR-binding protein 0.0189 0.0649 0.1077
Echinococcus multilocularis serine:threonine protein kinase N2 0.0072 0.0211 0.0211
Brugia malayi Sodium:solute symporter family protein 0.0045 0.0111 0.0183
Toxoplasma gondii diacylglycerol kinase, putative 0.003 0.0055 0.0131
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0476 0.1713 0.4265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0613 0.2224 0.2224
Onchocerca volvulus 0.0034 0.007 0.0314
Leishmania major protein kinase A catalytic subunit isoform 2 0.0476 0.1713 0.4249
Schistosoma mansoni hypothetical protein 0.0051 0.0133 0.0285
Echinococcus granulosus rhodopsin orphan GPCR 0.0613 0.2224 0.4677
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0534 0.1929 0.4802
Toxoplasma gondii bicoid-interacting protein BIN3 0.0051 0.0133 0.0327
Echinococcus multilocularis Smad4 0.0034 0.0069 0.0069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0075 0.0181
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0094 0.0169
Echinococcus granulosus rho-associated protein kinase 1 0.0466 0.1679 0.353
Schistosoma mansoni biogenic amine (5HT) receptor 0.0613 0.2224 0.4761
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0066 0.0191 0.0471
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0613 0.2224 0.4761
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0534 0.1929 0.3202
Loa Loa (eye worm) PXA domain-containing protein 0.0066 0.0191 0.0318
Schistosoma mansoni heat shock protein 0.002 0.0019 0.0041
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0013 0.0028
Entamoeba histolytica protein kinase, putative 0.006 0.0167 0.0417
Echinococcus granulosus neuropeptide s receptor 0.0613 0.2224 0.4677
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.021 0.0724 0.1201
Brugia malayi hypothetical protein 0.0613 0.2224 0.3693
Giardia lamblia Kinase, CMGC MAPK 0.0128 0.042 0.2334
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0057 0.0138
Schistosoma mansoni serine/threonine-protein kinase 0.0055 0.0148 0.0317
Schistosoma mansoni hypothetical protein 0.0072 0.0211 0.0451
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0055 0.0117
Echinococcus granulosus biogenic amine 5HT receptor 0.076 0.2771 0.5827
Brugia malayi protein kinase C II. 0.0108 0.0344 0.0572
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Plasmodium vivax glutathione reductase, putative 0.0101 0.0321 0.08
Leishmania major trypanothione reductase 0.0101 0.0321 0.0769
Loa Loa (eye worm) adenosylhomocysteinase 0.1094 0.4015 0.6665
Loa Loa (eye worm) hypothetical protein 0.022 0.0761 0.1263
Brugia malayi PXA domain containing protein 0.0066 0.0191 0.0318
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0094 0.0201
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0211 0.0451
Trichomonas vaginalis DNA helicase recq, putative 0.0074 0.0219 0.0541
Schistosoma mansoni protein kinase C mu 0.0039 0.0091 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0191 0.0471
Loa Loa (eye worm) AGC/NDR protein kinase 0.0072 0.0211 0.035
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0075 0.0154
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0058 0.0139
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0022 0.0027 0.0061
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0069 0.0145
Echinococcus granulosus lamin dm0 0.003 0.0057 0.012
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0026 0.006
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0026 0.0033
Schistosoma mansoni amine GPCR 0.0613 0.2224 0.4761
Loa Loa (eye worm) AGC/AKT protein kinase 0.0117 0.0379 0.0629
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0466 0.1677 0.3526
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0054 0.0144 0.0303
Entamoeba histolytica protein kinase, putative 0.0054 0.0144 0.036
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0022 0.0027 0.0058
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0031 0.0058 0.0058
Onchocerca volvulus 0.0613 0.2224 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0257 0.09 0.2095
Echinococcus granulosus Diacylglycerol kinase theta 0.003 0.0055 0.0115
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.1094 0.4015 1
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0379 0.0938
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0191 0.0471
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0066 0.0191 0.0318
Echinococcus granulosus rhodopsin orphan GPCR 0.0613 0.2224 0.4677
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Brugia malayi hypothetical protein 0.0613 0.2224 0.3693
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0022 0.0027 0.0122
Onchocerca volvulus 0.0613 0.2224 1
Onchocerca volvulus 0.0613 0.2224 1
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0191 0.0471
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.003 0.0055 0.0117
Brugia malayi MH1 domain containing protein 0.0019 0.0013 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0191 0.0471
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0022 0.0027 0.0045
Echinococcus granulosus biogenic amine 5HT receptor 0.0613 0.2224 0.4677
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0022 0.0027 0.0061
Giardia lamblia Sgs1 DNA helicase, putative 0.0031 0.0058 0.0186
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0075 0.0154
Echinococcus granulosus axis inhibition protein axin 0.0066 0.0191 0.0402
Onchocerca volvulus 0.0613 0.2224 1
Schistosoma mansoni serine/threonine protein kinase 0.0476 0.1713 0.3667
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.009 0.028 0.0692
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.003 0.0055 0.0115
Mycobacterium tuberculosis Probable reductase 0.0231 0.0804 0.1975
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0054 0.0144 0.0327
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0022 0.0027 0.0045
Brugia malayi Serotonin receptor 0.0613 0.2224 0.3693
Echinococcus multilocularis chromobox protein 1 0.0082 0.0249 0.0249
Echinococcus multilocularis rhodopsin orphan GPCR 0.0613 0.2224 0.2224
Plasmodium vivax SET domain protein, putative 0.0069 0.0202 0.0504
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0476 0.1713 0.3602
Schistosoma mansoni serine/threonine protein kinase 0.0301 0.1065 0.2279
Trypanosoma brucei heat shock protein, putative 0.003 0.0057 0.011
Entamoeba histolytica hypothetical protein 0.0066 0.0191 0.0477
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0022 0.0027 0.0061
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0044 0.0109
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Toxoplasma gondii AGC kinase 0.0476 0.1713 0.4265
Schistosoma mansoni thyroid hormone receptor 0.0153 0.0513 0.1098
Echinococcus granulosus calcium dependent protein kinase 0.0044 0.0108 0.0228
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Echinococcus multilocularis neuropeptide Y receptor 0.0613 0.2224 0.2224
Echinococcus granulosus regulator of G protein signaling 7 0.0066 0.0191 0.0402
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0613 0.2224 0.4761
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0476 0.1713 0.4249
Echinococcus multilocularis sex peptide receptor 0.0613 0.2224 0.2224
Echinococcus multilocularis dna polymerase eta 0.004 0.0094 0.0094
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0128 0.0313
Schistosoma mansoni growth hormone secretagogue receptor 0.0613 0.2224 0.4761
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0047 0.0085
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0075 0.018
Echinococcus multilocularis neuropeptide Y receptor 0.0613 0.2224 0.2224
Brugia malayi hypothetical protein 0.0613 0.2224 0.3693
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0094 0.0201
Brugia malayi Dopamine receptor protein 2 0.0613 0.2224 0.3693
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0051 0.0133 0.0325
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0022 0.0027 0.0122
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0051 0.0133 0.028
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0534 0.1929 0.4788
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0003
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0049 0.0128 0.0314
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0209 0.0446
Onchocerca volvulus 0.0613 0.2224 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0072 0.0211 0.0443
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0022 0.0027 0.0027
Schistosoma mansoni DNA helicase recq1 0.0031 0.0058 0.0124
Brugia malayi sulfakinin receptor protein 0.0613 0.2224 0.3693
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0075 0.0181
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0026 0.0044
Leishmania major protein kinase, putative 0.0022 0.0027 0.0033
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0075 0.0181
Echinococcus granulosus neuropeptides capa receptor 0.0613 0.2224 0.4677
Echinococcus multilocularis heat shock protein 90 0.003 0.0057 0.0057
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0022 0.0027 0.0027
Echinococcus granulosus neuropeptides capa receptor 0.0613 0.2224 0.4677
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0613 0.2224 0.3693
Brugia malayi Heterochromatin protein 1 0.0082 0.0249 0.0413
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0318
Entamoeba histolytica 90 kDa heat shock protein, putative 0.002 0.0019 0.0048
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Brugia malayi MH1 domain containing protein 0.0034 0.0069 0.0115
Schistosoma mansoni regulator of G protein signaling 0.0066 0.0191 0.0409
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0094 0.0228
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0893 0.3266 0.3266
Onchocerca volvulus 0.003 0.0057 0.0256
Echinococcus granulosus rhodopsin orphan GPCR 0.0613 0.2224 0.4677
Brugia malayi p70 ribosomal S6 kinase beta 0.0113 0.0364 0.0603
Echinococcus multilocularis neuropeptide receptor A26 0.0613 0.2224 0.2224
Echinococcus multilocularis Rac GTPase activating protein 1 0.003 0.0055 0.0055
Echinococcus multilocularis high affinity choline transporter 1 0.0405 0.1453 0.1452
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0211 0.052
Brugia malayi putative neuropeptide receptor 0.0613 0.2224 0.3693
Brugia malayi Ras association domain family 1 isoform A 0.003 0.0055 0.0091
Loa Loa (eye worm) heat shock protein 90 0.003 0.0057 0.0095
Schistosoma mansoni neuropeptide receptor 0.0613 0.2224 0.4761
Schistosoma mansoni opsin-like receptor 0.0613 0.2224 0.4761
Leishmania major DNA polymerase eta, putative 0.004 0.0094 0.0201
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0094 0.0201
Onchocerca volvulus 0.003 0.0057 0.0256
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0013 0.0013
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0613 0.2224 0.3693
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0613 0.2224 0.4761
Plasmodium falciparum thioredoxin reductase 0.0035 0.0075 0.018
Schistosoma mansoni serine/threonine kinase 0.0072 0.0211 0.0451
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0091 0.0221
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0476 0.1713 0.2844
Echinococcus granulosus neuropeptide FF receptor 2 0.0613 0.2224 0.4677
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0066 0.0191 0.0409
Schistosoma mansoni diacylglycerol kinase theta 0.003 0.0055 0.0117
Leishmania major arginine N-methyltransferase, type I 0.0051 0.0133 0.03
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0051 0.0133 0.0327
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0202 0.0433
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0202 0.0433
Echinococcus multilocularis low density lipoprotein receptor protein 0.0022 0.0027 0.0027
Echinococcus granulosus neuropeptide receptor 0.0613 0.2224 0.4677
Echinococcus granulosus regulator of G protein signaling 7 0.0066 0.0191 0.0402
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0476 0.1713 0.4265
Schistosoma mansoni histone J3 methyltransferase 0.0389 0.1392 0.298
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0231 0.0804 0.1975
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0613 0.2224 0.2224
Loa Loa (eye worm) hypothetical protein 0.0059 0.0164 0.0272
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0075 0.0154
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0476 0.1713 0.1713
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0039 0.0091 0.0151
Leishmania major protein kinase A catalytic subunit isoform 1 0.0476 0.1713 0.4249
Schistosoma mansoni neuropeptide F-like receptor 0.0613 0.2224 0.4761
Brugia malayi Protein arginine N-methyltransferase 0.0051 0.0133 0.0221
Trypanosoma brucei heat shock protein, putative 0.003 0.0057 0.011
Echinococcus multilocularis serotonin receptor 0.076 0.2771 0.2771
Echinococcus multilocularis lamin 0.003 0.0057 0.0057
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0148 0.0369
Schistosoma mansoni serine/threonine protein kinase 0.0476 0.1713 0.3667
Echinococcus multilocularis unc 13 (munc13) 0.0036 0.0078 0.0078
Echinococcus multilocularis mitogen activated protein kinase 0.0128 0.042 0.042
Leishmania major S-adenosylmethionine decarboxylase 0.0534 0.1929 0.4788
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.1094 0.4015 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0026 0.0026
Loa Loa (eye worm) variant SH3 domain-containing protein 0.003 0.0055 0.0091
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0148 0.0369
Echinococcus multilocularis g-protein coupled receptor 0.0613 0.2224 0.2224
Onchocerca volvulus 0.0613 0.2224 1
Echinococcus granulosus neuropeptide Y receptor 0.0613 0.2224 0.4677
Loa Loa (eye worm) TYRA-2 protein 0.0613 0.2224 0.3693
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0231 0.0804 0.1852
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.1094 0.4015 1
Echinococcus granulosus protein arginine methyltransferase 0.009 0.028 0.0588
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0044 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0115 0.028
Schistosoma mansoni lamin 0.003 0.0057 0.0122
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.002 0.0019 0.0085
Plasmodium vivax heat shock protein 90, putative 0.002 0.0019 0.0048
Echinococcus granulosus GPCR family 2 0.0072 0.0211 0.0443
Schistosoma mansoni protein kinase 0.0054 0.0144 0.0309
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0613 0.2224 0.4677
Loa Loa (eye worm) hypothetical protein 0.0036 0.0078 0.0129
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Echinococcus granulosus heat shock protein 90 0.003 0.0057 0.012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0045
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0104
Brugia malayi Protein kinase domain containing protein 0.0072 0.0211 0.035
Leishmania major DNA polymerase kappa, putative 0.004 0.0094 0.0201
Trypanosoma brucei trypanothione reductase 0.0101 0.0321 0.0769
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0058 0.0096
Brugia malayi G protein-coupled receptor F59B2.13 0.0613 0.2224 0.3693
Brugia malayi hypothetical protein 0.0141 0.0469 0.0779
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0141 0.0469 0.1164
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0074 0.0178
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0075 0.0154
Schistosoma mansoni protein kinase 0.0054 0.0144 0.0309
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0613 0.2224 0.2224
Brugia malayi Regulator of G protein signaling domain containing protein 0.0066 0.0191 0.0318
Loa Loa (eye worm) hypothetical protein 0.0389 0.1392 0.2311
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0072 0.0211 0.035
Schistosoma mansoni hypothetical protein 0.0042 0.0101 0.0217
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0231 0.0804 0.1975
Loa Loa (eye worm) hypothetical protein 0.0066 0.0191 0.0318
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0094 0.0201
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0476 0.1713 0.4268
Loa Loa (eye worm) nuclear factor I 0.0019 0.0013 0.0022
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0045 0.0111 0.027
Echinococcus multilocularis nervana 2 0.0041 0.0097 0.0097
Echinococcus granulosus tachykinin peptides receptor 99D 0.0613 0.2224 0.4677
Schistosoma mansoni hypothetical protein 0.0613 0.2224 0.4761
Onchocerca volvulus 0.0457 0.1643 0.7386
Echinococcus granulosus dro:myosuppressin receptor 0.0613 0.2224 0.4677
Giardia lamblia Kinase, AGC PKA 0.0476 0.1713 1
Echinococcus granulosus chromobox protein 1 0.0082 0.0249 0.0523
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0101 0.0217
Echinococcus multilocularis neuropeptide receptor 0.0613 0.2224 0.2224
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.003 0.0055 0.0091
Trypanosoma cruzi Protein kinase B 0.0055 0.0148 0.0364
Loa Loa (eye worm) hypothetical protein 0.0034 0.007 0.0116
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Schistosoma mansoni biogenic amine receptor 0.0613 0.2224 0.4761
Trypanosoma cruzi Heat shock protein 83, putative 0.003 0.0057 0.0138
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0343 0.1222 0.304
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0022 0.0027 0.0045
Echinococcus multilocularis G protein coupled receptor 139 0.0613 0.2224 0.2224
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0613 0.2224 0.2224
Entamoeba histolytica heat shock protein 90, putative 0.003 0.0057 0.0143
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0379 0.0938
Echinococcus granulosus mitogen activated protein kinase 3 0.0128 0.042 0.0883
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0028
Brugia malayi Dopamine receptor 0.0613 0.2224 0.3693
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0613 0.2224 0.3693
Echinococcus multilocularis serine threonine protein kinase 0.0272 0.0954 0.0954
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0613 0.2224 0.4677
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0075 0.5
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.004 0.0067
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0613 0.2224 1
Trypanosoma cruzi heat shock protein, putative 0.002 0.0019 0.0042
Echinococcus multilocularis rho associated protein kinase 0.0466 0.1679 0.1679
Leishmania major heat shock protein 83-1 0.003 0.0057 0.011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0021 0.0047
Echinococcus multilocularis endoplasmin 0.0035 0.0074 0.0074
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0122 0.026
Echinococcus multilocularis adenosylhomocysteinase 0.1094 0.4015 0.4015
Echinococcus granulosus g-protein coupled receptor 0.0613 0.2224 0.4677
Echinococcus multilocularis serine:threonine protein kinase 38 0.0072 0.0211 0.0211
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.002 0.0019 0.004
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0055 0.0148 0.0364
Schistosoma mansoni histamine h1 receptor 0.0613 0.2224 0.4761
Schistosoma mansoni biogenic amine (5HT) receptor 0.076 0.2771 0.5931
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0613 0.2224 0.4761
Onchocerca volvulus 0.0022 0.0027 0.0122
Echinococcus multilocularis neuropeptide receptor 0.0613 0.2224 0.2224
Onchocerca volvulus 0.0613 0.2224 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0613 0.2224 0.2224
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0013 0.0013
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0049 0.0128 0.0314
Schistosoma mansoni protein kinase C mu 0.003 0.0055 0.0117
Schistosoma mansoni regulator of G protein signaling 0.0066 0.0191 0.0409
Schistosoma mansoni cpg binding protein 0.0034 0.0071 0.0152
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0379 0.0938
Echinococcus granulosus protein kinase c eta type 0.003 0.0055 0.0115
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0128 0.042 0.1017
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0476 0.1713 0.4265
Brugia malayi A-kinase anchor protein 10, precursor 0.0066 0.0191 0.0318
Schistosoma mansoni endoplasmin 0.003 0.0057 0.0123
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0194 0.0665 0.0665
Loa Loa (eye worm) neuropeptide F receptor 0.0613 0.2224 0.3693
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0128 0.0574
Schistosoma mansoni cpg binding protein 0.0032 0.0064 0.0138
Loa Loa (eye worm) RhoGAP domain-containing protein 0.003 0.0055 0.0091
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0074 0.0178
Schistosoma mansoni ap endonuclease 0.0022 0.0026 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0613 0.2224 0.2224
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0141 0.0469 0.1139
Echinococcus granulosus solute carrier family 5 0.0045 0.0111 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0047 0.0085
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0051 0.0133 0.0332
Brugia malayi TAR-binding protein 0.0189 0.0649 0.1077
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Brugia malayi hypothetical protein 0.0066 0.0191 0.0318
Entamoeba histolytica hypothetical protein 0.0042 0.0101 0.0253
Toxoplasma gondii adenosylhomocysteinase, putative 0.1094 0.4015 1
Loa Loa (eye worm) endoplasmin 0.003 0.0057 0.0095
Loa Loa (eye worm) glutathione reductase 0.0101 0.0321 0.0533
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0094 0.0201
Brugia malayi Protein kinase domain containing protein 0.0117 0.0379 0.0629
Brugia malayi CHD4 protein 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0613 0.2224 1
Echinococcus granulosus nervana 2 0.0041 0.0097 0.0203
Echinococcus multilocularis Diacylglycerol kinase theta 0.003 0.0055 0.0055
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0051 0.0133 0.0133
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0051 0.0133 0.0327
Echinococcus granulosus sex peptide receptor 0.0613 0.2224 0.4677
Trichomonas vaginalis AGC family protein kinase 0.0072 0.0211 0.052
Echinococcus multilocularis RNA directed DNA polymerase 0.0194 0.0665 0.0665
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0031 0.0058 0.0096
Entamoeba histolytica hypothetical protein 0.0066 0.0191 0.0477
Brugia malayi Cam kinase protein 1 0.0054 0.0144 0.0239
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.1094 0.4015 1
Schistosoma mansoni unc-13 (munc13) 0.0038 0.0086 0.0184
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0054 0.0144 0.0144
Brugia malayi neuropeptide F receptor 0.0613 0.2224 0.3693
Trypanosoma brucei histone-lysine n-methyltransferase 0.0049 0.0128 0.0287
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0094 0.0197
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.042 0.1041
Echinococcus multilocularis chromobox protein 1 0.0082 0.0249 0.0249
Loa Loa (eye worm) transcription factor SMAD2 0.0493 0.1778 0.2951
Brugia malayi enteropeptidase precursor 0.0022 0.0027 0.0045
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.009 0.028 0.0692
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0476 0.1713 0.4249
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0069 0.0115
Entamoeba histolytica protein kinase, putative 0.0117 0.0379 0.0944
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0613 0.2224 0.3693
Echinococcus multilocularis musashi 0.003 0.0057 0.0057
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.0494 0.0819
Loa Loa (eye worm) raf kinase 0.003 0.0055 0.0091
Loa Loa (eye worm) hypothetical protein 0.0054 0.0144 0.0239
Echinococcus granulosus geminin 0.1271 0.4673 0.9824
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.0047 0.0085
Leishmania major hypothetical protein, conserved 0.0049 0.0128 0.0287
Echinococcus multilocularis neuropeptide s receptor 0.0613 0.2224 0.2224
Brugia malayi hypothetical protein 0.0613 0.2224 0.3693
Loa Loa (eye worm) Carm1-pending protein 0.0051 0.0133 0.0221
Echinococcus granulosus histone h3 methyltransferase 0.0389 0.1392 0.2927
Brugia malayi Pre-SET motif family protein 0.0069 0.0202 0.0336
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0075 0.0181
Onchocerca volvulus 0.0036 0.0078 0.035
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0051 0.0133 0.0327
Trichomonas vaginalis AGC family protein kinase 0.0076 0.0226 0.0558
Schistosoma mansoni high-affinity choline transporter 0.0405 0.1453 0.3109
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0054 0.0144 0.036
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0072 0.0211 0.0211
Echinococcus granulosus neuropeptide Y receptor 0.0613 0.2224 0.4677
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0249 0.0614
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0075 0.0154
Echinococcus granulosus rhodopsin orphan GPCR 0.0613 0.2224 0.4677
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0094 0.0201
Plasmodium vivax calcium-dependent protein kinase, putative 0.0054 0.0144 0.036
Schistosoma mansoni blooms syndrome DNA helicase 0.0058 0.0162 0.0345
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0066 0.019 0.04
Loa Loa (eye worm) AGC/PKA protein kinase 0.0476 0.1713 0.2844
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0057 0.0138
Echinococcus granulosus thioredoxin glutathione reductase 0.0101 0.0321 0.0675
Plasmodium falciparum glutathione reductase 0.0101 0.0321 0.0794
Schistosoma mansoni adenosylhomocysteinase 0.1094 0.4015 0.8592
Toxoplasma gondii thioredoxin reductase 0.0101 0.0321 0.0795
Brugia malayi Protein kinase domain containing protein 0.0072 0.0211 0.035
Loa Loa (eye worm) hypothetical protein 0.0223 0.0775 0.1287
Trichomonas vaginalis AGC family protein kinase 0.0476 0.1713 0.4264
Schistosoma mansoni hypothetical protein 0.0613 0.2224 0.4761
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0115 0.0516
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0613 0.2224 0.2224
Echinococcus granulosus protein kinase c iota type 0.0101 0.0321 0.0676
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0022 0.0027 0.0045
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.026 0.0911 0.2269
Onchocerca volvulus 0.0022 0.0027 0.0122
Loa Loa (eye worm) hypothetical protein 0.076 0.2771 0.4601
Plasmodium falciparum thioredoxin reductase 0.0101 0.0321 0.0794
Echinococcus granulosus rhodopsin orphan GPCR 0.0613 0.2224 0.4677
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0613 0.2224 0.2224
Entamoeba histolytica recQ family helicase, putative 0.004 0.0091 0.0227
Plasmodium falciparum heat shock protein 90, putative 0.002 0.0019 0.0041
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0051 0.0133 0.0279
Echinococcus granulosus protein kinase c epsilon type 0.0108 0.0344 0.0724
Loa Loa (eye worm) hypothetical protein 0.0613 0.2224 0.3693
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0051 0.0133 0.0326
Echinococcus multilocularis regulator of G protein signaling 7 0.0066 0.0191 0.0191
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0075 0.0181
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.003 0.0055 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0191 0.0471
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0022 0.0027 0.0045
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0022 0.0027 0.0057
Echinococcus granulosus RNA directed DNA polymerase 0.0194 0.0665 0.1397
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0893 0.3266 0.699
Onchocerca volvulus 0.0613 0.2224 1
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0051 0.0133 0.0331
Trichomonas vaginalis AGC family protein kinase 0.0117 0.0379 0.0938
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0144 0.0354
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0069 0.0148
Echinococcus granulosus regulator of G protein signaling 3 0.0066 0.0191 0.0402
Schistosoma mansoni chromobox protein 0.0082 0.0249 0.0532
Brugia malayi regulator of G-protein signaling egl-10 0.0066 0.0191 0.0318

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -7.7 Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement ChEMBL. 8568799
Ki (binding) = 20 nM Binding affinity at 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes by [3H]-8-OH-DPAT displacement. ChEMBL. No reference
Ki (binding) = 20 nM Binding affinity at 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes by [3H]-8-OH-DPAT displacement. ChEMBL. No reference
Ki (binding) = 33 nM Binding affinity at Alpha-1 adrenergic receptor in rat cerebral cortex membranes by [3H]-prazosin displacement. ChEMBL. No reference
Ki (binding) = 33 nM Binding affinity at Alpha-1 adrenergic receptor in rat cerebral cortex membranes by [3H]-prazosin displacement. ChEMBL. No reference
Log Ki (binding) = 7.7 Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement ChEMBL. 8568799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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