Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0019 | 0.0019 |
Chlamydia trachomatis | dihydrofolate reductase | 1.6545 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8973 | 0.5417 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1006 | 0.0594 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.8973 | 0.5417 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.2115 | 0.1265 | 0.1252 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.8973 | 0.5417 | 0.5 |
Brugia malayi | hypothetical protein | 0.1006 | 0.0594 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0022 | 0.0007 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.8973 | 0.5417 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0012 | 0.0012 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.001 | 0.001 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.8973 | 0.5417 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.6545 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 1.6545 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 1.6545 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 1.6545 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.8973 | 0.5417 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.6545 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.6545 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.0022 | 0.0012 |
Schistosoma mansoni | dihydrofolate reductase | 1.6545 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2115 | 0.1265 | 0.1265 |
Brugia malayi | thymidylate synthase | 0.2115 | 0.1265 | 0.1265 |
Echinococcus granulosus | thymidylate synthase | 0.2115 | 0.1265 | 0.1256 |
Echinococcus multilocularis | thymidylate synthase | 0.2115 | 0.1265 | 0.1256 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.6545 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0015 | 0.0015 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.0022 | 0.0012 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2115 | 0.1265 | 0.0713 |
Onchocerca volvulus | 0.2115 | 0.1265 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7 nM | In vitro functional activity measured by changes in cytosolic [Ca2+] concentrations against rat metabotropic glutamate receptor 5 | ChEMBL. | 16183275 |
IC50 (functional) | = 7 nM | In vitro functional activity measured by changes in cytosolic [Ca2+] concentrations against rat metabotropic glutamate receptor 5 | ChEMBL. | 16183275 |
Ki (binding) | = 26 nM | Ability to displace [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from binding to metabotropic glutamate receptor 5 in rat cortical membranes | ChEMBL. | 16183275 |
Ki (binding) | = 26 nM | Ability to displace [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from binding to metabotropic glutamate receptor 5 in rat cortical membranes | ChEMBL. | 16183275 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.