Detailed information for compound 345058

Basic information

Technical information
  • TDR Targets ID: 345058
  • Name: N-[(2S)-3-(4-chlorophenyl)-1-[2-(4-methoxyani lino)ethylamino]-1-oxopropan-2-yl]-3-methylbe nzamide
  • MW: 465.972 | Formula: C26H28ClN3O3
  • H donors: 3 H acceptors: 2 LogP: 5.18 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NCCNC(=O)[C@@H](NC(=O)c1cccc(c1)C)Cc1ccc(cc1)Cl
  • InChi: 1S/C26H28ClN3O3/c1-18-4-3-5-20(16-18)25(31)30-24(17-19-6-8-21(27)9-7-19)26(32)29-15-14-28-22-10-12-23(33-2)13-11-22/h3-13,16,24,28H,14-15,17H2,1-2H3,(H,29,32)(H,30,31)/t24-/m0/s1
  • InChiKey: SLCGCUWBLKUHMZ-DEOSSOPVSA-N  


Substructure search Similarity search

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Synonyms

  • N-[(1S)-1-[(4-chlorophenyl)methyl]-2-[2-(4-methoxyanilino)ethylamino]-2-oxo-ethyl]-3-methyl-benzamide
  • N-[(1S)-1-[(4-chlorophenyl)methyl]-2-[2-(4-methoxyanilino)ethylamino]-2-oxoethyl]-3-methylbenzamide
  • N-[(2S)-3-(4-chlorophenyl)-1-[2-[(4-methoxyphenyl)amino]ethylamino]-1-oxo-propan-2-yl]-3-methyl-benzamide
  • N-[(1S)-1-(4-chlorobenzyl)-2-keto-2-[2-(p-anisidino)ethylamino]ethyl]-3-methyl-benzamide
  • N-[(2S)-3-(4-chlorophenyl)-1-[2-[(4-methoxyphenyl)amino]ethylamino]-1-oxopropan-2-yl]-3-methylbenzamide
  • N-[(1S)-1-[(4-chlorophenyl)methyl]-2-[2-[(4-methoxyphenyl)amino]ethylamino]-2-oxo-ethyl]-3-methyl-benzamide
  • N-[(1S)-1-[(4-chlorophenyl)methyl]-2-[2-[(4-methoxyphenyl)amino]ethylamino]-2-oxoethyl]-3-methylbenzamide
  • N-[(1S)-1-(4-chlorobenzyl)-2-keto-2-[2-[(4-methoxyphenyl)amino]ethylamino]ethyl]-3-methyl-benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Brugia malayi Cathepsin L-like precursor 0.0054 1 1
Onchocerca volvulus 0.0052 0.9161 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Schistosoma mansoni biogenic amine receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.9161 0.9161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.9161 0.9161
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.9161 0.9161
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.9161 0.9161
Plasmodium vivax vivapain-2 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0054 1 1
Onchocerca volvulus 0.0054 1 1
Brugia malayi hypothetical protein 0.0052 0.9161 0.9161
Onchocerca volvulus 0.0052 0.9161 0.877
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Echinococcus multilocularis g protein coupled receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.9161 0.9161
Schistosoma mansoni amine GPCR 0.0052 0.9161 0.9161
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Schistosoma mansoni hypothetical protein 0.0052 0.9161 0.9161
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.9161 0.9161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Onchocerca volvulus 0.0054 1 1
Echinococcus granulosus cathepsin l1 0.0054 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.9161 0.877
Echinococcus multilocularis serotonin receptor 0.0052 0.9161 0.9161
Leishmania major cathepsin L-like protease 0.0054 1 0.5
Brugia malayi GnHR receptor homolog 0.0052 0.9161 0.9161
Echinococcus granulosus cathepsin L cysteine proteinase 0.0054 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.3182 0.3182
Echinococcus multilocularis neuropeptide receptor A26 0.0052 0.9161 0.9161
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.9161 0.9161
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.9161 0.9161
Echinococcus granulosus neuropeptide s receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 1 1
Brugia malayi Cathepsin L-like precursor 0.0036 0.3182 0.3182
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Schistosoma mansoni opsin-like receptor 0.0052 0.9161 0.9161
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.9161 0.9161
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Onchocerca volvulus 0.0054 1 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.9161 0.877
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.9161 0.9161
Brugia malayi hypothetical protein 0.0052 0.9161 0.9161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Schistosoma mansoni neuropeptide receptor 0.0052 0.9161 0.9161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0052 0.9161 0.9161
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) fibroinase 0.0054 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.9161 0.9161
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.9161 0.877
Onchocerca volvulus 0.0052 0.9161 0.877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 1 1
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.9161 0.9161
Echinococcus multilocularis g protein coupled receptor 0.0052 0.9161 0.9161
Brugia malayi hypothetical protein 0.0052 0.9161 0.9161
Schistosoma mansoni neuropeptide receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Leishmania major cathepsin L-like protease 0.0054 1 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.9161 0.9161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Echinococcus multilocularis g protein coupled receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.9161 0.9161
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.9161 0.9161
Trypanosoma cruzi cysteine peptidase, putative 0.0054 1 1
Brugia malayi neuropeptide F receptor 0.0052 0.9161 0.9161
Brugia malayi hypothetical protein 0.0052 0.9161 0.9161
Onchocerca volvulus 0.0052 0.9161 0.877
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.9161 0.9161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.9161 0.877
Onchocerca volvulus 0.0052 0.9161 0.877
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.9161 0.9161
Brugia malayi G-protein coupled receptor 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0054 1 1
Onchocerca volvulus 0.0052 0.9161 0.877
Plasmodium falciparum cysteine proteinase falcipain 3 0.0054 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.9161 0.9161
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 1 1
Onchocerca volvulus 0.0052 0.9161 0.877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Echinococcus multilocularis neuropeptide receptor 0.0052 0.9161 0.9161
Leishmania major cysteine peptidase A (CPA) 0.0054 1 0.5
Echinococcus granulosus cathepsin l cysteine peptidase 0.0054 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.9161 0.9161
Onchocerca volvulus 0.0052 0.9161 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Echinococcus granulosus g protein coupled receptor 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.9161 0.9161
Echinococcus multilocularis fmrfamide receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.9161 0.877
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis neuropeptide receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0052 0.9161 0.877
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) ctsf protein 0.0054 1 1
Echinococcus multilocularis sex peptide receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Trypanosoma cruzi cysteine peptidase, putative 0.0054 1 1
Echinococcus multilocularis orexin receptor type 2 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Brugia malayi hypothetical protein 0.0052 0.9161 0.9161
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.9161 0.9161
Schistosoma mansoni histamine h1 receptor 0.0052 0.9161 0.9161
Onchocerca volvulus 0.0054 1 1
Schistosoma mansoni neuropeptide receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.9161 0.877
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.9161 0.9161
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.9161 0.9161
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Onchocerca volvulus Cathepsin F homolog 0.0054 1 1
Brugia malayi G protein-coupled receptor 0.0052 0.9161 0.9161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0054 1 1
Brugia malayi Dopamine receptor protein 2 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.9161 0.9161
Echinococcus granulosus neuropeptide receptor 0.0052 0.9161 0.9161
Brugia malayi RE15519p 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Trypanosoma cruzi cruzipain precursor, putative 0.0054 1 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.9161 0.9161
Trypanosoma cruzi cysteine peptidase, putative 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Entamoeba histolytica cysteine proteinase, putative 0.0054 1 1
Brugia malayi hypothetical protein 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Onchocerca volvulus 0.0052 0.9161 0.877
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.9161 0.9161
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.9161 0.9161
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.9161 0.9161
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.9161 0.9161
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.9161 0.9161
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Onchocerca volvulus 0.0052 0.9161 0.877
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.9161 0.9161
Schistosoma mansoni amine GPCR 0.0052 0.9161 0.9161
Toxoplasma gondii cathepsin CPL 0.0054 1 0.5
Schistosoma mansoni amine GPCR 0.0052 0.9161 0.9161
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.9161 0.877
Brugia malayi follicle stimulating hormone receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.9161 0.9161
Onchocerca volvulus 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Plasmodium vivax vivapain-2 0.0054 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Brugia malayi hypothetical protein 0.0052 0.9161 0.9161
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.9161 0.9161
Schistosoma mansoni hypothetical protein 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Echinococcus multilocularis somatostatin receptor 0.0052 0.9161 0.9161
Onchocerca volvulus 0.0052 0.9161 0.877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0054 1 1
Echinococcus granulosus cathepsin l1 0.0036 0.3182 0.3182
Leishmania major cathepsin L-like protease 0.0054 1 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.9161 0.9161
Brugia malayi Cathepsin L-like precursor 0.0054 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 0.9161 0.9161
Onchocerca volvulus 0.0052 0.9161 0.877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Leishmania major cathepsin L-like protease 0.0054 1 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0054 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0054 1 1
Echinococcus granulosus orexin receptor type 2 0.0052 0.9161 0.9161
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 0.9161 0.877
Echinococcus granulosus somatostatin receptor 0.0052 0.9161 0.9161
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.9161 0.9161
Brugia malayi Cathepsin L-like precursor 0.0054 1 1
Schistosoma mansoni adenoreceptor 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Echinococcus multilocularis cysteine protease 0.0054 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.3182 0.3182
Schistosoma mansoni hypothetical protein 0.0052 0.9161 0.9161
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 0.9161 0.9161
Brugia malayi hypothetical protein 0.0052 0.9161 0.9161
Brugia malayi Dopamine receptor protein 1 0.0052 0.9161 0.9161
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Schistosoma mansoni hypothetical protein 0.0052 0.9161 0.9161
Schistosoma mansoni amine GPCR 0.0052 0.9161 0.9161
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.9161 0.9161
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis neuropeptide s receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis G protein coupled receptor 139 0.0052 0.9161 0.9161
Schistosoma mansoni opsin-like receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0054 1 1
Echinococcus granulosus g protein coupled receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.9161 0.9161
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.9161 0.9161
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.9161 0.877
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.9161 0.9161
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Brugia malayi Serotonin receptor 0.0052 0.9161 0.9161
Schistosoma mansoni myosin xvIII 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Schistosoma mansoni opsin-like receptor 0.0052 0.9161 0.9161
Onchocerca volvulus 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Loa Loa (eye worm) cysteine protease 0.0054 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 1 1
Brugia malayi Dopamine receptor 0.0052 0.9161 0.9161
Brugia malayi Melatonin receptor type 1A 0.0052 0.9161 0.9161
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0054 1 1
Echinococcus granulosus allatostatin A receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Onchocerca volvulus 0.0054 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Brugia malayi Cathepsin L-like precursor 0.0054 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.9161 0.9161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Onchocerca volvulus 0.0052 0.9161 0.877
Echinococcus multilocularis allatostatin A receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.9161 0.877
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0036 0.3182 0.3182
Brugia malayi larval opioid receptor 0.0052 0.9161 0.9161
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Brugia malayi ORL1-like opioid receptor 0.0052 0.9161 0.9161
Brugia malayi sulfakinin receptor protein 0.0052 0.9161 0.9161
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Echinococcus granulosus neuropeptide receptor 0.0052 0.9161 0.9161
Brugia malayi putative neuropeptide receptor 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 1 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Brugia malayi cathepsin L-like precursor 0.0036 0.3182 0.3182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.3182 0.3182
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.9161 0.877
Schistosoma mansoni neuropeptide receptor 0.0052 0.9161 0.9161
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis cysteine protease 0.0054 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.9161 0.9161
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.9161 0.9161
Onchocerca volvulus Cathepsin L homolog 0.0054 1 1
Brugia malayi Cathepsin L-like precursor 0.0036 0.3182 0.3182
Brugia malayi hypothetical protein 0.0052 0.9161 0.9161
Leishmania major cathepsin L-like protease 0.0054 1 0.5
Echinococcus granulosus g-protein coupled receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.9161 0.9161
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.9161 0.9161
Brugia malayi Papain family cysteine protease containing protein 0.0054 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.9161 0.9161
Brugia malayi neuropeptide F receptor 0.0052 0.9161 0.9161
Brugia malayi hypothetical protein 0.0052 0.9161 0.9161
Entamoeba histolytica cysteine protease, putative 0.0054 1 1
Brugia malayi Cathepsin L-like precursor 0.0054 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 0.9161 0.877
Echinococcus granulosus serotonin receptor 0.0052 0.9161 0.9161
Schistosoma mansoni biogenic amine receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Leishmania major cathepsin L-like protease 0.0054 1 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.9161 0.9161
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Echinococcus granulosus sex peptide receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.9161 0.9161
Schistosoma mansoni cathepsin F (C01 family) 0.0054 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0054 1 1
Onchocerca volvulus 0.0052 0.9161 0.877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0054 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.9161 0.9161
Echinococcus multilocularis serotonin receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Brugia malayi G-protein coupled receptor 0.0052 0.9161 0.9161
Leishmania major cathepsin L-like protease 0.0054 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Onchocerca volvulus 0.0052 0.9161 0.877
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.9161 0.9161
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.3182 0.3182
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 0.9161 0.9161
Echinococcus granulosus fmrfamide receptor 0.0052 0.9161 0.9161
Leishmania major cathepsin L-like protease 0.0054 1 0.5
Echinococcus multilocularis fmrfamide receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Schistosoma mansoni biogenic amine receptor 0.0052 0.9161 0.9161
Onchocerca volvulus Cathepsin L homolog 0.0054 1 1
Echinococcus granulosus hypothetical protein 0.0052 0.9161 0.9161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0054 1 1
Echinococcus granulosus g protein coupled receptor 0.0052 0.9161 0.9161
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.9161 0.9161
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.3182 0.3182
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0054 1 1
Brugia malayi Serotonin receptor 0.0052 0.9161 0.9161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0054 1 1
Schistosoma mansoni amine GPCR 0.0052 0.9161 0.9161
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.9161 0.9161
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.9161 0.9161
Loa Loa (eye worm) hypothetical protein 0.0052 0.9161 0.877
Onchocerca volvulus 0.0052 0.9161 0.877
Onchocerca volvulus 0.0052 0.9161 0.877
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0054 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.9161 0.9161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.9161 0.9161
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.9161 0.9161
Brugia malayi AKH receptor 0.0052 0.9161 0.9161

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1.4 nM Inhibitory concentration against recombinant human Cathepsin L at 37 degree C at pH 5.5 ChEMBL. 16183279
Ki (binding) = 1.4 nM Inhibitory concentration against recombinant human Cathepsin L at 37 degree C at pH 5.5 ChEMBL. 16183279
Ki (binding) = 16 nM Inhibitory concentration against recombinant human Cathepsin S at 37 degree C at pH 5.5 ChEMBL. 16183279
Ki (binding) = 16 nM Inhibitory concentration against recombinant human Cathepsin S at 37 degree C at pH 5.5 ChEMBL. 16183279
Ki (binding) > 100000 nM Inhibitory concentration against recombinant human Cathepsin K at 37 degree C at pH 5.5 ChEMBL. 16183279
Ki (binding) > 100000 nM Inhibitory concentration against recombinant human Cathepsin K at 37 degree C at pH 5.5 ChEMBL. 16183279

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.