Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | coup transcription factor | 0.0062 | 0.0061 | 0.1196 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0062 | 0.0061 | 0.1196 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0062 | 0.0061 | 0.1196 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0062 | 0.0061 | 0.1196 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | nuclear receptor NHR-88 | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0061 | 0.0063 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0062 | 0.0061 | 0.1196 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0062 | 0.0061 | 0.0063 |
Schistosoma mansoni | thyroid hormone receptor | 0.0062 | 0.0061 | 0.1196 |
Onchocerca volvulus | 0.0062 | 0.0061 | 0.0061 | |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0062 | 0.0061 | 0.1196 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0062 | 0.0061 | 0.0063 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0062 | 0.0061 | 0.1196 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0062 | 0.0061 | 0.1196 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0062 | 0.0061 | 0.0061 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0062 | 0.0061 | 0.1196 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0062 | 0.0061 | 0.0063 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0062 | 0.0061 | 0.1196 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1332 | 0.975 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0062 | 0.0061 | 0.1196 |
Schistosoma mansoni | lipoxygenase | 0.0121 | 0.0512 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0062 | 0.0061 | 0.1196 |
Brugia malayi | nuclear hormone receptor | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.1302 | 0.9527 | 0.9771 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0062 | 0.0061 | 0.1196 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0062 | 0.0061 | 0.0063 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0062 | 0.0061 | 0.1196 |
Brugia malayi | steroid hormone receptor | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0062 | 0.0061 | 0.0063 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0062 | 0.0061 | 0.1196 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0062 | 0.0061 | 0.1196 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0062 | 0.0061 | 0.1196 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0062 | 0.0061 | 0.1196 |
Schistosoma mansoni | nuclear hormone receptor | 0.0062 | 0.0061 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | nuclear hormone receptor | 0.1332 | 0.975 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0062 | 0.0061 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0062 | 0.0061 | 0.0063 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0062 | 0.0061 | 0.1196 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0062 | 0.0061 | 0.1196 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0062 | 0.0061 | 0.1196 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0062 | 0.0061 | 0.1196 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0062 | 0.0061 | 0.1196 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0062 | 0.0061 | 0.0061 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0062 | 0.0061 | 0.1196 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0062 | 0.0061 | 0.0063 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0121 | 0.0512 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0121 | 0.0512 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0085 | 0.0234 | 0.457 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0062 | 0.0061 | 0.0063 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0062 | 0.0061 | 0.1196 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0062 | 0.0061 | 0.0063 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0062 | 0.0061 | 0.1196 |
Brugia malayi | ecdysteroid receptor | 0.0062 | 0.0061 | 0.0063 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0062 | 0.0061 | 0.1196 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0062 | 0.0061 | 0.0063 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0062 | 0.0061 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0061 | 0.0063 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0062 | 0.0061 | 0.1196 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.0000000063 M | Effective concentration required for [35S]-GTP-gammaS binding towards Sphingosine 1-phosphate receptor G-protein complex expressed in HEK293T cells | ChEMBL. | 16125386 |
EC50 (functional) | = 0.000000014 M | Effective concentration required for [35S]-GTP-gammaS binding towards Sphingosine 1-phosphate receptor G-protein complex expressed in HEK293T cells | ChEMBL. | 16125386 |
EC50 (functional) | = 0.00000014 M | Effective concentration required for [35S]-GTP-gammaS binding towards Sphingosine 1-phosphate receptor G-protein complex expressed in HEK293T cells | ChEMBL. | 16125386 |
EC50 (functional) | = 0.00000016 M | Effective concentration required for [35S]-GTP-gammaS binding towards Sphingosine 1-phosphate receptor G-protein complex expressed in HEK293T cells | ChEMBL. | 16125386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.