Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0033 | 0.0033 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0169 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0169 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0172 | 0.0033 | 0.0033 |
Echinococcus granulosus | acetylcholinesterase | 0.1 | 1 | 1 |
Onchocerca volvulus | 0.0169 | 0 | 0.5 | |
Onchocerca volvulus | 0.0169 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0169 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0169 | 0 | 0.5 |
Onchocerca volvulus | 0.0169 | 0 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0169 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0169 | 0 | 0.5 |
Echinococcus granulosus | choline O acetyltransferase | 0.0172 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | carboxylesterase | 0.1 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0172 | 0.0033 | 0.0033 |
Onchocerca volvulus | 0.0169 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.1 | 1 | 1 |
Onchocerca volvulus | 0.0169 | 0 | 0.5 | |
Brugia malayi | Choline O-acetyltransferase | 0.0172 | 0.0033 | 0.0033 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0172 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0172 | 0.0033 | 0.0033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 24 nM | Inhibitory concentration aganist melanin concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]-MCH | ChEMBL. | 16161992 |
IC50 (binding) | = 24 nM | Inhibitory concentration aganist melanin concentrating hormone receptor 1 expressed in IMR-32 cells using [125I]-MCH | ChEMBL. | 16161992 |
IC50 (functional) | = 28 nM | Inhibition of melanin concentrating hormone receptor 1 mediated [Ca2+] release in IMR-32 cells in Ca+2 release cell assay | ChEMBL. | 16161992 |
IC50 (functional) | = 28 nM | Inhibition of melanin concentrating hormone receptor 1 mediated [Ca2+] release in IMR-32 cells in Ca+2 release cell assay | ChEMBL. | 16161992 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.