Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | fk506-binding protein 1-like protein | 0.0881 | 1 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0881 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0288 | 0.0288 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0881 | 1 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0881 | 1 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0881 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0881 | 1 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0881 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0881 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0881 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0288 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0288 | 0.0288 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0881 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0288 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0288 | 0.0288 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0881 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.076 | 0.8385 | 0.8385 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0881 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0881 | 1 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.076 | 0.8385 | 0.8337 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0881 | 1 | 0.5 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0881 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0288 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.0288 | 0.0288 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0881 | 1 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0881 | 1 | 0.5 |
Loa Loa (eye worm) | amino acid permease | 0.0152 | 0.0288 | 0.0288 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0881 | 1 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0881 | 1 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0881 | 1 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.0881 | 1 | 0.5 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0881 | 1 | 0.5 |
Schistosoma mansoni | immunophilin | 0.076 | 0.8385 | 0.8337 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0881 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0881 | 1 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0881 | 1 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0881 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0881 | 1 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0881 | 1 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0881 | 1 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.076 | 0.8385 | 0.8337 |
Loa Loa (eye worm) | FKBP5 protein | 0.0881 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 10 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 11 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 56 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Ki (binding) | = 6.77 | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 |
Ki (binding) | = 7.48 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Ki (binding) | = 6 nM | Binding affinity towards adenosine A1 receptor in rat cerebral cortical membranes with 1 nM [3H]-cyclohexyladenosine | ChEMBL. | 2993622 |
Ki (binding) | = 6 nM | Binding affinity towards adenosine A1 receptor in rat cerebral cortical membranes with 1 nM [3H]-cyclohexyladenosine | ChEMBL. | 2993622 |
Ki (functional) | = 16.3 nM | Antagonist activity against human A2B adenosine receptor expressed in HEK-293 cells uisng [3H]-ZM-241,385 or [125I]-IABOPX | ChEMBL. | 10737749 |
Ki (functional) | = 16.3 nM | Antagonist activity against human A2B adenosine receptor expressed in HEK-293 cells uisng [3H]-ZM-241,385 or [125I]-IABOPX | ChEMBL. | 10737749 |
Ki (functional) | = 20 nM | Antagonist activity against adenosine A1 receptor in rat brain membrane in presence of [3H]-R-PIA radioligand. | ChEMBL. | 10737749 |
Ki (functional) | = 20 nM | Antagonist activity against adenosine A1 receptor in rat brain membrane in presence of [3H]-R-PIA radioligand. | ChEMBL. | 10737749 |
Ki (binding) | = 47 nM | Binding affinity against A2 adenosine receptor in guinea pig cerebral cortical slices by [3H]-adenine displacement. | ChEMBL. | 2993622 |
Ki (binding) | = 47 nM | Binding affinity against A2 adenosine receptor in guinea pig cerebral cortical slices by [3H]-adenine displacement. | ChEMBL. | 2993622 |
Ki (functional) | = 76.3 nM | Antagonist activity against adenosine A2A receptor in rat striatal membrane in presence of [3H]-CGS-21,680 radioligand. | ChEMBL. | 10737749 |
Ki (functional) | = 76.3 nM | Antagonist activity against adenosine A2A receptor in rat striatal membrane in presence of [3H]-CGS-21,680 radioligand. | ChEMBL. | 10737749 |
Ratio (binding) | = 7.8 | Ratio of Ki for A1 and A2 receptors | ChEMBL. | 2993622 |
Solubility | = 26 uM | Solubility of the compound was determined in 0.1 M sodium phosphate, and at pH 7.2 | ChEMBL. | 2993622 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.