Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | enoyl-acyl carrier reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium channel protein | 0.0122 | 0.3408 | 0.9405 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0023 | 0.0129 | 0.0356 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0223 | 0.6787 | 0.5 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0128 | 0.3624 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0336 | 0.0926 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.6787 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.0651 | 0.0956 |
Trichomonas vaginalis | hypothetical protein | 0.0223 | 0.6787 | 1 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0029 | 0.0348 | 0.1098 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0087 | 0.2268 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0129 | 0.0407 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2609 | 0.8225 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0023 | 0.0129 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0922 | 0.2907 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0098 | 0.2609 | 0.7196 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0098 | 0.2609 | 0.7196 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.6787 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0052 | 0.1103 | 0.3039 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0098 | 0.2609 | 0.7196 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0128 | 0.3624 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0098 | 0.2609 | 0.7196 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0098 | 0.2609 | 0.7196 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0003 | 0.0009 |
Schistosoma mansoni | voltage-gated cation channel | 0.0098 | 0.2609 | 0.7196 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0336 | 0.1058 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.6787 | 0.6787 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0098 | 0.2609 | 0.7196 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0122 | 0.3408 | 0.9405 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0029 | 0.0348 | 0.0954 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0023 | 0.0129 | 0.0348 |
Echinococcus granulosus | voltage gated potassium channel | 0.0023 | 0.0129 | 0.0348 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0019 | 0.0003 | 0.0008 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0039 | 0.0651 | 0.0956 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0019 | 0.0003 | 0.0009 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0098 | 0.2609 | 0.7199 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0064 | 0.1489 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 0.6787 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0098 | 0.2609 | 0.7196 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0128 | 0.3624 | 1 |
Echinococcus granulosus | sodium channel protein | 0.0087 | 0.2268 | 0.6255 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0052 | 0.1103 | 0.3045 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0098 | 0.2609 | 0.7196 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0056 | 0.1229 | 0.3387 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0098 | 0.2609 | 0.7196 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0098 | 0.2609 | 0.7196 |
Loa Loa (eye worm) | calcium channel | 0.0098 | 0.2609 | 0.8225 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0056 | 0.1229 | 0.3387 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.032 | 1 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0019 | 0.0003 | 0.0009 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0023 | 0.0129 | 0.0348 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0098 | 0.2609 | 0.7196 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0023 | 0.0129 | 0.0348 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0023 | 0.0129 | 0.0348 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0064 | 0.1489 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.6787 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 0.6787 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0052 | 0.1103 | 0.3479 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0098 | 0.2609 | 0.7196 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0348 | 0.1098 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0052 | 0.1103 | 0.3039 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.0128 | 0.3624 | 1 |
Mycobacterium ulcerans | ion transport protein | 0.0086 | 0.2224 | 0.2224 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0115 | 0.3172 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 66.8 uM | Inhibition of drug sensitive Plasmodium falciparum 3D7 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
EC50 (functional) | = 66.8 uM | Inhibition of drug sensitive Plasmodium falciparum 3D7 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
EC50 (functional) | = 86.4 uM | Inhibition of drug resistant Plasmodium falciparum Dd2 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
EC50 (functional) | = 86.4 uM | Inhibition of drug resistant Plasmodium falciparum Dd2 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
EC50 (functional) | = 100 uM | Antimalarial activity against Plasmodium falciparum Dd2 assessed as inhibition of parasite growth | ChEMBL. | 23313245 |
IC50 (binding) | = 250 nM | Inhibition of PfENR enzymatic activity | ChEMBL. | 16198563 |
IC50 (binding) | = 250 nM | Inhibition of PfENR enzymatic activity | ChEMBL. | 16198563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.