Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arginine vasopressin receptor 1A | Starlite/ChEMBL | References |
Homo sapiens | oxytocin receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0823 | 0.0685 |
Echinococcus multilocularis | geminin | 0.0164 | 0.5941 | 0.7872 |
Brugia malayi | Animal haem peroxidase family protein | 0.0199 | 0.7493 | 0.7455 |
Schistosoma mansoni | peroxidasin | 0.0199 | 0.7493 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.0361 | 0.0216 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0246 | 0.9583 | 0.9577 |
Brugia malayi | Animal haem peroxidase family protein | 0.0199 | 0.7493 | 0.7455 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3077 | 0.3211 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.4195 | 0.5478 |
Onchocerca volvulus | Peroxidasin homolog | 0.0199 | 0.7493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Brugia malayi | Animal haem peroxidase family protein | 0.0199 | 0.7493 | 0.7455 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0823 | 0.0685 |
Onchocerca volvulus | Peroxidase homolog | 0.0199 | 0.7493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0361 | 0.0377 |
Schistosoma mansoni | jumonji domain containing protein | 0.0073 | 0.1936 | 0.2434 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0199 | 0.7493 | 0.7819 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0144 | 0.5079 | 0.6689 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0092 | 0.2776 | 0.3532 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0067 | 0.1671 | 0.1744 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 0.1671 | 0.2017 |
Echinococcus granulosus | chromobox protein 1 | 0.0067 | 0.1671 | 0.2017 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 0.1671 | 0.2017 |
Brugia malayi | hypothetical protein | 0.0199 | 0.7493 | 0.7455 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.02 | 0.0071 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.0426 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0823 | 0.0859 |
Brugia malayi | Animal haem peroxidase family protein | 0.0199 | 0.7493 | 0.7455 |
Echinococcus multilocularis | peroxidasin | 0.0199 | 0.7493 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0067 | 0.1671 | 0.2017 |
Onchocerca volvulus | 0.0199 | 0.7493 | 1 | |
Brugia malayi | jmjC domain containing protein | 0.0034 | 0.02 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5941 | 0.7887 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.9533 | 0.9948 |
Brugia malayi | Animal haem peroxidase family protein | 0.0199 | 0.7493 | 0.7455 |
Onchocerca volvulus | 0.0199 | 0.7493 | 1 | |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.0426 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.1671 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0099 | 0.3077 | 0.4107 |
Brugia malayi | Peroxidasin | 0.0199 | 0.7493 | 0.7455 |
Brugia malayi | jmjC domain containing protein | 0.0092 | 0.2776 | 0.2667 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.1671 | 0.2074 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.1266 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0246 | 0.9583 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0067 | 0.1671 | 0.1546 |
Schistosoma mansoni | peroxidasin | 0.0199 | 0.7493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0199 | 0.7493 | 0.7819 |
Brugia malayi | Blistered cuticle protein 3 | 0.0199 | 0.7493 | 0.7455 |
Echinococcus granulosus | peroxidasin | 0.0199 | 0.7493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Onchocerca volvulus | Peroxidase homolog | 0.0199 | 0.7493 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0199 | 0.7493 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0488 | 0.0969 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0488 | 0.0969 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0092 | 0.2776 | 0.3532 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0488 | 0.0651 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.4195 | 0.5478 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3077 | 0.3211 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.5941 | 0.7887 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Echinococcus granulosus | geminin | 0.0164 | 0.5941 | 0.7872 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0148 | 0.0155 |
Trichomonas vaginalis | chromobox protein, putative | 0.0067 | 0.1671 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0199 | 0.7493 | 0.7819 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0199 | 0.7493 | 0.7819 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0829 | 0.0865 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0034 | 0.02 | 0.0071 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0199 | 0.7493 | 1 |
Brugia malayi | Phospholipase A2 family protein | 0.0099 | 0.3077 | 0.2973 |
Onchocerca volvulus | Peroxidasin homolog | 0.0199 | 0.7493 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Onchocerca volvulus | 0.0199 | 0.7493 | 1 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0823 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0199 | 0.7493 | 0.7819 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0246 | 0.9583 | 0.9577 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0099 | 0.3077 | 0.4107 |
Schistosoma mansoni | thyroid hormone receptor | 0.0144 | 0.5079 | 0.6713 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.4195 | 0.5509 |
Schistosoma mansoni | thyroid hormone receptor | 0.0144 | 0.5079 | 0.6713 |
Schistosoma mansoni | chromobox protein | 0.0067 | 0.1671 | 0.2074 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7493 | 0.7819 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.0361 | 0.0482 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0034 | 0.02 | 0.0209 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | > 10000 nM | Displacement of [125I]-OVTA antagonist from human oxytocin receptor expressed in HEK293-EBNA cells | ChEMBL. | 16302826 |
Ki (functional) | > 10000 nM | Displacement of [125I]-LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells | ChEMBL. | 16302826 |
Ki (functional) | > 10000 nM | Displacement of [125I]-OVTA antagonist from human oxytocin receptor expressed in HEK293-EBNA cells | ChEMBL. | 16302826 |
Ki (functional) | > 10000 nM | Displacement of [125I]-LVA antagonist from human vasopressin 1a receptor expressed in HEK293-EBNA cells | ChEMBL. | 16302826 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.