Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanocortin 4 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 1 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0024 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0024 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.3107 | 0.3107 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0024 | 0 | 0.5 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0024 | 0 | 0.5 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.3107 | 0.3107 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0163 | 1 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0024 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.3107 | 0.3107 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3107 | 0.3107 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0024 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.3107 | 0.3107 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.3107 | 0.3107 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 0.3107 | 0.3107 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0024 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.3107 | 0.3107 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.3107 | 0.3107 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.3107 | 0.3107 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.3107 | 0.3107 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0024 | 0 | 0.5 |
Echinococcus granulosus | choline O acetyltransferase | 0.0163 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0163 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 0.3107 | 0.3107 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0163 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.3107 | 0.3107 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0024 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0024 | 0 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0163 | 1 | 1 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0024 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 440 nM | cAMP stimulation in HEK293 cells transfected with human MC4R | ChEMBL. | 16183282 |
EC50 (functional) | = 440 nM | cAMP stimulation in HEK293 cells transfected with human MC4R | ChEMBL. | 16183282 |
Emax (functional) | = 43 % | cAMP stimulation in HEK293 cells transfected with human MC4R | ChEMBL. | 16183282 |
Emax (functional) | = 43 % | cAMP stimulation in HEK293 cells transfected with human MC4R | ChEMBL. | 16183282 |
Ki (binding) | = 99 nM | Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells | ChEMBL. | 16183282 |
Ki (binding) | = 99 nM | Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells | ChEMBL. | 16183282 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.