TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 551.464 | Formula: C29H28Cl2N4O3
H donors: 2 H acceptors: 4 LogP: 4.7 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: N#Cc1cccc(c1)c1ccc(cc1)[C@H](N(C(=O)CN1CC[C@@H](C1)O)CC(=O)Nc1cc(Cl)cc(c1)Cl)C
InChi: 1S/C29H28Cl2N4O3/c1-19(21-5-7-22(8-6-21)23-4-2-3-20(11-23)15-32)35(29(38)18-34-10-9-27(36)16-34)17-28(37)33-26-13-24(30)12-25(31)14-26/h2-8,11-14,19,27,36H,9-10,16-18H2,1H3,(H,33,37)/t19-,27+/m1/s1
InChiKey: KEWLJSVNGHJZNQ-WINIVTDRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanin-concentrating hormone receptor 2	Starlite/ChEMBL	References
Homo sapiens	melanin-concentrating hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein coupled receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0089	0.7633	0.7633
Loa Loa (eye worm)	G-protein coupled receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	fmrfamide receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	neuropeptide s receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Onchocerca volvulus		0.0089	0.7633	1
Echinococcus granulosus	orexin receptor type 2	0.0089	0.7633	0.7633
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0089	0.7633	0.7633
Echinococcus multilocularis	g-protein coupled receptor	0.0089	0.7633	0.7633
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.1901	0.1901
Onchocerca volvulus		0.0089	0.7633	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0089	0.7633	0.7633
Brugia malayi	putative neuropeptide receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	g protein coupled receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.2418	0.2418
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.3105	0.3105
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.2143	0.2143
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0112	1	1
Mycobacterium tuberculosis	Probable trigger factor (TF) protein Tig	0.0015	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.1185	0.1185
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus multilocularis	fk506 binding protein	0.0112	1	1
Echinococcus granulosus	serotonin receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	histamine h1 receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0089	0.7633	0.7633
Brugia malayi	Serotonin receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus multilocularis	sex peptide receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0089	0.7633	0.7633
Brugia malayi	neuropeptide F receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.3105	0.3105
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0045	0.3105	0.3105
Loa Loa (eye worm)	G-protein coupled receptor	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.1901	0.1901
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0089	0.7633	0.7633
Onchocerca volvulus		0.0089	0.7633	1
Loa Loa (eye worm)	FKBP5 protein	0.0112	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0089	0.7633	0.7633
Giardia lamblia	GTOR	0.0045	0.3105	0.3105
Onchocerca volvulus		0.0089	0.7633	1
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0112	1	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0089	0.7633	0.7633
Brugia malayi	hypothetical protein	0.0089	0.7633	0.7633
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0045	0.3105	0.3105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.1213	0.1213
Brugia malayi	Serotonin receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	biogenic amine 5HT receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0089	0.7633	0.7633
Schistosoma mansoni	amine GPCR	0.0089	0.7633	0.7633
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0089	0.7633	0.7633
Leishmania major	peptidylprolyl isomerase-like protein	0.0112	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0943	0.0943
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0045	0.3105	0.3105
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0089	0.7633	0.7633
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0112	1	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0089	0.7633	0.7633
Brugia malayi	hypothetical protein	0.0089	0.7633	0.7633
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0089	0.7633	0.7633
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0089	0.7633	1
Brugia malayi	hypothetical protein	0.0089	0.7633	0.7633
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0089	0.7633	0.7633
Giardia lamblia	70 kDa peptidylprolyl isomerase, putative	0.0112	1	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Onchocerca volvulus		0.0089	0.7633	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.3105	0.3105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0939	0.0939
Onchocerca volvulus		0.0089	0.7633	1
Schistosoma mansoni	amine GPCR	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0089	0.7633	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0089	0.7633	0.7633
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.2147	0.2147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.1901	0.1901
Brugia malayi	putative neuropeptide receptor NPR1	0.0089	0.7633	0.7633
Schistosoma mansoni	amine GPCR	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus multilocularis	dro:myosuppressin receptor	0.0089	0.7633	0.7633
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Brugia malayi	G protein-coupled receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	neuropeptide F receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	biogenic amine receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	neuropeptide s receptor	0.0089	0.7633	0.7633
Onchocerca volvulus		0.0089	0.7633	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0034	0.1901	1
Schistosoma mansoni	opsin-like receptor	0.0089	0.7633	0.7633
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0045	0.3105	0.3105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0943	0.0943
Brugia malayi	Melatonin receptor type 1A	0.0089	0.7633	0.7633
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Echinococcus granulosus	tm gpcr rhodopsin	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0939	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Trypanosoma cruzi	target of rapamycin kinase 3	0.0036	0.2147	0.2147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Brugia malayi	hypothetical protein	0.0089	0.7633	0.7633
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0045	0.3105	0.3105
Echinococcus multilocularis	neuropeptide receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	G protein coupled receptor 139	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Echinococcus granulosus	sex peptide receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	neuropeptide F-like receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0089	0.7633	0.7633
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0112	1	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0089	0.7633	0.7633
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	neuropeptide FF receptor 2	0.0089	0.7633	0.7633
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0045	0.3105	0.3105
Brugia malayi	ORL1-like opioid receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus multilocularis	somatostatin receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0112	1	1
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0112	1	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0112	1	1
Brugia malayi	RE15519p	0.0089	0.7633	0.7633
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0097	0.8404	0.8404
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	adenoreceptor	0.0089	0.7633	0.7633
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Echinococcus granulosus	neuropeptides capa receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0015	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	biogenic amine 5HT receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0089	0.7633	0.7633
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.3105	0.3105
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.1557	0.1557
Brugia malayi	Dopamine receptor protein 2	0.0089	0.7633	0.7633
Echinococcus multilocularis	serotonin receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0112	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0089	0.7633	0.7633
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	g protein coupled receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.1213	0.1213
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.3105	0.3105
Echinococcus multilocularis	orexin receptor type 2	0.0089	0.7633	0.7633
Brugia malayi	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0089	0.7633	0.7633
Echinococcus granulosus	dro:myosuppressin receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.1901	0.1901
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	7tm_1 domain containing protein	0.0089	0.7633	0.7633
Schistosoma mansoni	neuropeptide f receptor 76f	0.0089	0.7633	0.7633
Brugia malayi	neuropeptide F receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Schistosoma mansoni	neuropeptide receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Echinococcus granulosus	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.1901	0.1901
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.1456	0.1456
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0112	1	1
Onchocerca volvulus		0.0089	0.7633	1
Giardia lamblia	FKBP-type peptidyl-prolyl cis-trans isomerase	0.0112	1	1
Brugia malayi	G-protein coupled receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	neuropeptide receptor A26	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.2143	0.2143
Brugia malayi	AKH receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	neuropeptide receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	g protein coupled receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	neuropeptide receptor	0.0089	0.7633	0.7633
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0112	1	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0089	0.7633	0.7633
Echinococcus multilocularis	neuropeptides capa receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	neuropeptide Y receptor	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0943	0.0943
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Onchocerca volvulus		0.0089	0.7633	1
Mycobacterium leprae	PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG	0.0015	0	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0089	0.7633	0.7633
Brugia malayi	G protein-coupled receptor F59B2.13	0.0089	0.7633	0.7633
Brugia malayi	G-protein coupled receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	neuropeptide receptor	0.0089	0.7633	0.7633
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0112	1	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0019	0.0357	0.0357
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0089	0.7633	0.7633
Schistosoma mansoni	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus multilocularis	neuropeptide receptor A26	0.0089	0.7633	0.7633
Brugia malayi	sulfakinin receptor protein	0.0089	0.7633	0.7633
Schistosoma mansoni	biogenic amine receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0112	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0089	0.7633	0.7633
Brugia malayi	GnHR receptor homolog	0.0089	0.7633	0.7633
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Loa Loa (eye worm)	TYRA-2 protein	0.0089	0.7633	0.7633
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0089	0.7633	0.7633
Schistosoma mansoni	growth hormone secretagogue receptor	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0939	0.0939
Brugia malayi	follicle stimulating hormone receptor	0.0089	0.7633	0.7633
Trichomonas vaginalis	fk506-binding protein, putative	0.0112	1	1
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0112	1	1
Schistosoma mansoni	opsin-like receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0112	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.1901	0.1901
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0089	0.7633	0.7633
Onchocerca volvulus		0.0089	0.7633	1
Schistosoma mansoni	immunophilin	0.0112	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0089	0.7633	0.7633
Brugia malayi	Dopamine receptor protein 1	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.1213	0.1213
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	hypothetical protein	0.0089	0.7633	0.7633
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0045	0.3105	0.3105
Schistosoma mansoni	opsin-like receptor	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.2143	0.2143
Echinococcus multilocularis	neuropeptide receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0089	0.7633	0.7633
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0089	0.7633	0.7633
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.0627	0.0627
Echinococcus granulosus	neuropeptides capa receptor	0.0089	0.7633	0.7633
Brugia malayi	hypothetical protein	0.0089	0.7633	0.7633
Brugia malayi	Dopamine receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0045	0.3105	0.3105
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0112	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0089	0.7633	0.7633
Onchocerca volvulus		0.0089	0.7633	1
Onchocerca volvulus		0.0089	0.7633	1
Schistosoma mansoni	immunophilin	0.0097	0.8404	0.8404
Echinococcus multilocularis	allatostatin A receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0045	0.3105	0.3105
Echinococcus granulosus	neuropeptide Y receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	fmrfamide receptor	0.0089	0.7633	0.7633
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0045	0.3105	0.3105
Schistosoma mansoni	hypothetical protein	0.0089	0.7633	0.7633
Onchocerca volvulus		0.0089	0.7633	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0097	0.8404	0.8404
Onchocerca volvulus		0.0089	0.7633	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0089	0.7633	0.7633
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0112	1	1
Schistosoma mansoni	neuropeptide receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	allatostatin A receptor	0.0089	0.7633	0.7633
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0036	0.2147	0.2147
Echinococcus granulosus	somatostatin receptor	0.0089	0.7633	0.7633
Brugia malayi	hypothetical protein	0.0089	0.7633	0.7633
Schistosoma mansoni	biogenic amine receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0089	0.7633	0.7633
Echinococcus granulosus	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Schistosoma mansoni	hypothetical protein	0.0089	0.7633	0.7633
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0112	1	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.1185	0.1185
Echinococcus multilocularis	neuropeptide Y receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	myosin xvIII	0.0089	0.7633	0.7633
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0089	0.7633	0.7633
Schistosoma mansoni	amine GPCR	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.3105	0.3105
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0112	1	1
Chlamydia trachomatis	peptidyl-prolyl cis-trans isomerase	0.0015	0	0.5
Onchocerca volvulus		0.0089	0.7633	1
Echinococcus multilocularis	serotonin receptor	0.0089	0.7633	0.7633
Echinococcus granulosus	g-protein coupled receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	fmrfamide receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	rhodopsin orphan GPCR	0.0089	0.7633	0.7633
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0943	0.0943
Wolbachia endosymbiont of Brugia malayi	FKBP-type peptidylprolyl isomerase	0.0015	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8404	0.8404
Echinococcus multilocularis	g protein coupled receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	neuropeptide F receptor	0.0089	0.7633	0.7633
Brugia malayi	hypothetical protein	0.0089	0.7633	0.7633
Onchocerca volvulus		0.0089	0.7633	1
Brugia malayi	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	tm gpcr rhodopsin	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus multilocularis	G protein coupled receptor 139	0.0089	0.7633	0.7633
Echinococcus granulosus	g protein coupled receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0089	0.7633	0.7633
Onchocerca volvulus		0.0089	0.7633	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0089	0.7633	0.7633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.1901	0.1901
Schistosoma mansoni	hypothetical protein	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Trichomonas vaginalis	immunophilin, putative	0.0112	1	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Brugia malayi	larval opioid receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	amine GPCR	0.0089	0.7633	0.7633
Loa Loa (eye worm)	hypothetical protein	0.0089	0.7633	0.7633
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0112	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.2143	0.2143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.2143	0.2143
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0089	0.7633	0.7633
Loa Loa (eye worm)	melatonin receptor type 1A	0.0089	0.7633	0.7633
Schistosoma mansoni	neuropeptide receptor	0.0089	0.7633	0.7633
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0089	0.7633	0.7633
Schistosoma mansoni	immunophilin	0.0112	1	1
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0112	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0089	0.7633	0.7633
Leishmania major	fk506-binding protein 1-like protein	0.0112	1	1
Brugia malayi	hypothetical protein	0.0089	0.7633	0.7633

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (functional)	= 31 nM	Antagonist activity against human MCH1 receptor	ChEMBL.	16202583
Ki (functional)	= 31 nM	Antagonist activity against human MCH1 receptor	ChEMBL.	16202583
Ki (functional)	> 3 uM	Antagonist activity against human MCH2 receptor	ChEMBL.	16202583
Ki (functional)	> 3 uM	Antagonist activity against human MCH2 receptor	ChEMBL.	16202583

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL197065

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 346248