Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 207 aa | 30.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0585 | 1 | 1 |
Onchocerca volvulus | 0.0585 | 1 | 0.5 | |
Onchocerca volvulus | 0.0585 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0585 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0585 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0208 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0585 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0208 | 0 | 0.5 |
Onchocerca volvulus | 0.0585 | 1 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0585 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0585 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0585 | 1 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0585 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0585 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0585 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0585 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0585 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0208 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0585 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0585 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0585 | 1 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0585 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0585 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0585 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.015 uM | Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cells | ChEMBL. | 3385730 |
IC50 (binding) | = 0.015 uM | Inhibition of dihydrofolate reductase (DHFR) from murine leukemia cells | ChEMBL. | 3385730 |
IC50 (functional) | = 0.2 uM | Inhibitory concentration against growth of L1210 cell line | ChEMBL. | 3385730 |
IC50 (functional) | = 0.2 uM | Inhibitory concentration against growth of L1210 cell line | ChEMBL. | 3385730 |
IC50 (functional) | > 200 uM | Inhibitory concentration against growth of L1210/R81 cell line | ChEMBL. | 3385730 |
IC50 (functional) | > 200 uM | Inhibitory concentration against growth of L1210/R81 cell line | ChEMBL. | 3385730 |
Ki (functional) | > 100 uM | Inhibition of FPGS from mouse liver in the presence of folic acid | ChEMBL. | 3385730 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 3385730 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.