Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Choline O-acetyltransferase | 0.0167 | 0.2128 | 0.2128 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.5264 | 0.5264 |
Echinococcus granulosus | acetylcholinesterase | 0.0482 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.5264 | 0.5264 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.5264 | 0.5264 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0167 | 0.2128 | 0.2128 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0081 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0482 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.5264 | 0.5264 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.5264 | 0.5264 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0482 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.5264 | 0.5264 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0081 | 0 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0167 | 0.2128 | 0.2128 |
Brugia malayi | Choline O-acetyltransferase | 0.0167 | 0.2128 | 0.2128 |
Loa Loa (eye worm) | carboxylesterase | 0.0482 | 1 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0167 | 0.2128 | 0.2128 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.5264 | 0.5264 |
Echinococcus granulosus | choline O acetyltransferase | 0.0167 | 0.2128 | 0.2128 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.5264 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0482 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0482 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.5264 | 0.5264 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.2128 | 0.2128 |
Echinococcus granulosus | carboxylesterase 5A | 0.0482 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.5264 | 0.5264 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0081 | 0 | 0.5 |
Onchocerca volvulus | 0.0292 | 0.5264 | 1 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0081 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0482 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0482 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0081 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0081 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.5264 | 0.5264 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.5264 | 0.5264 |
Echinococcus multilocularis | acetylcholinesterase | 0.0482 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 50 nM | Displacement of [3H]CFT from human DAT expressed in COS7 cells | ChEMBL. | 16302792 |
Ki (binding) | = 50 nM | Displacement of [3H]CFT from human DAT expressed in COS7 cells | ChEMBL. | 16302792 |
Ki (binding) | = 227 nM | Displacement of [3H]5HT from human SERT expressed in COS7 cells | ChEMBL. | 16302792 |
Ki (binding) | = 227 nM | Displacement of [3H]5HT from human SERT expressed in COS7 cells | ChEMBL. | 16302792 |
Ki (binding) | = 250 nM | Displacement of [3H]dopamine from human DAT expressed in COS7 cells | ChEMBL. | 16302792 |
Ki (binding) | = 250 nM | Displacement of [3H]dopamine from human DAT expressed in COS7 cells | ChEMBL. | 16302792 |
Ki (binding) | = 308 nM | Displacement of [3H]dopamine from human NET expressed in COS7 cells | ChEMBL. | 16302792 |
Ki (binding) | = 308 nM | Displacement of [3H]dopamine from human NET expressed in COS7 cells | ChEMBL. | 16302792 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.