Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.0488 | 0.0488 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0935 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.0488 | 0.0488 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0935 | 1 | 0.5 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0935 | 1 | 0.5 |
Loa Loa (eye worm) | amino acid permease | 0.0248 | 0.0488 | 0.0488 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0935 | 1 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.0935 | 1 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0935 | 1 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0935 | 1 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0935 | 1 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0935 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0935 | 1 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0935 | 1 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0935 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0806 | 0.8219 | 0.8127 |
Loa Loa (eye worm) | FKBP5 protein | 0.0935 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0806 | 0.8219 | 0.8127 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0935 | 1 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0935 | 1 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0935 | 1 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0935 | 1 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0935 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0935 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0935 | 1 | 0.5 |
Leishmania major | fk506-binding protein 1-like protein | 0.0935 | 1 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0935 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.0488 | 0.0488 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0935 | 1 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0935 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.0488 | 0.0488 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0935 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0935 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0806 | 0.8219 | 0.8127 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0935 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0806 | 0.8219 | 0.8219 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0935 | 1 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0935 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 0.0488 | 0.0488 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0935 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6 uM | Tested in vitro for inhibition of chymotrypsin like activity of purified human 20S proteasome | ChEMBL. | 11992770 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.