Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Cholecystokinin B receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Cholecystokinin A receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Brugia malayi | sulfakinin receptor protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132882 | All targets in OG5_132882 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.2269 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 1.2269 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.2269 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 1.2269 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.6613 | 0.5098 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.2269 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 1.2269 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 1.2269 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.073 | 0 | 0.5 |
Onchocerca volvulus | 0.1535 | 0.0697 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 1.2269 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1535 | 0.0697 | 0.0697 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.2269 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6613 | 0.5098 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.6613 | 0.5098 | 0.5 |
Brugia malayi | thymidylate synthase | 0.1535 | 0.0697 | 0.0697 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.6613 | 0.5098 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.6613 | 0.5098 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6613 | 0.5098 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Displacement of [3H]propionylCCK8 from rat pancreatic CCK1 | ChEMBL. | 16302807 |
IC50 (binding) | > 10000 nM | Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2 | ChEMBL. | 16302807 |
IC50 (binding) | > 10000 nM | Displacement of [3H]propionylCCK8 from rat pancreatic CCK1 | ChEMBL. | 16302807 |
IC50 (binding) | > 10000 nM | Displacement of [3H]propionylCCK8 from rat cerebral cortex CCK2 | ChEMBL. | 16302807 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.