Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0223 | 0.4808 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0365 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0313 | 0.8118 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0313 | 0.8118 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0223 | 0.4808 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0365 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0223 | 0.4808 | 0.4808 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0223 | 0.4808 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0365 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0365 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0223 | 0.4808 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0223 | 0.4808 | 0.4808 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0313 | 0.8118 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0106 | 0.0552 | 0.1148 |
Loa Loa (eye worm) | thymidylate synthase | 0.0223 | 0.4808 | 0.4808 |
Brugia malayi | hypothetical protein | 0.0106 | 0.0552 | 0.0552 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0365 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0106 | 0.0552 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0223 | 0.4808 | 0.4808 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0313 | 0.8118 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0091 | 0 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0313 | 0.8118 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0365 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0313 | 0.8118 | 0.5 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0365 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.6 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP | ChEMBL. | 16302797 |
IC50 (binding) | = 5.2 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasma | ChEMBL. | 16302797 |
IC50 (binding) | = 8.8 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathione | ChEMBL. | 16302797 |
IC50 (binding) | = 10.4 nM | Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 1 mm ATP | ChEMBL. | 16302797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.