Detailed information for compound 346941

Basic information

Technical information
  • TDR Targets ID: 346941
  • Name: 2-morpholin-4-yl-7-[4-(trifluoromethoxy)pheny l]chromen-4-one
  • MW: 391.341 | Formula: C20H16F3NO4
  • H donors: 0 H acceptors: 1 LogP: 4.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(oc2c1ccc(c2)c1ccc(cc1)OC(F)(F)F)N1CCOCC1
  • InChi: 1S/C20H16F3NO4/c21-20(22,23)28-15-4-1-13(2-5-15)14-3-6-16-17(25)12-19(27-18(16)11-14)24-7-9-26-10-8-24/h1-6,11-12H,7-10H2
  • InChiKey: WYNPLBBFDMWFAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-morpholino-7-[4-(trifluoromethoxy)phenyl]chromen-4-one
  • 2-morpholino-7-[4-(trifluoromethoxy)phenyl]-1-benzopyran-4-one
  • 2-morpholino-7-[4-(trifluoromethoxy)phenyl]chromone
  • 2-morpholino-7-[4-(trifluoromethoxy)phenyl]-4-chromenone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis RUN 0.0243 0.1616 0.1605
Brugia malayi MH2 domain containing protein 0.014 0.0771 0.1742
Echinococcus multilocularis lipoxygenase domain containing protein 0.0243 0.1616 0.1605
Onchocerca volvulus 0.0089 0.0357 0.1402
Loa Loa (eye worm) solute carrier family 6 member 4 0.0239 0.1586 0.3584
Loa Loa (eye worm) hypothetical protein 0.0168 0.1001 0.2261
Echinococcus multilocularis geminin 0.0187 0.1156 0.1144
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0151 0.2192
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0168 0.1001 0.0988
Brugia malayi nuclear hormone receptor 0.0079 0.0273 0.0617
Onchocerca volvulus 0.0168 0.1001 0.421
Brugia malayi RNA, U transporter 1 0.0096 0.0411 0.0929
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0168 0.1001 0.2261
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.05 0.113
Onchocerca volvulus Protein ultraspiracle homolog 0.0168 0.1001 0.421
Echinococcus granulosus death domain containing protein 0.0058 0.0098 0.0084
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0168 0.1001 0.0988
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0168 0.1001 0.2261
Loa Loa (eye worm) blistered cuticle protein 3 0.0089 0.0357 0.0806
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Brugia malayi nuclear receptor RXR 0.0089 0.0351 0.0793
Brugia malayi hypothetical protein 0.0079 0.0273 0.0617
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0131 0.0701 0.1094
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0079 0.0273 0.0259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0168 0.1001 0.2261
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0168 0.1001 0.2261
Echinococcus granulosus thyroid hormone receptor alpha 0.0079 0.0273 0.0259
Echinococcus multilocularis ecdysone induced protein 78C 0.0168 0.1001 0.0988
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0821 0.6365 0.636
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Brugia malayi small heat shock protein 0.0584 0.4425 1
Schistosoma mansoni retinoic acid receptor RXR 0.027 0.1843 0.1831
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Onchocerca volvulus Peroxidasin homolog 0.0089 0.0357 0.1402
Brugia malayi ShTK domain containing protein 0.0095 0.0406 0.0917
Brugia malayi Protein kinase domain containing protein 0.0058 0.0098 0.0221
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0351 0.0793
Schistosoma mansoni loxhd1 0.0243 0.1616 0.1605
Onchocerca volvulus 0.0095 0.0406 0.1615
Echinococcus granulosus retinoic acid receptor rxr beta a 0.027 0.1843 0.1831
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0151 0.2156
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0151 0.0342
Schistosoma mansoni coup transcription factor 0.0168 0.1001 0.0988
Loa Loa (eye worm) norepinephrine transporter 0.0239 0.1586 0.3584
Loa Loa (eye worm) DR-78 0.0079 0.0273 0.0617
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0079 0.0273 0.0617
Echinococcus granulosus Polycystic kidney disease protein 0.0243 0.1616 0.1605
Onchocerca volvulus 0.0079 0.0273 0.1037
Brugia malayi hypoxia-induced factor 1 0.0305 0.2128 0.481
Echinococcus multilocularis jun protein 0.0419 0.3068 0.3058
Leishmania major cathepsin L-like protease 0.0129 0.0684 0.9759
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0168 0.1001 0.2261
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0168 0.1001 0.0988
Schistosoma mansoni hypothetical protein 0.0341 0.2422 0.2412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0168 0.1001 0.2261
Brugia malayi Blistered cuticle protein 3 0.0089 0.0357 0.0806
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0079 0.0273 0.0259
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.05 0.113
Onchocerca volvulus Dual oxidase homolog 0.0089 0.0357 0.1402
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0168 0.1001 0.2261
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0079 0.0273 0.0259
Loa Loa (eye worm) hypothetical protein 0.0095 0.0406 0.0917
Schistosoma mansoni survival motor neuron protein 0.005 0.0035 0.0021
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.034 0.2414 0.3652
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0222 0.0503
Schistosoma mansoni tyrosinase precursor 0.0095 0.0406 0.0392
Loa Loa (eye worm) nuclear receptor NHR-67 0.0079 0.0273 0.0617
Brugia malayi Uncoordinated protein 44 0.0058 0.0098 0.0221
Schistosoma mansoni hypothetical protein 0.0073 0.0222 0.0209
Loa Loa (eye worm) hypothetical protein 0.0239 0.1586 0.3584
Schistosoma mansoni nuclear hormone receptor 0.0079 0.0273 0.0259
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0116 0.0181
Loa Loa (eye worm) hypothetical protein 0.0408 0.2973 0.672
Brugia malayi Nuclear hormone receptor-like 1 0.0089 0.0351 0.0793
Leishmania major dihydrofolate reductase-thymidylate synthase 0.013 0.069 0.9839
Trypanosoma cruzi cruzipain precursor, putative 0.0129 0.0684 0.9918
Brugia malayi Nuclear hormone receptor-like 1 0.0168 0.1001 0.2261
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.1643 0.1632
Schistosoma mansoni netrin receptor unc5 0.0058 0.0098 0.0084
Schistosoma mansoni hypothetical protein 0.0243 0.1616 0.1605
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0182 0.1115 0.1103
Schistosoma mansoni hypothetical protein 0.0124 0.0645 0.0632
Onchocerca volvulus 0.0095 0.0406 0.1615
Schistosoma mansoni lipoxygenase 0.1263 1 1
Onchocerca volvulus 0.0243 0.1616 0.6896
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0116 0.0181
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0014 0.0031
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0151 0.5
Loa Loa (eye worm) hypoxia-induced factor 1 0.0305 0.2128 0.481
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0406 0.0917
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0151 0.0138
Onchocerca volvulus 0.0073 0.0222 0.0815
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0079 0.0273 0.0259
Echinococcus granulosus FTZ F1 alpha 0.0168 0.1001 0.0988
Echinococcus multilocularis Ankyrin 0.0058 0.0102 0.0088
Loa Loa (eye worm) hypothetical protein 0.0168 0.1001 0.2261
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0168 0.1001 0.0988
Loa Loa (eye worm) hypothetical protein 0.0246 0.1643 0.3714
Loa Loa (eye worm) hypothetical protein 0.0095 0.0406 0.0917
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0079 0.0273 0.1037
Loa Loa (eye worm) hypothetical protein 0.0089 0.0351 0.0793
Loa Loa (eye worm) cytochrome P450 family protein 0.0159 0.0931 0.2103
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0296 0.2055 0.2044
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0131 0.0701 0.093
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.0406 0.0917
Echinococcus granulosus Nuclear hormone receptor HR96 0.0079 0.0273 0.0259
Brugia malayi hypothetical protein 0.0243 0.1616 0.3653
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0118 0.0592 0.8584
Schistosoma mansoni nuclear hormone receptor 0.0168 0.1001 0.0988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0168 0.1001 0.2261
Echinococcus granulosus Ankyrin 0.0058 0.0102 0.0088
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0089 0.0351 0.0337
Echinococcus granulosus ecdysone induced protein 78C 0.0168 0.1001 0.0988
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0168 0.1001 0.2261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0151 0.0342
Onchocerca volvulus Netrin receptor homolog 0.0058 0.0098 0.0273
Brugia malayi Common central domain of tyrosinase family protein 0.0095 0.0406 0.0917
Brugia malayi nuclear receptor NHR-88 0.0079 0.0273 0.0617
Echinococcus granulosus Nuclear hormone receptor HR96 0.0079 0.0273 0.0259
Echinococcus granulosus single minded 2 0.0073 0.0222 0.0209
Brugia malayi Nuclear hormone receptor E75 0.0079 0.0273 0.0617
Brugia malayi Animal haem peroxidase family protein 0.0089 0.0357 0.0806
Onchocerca volvulus Bile acid receptor homolog 0.0168 0.1001 0.421
Schistosoma mansoni tyrosinase precursor 0.0095 0.0406 0.0392
Brugia malayi orphan nuclear receptor NR2E1 0.0079 0.0273 0.0617
Plasmodium vivax multidomain scavenger receptor, putative 0.0243 0.1616 1
Schistosoma mansoni hypothetical protein 0.0187 0.1156 0.1144
Brugia malayi nuclear receptor NHR-67 0.0079 0.0273 0.0617
Loa Loa (eye worm) doublecortin family protein 0.0243 0.1616 0.3653
Brugia malayi nuclear receptor NHR-88 0.0168 0.1001 0.2261
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Brugia malayi Animal haem peroxidase family protein 0.0089 0.0357 0.0806
Echinococcus multilocularis FTZ F1 alpha 0.0168 0.1001 0.0988
Echinococcus granulosus lipoxygenase domain containing protein 0.0243 0.1616 0.1605
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0151 0.0138
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0419 0.3068 0.3058
Echinococcus granulosus peroxidasin 0.0089 0.0357 0.0343
Echinococcus multilocularis tar DNA binding protein 0.0144 0.0805 0.0792
Loa Loa (eye worm) animal heme peroxidase 0.0089 0.0357 0.0806
Schistosoma mansoni thyroid hormone receptor 0.0292 0.2023 0.2011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0168 0.1001 0.2261
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0168 0.1001 0.0988
Schistosoma mansoni rab6-interacting 0.0243 0.1616 0.1605
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0098 0.0221
Schistosoma mansoni single-minded 0.0099 0.0432 0.0419
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0079 0.0273 0.0259
Schistosoma mansoni nuclear receptor 0.0079 0.0273 0.0259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.036 0.2582 0.5835
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0826 0.6409 1
Echinococcus granulosus jun protein 0.0419 0.3068 0.3058
Loa Loa (eye worm) TAR-binding protein 0.0144 0.0805 0.1819
Leishmania major cathepsin L-like protease 0.0129 0.0684 0.9759
Schistosoma mansoni thyroid hormone receptor 0.0292 0.2023 0.2011
Echinococcus granulosus dihydrofolate reductase 0.034 0.2414 0.2403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0151 0.2192
Brugia malayi hypothetical protein 0.0089 0.0351 0.0793
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0089 0.0351 0.0337
Brugia malayi RNA binding protein 0.0144 0.0805 0.1819
Brugia malayi nuclear hormone receptor family member odr-7 0.0079 0.0273 0.0617
Schistosoma mansoni peroxidasin 0.0089 0.0357 0.0343
Schistosoma mansoni aryl hydrocarbon receptor 0.0099 0.0432 0.0419
Plasmodium falciparum LCCL domain-containing protein 0.0243 0.1616 1
Loa Loa (eye worm) animal heme peroxidase 0.0089 0.0357 0.0806
Brugia malayi bHLH-PAS transcription factor 0.0073 0.0222 0.0502
Schistosoma mansoni hypothetical protein 0.0187 0.1156 0.1144
Brugia malayi tailless protein 0.0079 0.0273 0.0617
Brugia malayi nuclear hormone receptor 0.0168 0.1001 0.2261
Echinococcus multilocularis transfer RNA-Lys 0.0073 0.0222 0.0209
Loa Loa (eye worm) hypothetical protein 0.0073 0.0222 0.0503
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0406 0.0917
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0168 0.1001 0.0988
Schistosoma mansoni nuclear receptor nhr-48 0.0079 0.0273 0.0259
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.034 0.2414 0.3766
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0684 0.9918
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0684 0.9918
Loa Loa (eye worm) hypothetical protein 0.0089 0.0351 0.0793
Brugia malayi nuclear hormone receptor family member nhr-6 0.0079 0.0273 0.0617
Onchocerca volvulus 0.0239 0.1586 0.6763
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0168 0.1001 0.0988
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0168 0.1001 0.2261
Brugia malayi hypothetical protein 0.0329 0.2328 0.5262
Onchocerca volvulus 0.0095 0.0406 0.1615
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0168 0.1001 0.0988
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0116 0.0102
Echinococcus granulosus nuclear factor of activated T cells 5 0.0296 0.2055 0.2044
Onchocerca volvulus 0.0089 0.0357 0.1402
Brugia malayi steroid hormone receptor 0.0168 0.1001 0.2261
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0805 0.0792
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Brugia malayi Doublecortin family protein 0.0243 0.1616 0.3653
Echinococcus multilocularis peroxidasin 0.0089 0.0357 0.0343
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0144 0.0805 0.1819
Schistosoma mansoni ankyrin 23/unc44 0.0058 0.0098 0.0084
Loa Loa (eye worm) hypothetical protein 0.0089 0.0351 0.0793
Loa Loa (eye worm) hypothetical protein 0.0239 0.1586 0.3584
Brugia malayi Steroid receptor seven-up type 2 0.0168 0.1001 0.2261
Loa Loa (eye worm) hypothetical protein 0.0058 0.0102 0.023
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0131 0.0701 0.0688
Onchocerca volvulus Chorion peroxidase homolog 0.0089 0.0357 0.1402
Brugia malayi nuclear receptor RXR 0.0079 0.0273 0.0617
Loa Loa (eye worm) hypothetical protein 0.0243 0.1616 0.3653
Brugia malayi Animal haem peroxidase family protein 0.0089 0.0357 0.0806
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0168 0.1001 0.0988
Schistosoma mansoni hypothetical protein 0.0058 0.0098 0.0084
Brugia malayi dihydrofolate reductase family protein 0.034 0.2414 0.5455
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0151 0.2192
Loa Loa (eye worm) nuclear hormone receptor 0.0079 0.0273 0.0617
Loa Loa (eye worm) ShTK domain-containing protein 0.0095 0.0406 0.0917
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0058 0.0098 0.0221
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0079 0.0273 0.0259
Echinococcus granulosus geminin 0.0187 0.1156 0.1144
Trypanosoma cruzi major cysteine proteinase, putative 0.0102 0.0457 0.6627
Schistosoma mansoni lipoxygenase 0.0826 0.6412 0.6407
Loa Loa (eye worm) hypothetical protein 0.0058 0.0098 0.0221
Echinococcus multilocularis thyroid hormone receptor alpha 0.0292 0.2023 0.2011
Echinococcus multilocularis lipoxygenase domain containing protein 0.0243 0.1616 0.1605
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0168 0.1001 0.0988
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0089 0.0351 0.0337
Treponema pallidum sodium- and chloride- dependent transporter 0.0239 0.1586 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0239 0.1586 0.3584
Loa Loa (eye worm) hypothetical protein 0.0584 0.4425 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.069 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.05 0.113
Brugia malayi hypothetical protein 0.0243 0.1616 0.3653
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0058 0.0102 0.0088
Schistosoma mansoni steroid hormone receptor ad4bp 0.0168 0.1001 0.0988
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Schistosoma mansoni peroxidasin 0.0089 0.0357 0.0343
Loa Loa (eye worm) hypothetical protein 0.0239 0.1586 0.3584
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0645 0.0632
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Schistosoma mansoni nuclear hormone receptor 0.0079 0.0273 0.0259
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.1643 0.1632
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0168 0.1001 0.2261
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0151 0.0138
Schistosoma mansoni rab6-interacting 0.0243 0.1616 0.1605
Brugia malayi PAS domain containing protein 0.0099 0.0432 0.0977
Schistosoma mansoni dihydrofolate reductase 0.034 0.2414 0.2403
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Mycobacterium ulcerans putative regulatory protein 0.0073 0.0222 0.0347
Brugia malayi RNA recognition motif domain containing protein 0.0144 0.0805 0.1819
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0168 0.1001 0.421
Onchocerca volvulus Peroxidasin homolog 0.0089 0.0357 0.1402
Echinococcus multilocularis netrin receptor unc 5 0.0058 0.0098 0.0084
Loa Loa (eye worm) RNA binding protein 0.0144 0.0805 0.1819
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.057 0.1289
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0168 0.1001 0.2261
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0419 0.3068 0.3058
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0131 0.0701 0.1585
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0168 0.1001 0.0988
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0116 0.0102
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0168 0.1001 0.2261
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0116 0.1653
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0805 0.0792
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0089 0.0351 0.0337
Brugia malayi hypothetical protein 0.0246 0.1643 0.3714
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0168 0.1001 0.2261
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0645 0.0632
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0058 0.0098 0.0084
Echinococcus granulosus snurportin 1 0.036 0.2582 0.2571
Echinococcus granulosus tm gpcr rhodopsin 0.0821 0.6365 0.636
Schistosoma mansoni polycystin 1-related 0.0243 0.1616 0.1605
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Loa Loa (eye worm) animal heme peroxidase 0.0089 0.0357 0.0806
Echinococcus granulosus nuclear receptor nhr 48 0.0079 0.0273 0.0259
Echinococcus multilocularis snurportin 1 0.036 0.2582 0.2571
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0116 0.0102
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Leishmania major cathepsin L-like protease 0.0129 0.0684 0.9759
Loa Loa (eye worm) hypothetical protein 0.0168 0.1001 0.2261
Loa Loa (eye worm) hypothetical protein 0.0089 0.0351 0.0793
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1263 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0079 0.0273 0.1037
Brugia malayi hypothetical protein 0.0089 0.0357 0.0806
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0168 0.1001 0.2261
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0089 0.0351 0.0793
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0168 0.1001 0.2261
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0079 0.0273 0.0259
Schistosoma mansoni RAR-like nuclear receptor 0.0168 0.1001 0.0988
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.013 0.069 1
Brugia malayi hypothetical protein 0.0089 0.0351 0.0793
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Loa Loa (eye worm) hypothetical protein 0.0089 0.0351 0.0793
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.05 0.113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Schistosoma mansoni hypothetical protein 0.036 0.2582 0.2571
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0058 0.0098 0.0084
Brugia malayi ecdysone receptor 0.0079 0.0273 0.0617
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0168 0.1001 0.0988
Loa Loa (eye worm) dihydrofolate reductase 0.034 0.2414 0.5455
Loa Loa (eye worm) hypothetical protein 0.0168 0.1001 0.2261
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0168 0.1001 0.0988
Brugia malayi Death domain containing protein 0.0058 0.0098 0.0221
Onchocerca volvulus 0.0243 0.1616 0.6896
Brugia malayi Nuclear hormone receptor E75 0.0079 0.0273 0.0617
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0116 0.0181
Loa Loa (eye worm) hypothetical protein 0.0243 0.1616 0.3653
Loa Loa (eye worm) steroid hormone receptor 0.0168 0.1001 0.2261
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0805 0.0792
Schistosoma mansoni zinc finger protein 0.0079 0.0273 0.0259
Brugia malayi Animal haem peroxidase family protein 0.0089 0.0357 0.0806
Loa Loa (eye worm) hypothetical protein 0.0168 0.1001 0.2261
Brugia malayi hypothetical protein 0.033 0.2338 0.5285
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.0771 0.1742
Loa Loa (eye worm) hypothetical protein 0.0168 0.1001 0.2261
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.013 0.069 1
Onchocerca volvulus 0.0089 0.0357 0.1402
Brugia malayi Dihydrofolate reductase 0.034 0.2414 0.5455
Echinococcus granulosus netrin receptor unc 5 0.0058 0.0098 0.0084
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0131 0.0701 1
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0095 0.0406 0.0917
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Brugia malayi hypothetical protein 0.0079 0.0273 0.0617
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0826 0.6409 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0168 0.1001 0.2261
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.0771 0.1742
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0131 0.0701 0.0688
Echinococcus multilocularis Polycystic kidney disease protein 0.0243 0.1616 0.1605
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0116 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0805 0.0792
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0168 0.1001 0.0988
Schistosoma mansoni hypothetical protein 0.005 0.0035 0.0021
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0131 0.0701 0.1094
Brugia malayi Animal haem peroxidase family protein 0.0089 0.0357 0.0806
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0131 0.0701 0.0688
Echinococcus granulosus tar DNA binding protein 0.0144 0.0805 0.0792
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0168 0.1001 0.2261
Loa Loa (eye worm) hypothetical protein 0.0168 0.1001 0.2261
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Onchocerca volvulus 0.0079 0.0273 0.1037
Echinococcus multilocularis dihydrofolate reductase 0.034 0.2414 0.2403
Echinococcus granulosus lipoxygenase domain containing protein 0.0243 0.1616 0.1605
Echinococcus multilocularis serotonin transporter 0.0239 0.1586 0.1574
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Loa Loa (eye worm) serotonin transporter b 0.0239 0.1586 0.3584
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0168 0.1001 0.0988
Loa Loa (eye worm) animal heme peroxidase 0.0089 0.0357 0.0806
Onchocerca volvulus Peroxidase homolog 0.0089 0.0357 0.1402
Brugia malayi conserved hypotetical protein 0.0079 0.0273 0.0617
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0079 0.0273 0.0617
Echinococcus granulosus serotonin transporter 0.0239 0.1586 0.1574
Loa Loa (eye worm) hypothetical protein 0.0168 0.1001 0.2261
Loa Loa (eye worm) tyrosinase 1 0.0095 0.0406 0.0917
Brugia malayi Peroxidasin 0.0089 0.0357 0.0806
Onchocerca volvulus 0.0329 0.2328 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0168 0.1001 0.2261
Loa Loa (eye worm) hypothetical protein 0.033 0.2338 0.5285
Brugia malayi photoreceptor-specific nuclear receptor 0.0168 0.1001 0.2261
Brugia malayi TAR-binding protein 0.0144 0.0805 0.1819
Onchocerca volvulus Peroxidase homolog 0.0089 0.0357 0.1402
Loa Loa (eye worm) hypothetical protein 0.0089 0.0357 0.0806
Loa Loa (eye worm) hypothetical protein 0.0079 0.0273 0.0617
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0168 0.1001 0.0988
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0168 0.1001 0.0988
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0168 0.1001 0.0988
Echinococcus granulosus RUN 0.0243 0.1616 0.1605
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Schistosoma mansoni sodium/chloride dependent transporter 0.0239 0.1586 0.1574
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0095 0.0406 0.0917
Mycobacterium ulcerans proteasome PrcA 0.0826 0.6409 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Brugia malayi ecdysteroid receptor 0.0168 0.1001 0.2261
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0684 0.9918
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0035 0.0079
Echinococcus multilocularis nuclear receptor nhr 48 0.0079 0.0273 0.0259
Brugia malayi bZIP transcription factor family protein 0.0419 0.3068 0.6934
Schistosoma mansoni nuclear receptor 0.0079 0.0273 0.0259
Chlamydia trachomatis dihydrofolate reductase 0.034 0.2414 0.5
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0438 0.3221 0.3211
Schistosoma mansoni tar DNA-binding protein 0.0144 0.0805 0.0792
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0684 0.9918
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0239 0.1586 0.1574
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0014 0.0031
Schistosoma mansoni jun-related protein 0.0341 0.2422 0.2412
Onchocerca volvulus 0.0095 0.0406 0.1615
Brugia malayi Cytochrome P450 family protein 0.0159 0.0931 0.2103

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 39 % Inhibition against DNA-dependent protein kinase receptor at 0.5uM ChEMBL. 16302822
Inhibition (binding) = 39 % Inhibition against DNA-dependent protein kinase receptor at 0.5uM ChEMBL. 16302822

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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