Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0614 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0062 | 0.0445 | 0.0445 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.053 | 0.8538 | 0.8538 |
Entamoeba histolytica | protein kinase, putative | 0.0037 | 0.0012 | 0.0012 |
Entamoeba histolytica | protein kinase, putative | 0.0037 | 0.0012 | 0.0012 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0085 | 0.0837 | 0.041 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0085 | 0.0837 | 0.0837 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0614 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.0614 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0085 | 0.0837 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.0614 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0085 | 0.0837 | 0.0826 |
Onchocerca volvulus | 0.0085 | 0.0837 | 0.5 | |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0614 | 1 | 1 |
Echinococcus multilocularis | 0.0085 | 0.0837 | 0.0837 | |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 | 0.0085 | 0.0837 | 0.0837 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0061 | 0.0432 | 0.0421 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0062 | 0.0445 | 0.0445 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0614 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0085 | 0.0837 | 0.041 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0614 | 1 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0614 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0614 | 1 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0062 | 0.0445 | 0.0445 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0614 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0614 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0085 | 0.0837 | 0.0837 |
Entamoeba histolytica | protein kinase, putative | 0.0037 | 0.0012 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.0837 | 0.0837 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0085 | 0.0837 | 0.0837 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0194 | 0.2732 | 0.2732 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0614 | 1 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0614 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0085 | 0.0837 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0062 | 0.0445 | 0.0445 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0085 | 0.0837 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0085 | 0.0837 | 0.041 |
Entamoeba histolytica | protein kinase, putative | 0.0062 | 0.0445 | 0.0445 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0614 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0614 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0614 | 1 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0062 | 0.0445 | 0.0445 |
Trichomonas vaginalis | STE family protein kinase | 0.0062 | 0.0445 | 0.0433 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0085 | 0.0837 | 0.5 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0085 | 0.0837 | 0.5 |
Onchocerca volvulus | 0.0085 | 0.0837 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0837 | 0.0837 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0614 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0614 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0085 | 0.0837 | 0.0826 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.053 | 0.8538 | 0.8538 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0614 | 1 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0614 | 1 | 1 |
Brugia malayi | serine/threonine-protein kinase PAK 7 | 0.023 | 0.3357 | 0.3357 |
Leishmania major | fk506-binding protein 1-like protein | 0.0614 | 1 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0062 | 0.0445 | 0.0445 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0614 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 | 0.0085 | 0.0837 | 0.0837 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0085 | 0.0837 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 | 0.0085 | 0.0837 | 0.0837 |
Echinococcus multilocularis | fk506 binding protein | 0.0614 | 1 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.0614 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0037 | 0.0012 | 0.0012 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0085 | 0.0837 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0432 | 0.0432 |
Schistosoma mansoni | immunophilin | 0.053 | 0.8538 | 0.8538 |
Schistosoma mansoni | immunophilin | 0.0614 | 1 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0085 | 0.0837 | 0.0837 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0614 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0062 | 0.0445 | 0.0433 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0085 | 0.0837 | 0.0826 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0085 | 0.0837 | 0.0837 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0085 | 0.0837 | 0.0837 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0062 | 0.0445 | 0.0445 |
Brugia malayi | Protein kinase domain | 0.0062 | 0.0445 | 0.0445 |
Schistosoma mansoni | fk506 binding protein | 0.0085 | 0.0837 | 0.0837 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0614 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0085 | 0.0837 | 0.0826 |
Trichomonas vaginalis | STE family protein kinase | 0.0062 | 0.0445 | 0.0433 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0614 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0194 | 0.2732 | 0.2732 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0085 | 0.0837 | 0.5 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0085 | 0.0837 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0614 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0062 | 0.0445 | 0.0445 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0085 | 0.0837 | 0.0837 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0085 | 0.0837 | 0.041 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.023 | 0.3357 | 0.3357 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0037 | 0.0012 | 0.0012 |
Trichomonas vaginalis | STE family protein kinase | 0.0062 | 0.0445 | 0.0433 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0085 | 0.0837 | 0.0837 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0085 | 0.0837 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.053 | 0.8538 | 0.8538 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0614 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0062 | 0.0445 | 0.0445 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.23 uM | Ability to block capsaicin-induced calcium influx in rat-human chimera TRPV1 expressing CHO cells | ChEMBL. | 16203144 |
IC50 (binding) | = 0.23 uM | Ability to block acid-induced calcium influx in rat-human chimera TRPV1 expressing CHO cells | ChEMBL. | 16203144 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.