Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | enoyl-acyl carrier reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cyclin B | 0.0272 | 1 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0272 | 1 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.0272 | 1 | 0.5 |
Echinococcus granulosus | cyclins | 0.0272 | 1 | 0.5 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0272 | 1 | 0.5 |
Echinococcus granulosus | cyclin B | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | cyclin B | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.0272 | 1 | 0.5 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0272 | 1 | 0.5 |
Onchocerca volvulus | 0.0272 | 1 | 0.5 | |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0223 | 0.2588 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.0272 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0272 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0223 | 0.2588 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0223 | 0.2588 | 1 |
Echinococcus multilocularis | cyclins | 0.0272 | 1 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0223 | 0.2588 | 0.5 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0272 | 1 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.0272 | 1 | 0.5 |
Schistosoma mansoni | cyclins | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0272 | 1 | 1 |
Schistosoma mansoni | cyclin B3 | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0272 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0272 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0272 | 1 | 1 |
Leishmania major | cyclin | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | cyclin D, putative | 0.0272 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0272 | 1 | 1 |
Echinococcus granulosus | cyclin B3 1 | 0.0272 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0223 | 0.2588 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | cyclin b3 | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0272 | 1 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0272 | 1 | 0.5 |
Trypanosoma cruzi | cyclin 6, putative | 0.0272 | 1 | 0.5 |
Plasmodium falciparum | cyclin | 0.0272 | 1 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0272 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0272 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 1 | 0.5 |
Echinococcus granulosus | cyclin b3 | 0.0272 | 1 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0223 | 0.2588 | 0.5 |
Echinococcus granulosus | cyclins | 0.0272 | 1 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.0272 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0272 | 1 | 0.5 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0223 | 0.2588 | 0.5 |
Echinococcus granulosus | cyclins | 0.0272 | 1 | 0.5 |
Giardia lamblia | Cyclin A | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0272 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0272 | 1 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.0272 | 1 | 1 |
Echinococcus multilocularis | cyclins | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | cyclins | 0.0272 | 1 | 0.5 |
Echinococcus granulosus | cyclins | 0.0272 | 1 | 0.5 |
Echinococcus multilocularis | cyclin B3 1 | 0.0272 | 1 | 0.5 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0272 | 1 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0272 | 1 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0272 | 1 | 1 |
Echinococcus granulosus | cyclins | 0.0272 | 1 | 0.5 |
Trichomonas vaginalis | cyclin B3, putative | 0.0272 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 30.6 uM | Inhibition of drug resistant Plasmodium falciparum Dd2 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
EC50 (functional) | = 30.6 uM | Inhibition of drug resistant Plasmodium falciparum Dd2 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
EC50 (functional) | = 31.2 uM | Inhibition of drug sensitive Plasmodium falciparum 3D7 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
EC50 (functional) | = 31.2 uM | Inhibition of drug sensitive Plasmodium falciparum 3D7 whole cell growth after 72 hrs exposure | ChEMBL. | 16198563 |
IC50 (binding) | = 1200 nM | Inhibition of PfENR enzymatic activity | ChEMBL. | 16198563 |
IC50 (binding) | = 1200 nM | Inhibition of PfENR enzymatic activity | ChEMBL. | 16198563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.