TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 368.211 | Formula: C17H15Cl2NO4
H donors: 1 H acceptors: 2 LogP: 3.44 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)O)Oc1ccc(cc1Cl)C(=O)N1CCOCC1
InChi: 1S/C17H15Cl2NO4/c18-12-2-4-16(14(21)10-12)24-15-3-1-11(9-13(15)19)17(22)20-5-7-23-8-6-20/h1-4,9-10,21H,5-8H2
InChiKey: UQGWPOKQQKXNNN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Plasmodium falciparum	enoyl-acyl carrier reductase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	hypothetical protein	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium knowlesi	enoyl-acyl carrier reductase, putative	Get druggable targets OG5_130466	All targets in OG5_130466
Neospora caninum	enoyl-acyl carrier reductase, putative	Get druggable targets OG5_130466	All targets in OG5_130466
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium falciparum	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	Get druggable targets OG5_130466	All targets in OG5_130466
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium vivax	enoyl-acyl carrier protein reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	Get druggable targets OG5_130466	All targets in OG5_130466
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium yoelii	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466
Plasmodium berghei	enoyl-acyl carrier reductase	Get druggable targets OG5_130466	All targets in OG5_130466

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	adenoreceptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	melatonin receptor type 1A	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0091	0.0091
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0358	1	1
Brugia malayi	G protein-coupled receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0012	0.0091	0.0091
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0015	0.0173	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0012	0.0091	0.0091
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0091	0.0091
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0091	0.0091
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0012	0.0091	0.0091
Echinococcus multilocularis	orexin receptor type 2	0.0012	0.0091	0.0091
Brugia malayi	neuropeptide F receptor	0.0012	0.0091	0.0091
Trypanosoma brucei	pteridine reductase 1	0.0015	0.0173	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0091	0.0091
Echinococcus granulosus	hypothetical protein	0.0012	0.0091	0.0091
Brugia malayi	neuropeptide F receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0223	0.6142	1
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0015	0.0173	0.0173
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus granulosus	sex peptide receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0012	0.0091	0.0091
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0012	0.0091	0.0091
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0015	0.0173	0.0173
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0012	0.0091	0.0091
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0012	0.0091	0.0091
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0091	0.0091
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0012	0.0091	0.0091
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0015	0.0173	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0091	0.0091
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0012	0.0091	0.5267
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Brugia malayi	G-protein coupled receptor	0.0012	0.0091	0.0091
Brugia malayi	Dopamine receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0091	0.0091
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0223	0.6142	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0012	0.0091	0.0091
Brugia malayi	sulfakinin receptor protein	0.0012	0.0091	0.0091
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0091	0.0091
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0091	0.0091
Leishmania major	oxidoreductase-like protein	0.0015	0.0173	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0091	0.0091
Brugia malayi	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	amine GPCR	0.0012	0.0091	0.0091
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0015	0.0173	1
Onchocerca volvulus		0.0012	0.0091	0.5267
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0091	0.0091
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0012	0.0091	0.0091
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Giardia lamblia	Protein tyrosine phosphatase	0.0009	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0173	0.0173
Brugia malayi	hypothetical protein	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0012	0.0091	0.5267
Onchocerca volvulus		0.0012	0.0091	0.5267
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0091	0.0091
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0173	0.0173
Echinococcus granulosus	neuropeptide s receptor	0.0012	0.0091	0.0091
Brugia malayi	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0091	0.0091
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0012	0.0091	0.5267
Echinococcus granulosus	G protein coupled receptor 139	0.0012	0.0091	0.0091
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	serotonin receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0091	0.0091
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	oxidoreductase	0.0015	0.0173	0.0173
Echinococcus granulosus	neuropeptide FF receptor 2	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0012	0.0091	0.5267
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0358	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0012	0.0091	0.0091
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0012	0.0091	0.0091
Brugia malayi	follicle stimulating hormone receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0012	0.0091	0.0091
Trichomonas vaginalis	hypothetical protein	0.0223	0.6142	1
Onchocerca volvulus		0.0015	0.0173	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0015	0.0173	0.0173
Brugia malayi	hypothetical protein	0.0012	0.0091	0.0091
Brugia malayi	putative neuropeptide receptor NPR1	0.0012	0.0091	0.0091
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Brugia malayi	hypothetical protein	0.0012	0.0091	0.0091
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0223	0.6142	1
Brugia malayi	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0012	0.0091	0.0091
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0015	0.0173	0.0173
Schistosoma mansoni	myosin xvIII	0.0012	0.0091	0.0091
Echinococcus granulosus	7tm_1 domain containing protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0012	0.0091	0.5267
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0012	0.0091	0.0091
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0091	0.0091
Echinococcus multilocularis	G protein coupled receptor 139	0.0012	0.0091	0.0091
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0012	0.0091	0.0091
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0015	0.0173	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0091	0.0091
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0015	0.0173	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Brugia malayi	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0015	0.0173	1
Onchocerca volvulus		0.0012	0.0091	0.5267
Onchocerca volvulus		0.0012	0.0091	0.5267
Schistosoma mansoni	opsin-like receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	somatostatin receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0012	0.0091	0.0091
Schistosoma mansoni	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0091	0.0091
Echinococcus granulosus	g-protein coupled receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0091	0.0091
Schistosoma mansoni	opsin-like receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	amine GPCR	0.0012	0.0091	0.0091
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0358	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0091	0.0091
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0091	0.0091
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus multilocularis	sex peptide receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0223	0.6142	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	amine GPCR	0.0012	0.0091	0.0091
Brugia malayi	hypothetical protein	0.0012	0.0091	0.0091
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0223	0.6142	1
Onchocerca volvulus		0.0012	0.0091	0.5267
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Echinococcus granulosus	7TM GPCR rhodopsin	0.0012	0.0091	0.0091
Schistosoma mansoni	neuropeptide f receptor 76f	0.0012	0.0091	0.0091
Echinococcus multilocularis	dro:myosuppressin receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0091	0.0091
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0012	0.0091	0.0091
Echinococcus multilocularis	g-protein coupled receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0091	0.0091
Brugia malayi	AKH receptor	0.0012	0.0091	0.0091
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0012	0.0091	0.5267
Echinococcus granulosus	neuropeptide receptor A26	0.0012	0.0091	0.0091
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0091	0.0091
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0091	0.0091
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0091	0.0091
Brugia malayi	Serotonin receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Brugia malayi	ORL1-like opioid receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Brugia malayi	Dopamine receptor protein 2	0.0012	0.0091	0.0091
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0358	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0012	0.0091	0.5267
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0012	0.0091	0.0091
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus granulosus	serotonin receptor	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0015	0.0173	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0015	0.0173	0.0173
Brugia malayi	Melatonin receptor type 1A	0.0012	0.0091	0.0091
Echinococcus granulosus	allatostatin A receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0012	0.0091	0.0091
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0091	0.0091
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0091	0.0091
Echinococcus multilocularis	allatostatin A receptor	0.0012	0.0091	0.0091
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0223	0.6142	1
Brugia malayi	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	histamine h1 receptor	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0012	0.0091	0.5267
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0015	0.0173	0.0173
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0012	0.0091	0.0091
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0091	0.0091
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Brugia malayi	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus multilocularis	neuropeptide s receptor	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0012	0.0091	0.5267
Echinococcus granulosus	orexin receptor type 2	0.0012	0.0091	0.0091
Brugia malayi	G protein-coupled receptor F59B2.13	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus multilocularis	serotonin receptor	0.0012	0.0091	0.0091
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0091	0.0091
Echinococcus granulosus	fmrfamide receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0012	0.0091	0.0091
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	opsin-like receptor	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0012	0.0091	0.5267
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0012	0.0091	0.5267
Echinococcus granulosus	dro:myosuppressin receptor	0.0012	0.0091	0.0091
Trypanosoma brucei	oxidoreductase-like protein	0.0015	0.0173	1
Onchocerca volvulus		0.0012	0.0091	0.5267
Onchocerca volvulus		0.0012	0.0091	0.5267
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0091	0.0091
Brugia malayi	RE15519p	0.0012	0.0091	0.0091
Leishmania major	pteridine reductase 1	0.0015	0.0173	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Brugia malayi	Dopamine receptor protein 1	0.0012	0.0091	0.0091
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Schistosoma mansoni	growth hormone secretagogue receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	amine GPCR	0.0012	0.0091	0.0091
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0012	0.0091	0.0091
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0091	0.0091
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0015	0.0173	1
Brugia malayi	Serotonin receptor	0.0012	0.0091	0.0091
Brugia malayi	larval opioid receptor	0.0012	0.0091	0.0091
Brugia malayi	GnHR receptor homolog	0.0012	0.0091	0.0091
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0012	0.0091	0.0091
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0223	0.6142	1
Brugia malayi	putative neuropeptide receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Schistosoma mansoni	dihydropteridine reductase	0.0015	0.0173	0.0173
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0223	0.6142	1
Brugia malayi	G-protein coupled receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0012	0.0091	0.0091
Loa Loa (eye worm)	TYRA-2 protein	0.0012	0.0091	0.0091
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0091	0.0091
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0091	0.0091
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0091	0.0091
Schistosoma mansoni	amine GPCR	0.0012	0.0091	0.0091
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0015	0.0173	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Echinococcus granulosus	somatostatin receptor	0.0012	0.0091	0.0091
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0091
Onchocerca volvulus		0.0012	0.0091	0.5267

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 63.5 uM	Inhibition of drug sensitive Plasmodium falciparum 3D7 whole cell growth after 72 hrs exposure	ChEMBL.	16198563
EC50 (functional)	= 63.5 uM	Inhibition of drug sensitive Plasmodium falciparum 3D7 whole cell growth after 72 hrs exposure	ChEMBL.	16198563
EC50 (functional)	= 94.5 uM	Inhibition of drug resistant Plasmodium falciparum Dd2 whole cell growth after 72 hrs exposure	ChEMBL.	16198563
EC50 (functional)	= 94.5 uM	Inhibition of drug resistant Plasmodium falciparum Dd2 whole cell growth after 72 hrs exposure	ChEMBL.	16198563
IC50 (binding)	= 200 nM	Inhibition of PfENR enzymatic activity	ChEMBL.	16198563
IC50 (binding)	= 200 nM	Inhibition of PfENR enzymatic activity	ChEMBL.	16198563

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL197111

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 347221