Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase, DNA-activated, catalytic polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | DNA dependent protein kinase catalytic subunit | Get druggable targets OG5_132688 | All targets in OG5_132688 |
Echinococcus multilocularis | DNA dependent protein kinase catalytic subunit | Get druggable targets OG5_132688 | All targets in OG5_132688 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0646 | 0.0422 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 1.4817 | 1 | 1 |
Giardia lamblia | GTOR | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 1.4817 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 1.4817 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.4817 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1358 | 0.0903 | 0.0903 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.4817 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1358 | 0.0903 | 0.0502 |
Brugia malayi | thymidylate synthase | 0.1358 | 0.0903 | 0.0903 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7365 | 0.4963 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.7365 | 0.4963 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.7365 | 0.4963 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.4817 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0646 | 0.0422 | 0.0422 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.011 | 0.0059 | 0.012 |
Loa Loa (eye worm) | thymidylate synthase | 0.1358 | 0.0903 | 0.0903 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0646 | 0.0422 | 0.085 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.7365 | 0.4963 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.7365 | 0.4963 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0114 | 0.0062 | 0.0125 |
Brugia malayi | Dihydrofolate reductase | 1.4817 | 1 | 1 |
Onchocerca volvulus | 0.1358 | 0.0903 | 0.5 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1358 | 0.0903 | 0.0903 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0022 | 0 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.7365 | 0.4963 | 1 |
Echinococcus multilocularis | DNA dependent protein kinase catalytic subunit | 0.0313 | 0.0197 | 0.0197 |
Echinococcus granulosus | thymidylate synthase | 0.1358 | 0.0903 | 0.0903 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.4817 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 1.4817 | 1 | 0.5 |
Echinococcus granulosus | DNA dependent protein kinase catalytic subunit | 0.0313 | 0.0197 | 0.0197 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0022 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.