TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 613.232 | Formula: C28H41ClN4O5S2
H donors: 4 H acceptors: 5 LogP: 3.6 Rotable bonds: 21
Rule of 5 violations (Lipinski): 2
SMILES: CCNC(=O)C(=O)[C@H](Cc1ccc(cc1)Cl)NC(=O)[C@H](C(C)C)NC(=O)CCNC(=O)CCCCC1SSCC1
InChi: 1S/C28H41ClN4O5S2/c1-4-30-28(38)26(36)22(17-19-9-11-20(29)12-10-19)32-27(37)25(18(2)3)33-24(35)13-15-31-23(34)8-6-5-7-21-14-16-39-40-21/h9-12,18,21-22,25H,4-8,13-17H2,1-3H3,(H,30,38)(H,31,34)(H,32,37)(H,33,35)/t21?,22-,25-/m0/s1
InChiKey: WNEVUTVANLRIEB-IJYFBAFXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Calpain 1		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	hypothetical protein	Calpain 1	714 aa	716 aa	33.1 %
Echinococcus granulosus	calpain A	Calpain 1	714 aa	753 aa	31.5 %
Echinococcus granulosus	calpain	Calpain 1	714 aa	695 aa	38.6 %
Schistosoma japonicum	Calpain-9, putative	Calpain 1	714 aa	671 aa	33.8 %
Schistosoma mansoni	calpain (C02 family)	Calpain 1	714 aa	684 aa	31.0 %
Schistosoma mansoni	calpain C (C02 family)	Calpain 1	714 aa	715 aa	33.4 %
Echinococcus multilocularis	calpain	Calpain 1	714 aa	695 aa	38.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glycoprotein Antigen 5	0.0415	0.0238	0.0238
Brugia malayi	EGF-like domain containing protein	0.0168	0.0075	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.7641	0.501	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.028	0.0148	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Echinococcus granulosus	thymidylate synthase	0.1462	0.0929	0.0929
Loa Loa (eye worm)	thymidylate synthase	0.1462	0.0929	0.0862
Echinococcus multilocularis	neurogenic locus notch protein	0.0168	0.0075	0.0075
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0168	0.0075	0.0075
Toxoplasma gondii	calcium binding egf domain-containing protein	0.039	0.0221	0.0297
Echinococcus multilocularis	cathepsin b	0.0166	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Loa Loa (eye worm)	notch protein	0.0168	0.0075	0.0002
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.2388	0.1541	0.1541
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.0073	0.0073
Brugia malayi	EGF-like domain containing protein	0.0168	0.0075	0.0002
Schistosoma mansoni	hypothetical protein	0.0299	0.0161	0.0161
Echinococcus granulosus	cathepsin b	0.0166	0.0073	0.0073
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Schistosoma mansoni	notch	0.0168	0.0075	0.0075
Schistosoma mansoni	notch	0.0168	0.0075	0.0075
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.039	0.0221	0.0149
Chlamydia trachomatis	dihydrofolate reductase	1.5197	1	0.5
Echinococcus multilocularis	tissue type plasminogen activator	0.028	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0299	0.0161	0.0161
Brugia malayi	notch-like transmembrane receptor	0.0168	0.0075	0.0002
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0299	0.0161	0.0161
Onchocerca volvulus		0.2089	0.1343	0.8653
Schistosoma mansoni	hypothetical protein	0.0168	0.0075	0.0075
Brugia malayi	Cadherin domain containing protein	0.0168	0.0075	0.0002
Brugia malayi	Muscle positioning protein 4	0.0168	0.0075	0.0002
Loa Loa (eye worm)	dihydrofolate reductase	1.5197	1	1
Toxoplasma gondii	histone arginine methyltransferase PRMT4/CARM1	0.0249	0.0128	0.0108
Echinococcus multilocularis	fibrillin 1	0.039	0.0221	0.0221
Giardia lamblia	High cysteine protein	0.0168	0.0075	0.5
Brugia malayi	Trypsin family protein	0.0299	0.0161	0.0089
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Loa Loa (eye worm)	Carm1-pending protein	0.0249	0.0128	0.0055
Mycobacterium ulcerans	dihydrofolate reductase DfrA	1.5197	1	1
Schistosoma mansoni	cell polarity protein	0.0168	0.0075	0.0075
Brugia malayi	Cadherin domain containing protein	0.0168	0.0075	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Brugia malayi	Fibulin-1 precursor	0.039	0.0221	0.0149
Echinococcus multilocularis	neurogenic locus notch protein	0.0168	0.0075	0.0075
Brugia malayi	Kringle domain containing protein	0.028	0.0148	0.0076
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.2388	0.1541	0.1541
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Echinococcus granulosus	enteropeptidase	0.0415	0.0238	0.0238
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	1.5197	1	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.7641	0.501	1
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Echinococcus granulosus	neurogenic locus notch protein	0.0168	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.039	0.0221	0.0149
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.7641	0.501	0.5
Echinococcus multilocularis	transmembrane protease serine 3	0.0299	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.039	0.0221	0.0149
Onchocerca volvulus	Arrow homolog	0.039	0.0221	0.0999
Echinococcus multilocularis	histone arginine methyltransferase CARMER	0.0249	0.0128	0.0128
Brugia malayi	Carm1-pending protein	0.0249	0.0128	0.0055
Echinococcus granulosus	dihydrofolate reductase	1.5197	1	1
Schistosoma mansoni	hypothetical protein	0.0168	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Trypanosoma cruzi	hypothetical protein, conserved	0.028	0.0148	0.0152
Echinococcus granulosus	neurogenic locus notch protein 4	0.0168	0.0075	0.0075
Schistosoma mansoni	laminin gamma-3 chain	0.0168	0.0075	0.0075
Echinococcus multilocularis	neurogenic locus protein delta	0.0168	0.0075	0.0075
Brugia malayi	Trypsin family protein	0.0299	0.0161	0.0089
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0695	0.0423	0.0709
Schistosoma mansoni	septate junction protein	0.0168	0.0075	0.0075
Schistosoma mansoni	notch	0.0168	0.0075	0.0075
Brugia malayi	Calcium binding EGF domain containing protein	0.0168	0.0075	0.0002
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0168	0.0075	0.0002
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Echinococcus granulosus	protein jagged 1	0.0168	0.0075	0.0075
Toxoplasma gondii	PAN domain-containing protein	0.0618	0.0372	0.0602
Loa Loa (eye worm)	hypothetical protein	0.039	0.0221	0.0149
Toxoplasma gondii	kringle domain-containing protein	0.028	0.0148	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0161	0.0089
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0299	0.0161	0.0161
Echinococcus granulosus	histone arginine methyltransferase CARMER	0.0249	0.0128	0.0128
Echinococcus multilocularis	slit 2 protein	0.0168	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0161	0.0089
Loa Loa (eye worm)	hypothetical protein	0.039	0.0221	0.0149
Echinococcus granulosus	protein jagged 2	0.0168	0.0075	0.0075
Brugia malayi	Trypsin family protein	0.2388	0.1541	0.1479
Schistosoma mansoni	slit	0.0168	0.0075	0.0075
Loa Loa (eye worm)	Notch2	0.0168	0.0075	0.0002
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.0073	0.0073
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.7641	0.501	1
Loa Loa (eye worm)	hypothetical protein	0.2388	0.1541	0.1479
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0299	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0166	0.0073	0.0073
Brugia malayi	hypothetical protein	0.0299	0.0161	0.0089
Onchocerca volvulus		0.0299	0.0161	0.059
Brugia malayi	Protein kinase domain containing protein	0.028	0.0148	0.0076
Brugia malayi	hypothetical protein	0.0695	0.0423	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Brugia malayi	Delta serrate ligand family protein	0.0168	0.0075	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0161	0.0089
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.039	0.0221	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Toxoplasma gondii	PAN domain-containing protein	0.0618	0.0372	0.0602
Echinococcus granulosus	neurogenic locus notch protein	0.0168	0.0075	0.0075
Brugia malayi	EGF-like domain containing protein	0.0168	0.0075	0.0002
Onchocerca volvulus		0.2388	0.1541	1
Schistosoma mansoni	protein arginine n-methyltransferase	0.0249	0.0128	0.0128
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0299	0.0161	0.0089
Loa Loa (eye worm)	hypothetical protein	0.2388	0.1541	0.1479
Loa Loa (eye worm)	hypothetical protein	0.039	0.0221	0.0149
Schistosoma mansoni	hypothetical protein	0.0168	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0161	0.0089
Onchocerca volvulus		0.0299	0.0161	0.059
Schistosoma mansoni	notch	0.0168	0.0075	0.0075
Brugia malayi	EGF-like domain containing protein	0.0168	0.0075	0.0002
Echinococcus multilocularis	thymidylate synthase	0.1462	0.0929	0.0929
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0299	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.028	0.0148	0.0076
Schistosoma mansoni	hypothetical protein	0.0168	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Echinococcus granulosus	cathepsin b	0.0166	0.0073	0.0073
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Onchocerca volvulus		0.1462	0.0929	0.5826
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.1462	0.0929	0.0529
Echinococcus granulosus	Tolloid protein 1	0.039	0.0221	0.0221
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Echinococcus multilocularis	enteropeptidase	0.0415	0.0238	0.0238
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	1.5197	1	1
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Echinococcus multilocularis	notch	0.0168	0.0075	0.0075
Schistosoma mansoni	dihydrofolate reductase	1.5197	1	1
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0168	0.0075	0.0075
Echinococcus multilocularis	cathepsin b	0.0166	0.0073	0.0073
Echinococcus granulosus	glycoprotein Antigen 5	0.0415	0.0238	0.0238
Echinococcus granulosus	neurogenic locus protein delta	0.0168	0.0075	0.0075
Onchocerca volvulus		0.0227	0.0113	0.0263
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.039	0.0221	0.0149
Echinococcus granulosus	protein jagged 1	0.0168	0.0075	0.0075
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.0073	0.0073
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0299	0.0161	0.0161
Schistosoma mansoni	notch	0.0168	0.0075	0.0075
Onchocerca volvulus		0.028	0.0148	0.0502
Echinococcus multilocularis	laminin	0.039	0.0221	0.0221
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Echinococcus multilocularis	fibropellin Ia	0.0168	0.0075	0.0075
Schistosoma mansoni	hypothetical protein	0.028	0.0148	0.0148
Brugia malayi	Calcium binding EGF domain containing protein	0.0168	0.0075	0.0002
Mycobacterium ulcerans	thymidylate synthase	0.1462	0.0929	0.078
Echinococcus granulosus	fibropellin Ia	0.0168	0.0075	0.0075
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0299	0.0161	0.0161
Echinococcus multilocularis	Tolloid protein 1	0.039	0.0221	0.0221
Toxoplasma gondii	calcium binding egf domain-containing protein	0.039	0.0221	0.0297
Schistosoma mansoni	hypothetical protein	0.0168	0.0075	0.0075
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Echinococcus granulosus	Mastin	0.0415	0.0238	0.0238
Brugia malayi	Calcium binding EGF domain containing protein	0.039	0.0221	0.0149
Loa Loa (eye worm)	trypsin family protein	0.0299	0.0161	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Brugia malayi	Trypsin-like protease protein 5	0.0299	0.0161	0.0089
Echinococcus multilocularis	protein jagged 1	0.0168	0.0075	0.0075
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.1462	0.0929	0.0929
Echinococcus granulosus	transmembrane protease serine 3	0.0299	0.0161	0.0161
Brugia malayi	GCC2 and GCC3 family protein	0.0168	0.0075	0.0002
Onchocerca volvulus		0.0299	0.0161	0.059
Schistosoma mansoni	cercarial elastase (S01 family)	0.0299	0.0161	0.0161
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.7641	0.501	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0168	0.0075	0.0075
Echinococcus granulosus	tissue type plasminogen activator	0.028	0.0148	0.0148
Echinococcus granulosus	laminin	0.039	0.0221	0.0221
Brugia malayi	Calcium binding EGF domain containing protein	0.0168	0.0075	0.0002
Schistosoma mansoni	notch	0.0168	0.0075	0.0075
Schistosoma mansoni	hypothetical protein	0.0299	0.0161	0.0161
Echinococcus granulosus	protein jagged 2	0.0168	0.0075	0.0075
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0415	0.0238	0.0238
Brugia malayi	thymidylate synthase	0.1462	0.0929	0.0862
Brugia malayi	EGF-like domain containing protein	0.0168	0.0075	0.0002
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0299	0.0161	0.0161
Schistosoma mansoni	hypothetical protein	0.0168	0.0075	0.0075
Trichomonas vaginalis	conserved hypothetical protein	0.0695	0.0423	0.5
Onchocerca volvulus		0.0299	0.0161	0.059
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0299	0.0161	0.0161
Echinococcus multilocularis	neural cadherin	0.0168	0.0075	0.0075
Echinococcus multilocularis	dihydrofolate reductase	1.5197	1	1
Brugia malayi	EGF-like domain containing protein	0.0168	0.0075	0.0002
Schistosoma mansoni	hypothetical protein	0.0168	0.0075	0.0075
Echinococcus multilocularis	protein jagged 2	0.0168	0.0075	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Brugia malayi	Dihydrofolate reductase	1.5197	1	1
Echinococcus granulosus	slit 2 protein	0.0168	0.0075	0.0075
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.039	0.0221	0.0221
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.039	0.0221	0.0149
Echinococcus granulosus	neural cadherin	0.0168	0.0075	0.0075
Onchocerca volvulus		0.0299	0.0161	0.059
Echinococcus granulosus	notch	0.0168	0.0075	0.0075
Echinococcus multilocularis	Mastin	0.0415	0.0238	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0075	0.0002
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.7641	0.501	1
Echinococcus multilocularis	protein jagged 1	0.0168	0.0075	0.0075
Brugia malayi	Trypsin family protein	0.0299	0.0161	0.0089
Brugia malayi	EGF-like domain containing protein	0.0168	0.0075	0.0002
Echinococcus granulosus	delta-like protein 1	0.0168	0.0075	0.0075
Schistosoma mansoni	egf-like domain protein	0.039	0.0221	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0299	0.0161	0.0089
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0168	0.0075	0.0075

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.04 uM	Inhibitory activity against porcine calpain I using Suc-Leu-Tyr-AMC fluorogenic substrate	ChEMBL.	16185867
IC50 (binding)	= 0.04 uM	Inhibitory activity against porcine calpain I using Suc-Leu-Tyr-AMC fluorogenic substrate	ChEMBL.	16185867
IC50 (functional)	= 30 uM	Inhibition of calpain I in C2C12 myoblasts loaded with Suc-Leu-Tyr-AMC	ChEMBL.	16185867

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL200468

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 347230