Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydroorotate dehydrogenase (quinone) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | dihydroorotate dehydrogenase (quinone) | 395 aa | 361 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 0.4264 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 0.4264 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.02 | 0.4264 | 1 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0092 | 0 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 0.4264 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.02 | 0.4264 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 0.4264 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.01 | 0.0309 | 0.0309 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.01 | 0.0309 | 0.0309 |
Trypanosoma brucei | RNA helicase, putative | 0.0345 | 1 | 1 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 0.4264 | 0.5 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0092 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.01 | 0.0309 | 0.0309 |
Echinococcus multilocularis | ribonuclease H1 | 0.0092 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.01 | 0.0309 | 0.0309 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 0.4264 | 0.5 |
Echinococcus granulosus | ribonuclease H1 | 0.0092 | 0 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 0.4264 | 0.5 |
Giardia lamblia | Ribonuclease H | 0.0092 | 0 | 0.5 |
Trypanosoma brucei | ingi protein (ORF1) | 0.01 | 0.0309 | 0.0309 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.02 | 0.4264 | 0.4264 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.02 | 0.4264 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.02 | 0.4264 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.02 | 0.4264 | 0.4264 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.02 | 0.4264 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.02 | 0.4264 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.