Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Aph-1 protein, putative | 0.0115 | 0 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0395 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0395 | 1 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0395 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0395 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0395 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0 | 0.5 |
Onchocerca volvulus | 0.0395 | 1 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0395 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0395 | 1 | 1 |
Onchocerca volvulus | 0.0395 | 1 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0395 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0395 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0395 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0395 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0395 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0395 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0395 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0395 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Onchocerca volvulus | 0.0395 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0395 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.