Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Dopamine D3 receptor | 446 aa | 462 aa | 26.0 % | |
Echinococcus multilocularis | alpha 1A adrenergic receptor | Dopamine D3 receptor | 446 aa | 473 aa | 21.6 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D3 receptor | 446 aa | 489 aa | 22.9 % |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | Dopamine D3 receptor | 446 aa | 463 aa | 25.5 % |
Echinococcus granulosus | alpha 1A adrenergic receptor | Dopamine D3 receptor | 446 aa | 460 aa | 21.1 % |
Loa Loa (eye worm) | TYRA-2 protein | Dopamine D3 receptor | 446 aa | 494 aa | 24.3 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D3 receptor | 446 aa | 426 aa | 28.6 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D3 receptor | 446 aa | 455 aa | 28.6 % |
Schistosoma mansoni | amine GPCR | Dopamine D3 receptor | 446 aa | 420 aa | 31.4 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D3 receptor | 446 aa | 425 aa | 21.4 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D3 receptor | 446 aa | 463 aa | 29.8 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D3 receptor | 446 aa | 478 aa | 22.8 % |
Onchocerca volvulus | Dopamine D3 receptor | 446 aa | 434 aa | 19.4 % | |
Echinococcus multilocularis | biogenic amine (5HT) receptor | Dopamine D3 receptor | 446 aa | 499 aa | 30.9 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D3 receptor | 446 aa | 501 aa | 28.5 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 51 nM | Displacement of [3H]PD 128907 from rat ventral striatal membrane dopamine D3-like receptor | ChEMBL. | 16290142 |
Ki (binding) | = 51 nM | Displacement of [3H]PD 128907 from rat ventral striatal membrane dopamine D3-like receptor | ChEMBL. | 16290142 |
Ki (binding) | = 1360 nM | Displacement of [3H]spiperone from rat brain dopamine D2-like receptor | ChEMBL. | 16290142 |
Ki (binding) | > 50000 nM | Displacement of [3H]SCH 23390 from rat caudate putamen dopamine D1-like receptor | ChEMBL. | 16290142 |
Ratio Ki (binding) | = 27 | Selectivity ratio for dopamine D2-like receptor over dopamine D3 receptor | ChEMBL. | 16290142 |
Ratio Ki (binding) | > 980 | Selectivity ratio for dopamine D1-like receptor over dopamine D3 receptor | ChEMBL. | 16290142 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.