Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0327 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0327 | 1 | 1 |
Onchocerca volvulus | 0.0175 | 0 | 0.5 | |
Schistosoma mansoni | lipoxygenase | 0.0183 | 0.0523 | 0.0523 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0175 | 0 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0262 | 0.5703 | 0.5703 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0262 | 0.5703 | 0.5703 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0327 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0262 | 0.5703 | 0.5703 |
Brugia malayi | Carboxylesterase family protein | 0.0327 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0327 | 1 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0175 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0327 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 1 | 1 |
Onchocerca volvulus | 0.0175 | 0 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0175 | 0 | 0.5 |
Onchocerca volvulus | 0.0175 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0175 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0175 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0175 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.45 nM | Inhibition of human AChE | ChEMBL. | 16420031 |
IC50 (binding) | = 0.45 nM | Inhibition of human AChE | ChEMBL. | 16420031 |
IC50 (binding) | = 1 nM | Inhibition of human BuChE | ChEMBL. | 16420031 |
IC50 (binding) | = 1 nM | Inhibition of human BuChE | ChEMBL. | 16420031 |
IC50 (binding) | = 3.5 nM | Inhibition of BuChE from horse serum | ChEMBL. | 16420031 |
IC50 (binding) | = 3.5 nM | Inhibition of BuChE from horse serum | ChEMBL. | 16420031 |
IC50 (binding) | = 35 nM | Inhibition of AchE from bovine erythrocytes | ChEMBL. | 16420031 |
IC50 (binding) | = 35 nM | Inhibition of AchE from bovine erythrocytes | ChEMBL. | 16420031 |
permeability (ADMET) | = 2 ucm/s | Permeability in BBB by PAMPA using a lipid extract of porcine brain | ChEMBL. | 16420031 |
Ratio IC50 (binding) | = 2 | Selectivity for human AChE over human BuChE | ChEMBL. | 16420031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.