Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | Starlite/ChEMBL | References |
Homo sapiens | conserved helix-loop-helix ubiquitous kinase | Starlite/ChEMBL | References |
Homo sapiens | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.1468 | 0.4553 | 0.4553 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.2385 | 0.9302 | 0.9302 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.252 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2123 | 0.7943 | 0.7943 |
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.252 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2385 | 0.9302 | 0.9302 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2385 | 0.9302 | 0.9302 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.2385 | 0.9302 | 0.9302 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.1315 | 0.376 | 0.376 |
Brugia malayi | Protein kinase c protein 2 | 0.1814 | 0.6345 | 0.6345 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1973 | 0.7165 | 0.7165 |
Onchocerca volvulus | 0.1534 | 0.4892 | 0.5 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0589 | 0 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.1973 | 0.7165 | 0.7165 |
Schistosoma mansoni | serine/threonine protein kinase | 0.252 | 1 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.1002 | 0.2137 | 0.2137 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.2039 | 0.751 | 0.751 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.1315 | 0.376 | 0.376 |
Loa Loa (eye worm) | hypothetical protein | 0.1534 | 0.4892 | 0.4892 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.1402 | 0.4208 | 0.4208 |
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1534 | 0.4892 | 0.4892 |
Loa Loa (eye worm) | hypothetical protein | 0.1534 | 0.4892 | 0.4892 |
Echinococcus granulosus | protein kinase c iota type | 0.1002 | 0.2137 | 0.2137 |
Echinococcus multilocularis | protein kinase c iota type | 0.1002 | 0.2137 | 0.2137 |
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1468 | 0.4553 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Echinococcus granulosus | protein kinase c epsilon type | 0.252 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1728 | 0.5897 | 0.5897 |
Loa Loa (eye worm) | hypothetical protein | 0.1315 | 0.376 | 0.376 |
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1946 | 0.7028 | 0.7028 |
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.0589 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0589 | 0 | 0.5 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.1315 | 0.376 | 0.376 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 uM | Inhibitory activity against IKK2 | ChEMBL. | 16236504 |
IC50 (binding) | = 0.1 uM | Inhibitory activity against IKK complex isolated from HeLa cells | ChEMBL. | 16236504 |
IC50 (binding) | = 0.1 uM | Inhibitory activity against IKK2 | ChEMBL. | 16236504 |
IC50 (binding) | = 0.1 uM | Inhibitory activity against IKK complex isolated from HeLa cells | ChEMBL. | 16236504 |
IC50 (functional) | = 0.4 uM | Inhibition of TNFalpha-stimulated expression of E-selectin in HUVEC cells | ChEMBL. | 16236504 |
IC50 (functional) | = 0.4 uM | Inhibition of TNFalpha-stimulated expression of E-selectin in HUVEC cells | ChEMBL. | 16236504 |
IC50 (functional) | = 0.5 uM | Inhibition of TNFalpha-stimulated expression of VCAM1 in HUVEC cells | ChEMBL. | 16236504 |
IC50 (functional) | = 0.5 uM | Inhibition of TNFalpha-stimulated expression of VCAM1 in HUVEC cells | ChEMBL. | 16236504 |
IC50 (functional) | = 0.6 uM | Inhibition of TNFalpha-stimulated expression of ICAM1 in HUVEC cells | ChEMBL. | 16236504 |
IC50 (functional) | = 0.6 uM | Inhibition of TNFalpha-stimulated expression of ICAM1 in HUVEC cells | ChEMBL. | 16236504 |
IC50 (binding) | = 1 uM | Inhibitory activity against IKK1 | ChEMBL. | 16236504 |
IC50 (functional) | = 1 uM | Inhibition of TNFalpha-stimulated IkappaBalpha degradation | ChEMBL. | 16236504 |
IC50 (binding) | = 1 uM | Inhibitory activity against IKK1 | ChEMBL. | 16236504 |
IC50 (functional) | = 1 uM | Inhibition of TNFalpha-stimulated IkappaBalpha degradation | ChEMBL. | 16236504 |
IC50 (functional) | = 2 uM | Inhibition of IFNgamma-stimulated expression of HLA-DR | ChEMBL. | 16236504 |
IC50 (functional) | = 5 uM | Inhibition of IFNgamma-stimulated expression of beta2 microglobulin | ChEMBL. | 16236504 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.