Detailed information for compound 348146

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 433.609 | Formula: C26H31N3OS
  • H donors: 2 H acceptors: 2 LogP: 4.58 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cccc(c1)CN1CCC[C@@H]1[C@@H](CNC(Cc1csc2c1cccc2)(C)C)O
  • InChi: 1S/C26H31N3OS/c1-26(2,14-21-18-31-25-11-4-3-9-22(21)25)28-16-24(30)23-10-6-12-29(23)17-20-8-5-7-19(13-20)15-27/h3-5,7-9,11,13,18,23-24,28,30H,6,10,12,14,16-17H2,1-2H3/t23-,24-/m1/s1
  • InChiKey: BNJSVXAJEDIILM-DNQXCXABSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium-sensing receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127276 All targets in OG5_127276
Schistosoma japonicum Metabotropic glutamate receptor 7 precursor, putative Get druggable targets OG5_127276 All targets in OG5_127276
Schistosoma japonicum Metabotropic glutamate receptor 7 precursor, putative Get druggable targets OG5_127276 All targets in OG5_127276

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Onchocerca volvulus Peroxidasin homolog 0.0052 0.015 0.0603
Brugia malayi Serotonin receptor 0.1044 0.5156 1
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus multilocularis glutamate synthase 0.0155 0.0669 0.0753
Schistosoma mansoni hypothetical protein 0.0028 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0468 0.2248 0.4793
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0038 0.0108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0195 0.0666
Toxoplasma gondii NADPH-glutathione reductase 0.0584 0.2837 0.754
Trypanosoma brucei protein kinase, putative 0.005 0.0137 0.0131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0135 0.0199
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0138 0.0156
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0155 0.0669 0.167
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0195 0.0219
Giardia lamblia Thioredoxin reductase 0.0155 0.0669 0.2344
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0155 0.0669 0.1296
Onchocerca volvulus 0.0447 0.2143 0.9372
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.2483 0.8749
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0051 0.0145 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0224 0.0765
Echinococcus multilocularis neuropeptides capa receptor 0.0121 0.0497 0.0559
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0038 0.0032
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0155 0.0669 0.0753
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0151 0.0321
Trichomonas vaginalis glutamate synthase, putative 0.0155 0.0669 0.2337
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0121 0.0497 0.0559
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus granulosus calcium activated potassium channel 0.0023 0.0004 0.0004
Schistosoma mansoni opsin-like receptor 0.0121 0.0497 0.0733
Brugia malayi hypothetical protein 0.0121 0.0497 0.0963
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0073 0.0083
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0155 0.0669 0.1296
Brugia malayi intermediate filament protein 0.0053 0.0151 0.0292
Brugia malayi Animal haem peroxidase family protein 0.0052 0.015 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0224 0.0765
Brugia malayi Peroxidasin 0.0052 0.015 0.029
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0155 0.0669 0.1765
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0141 0.0358
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Loa Loa (eye worm) hypothetical protein 0.003 0.0036 0.0076
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0029 0.003 0.0083
Brugia malayi Dopamine receptor protein 2 0.0121 0.0497 0.0963
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0121 0.0497 0.0733
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0155 0.0669 0.1707
Echinococcus multilocularis short transient receptor potential channel 6 0.0023 0.0001 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1589 0.5592
Leishmania major hypothetical protein, conserved 0.0068 0.0228 0.0222
Brugia malayi cytochrome P450 0.0029 0.003 0.0057
Onchocerca volvulus 0.0053 0.0151 0.061
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0029 0.003 0.0083
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0034 0.0059 0.0053
Schistosoma mansoni cytochrome P450 0.0029 0.003 0.0044
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.0684 0.1458
Leishmania major hypothetical protein, conserved 0.0155 0.0669 0.0663
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0062 0.0091
Trichomonas vaginalis glutathione reductase, putative 0.0584 0.2837 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0051 0.0145 0.0164
Echinococcus multilocularis jun protein 0.0249 0.1141 0.1285
Echinococcus granulosus tachykinin peptides receptor 99D 0.0121 0.0497 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0157 0.053
Plasmodium falciparum transporter, putative 0.0051 0.0145 0.037
Schistosoma mansoni hypothetical protein 0.0035 0.0062 0.0091
Plasmodium falciparum thioredoxin reductase 0.0767 0.376 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0155 0.0669 0.0753
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0196 0.0416
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0009 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0073 0.0155
Schistosoma mansoni amine GPCR 0.1117 0.5528 0.8154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0497 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0137 0.0202
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0032 0.0048 0.0054
Brugia malayi sulfakinin receptor protein 0.0121 0.0497 0.0963
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0073 0.0083
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0038 0.0032
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0195 0.0431
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0309
Loa Loa (eye worm) hypothetical protein 0.0303 0.1416 0.3018
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0188 0.0483
Echinococcus multilocularis Ankyrin 0.0028 0.0028 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.0684 0.1326
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0584 0.2837 0.4184
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0038 0.0032
Schistosoma mansoni single-minded 0.0097 0.0375 0.0553
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0013 0.0014
Echinococcus multilocularis peroxidasin 0.0052 0.015 0.0169
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0029 0.003 0.0083
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0161 0.07 0.0788
Echinococcus granulosus glutamate synthase 0.0155 0.0669 0.0753
Echinococcus multilocularis orexin receptor type 2 0.0121 0.0497 0.0559
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0071 0.0246 0.0363
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Echinococcus granulosus nuclear factor of activated T cells 5 0.0144 0.0611 0.0688
Schistosoma mansoni neuropeptide f receptor 76f 0.0121 0.0497 0.0733
Onchocerca volvulus 0.0121 0.0497 0.213
Schistosoma mansoni glutaminase 0.0295 0.1377 0.2031
Echinococcus granulosus lamin dm0 0.0053 0.0151 0.017
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0121 0.0497 0.0733
Echinococcus multilocularis sodium and chloride dependent glycine 0.0051 0.0145 0.0164
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0249 0.1141 0.1285
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.2483 0.8749
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.015 0.0603
Onchocerca volvulus 0.0053 0.0151 0.061
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0131 0.0437
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0013 0.0018
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0137 0.0131
Loa Loa (eye worm) hypothetical protein 0.0102 0.0403 0.0858
Echinococcus granulosus neuropeptide s receptor 0.0585 0.2841 0.3199
Brugia malayi hypothetical protein 0.0121 0.0497 0.0963
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0138 0.0156
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0155 0.0669 1
Loa Loa (eye worm) glutamate receptor 0.0024 0.0007 0.0014
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0029 0.003 0.0083
Schistosoma mansoni disulfide oxidoreductase 0.0155 0.0669 0.0986
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0121 0.0497 0.1058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0131 0.0437
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0196 0.0288
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0048 0.0054
Schistosoma mansoni ap endonuclease 0.0037 0.0073 0.0108
Plasmodium falciparum ferrodoxin reductase-like protein 0.0155 0.0669 0.1765
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0137 0.0458
Onchocerca volvulus 0.0121 0.0497 0.213
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0068 0.0228 0.0591
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0497 0.0733
Schistosoma mansoni lipoxygenase 0.0054 0.0159 0.0235
Onchocerca volvulus 0.0052 0.015 0.0603
Treponema pallidum thioredoxin reductase (trxB) 0.0155 0.0669 0.2155
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0155 0.0669 0.1765
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0048 0.0071
Loa Loa (eye worm) hypothetical protein 0.0325 0.1525 0.325
Echinococcus granulosus tumor protein p63 0.0346 0.1631 0.1837
Echinococcus multilocularis neuropeptide s receptor 0.0585 0.2841 0.3199
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0584 0.2837 0.2832
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0137 0.0131
Echinococcus multilocularis microtubule associated protein 2 0.1365 0.678 0.7633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0224 0.0765
Brugia malayi Thioredoxin reductase 0.0767 0.376 0.7293
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0121 0.0497 0.0733
Echinococcus multilocularis Protein lozenge 0.0056 0.0169 0.019
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0013 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0181 0.0613
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.0341 0.0334
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0357 0.1689 0.4335
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0048 0.0143
Echinococcus multilocularis conserved hypothetical protein 0.1384 0.6874 0.7738
Echinococcus granulosus short transient receptor potential channel 6 0.0023 0.0001 0.0001
Trichomonas vaginalis DNA helicase recq, putative 0.0046 0.0118 0.0389
Schistosoma mansoni peroxidasin 0.0052 0.015 0.0221
Loa Loa (eye worm) blistered cuticle protein 3 0.0126 0.052 0.1108
Schistosoma mansoni ap endonuclease 0.0037 0.0073 0.0108
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0786 0.3857 1
Brugia malayi hypothetical protein 0.0125 0.0514 0.0997
Schistosoma mansoni hypothetical protein 0.0029 0.003 0.0044
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0155 0.0669 0.167
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0303 0.1416 0.2088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0131 0.0436
Plasmodium falciparum glutathione reductase 0.0767 0.376 1
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0155 0.0669 0.2155
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.0341 0.5046
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0155 0.0669 0.0663
Loa Loa (eye worm) glutaminase 0.0295 0.1377 0.2936
Echinococcus granulosus somatostatin receptor 0.0121 0.0497 0.0559
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0514 0.2483 0.4815
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0132 0.0551 0.1361
Loa Loa (eye worm) hypothetical protein 0.0325 0.1528 0.3257
Leishmania major protein kinase, putative 0.0036 0.0066 0.006
Schistosoma mansoni amine GPCR 0.0121 0.0497 0.0733
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0013 0.0006
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0027 0.0031
Brugia malayi glutamate synthase 0.0155 0.0669 0.1296
Loa Loa (eye worm) hypothetical protein 0.0108 0.0432 0.0919
Schistosoma mansoni hypothetical protein 0.0155 0.0669 0.0986
Echinococcus multilocularis somatostatin receptor 0.0121 0.0497 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0224 0.0765
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0157 0.053
Schistosoma mansoni alpha-1 adrenergic receptor 0.0121 0.0497 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0224 0.0765
Brugia malayi Inositol-1 0.0147 0.0629 0.1218
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0068 0.0228 0.0222
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0073 0.0237
Echinococcus multilocularis g protein coupled receptor 0.0121 0.0497 0.0559
Brugia malayi TAR-binding protein 0.0061 0.0196 0.0378
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0073 0.0242
Schistosoma mansoni lamin 0.0053 0.0151 0.0223
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0041 0.0091
Schistosoma mansoni lamin 0.0053 0.0151 0.0223
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0027 0.0057
Brugia malayi G-protein coupled receptor 0.0121 0.0497 0.0963
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0137 0.0131
Echinococcus multilocularis 0.0029 0.003 0.0034
Echinococcus multilocularis inositol monophosphatase 1 0.0147 0.0629 0.0708
Mycobacterium ulcerans putative regulatory protein 0.0072 0.0248 0.0853
Onchocerca volvulus 0.0121 0.0497 0.213
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0155 0.0669 0.2341
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0147 0.0629 0.2009
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0155 0.0669 0.2341
Trypanosoma brucei cytochrome P450, putative 0.0038 0.0075 0.0069
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0121 0.0497 0.0733
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0138 0.0267
Schistosoma mansoni hypothetical protein 0.005 0.0138 0.0204
Echinococcus multilocularis serotonin receptor 0.0365 0.173 0.1948
Echinococcus multilocularis neuropeptide Y receptor 0.0121 0.0497 0.0559
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0155 0.0669 0.0753
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0137 0.0131
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0137 0.0155
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0013 0.0018
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0038 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Brugia malayi hypothetical protein 0.0035 0.0062 0.0118
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0013 0.0026
Schistosoma mansoni voltage-gated potassium channel 0.0097 0.0377 0.0557
Echinococcus granulosus survival motor neuron protein 1 0.0468 0.2248 0.2531
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0051 0.0145 0.0281
Brugia malayi hypothetical protein 0.0121 0.0497 0.0963
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0429 0.2053 0.3982
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0151 0.0321
Plasmodium vivax amine transporter, putative 0.0051 0.0145 0.037
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0017 0.0011
Echinococcus multilocularis neuropeptide receptor 0.0121 0.0497 0.0559
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0121 0.0497 0.0733
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0138 0.0156
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.003 0.0034
Loa Loa (eye worm) TYRA-2 protein 0.0121 0.0497 0.1058
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.0028 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0247 0.0848
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0155 0.0669 0.1707
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0051 0.0145 0.0214
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0309
Schistosoma mansoni neuropeptide receptor 0.0121 0.0497 0.0733
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0029 0.003 0.0083
Schistosoma mansoni hypothetical protein 0.0202 0.0906 0.1336
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0155 0.0669 1
Schistosoma mansoni hypothetical protein 0.0121 0.0497 0.0733
Mycobacterium ulcerans hypothetical protein 0.0155 0.0669 0.2341
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.015 0.0318
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0584 0.2837 0.3193
Echinococcus granulosus neuropeptide Y receptor 0.0121 0.0497 0.0559
Brugia malayi G-protein coupled receptor 0.0121 0.0497 0.0963
Onchocerca volvulus 0.0051 0.0141 0.0565
Loa Loa (eye worm) hypothetical protein 0.0377 0.1791 0.3819
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0121 0.0497 0.0559
Plasmodium falciparum glutathione reductase 0.0584 0.2837 0.754
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0038 0.0108
Onchocerca volvulus 0.0121 0.0497 0.213
Schistosoma mansoni transient receptor potential channel 0.0023 0.0001 0.0001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0357 0.1689 0.4361
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0137 0.0155
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.2483 0.8749
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0137 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0497 0.0733
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0497 0.0733
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0137 0.0131
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Brugia malayi Cytochrome P450 family protein 0.0038 0.0075 0.0145
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1782 0.8883 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0121 0.0497 0.0559
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0001 0.0001
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0038 0.008
Entamoeba histolytica thioredoxin reductase, putative 0.0155 0.0669 1
Loa Loa (eye worm) runx1 0.0056 0.0169 0.0359
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0155 0.0669 0.0663
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0155 0.0669 0.1296
Entamoeba histolytica hypothetical protein 0.0035 0.0062 0.0834
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0155 0.0669 0.1765
Brugia malayi Serotonin receptor 0.0121 0.0497 0.0963
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0234 0.1065 0.106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0135 0.0199
Brugia malayi glutaminase DH11.1 0.0295 0.1377 0.267
Echinococcus granulosus microtubule associated protein 2 0.1365 0.678 0.7633
Schistosoma mansoni histamine h1 receptor 0.0121 0.0497 0.0733
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0177 0.0199
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.0341 0.0383
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0051 0.0145 0.0281
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0155 0.0669 0.2341
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0155 0.0669 0.0663
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Echinococcus granulosus death domain containing protein 0.0028 0.0027 0.0031
Echinococcus granulosus tm gpcr rhodopsin 0.0121 0.0497 0.0559
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0121 0.0497 0.0559
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.03
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0121 0.0497 0.1058
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0073 0.0141
Loa Loa (eye worm) hypothetical protein 0.0053 0.0151 0.0321
Onchocerca volvulus 0.0051 0.0145 0.0583
Brugia malayi Animal haem peroxidase family protein 0.0052 0.015 0.029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0341 0.066
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0141 0.0208
Onchocerca volvulus 0.0121 0.0497 0.213
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.0033 0.0049
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0155 0.0669 0.0753
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0073 0.0067
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0027 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0121 0.0497 0.0559
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.015 0.0318
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0082 0.0092
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0034 0.0059 0.0053
Brugia malayi hypothetical protein 0.0121 0.0497 0.0963
Schistosoma mansoni glutamate synthase 0.0155 0.0669 0.0986
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0027 0.0031
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.0341 0.0334
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0429 0.2053 0.3982
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0195 0.0666
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.0224 0.058
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Loa Loa (eye worm) inositol-1 0.0147 0.0629 0.1339
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0195 0.0189
Schistosoma mansoni metabotropic glutamate receptor 0.02 0.0896 0.1321
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0584 0.2837 0.7334
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1691 0.8424 0.8423
Entamoeba histolytica hypothetical protein 0.0035 0.0062 0.0834
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0051 0.0145 0.0164
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0155 0.0669 0.0663
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0051 0.0145 0.0309
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0584 0.2837 0.754
Plasmodium falciparum thioredoxin reductase 0.0584 0.2837 0.754
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0145 0.037
Onchocerca volvulus 0.0121 0.0497 0.213
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0155 0.0669 0.2344
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0038 0.0032
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0161 0.07 0.0788
Brugia malayi Cytochrome P450 family protein 0.0029 0.003 0.0057
Brugia malayi Dopamine receptor 0.0121 0.0497 0.0963
Entamoeba histolytica hypothetical protein 0.0035 0.0062 0.0834
Onchocerca volvulus 0.0071 0.0246 0.1026
Brugia malayi Protein kinase domain containing protein 0.0029 0.0032 0.0061
Brugia malayi hypothetical protein 0.0121 0.0497 0.0963
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0155 0.0669 0.0753
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0155 0.0669 0.2341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0188 0.0277
Echinococcus multilocularis dro:myosuppressin receptor 0.0121 0.0497 0.0559
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.017 0.0164
Schistosoma mansoni hypothetical protein 0.0121 0.0497 0.0733
Echinococcus granulosus voltage gated potassium channel 0.0039 0.0082 0.0092
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0029 0.003 0.0083
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0155 0.0669 0.2337
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0048 0.0071
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.017 0.0251
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0196 0.0288
Echinococcus granulosus intermediate filament protein 0.0053 0.0151 0.017
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0131 0.0437
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0195 0.0219
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0018
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.017 0.0578
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0032 0.0048 0.0054
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0048 0.0054
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0051 0.0145 0.037
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0432 0.0836
Echinococcus granulosus alpha 1A adrenergic receptor 0.0121 0.0497 0.0559
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0584 0.2837 0.2832
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0017 0.0011
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0738 0.3614 0.361
Chlamydia trachomatis thioredoxin reductase 0.0155 0.0669 0.2323
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0191 0.0647
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0497 0.0733
Toxoplasma gondii thioredoxin reductase 0.0767 0.376 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0121 0.0497 0.0559
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus multilocularis ATP binding cassette sub family G 0.0024 0.0006 0.0007
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0048 0.0071
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0161 0.07 0.1492
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0024 0.0007 0.001
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0051 0.0145 0.037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Onchocerca volvulus Peroxidase homolog 0.0052 0.015 0.0603
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0091 0.0344 0.0387
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Trichomonas vaginalis glutamate synthase, putative 0.0155 0.0669 0.2337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0497 0.0733
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0137 0.0155
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.0341 0.0383
Entamoeba histolytica recQ family helicase, putative 0.0025 0.0009 0.0047
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0029 0.003 0.0083
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.0341 0.5046
Loa Loa (eye worm) cytochrome P450 0.0029 0.003 0.0062
Schistosoma mansoni voltage-gated potassium channel 0.0097 0.0377 0.0557
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0121 0.0497 0.0963
Echinococcus granulosus tar DNA binding protein 0.0061 0.0196 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0224 0.0765
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0155 0.0669 0.1765
Echinococcus granulosus biogenic amine 5HT receptor 0.0121 0.0497 0.0559
Schistosoma mansoni biogenic amine receptor 0.0121 0.0497 0.0733
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0188 0.0277
Echinococcus multilocularis lamin 0.0053 0.0151 0.017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0073 0.0067
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.017 0.0191
Loa Loa (eye worm) hypothetical protein 0.0303 0.1416 0.3018
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0147 0.0629 0.9392
Echinococcus granulosus inositol monophosphatase 1 0.0147 0.0629 0.0708
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0013 0.0006
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0121 0.0497 0.0559
Schistosoma mansoni biogenic amine receptor 0.0121 0.0497 0.0733
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.1681 0.5916
Echinococcus multilocularis ATP binding cassette sub family G 0.0024 0.0006 0.0007
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0155 0.0669 0.0753
Echinococcus granulosus transient receptor potential cation channel 0.0023 0.0001 0.0001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0155 0.0669 0.2337
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0013 0.0018
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0051 0.0145 0.0164
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0017 0.0011
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0155 0.0669 0.0753
Loa Loa (eye worm) hypothetical protein 0.0024 0.0009 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0247 0.0848
Schistosoma mansoni neuropeptide F-like receptor 0.0121 0.0497 0.0733
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0151 0.0292
Onchocerca volvulus Dual oxidase homolog 0.0126 0.052 0.2232
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0195 0.0288
Brugia malayi hypothetical protein 0.0468 0.2248 0.436
Brugia malayi hypothetical protein 0.0102 0.0403 0.078
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0767 0.376 0.9747
Brugia malayi ORL1-like opioid receptor 0.0121 0.0497 0.0963
Onchocerca volvulus 0.0052 0.015 0.0603
Loa Loa (eye worm) solute carrier family 6 member 4 0.0303 0.1416 0.3018
Brugia malayi hypothetical protein 0.0033 0.005 0.0097
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0121 0.0497 0.1058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0135 0.0199
Brugia malayi hypoxia-induced factor 1 0.03 0.14 0.2716
Echinococcus granulosus hypothetical protein 0.1505 0.7485 0.8427
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0009 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0121 0.0497 0.0559
Giardia lamblia GTOR 0.009 0.0341 0.1185
Brugia malayi RE15519p 0.0121 0.0497 0.0963
Echinococcus granulosus allatostatin A receptor 0.0121 0.0497 0.0559
Loa Loa (eye worm) neuropeptide F receptor 0.0121 0.0497 0.1058
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0027 0.0064
Trypanosoma cruzi NADH dehydrogenase, putative 0.0155 0.0669 0.0663
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0121 0.0497 0.0733
Loa Loa (eye worm) norepinephrine transporter 0.0303 0.1416 0.3018
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0073 0.0233
Brugia malayi follicle stimulating hormone receptor 0.0356 0.1685 0.3268
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0155 0.0669 0.0753
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0188 0.0211
Entamoeba histolytica disulphide oxidoreductase, putative 0.0155 0.0669 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0303 0.1416 0.2746
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0161 0.07 0.1357
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus multilocularis g-protein coupled receptor 0.0121 0.0497 0.0559
Echinococcus multilocularis tumor protein p63 0.0346 0.1631 0.1837
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0082 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Loa Loa (eye worm) RecQ helicase 0.0046 0.0118 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0155 0.052
Trypanosoma cruzi trypanothione reductase, putative 0.0584 0.2837 0.2832
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0155 0.0669 0.0663
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0147 0.0629 0.1658
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0048 0.0071
Onchocerca volvulus 0.0121 0.0497 0.213
Schistosoma mansoni netrin receptor unc5 0.0028 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus granulosus GPCR family 2 0.005 0.0138 0.0156
Schistosoma mansoni survival motor neuron protein 0.0095 0.0367 0.0542
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0091 0.0344 0.0732
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0075 0.0069
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0018
Onchocerca volvulus 0.0051 0.0145 0.0583
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0121 0.0497 0.0559
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0013 0.0018
Echinococcus granulosus ATP binding cassette sub family G 0.0024 0.0006 0.0007
Brugia malayi M-phase phosphoprotein, mpp8 0.0102 0.0402 0.0778
Echinococcus granulosus neuropeptide receptor A26 0.0585 0.2841 0.3199
Brugia malayi hypothetical protein 0.0447 0.2143 0.4155
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0032 0.0048 0.0143
Echinococcus granulosus sodium and chloride dependent glycine 0.0051 0.0145 0.0164
Schistosoma mansoni biogenic amine receptor 0.0121 0.0497 0.0733
Echinococcus multilocularis metabotropic glutamate receptor 5 0.003 0.0036 0.004
Echinococcus multilocularis survival motor neuron protein 1 0.0468 0.2248 0.2531
Echinococcus multilocularis sodium channel protein 0.0234 0.1065 0.1199
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0155 0.0669 0.2337
Brugia malayi GnHR receptor homolog 0.0121 0.0497 0.0963
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0135 0.0152
Schistosoma mansoni glutamate synthase 0.0155 0.0669 0.0986
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.2483 0.8749
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0497 0.0733
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0155 0.0669 0.2341
Echinococcus granulosus single minded 2 0.0078 0.0282 0.0317
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0072 0.0248 0.0242
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0013 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0038 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1589 0.5592
Mycobacterium ulcerans glutamate synthase subunit beta 0.0155 0.0669 0.2341
Loa Loa (eye worm) G-protein coupled receptor 0.0121 0.0497 0.1058
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0584 0.2837 0.754
Schistosoma mansoni inositol monophosphatase 0.0147 0.0629 0.0927
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0155 0.0669 0.2337
Trypanosoma brucei C-8 sterol isomerase, putative 0.0738 0.3614 0.361
Brugia malayi Animal haem peroxidase family protein 0.0052 0.015 0.029
Echinococcus multilocularis neuropeptide Y receptor 0.0121 0.0497 0.0559
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0073 0.0067
Brugia malayi MAP kinase sur-1 0.005 0.0137 0.0265
Echinococcus granulosus lamin 0.0053 0.0151 0.017
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.2003 1 1
Loa Loa (eye worm) hepatopoietin HPO2 0.0068 0.0228 0.0486
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0009 0.0003
Schistosoma mansoni hypothetical protein 0.0121 0.0497 0.0733
Echinococcus granulosus peroxidasin 0.0052 0.015 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0038 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0341 0.1177
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0091 0.0344 0.0387
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0121 0.0497 0.0733
Loa Loa (eye worm) glutaminase 2 0.0295 0.1377 0.2936
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus granulosus bloom syndrome protein 0.0046 0.0118 0.0132
Mycobacterium tuberculosis Probable reductase 0.0357 0.1689 0.4335
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0367 0.0712
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2003 1 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0029 0.003 0.0083
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0151 0.0321
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0234 0.1065 0.1199
Loa Loa (eye worm) hypothetical protein 0.0091 0.0346 0.0737
Loa Loa (eye worm) hypothetical protein 0.0951 0.469 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1691 0.8424 0.8423
Schistosoma mansoni inositol monophosphatase 0.0147 0.0629 0.0927
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0196 0.0288
Schistosoma mansoni microtubule-associated protein tau 0.1365 0.678 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0188 0.0211
Schistosoma mansoni biogenic amine (5HT) receptor 0.0365 0.173 0.2552
Echinococcus multilocularis G-protein coupled receptor, putative 0.0121 0.0497 0.0559
Schistosoma mansoni lozenge 0.0056 0.0169 0.0249
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0121 0.0497 0.0963
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1589 0.5592
Loa Loa (eye worm) programmed cell death 8 0.0155 0.0669 0.1425
Onchocerca volvulus 0.0121 0.0497 0.213
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0029 0.003 0.0083
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0121 0.0497 0.0733
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0091 0.0344 0.0387
Schistosoma mansoni sulfide quinone reductase 0.0155 0.0669 0.0986
Leishmania major cytochrome p450-like protein 0.0029 0.003 0.0023
Echinococcus multilocularis G protein coupled receptor 139 0.0121 0.0497 0.0559
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0073 0.0114
Loa Loa (eye worm) G-protein coupled receptor 0.0121 0.0497 0.1058
Giardia lamblia Glutamate synthase 0.0155 0.0669 0.2344
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0031 0.0042 0.0096
Brugia malayi putative neuropeptide receptor NPR1 0.0121 0.0497 0.0963
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0081 0.0295 0.0628
Brugia malayi bZIP transcription factor family protein 0.0249 0.1141 0.2212
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Echinococcus granulosus neuropeptide receptor 0.0121 0.0497 0.0559
Loa Loa (eye worm) hypothetical protein 0.0242 0.1107 0.2359
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1482 0.737 0.7368
Echinococcus multilocularis neuropeptide receptor 0.0121 0.0497 0.0559
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0013 0.0018
Schistosoma mansoni sodium/chloride dependent transporter 0.0051 0.0145 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0018
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0144 0.0611 0.0688
Echinococcus granulosus sex peptide receptor 0.0121 0.0497 0.0559
Schistosoma mansoni 60S ribosomal protein L21 0.0029 0.0033 0.0049
Schistosoma mansoni blooms syndrome DNA helicase 0.0036 0.0069 0.0101
Echinococcus multilocularis neuropeptide FF receptor 2 0.0121 0.0497 0.0559
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0029 0.003 0.0083
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0034 0.0059 0.0053
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0155 0.0669 0.2155
Onchocerca volvulus 0.0303 0.1416 0.6174
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0188 0.0211
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0309
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.0341 0.0502
Schistosoma mansoni hypothetical protein 0.005 0.0138 0.0204
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0141 0.0134
Echinococcus multilocularis sodium and chloride dependent glycine 0.0051 0.0145 0.0164
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0786 0.3857 1
Plasmodium vivax SET domain protein, putative 0.006 0.0188 0.0483
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0155 0.0669 0.0663
Brugia malayi Tachykinin-like peptides receptor 99D 0.0121 0.0497 0.0963
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.2483 0.8749
Leishmania major NADH dehydrogenase, putative 0.0155 0.0669 0.0663
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0155 0.0669 0.0663
Schistosoma mansoni neuropeptide receptor 0.0121 0.0497 0.0733
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0121 0.0497 0.0559
Plasmodium falciparum amino acid transporter, putative 0.0051 0.0145 0.037
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.0341 0.0334
Loa Loa (eye worm) hypothetical protein 0.0738 0.3614 0.7707
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0155 0.0669 0.2337
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0147 0.0629 0.0623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0131 0.0436
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0048 0.0071
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0027 0.0031
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0138 0.0156
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0121 0.0497 0.0559
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0135 0.0287
Onchocerca volvulus 0.0051 0.0145 0.0583
Toxoplasma gondii exonuclease III APE 0.0037 0.0073 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0274 0.0942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0155 0.052
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0048 0.0071
Echinococcus granulosus dro:myosuppressin receptor 0.0121 0.0497 0.0559
Treponema pallidum sodium- and chloride- dependent transporter 0.0303 0.1416 0.4859
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0051 0.0145 0.0214
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0059
Treponema pallidum oxidoreductase 0.0155 0.0669 0.2155
Brugia malayi G protein-coupled receptor 0.0121 0.0497 0.0963
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0196 0.0288
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0029 0.003 0.0083
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0584 0.2837 0.754
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0101
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0051 0.0145 0.0214
Trichomonas vaginalis glucosylceramidase, putative 0.0356 0.1681 0.5916
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0029 0.003 0.0083
Echinococcus multilocularis serotonin receptor 0.0365 0.173 0.1948
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0009 0.0003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0121 0.0497 0.0559
Brugia malayi Uncoordinated protein 44 0.0028 0.0027 0.0052
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Schistosoma mansoni glutamate synthase 0.0155 0.0669 0.0986
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.003 0.0062
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0155 0.0669 0.167
Echinococcus multilocularis GPCR, family 2 0.005 0.0138 0.0156
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.0001 0.0001
Brugia malayi Pre-SET motif family protein 0.0417 0.1993 0.3865
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.1482 0.737 0.7368
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0121 0.0497 0.0733
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0309
Echinococcus granulosus sodium and chloride dependent glycine 0.0051 0.0145 0.0164
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0249 0.1141 0.1285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0247 0.0848
Loa Loa (eye worm) RNA binding protein 0.0061 0.0196 0.0416
Echinococcus granulosus thioredoxin glutathione reductase 0.0767 0.376 0.4233
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.015 0.0318
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Onchocerca volvulus 0.0155 0.0669 0.2887
Mycobacterium ulcerans NADH dehydrogenase 0.0155 0.0669 0.2341
Onchocerca volvulus 0.0102 0.0402 0.1711
Leishmania major protein kinase, putative 0.0026 0.0017 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0137 0.0458
Schistosoma mansoni sulfide quinone reductase 0.0155 0.0669 0.0986
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.0344 0.0507
Loa Loa (eye worm) thioredoxin reductase 0.0767 0.376 0.8017
Brugia malayi neuropeptide F receptor 0.0121 0.0497 0.0963
Toxoplasma gondii hypothetical protein 0.0051 0.0145 0.037
Echinococcus granulosus sodium channel protein 0.0234 0.1065 0.1199
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0155 0.0669 0.2337
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus multilocularis calcium activated potassium channel 0.0023 0.0004 0.0004
Echinococcus granulosus g protein coupled receptor 0.0121 0.0497 0.0559
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0226 0.048
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0155 0.0669 0.0663
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0051 0.0145 0.0164
Brugia malayi Cytochrome P450 family protein 0.0067 0.0226 0.0437
Schistosoma mansoni hypothetical protein 0.005 0.0138 0.0204
Echinococcus granulosus geminin 0.0506 0.2442 0.2749
Echinococcus multilocularis hyperpolarization activated cyclic 0.0032 0.0048 0.0054
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0039 0.0082 0.0158
Echinococcus granulosus Ankyrin 0.0028 0.0028 0.0032
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0051 0.0145 0.0214
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0032 0.0048 0.0054
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0137 0.0292
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0584 0.2837 0.754
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0121 0.0497 0.0559
Schistosoma mansoni jun-related protein 0.0202 0.0906 0.1336
Echinococcus multilocularis allatostatin A receptor 0.0121 0.0497 0.0559
Brugia malayi neuropeptide F receptor 0.0121 0.0497 0.0963
Loa Loa (eye worm) hypothetical protein 0.005 0.0138 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1589 0.5592
Echinococcus granulosus neuropeptides capa receptor 0.0121 0.0497 0.0559
Onchocerca volvulus 0.0121 0.0497 0.213
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0051 0.0145 0.037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0073 0.0067
Brugia malayi hypothetical protein 0.0121 0.0497 0.0963
Onchocerca volvulus 0.0121 0.0497 0.213
Echinococcus granulosus serotonin transporter 0.0303 0.1416 0.1594
Brugia malayi hypothetical protein 0.0121 0.0497 0.0963
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0155 0.0669 1
Echinococcus granulosus neuropeptide Y receptor 0.0121 0.0497 0.0559
Onchocerca volvulus Neuropeptide F receptor homolog 0.0121 0.0497 0.213
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0497 0.0733
Echinococcus granulosus g protein coupled receptor 0.0121 0.0497 0.0559
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0786 0.3857 1
Echinococcus multilocularis lamin dm0 0.0053 0.0151 0.017
Onchocerca volvulus 0.0102 0.0402 0.1711
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0137 0.0467
Echinococcus multilocularis ATP binding cassette sub family G 0.0024 0.0006 0.0007
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0051 0.0145 0.047
Brugia malayi hypothetical protein 0.0195 0.0871 0.1689
Brugia malayi bHLH-PAS transcription factor 0.0072 0.0248 0.048
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0141 0.0134
Onchocerca volvulus 0.0195 0.0871 0.3778
Mycobacterium tuberculosis Probable oxidoreductase 0.0786 0.3857 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0038 0.0056
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0137 0.0458
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0506 0.2442 0.3602
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0121 0.0497 0.0559
Echinococcus multilocularis serotonin transporter 0.0303 0.1416 0.1594
Trypanosoma cruzi hypothetical protein, conserved 0.0155 0.0669 0.0663
Leishmania major hypothetical protein, conserved 0.0051 0.0141 0.0134
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.0299
Onchocerca volvulus Glucosylceramidase homolog 0.0337 0.1589 0.6938
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0029 0.003 0.0083
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0121 0.0497 0.0733
Loa Loa (eye worm) hypothetical protein 0.0155 0.0669 0.1425
Loa Loa (eye worm) serotonin transporter b 0.0303 0.1416 0.3018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0157 0.053
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0121 0.0497 0.0733
Echinococcus multilocularis voltage gated potassium channel 0.0039 0.0082 0.0092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0135 0.0152
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0155 0.0669 0.1765
Brugia malayi Cytochrome P450 family protein 0.0038 0.0075 0.0145
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0048 0.0054
Brugia malayi Latrophilin receptor protein 2 0.005 0.0138 0.0267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.2003 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0341 0.1177
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.1993 0.4249
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.003 0.0023
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0147 0.0629 0.0623
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Onchocerca volvulus 0.0072 0.0248 0.1034
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0121 0.0497 0.0559
Schistosoma mansoni hypothetical protein 0.0108 0.0432 0.0636
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0131 0.0437
Brugia malayi hypothetical protein 0.0051 0.0141 0.0272
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0155 0.0669 0.2341
Echinococcus granulosus neuropeptide FF receptor 2 0.0121 0.0497 0.0559
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0121 0.0497 0.0559
Brugia malayi Animal haem peroxidase family protein 0.0052 0.015 0.029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0038 0.0073
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0048 0.0101
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0196 0.0378
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0141 0.0358
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.003 0.0023
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0147 0.0629 0.2198
Leishmania major acetoin dehydrogenase e3 component-like protein 0.1482 0.737 0.7368
Brugia malayi hypothetical protein 0.0121 0.0497 0.0963
Loa Loa (eye worm) hypothetical protein 0.0158 0.0684 0.1458
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0155 0.0669 0.2155
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0155 0.0669 0.0753
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0155 0.0669 0.2337
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0584 0.2837 0.2832
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0073 0.0233
Brugia malayi glutathione reductase 0.0767 0.376 0.7293
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0138 0.0294
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0013 0.0006
Echinococcus multilocularis g protein coupled receptor 0.0121 0.0497 0.0559
Echinococcus multilocularis fmrfamide receptor 0.0121 0.0497 0.0559
Loa Loa (eye worm) hypothetical protein 0.0447 0.2143 0.4568
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0051 0.0145 0.0281
Brugia malayi PAS domain containing protein 0.0097 0.0375 0.0726
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0161 0.07 0.1492
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0121 0.0497 0.0963
Echinococcus multilocularis geminin 0.0506 0.2442 0.2749
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0121 0.0497 0.0559
Onchocerca volvulus 0.0052 0.015 0.0603
Leishmania major trypanothione reductase 0.0767 0.376 0.3756
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0121 0.0497 0.0963
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0121 0.0497 0.1058
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0584 0.2837 0.3193
Echinococcus multilocularis transfer RNA-Lys 0.0072 0.0248 0.0279
Schistosoma mansoni adenoreceptor 0.0121 0.0497 0.0733
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0584 0.2837 1
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1589 0.5592
Echinococcus granulosus peptide allatostatin:somatostatin 0.0121 0.0497 0.0559
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.0036 0.0069
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0121 0.0497 0.0963
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0147 0.0629 0.0623
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.023 0.0785
Brugia malayi larval opioid receptor 0.0121 0.0497 0.0963
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0082 0.0121
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0068 0.0228 0.0257
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0051 0.0145 0.0214
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0584 0.2837 0.5501
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0075 0.0159
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0075 0.0069
Brugia malayi RNA binding protein 0.0061 0.0196 0.0378
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0132 0.0551 0.14
Leishmania major hypothetical protein, conserved 0.0155 0.0669 0.0663
Echinococcus multilocularis sex peptide receptor 0.0121 0.0497 0.0559
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.003 0.0023
Schistosoma mansoni hypothetical protein 0.0121 0.0497 0.0733
Schistosoma mansoni intermediate filament proteins 0.0053 0.0151 0.0223
Schistosoma mansoni neuropeptide F-like receptor 0.0121 0.0497 0.0733
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0029 0.003 0.0083
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0068 0.0228 0.0257
Loa Loa (eye worm) neuropeptide F receptor 0.0121 0.0497 0.1058
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus granulosus biogenic amine 5HT receptor 0.0365 0.173 0.1948
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0188 0.0277
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0091 0.0344 0.0387
Brugia malayi Animal haem peroxidase family protein 0.0052 0.015 0.029
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0121 0.0497 0.213
Echinococcus multilocularis neuropeptide receptor A26 0.0585 0.2841 0.3199
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0062 0.0069
Giardia lamblia NADH oxidase lateral transfer candidate 0.0584 0.2837 1
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0024 0.0006 0.0009
Schistosoma mansoni growth hormone secretagogue receptor 0.0121 0.0497 0.0733
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0029 0.003 0.0083
Mycobacterium ulcerans glutaminase 0.0295 0.1377 0.4843
Trichomonas vaginalis inositol monophosphatase, putative 0.0147 0.0629 0.2195
Loa Loa (eye worm) melatonin receptor type 1A 0.0121 0.0497 0.1058
Loa Loa (eye worm) glutathione reductase 0.0767 0.376 0.8017
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.017 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0247 0.0848
Trypanosoma brucei hypothetical protein, conserved 0.0155 0.0669 0.0663
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0038 0.0075 0.0243
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0196 0.0416
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0584 0.2837 1
Brugia malayi hypothetical protein 0.0121 0.0497 0.0963
Brugia malayi Augmenter of liver regeneration 0.0068 0.0228 0.0442
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0161 0.07 0.3024
Echinococcus granulosus neuropeptides capa receptor 0.0121 0.0497 0.0559
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0027 0.0031
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0048 0.0092
Echinococcus granulosus G protein coupled receptor 139 0.0121 0.0497 0.0559
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0155 0.0669 0.2341
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0155 0.0669 0.167
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0147 0.0629 0.2195
Echinococcus multilocularis rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Leishmania major cytochrome p450-like protein 0.0038 0.0075 0.0069
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0195 0.0502
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus multilocularis musashi 0.0053 0.0151 0.017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0135 0.0152
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0137 0.0155
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0155 0.0669 0.2337
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0073 0.0179
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0051 0.0145 0.0214
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.0341 0.0334
Schistosoma mansoni hypothetical protein 0.0104 0.0409 0.0604
Onchocerca volvulus 0.0121 0.0497 0.213
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0584 0.2837 1
Plasmodium vivax glutathione reductase, putative 0.0767 0.376 1
Brugia malayi hypothetical protein 0.0051 0.0145 0.0281
Schistosoma mansoni amine GPCR 0.0121 0.0497 0.0733
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0051 0.0145 0.0164
Schistosoma mansoni myosin xvIII 0.0121 0.0497 0.0733
Loa Loa (eye worm) hypothetical protein 0.0052 0.0146 0.0311
Schistosoma mansoni hypothetical protein 0.0506 0.2442 0.3602
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0032 0.0048 0.0054
Mycobacterium ulcerans dehydrogenase 0.0155 0.0669 0.2341
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0147 0.0629 0.2195
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0121 0.0497 0.0559
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0048 0.0101
Onchocerca volvulus 0.0121 0.0497 0.213
Onchocerca volvulus 0.0475 0.2286 1
Toxoplasma gondii hypothetical protein 0.0051 0.0145 0.037
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0155 0.0669 0.167
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0029 0.003 0.0083
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0068 0.0228 0.0222
Brugia malayi Dopamine receptor protein 1 0.0121 0.0497 0.0963
Brugia malayi Pre-SET motif family protein 0.006 0.0188 0.0363
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0091 0.0344 0.0666
Echinococcus granulosus metabotropic glutamate receptor 5 0.003 0.0036 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0247 0.0848
Toxoplasma gondii Erv1 / Alr family protein 0.0068 0.0228 0.0591
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0155 0.0669 0.1707
Treponema pallidum NADH oxidase 0.0584 0.2837 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0082 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0224 0.0765
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Schistosoma mansoni aryl hydrocarbon receptor 0.0097 0.0375 0.0553
Brugia malayi hypothetical protein 0.0052 0.015 0.029
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0141 0.0134
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Loa Loa (eye worm) hypothetical protein 0.0365 0.173 0.3688
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0013 0.0018
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0051 0.0145 0.0214
Loa Loa (eye worm) hypothetical protein 0.0144 0.0611 0.1302
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0073 0.1012
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0141 0.0358
Echinococcus granulosus ATP binding cassette sub family G 0.0024 0.0006 0.0007
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0051 0.0145 0.0164
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0027 0.0052
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0072 0.0248 0.0242
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0155 0.0669 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0155 0.0669 0.1765
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0051 0.0145 0.0281
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0013 0.0014
Plasmodium vivax ferrodoxin reductase, putative 0.0155 0.0669 0.1765
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.0344 0.0507
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0038 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0137 0.0458
Echinococcus granulosus orexin receptor type 2 0.0121 0.0497 0.0559
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0159 0.0179
Schistosoma mansoni amine GPCR 0.0121 0.0497 0.0733
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1589 0.5592
Schistosoma mansoni opsin-like receptor 0.0121 0.0497 0.0733
Loa Loa (eye worm) hypothetical protein 0.0028 0.0027 0.0057
Brugia malayi Bloom's syndrome protein homolog 0.0046 0.0118 0.0227
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0014 0.0016
Onchocerca volvulus Peroxidasin homolog 0.0052 0.015 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.07 0.1032
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0155 0.0669 0.0753
Onchocerca volvulus 0.0121 0.0497 0.213
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0155 0.0669 0.167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0131 0.0436
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0357 0.1689 0.4335
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0029 0.003 0.0083
Brugia malayi Melatonin receptor type 1A 0.0121 0.0497 0.0963
Schistosoma mansoni hypothetical protein 0.005 0.0138 0.0204
Trichomonas vaginalis mercuric reductase, putative 0.0584 0.2837 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.004 0.0089 0.0221
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0155 0.0669 0.1707
Echinococcus granulosus jun protein 0.0249 0.1141 0.1285
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0155 0.0669 0.1765
Onchocerca volvulus 0.0121 0.0497 0.213
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0029 0.003 0.0083
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0121 0.0497 0.0733
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0028 0.0053
Onchocerca volvulus 0.0095 0.0367 0.1561
Echinococcus granulosus g protein coupled receptor 0.0121 0.0497 0.0559
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Schistosoma mansoni biogenic amine (5HT) receptor 0.0121 0.0497 0.0733
Schistosoma mansoni sodium/chloride dependent transporter 0.0303 0.1416 0.2088
Trichomonas vaginalis apoptosis inducing factor, putative 0.0155 0.0669 0.2337
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0155 0.0669 0.2337
Loa Loa (eye worm) hypothetical protein 0.0365 0.173 0.3688
Onchocerca volvulus Peroxidase homolog 0.0052 0.015 0.0603
Trichomonas vaginalis glucosylceramidase, putative 0.0514 0.2483 0.8749
Schistosoma mansoni amine GPCR 0.0121 0.0497 0.0733
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0121 0.0497 0.0559
Mycobacterium ulcerans ferredoxin reductase 0.0155 0.0669 0.2341
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0584 0.2837 1
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0155 0.0669 0.2337
Echinococcus granulosus tm gpcr rhodopsin 0.1782 0.8883 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0357 0.1689 0.4335
Plasmodium vivax thioredoxin reductase, putative 0.0767 0.376 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Mycobacterium ulcerans monoxygenase 0.0155 0.0669 0.2341
Echinococcus granulosus 7TM GPCR rhodopsin 0.0121 0.0497 0.0559
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.003 0.0023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0356 0.1685 0.3593
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0068 0.023 0.0785
Onchocerca volvulus 0.0121 0.0497 0.213
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0137 0.0349
Trypanosoma brucei NADH dehydrogenase 0.0155 0.0669 0.0663
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0155 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0188 0.0399
Echinococcus multilocularis neuropeptides capa receptor 0.0121 0.0497 0.0559
Trichomonas vaginalis set domain proteins, putative 0.0475 0.2284 0.8048
Loa Loa (eye worm) CYP4Cod1 0.0038 0.0075 0.0159
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Brugia malayi Blistered cuticle protein 3 0.0126 0.052 0.1008
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0155 0.0669 0.1425
Leishmania major cytochrome p450-like protein 0.0029 0.003 0.0023
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0101 0.0094
Onchocerca volvulus 0.0121 0.0497 0.213
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0029 0.003 0.0083
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Leishmania major hypothetical protein, conserved 0.0155 0.0669 0.0663
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0155 0.0669 0.1765
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Mycobacterium leprae Conserved hypothetical protein 0.0029 0.003 0.0045
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0068 0.0228 0.0222
Onchocerca volvulus 0.0121 0.0497 0.213
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.015 0.0318
Mycobacterium tuberculosis Probable dehydrogenase 0.0357 0.1689 0.4335
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0514 0.2483 0.5293
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0147 0.0629 0.0623
Echinococcus granulosus ATP binding cassette sub family G 0.0024 0.0006 0.0007
Echinococcus multilocularis fmrfamide receptor 0.0121 0.0497 0.0559
Trypanosoma cruzi target of rapamycin kinase 3 0.0072 0.0248 0.0242
Schistosoma mansoni neuropeptide receptor 0.0121 0.0497 0.0733
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0135 0.0261
Schistosoma mansoni sodium-dependent amino acid transporter 0.0051 0.0145 0.0214
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0584 0.2837 0.2832
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1691 0.8424 0.8423
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0155 0.0669 0.1765
Trypanosoma cruzi hypothetical protein, conserved 0.0155 0.0669 0.0663
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0121 0.0497 0.0559
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0155 0.0669 0.0663
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Loa Loa (eye worm) hypothetical protein 0.0303 0.1416 0.3018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.0684 0.1326
Echinococcus multilocularis thioredoxin glutathione reductase 0.0767 0.376 0.4233
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0073 0.0179
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0341 0.0334
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0075 0.0068
Echinococcus multilocularis bloom syndrome protein 0.0046 0.0118 0.0132
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0196 0.022
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Brugia malayi Protein kinase domain containing protein 0.0161 0.07 0.1357
Schistosoma mansoni opsin-like receptor 0.0121 0.0497 0.0733
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.017 0.0191
Schistosoma mansoni peroxidasin 0.0052 0.015 0.0221
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0121 0.0497 0.0559
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0155 0.0669 0.0663
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0062 0.0069
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0038 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0038 0.0108
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0155 0.0669 0.0753
Leishmania major C-8 sterol isomerase-like protein 0.0738 0.3614 0.361
Entamoeba histolytica hypothetical protein 0.0035 0.0062 0.0834
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0195 0.0666
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0137 0.0131
Trypanosoma cruzi NADH dehydrogenase, putative 0.0155 0.0669 0.0663
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0051 0.0145 0.0309
Schistosoma mansoni neuropeptide receptor 0.0121 0.0497 0.0733
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0068 0.0228 0.0222
Echinococcus granulosus hyperpolarization activated cyclic 0.0032 0.0048 0.0054
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0159 0.0179
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0082 0.0092
Echinococcus multilocularis g protein coupled receptor 0.0121 0.0497 0.0559
Loa Loa (eye worm) hypothetical protein 0.0121 0.0497 0.1058
Schistosoma mansoni hypothetical protein 0.0095 0.0367 0.0542
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0135 0.0152
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0195 0.0288
Echinococcus granulosus serotonin receptor 0.0121 0.0497 0.0559
Brugia malayi AKH receptor 0.0121 0.0497 0.0963
Brugia malayi putative neuropeptide receptor 0.0121 0.0497 0.0963
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0038 0.0043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1691 0.8424 0.8423
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0121 0.0497 0.0733
Schistosoma mansoni sodium/chloride dependent transporter 0.0052 0.015 0.0221
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0028 0.0058
Brugia malayi hypothetical protein 0.0325 0.1528 0.2962
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0584 0.2837 0.754
Echinococcus granulosus g-protein coupled receptor 0.0121 0.0497 0.0559
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0029 0.003 0.0083
Echinococcus granulosus fmrfamide receptor 0.0121 0.0497 0.0559
Echinococcus granulosus rhodopsin orphan GPCR 0.0121 0.0497 0.0559
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0584 0.2837 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0051 0.0145 0.0214
Trypanosoma cruzi trypanothione reductase, putative 0.0767 0.376 0.3756
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.017 0.0578
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0584 0.2837 1
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.1589 0.5592
Brugia malayi Death domain containing protein 0.0028 0.0027 0.0052
Brugia malayi hypothetical protein 0.0121 0.0497 0.0963
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0032 0.0048 0.0054
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0738 0.3614 0.701
Echinococcus granulosus neuropeptide receptor 0.0121 0.0497 0.0559
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0341 0.1177
Trichomonas vaginalis DNA helicase recq1, putative 0.0046 0.0118 0.0389
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0309
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0357 0.1689 0.4335
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0196 0.0288
Toxoplasma gondii selenide, water dikinase 0.0155 0.0669 0.1765
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0075 0.0159
Loa Loa (eye worm) hypothetical protein 0.0951 0.469 1
Mycobacterium leprae putative cytochrome p450 0.0029 0.003 0.0045
Trypanosoma brucei trypanothione reductase 0.0767 0.376 0.3756
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0318
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1482 0.737 0.7368
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0028
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0032 0.0048 0.0054
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.017 0.0366
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0309
Toxoplasma gondii Erv1 / Alr family protein 0.0068 0.0228 0.0591
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0155 0.0669 0.0663
Trichomonas vaginalis glutaminase, putative 0.0295 0.1377 0.4841
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0121 0.0497 0.0733
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.0341 0.0334
Loa Loa (eye worm) hypothetical protein 0.0447 0.2143 0.4568
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0341 0.0725
Brugia malayi G protein-coupled receptor F59B2.13 0.0121 0.0497 0.0963
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0068 0.0228 0.0591
Loa Loa (eye worm) hypothetical protein 0.0102 0.0402 0.0855
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.003 0.0023
Leishmania major ferric reductase, putative 0.0034 0.0059 0.0053
Loa Loa (eye worm) hypoxia-induced factor 1 0.03 0.14 0.2985
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0155 0.0669 0.0753
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0141 0.0358

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1 uM Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR ChEMBL. 16216508
IC50 (functional) = 1 uM Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR ChEMBL. 16216508

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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