TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 422.947 | Formula: C25H27ClN2O2
H donors: 1 H acceptors: 2 LogP: 5.48 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1c(cccc1Cl)OC[C@@H](CN(C(Cc1ccc2c(c1)cccc2)(C)C)C)O
InChi: 1S/C25H27ClN2O2/c1-25(2,14-18-11-12-19-7-4-5-8-20(19)13-18)28(3)16-21(29)17-30-24-10-6-9-23(26)22(24)15-27/h4-13,21,29H,14,16-17H2,1-3H3/t21-/m1/s1
InChiKey: ONQBSDHBBICEQE-OAQYLSRUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calcium-sensing receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Metabotropic glutamate receptor 7 precursor, putative	Get druggable targets OG5_127276	All targets in OG5_127276
Schistosoma japonicum	Metabotropic glutamate receptor 7 precursor, putative	Get druggable targets OG5_127276	All targets in OG5_127276
Schistosoma mansoni	metabotropic glutamate receptor	Get druggable targets OG5_127276	All targets in OG5_127276

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.0025	0.0041
Loa Loa (eye worm)	hypothetical protein	0.005	0.0025	0.009
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.0025	0.0042
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0211	0.0387	0.1381
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0052	0.003	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0025	0.009
Echinococcus multilocularis	acetylcholinesterase	0.1246	0.2722	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.0571	0.2058
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0025	0.0042
Onchocerca volvulus		0.005	0.0025	0.0184
Schistosoma mansoni	acetylcholinesterase	0.0211	0.0387	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Brugia malayi	amine oxidase, flavin-containing family protein	0.0315	0.0623	0.2252
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0623	0.229
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0079	0.0092	0.0091
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0211	0.0387	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0387	0.1424
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.0571	0.5
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Onchocerca volvulus		0.0211	0.0387	0.6134
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0072	0.0075	0.0229
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.004	0.0877
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0089	0.0114	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0623	0.229
Mycobacterium ulcerans	carboxylesterase, LipT	0.0211	0.0387	0.0298
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0211	0.0387	0.1382
Echinococcus granulosus	para nitrobenzyl esterase	0.0211	0.0387	0.1382
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0052	0.003	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Schistosoma mansoni	amine oxidase	0.0315	0.0623	0.2252
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0315	0.0623	0.2252
Loa Loa (eye worm)	carboxylesterase	0.1246	0.2722	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Onchocerca volvulus		0.005	0.0025	0.0184
Echinococcus multilocularis	neuroligin	0.0211	0.0387	0.1382
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0025	0.0041
Echinococcus granulosus	carboxylesterase 5A	0.1246	0.2722	1
Mycobacterium ulcerans	monoamine oxidase	0.0315	0.0623	0.0536
Loa Loa (eye worm)	hypothetical protein	0.005	0.0025	0.009
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1246	0.2722	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0234	0.0439	0.1615
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0052	0.003	0.0362
Loa Loa (eye worm)	hypothetical protein	0.005	0.0025	0.009
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0052	0.003	0.0608
Echinococcus multilocularis	para nitrobenzyl esterase	0.0211	0.0387	0.1382
Loa Loa (eye worm)	hypothetical protein	0.005	0.0025	0.009
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0052	0.003	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.4477	1	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0244	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0025	0.0042
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.0013	0.0049
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0315	0.0623	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0052	0.003	0.0608
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0315	0.0623	0.2252
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0094	0.0124	0.3092
Brugia malayi	Carboxylesterase family protein	0.0211	0.0387	0.1382
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0315	0.0623	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0025	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Echinococcus granulosus	BC026374 protein S09 family	0.0211	0.0387	0.1382
Loa Loa (eye worm)	hypothetical protein	0.005	0.0025	0.009
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0271	0.0524	0.1925
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0571	0.2097
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Plasmodium vivax	hypothetical protein, conserved	0.0315	0.0623	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0025	0.0041
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0025	0.0041
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0147	0.0244	0.0851
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0315	0.0623	0.2252
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0025	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Schistosoma mansoni	gliotactin	0.0211	0.0387	0.1381
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0052	0.003	0.0608
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0047	0.0019	0.0069
Echinococcus granulosus	serotonin transporter	0.0292	0.0571	0.2059
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0211	0.0387	0.1381
Brugia malayi	Carboxylesterase family protein	0.1246	0.2722	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0025	0.0041
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0315	0.0623	1
Mycobacterium ulcerans	dehydrogenase	0.0315	0.0623	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0019	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0094	0.0124	0.3092
Plasmodium falciparum	protoporphyrinogen oxidase	0.0315	0.0623	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0052	0.003	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0387	0.1424
Echinococcus granulosus	acetylcholinesterase	0.1246	0.2722	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0025	0.0042
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0047	0.0019	0.0069
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0025	0.0041
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0211	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0623	0.229
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0315	0.0623	0.5
Brugia malayi	Carboxylesterase family protein	0.1246	0.2722	1
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0022	0.0034
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Mycobacterium ulcerans	oxidoreductase	0.0315	0.0623	0.0536
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0052	0.003	0.0608
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0052	0.003	0.0362
Leishmania major	UDP-galactopyranose mutase	0.0315	0.0623	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Brugia malayi	hypothetical protein	0.0315	0.0623	0.2252
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Brugia malayi	hypothetical protein	0.0211	0.0387	0.1382
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0211	0.0387	0.1381
Onchocerca volvulus		0.0211	0.0387	0.6134
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0025	0.009
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0025	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0387	0.1424
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0052	0.003	0.0061
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0045	0.0013	0.0049
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.0025	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0571	0.2097
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0114	0.042
Schistosoma mansoni	amine oxidase	0.0315	0.0623	0.2252
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0623	0.229
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.0013	0.0049
Loa Loa (eye worm)	carboxylesterase	0.0211	0.0387	0.1424
Mycobacterium tuberculosis	Possible oxidoreductase	0.0315	0.0623	0.0663
Echinococcus multilocularis	serotonin transporter	0.0292	0.0571	0.2059
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0211	0.0387	0.1382
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Onchocerca volvulus		0.0211	0.0387	0.6134
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Echinococcus multilocularis	acetylcholinesterase	0.1246	0.2722	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0315	0.0623	1
Schistosoma mansoni	metabotropic glutamate receptor	0.06	0.1265	0.4622
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0025	0.009
Brugia malayi	Carboxylesterase family protein	0.0211	0.0387	0.1382
Onchocerca volvulus		0.0292	0.0571	0.9141
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0286	0.0556	0.2005
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0025	0.0042
Loa Loa (eye worm)	hypothetical protein	0.1246	0.2722	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0315	0.0623	0.2252
Echinococcus multilocularis	carboxylesterase 5A	0.1246	0.2722	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0315	0.0623	0.0663
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0025	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.0571	0.2097
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0056	0.004	0.0877
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.005	0.0025	0.009
Onchocerca volvulus		0.005	0.0025	0.0184
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0025	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0623	0.229
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0623	0.229
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0025	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0387	0.1424
Loa Loa (eye worm)	melatonin receptor type 1A	0.0045	0.0013	0.0049
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Echinococcus multilocularis		0.0315	0.0623	0.2252
Trichomonas vaginalis	spcc417.12 protein, putative	0.0211	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0094	0.0124	0.3092
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0315	0.0623	0.2252
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Brugia malayi	Carboxylesterase family protein	0.0211	0.0387	0.1382
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0089	0.0114	0.0373
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0315	0.0623	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0315	0.0623	1
Brugia malayi	hypothetical protein	0.005	0.0025	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0147	0.0244	0.0851
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0052	0.003	0.0608
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.0025	0.0042
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0292	0.0571	0.2097
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0047	0.0019	0.002
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0286	0.0556	0.2005
Onchocerca volvulus		0.0211	0.0387	0.6134
Brugia malayi	Carboxylesterase family protein	0.0211	0.0387	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Echinococcus granulosus	neuroligin	0.0211	0.0387	0.1382
Toxoplasma gondii	histone lysine-specific demethylase	0.0315	0.0623	1
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.0124	0.3092
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.0025	0.0042
Echinococcus granulosus	acetylcholinesterase	0.1246	0.2722	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0052	0.003	0.0608
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0286	0.0556	0.2005
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0315	0.0623	0.2252
Plasmodium vivax	hypothetical protein, conserved	0.0315	0.0623	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0052	0.003	0.0608
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0045	0.0013	0.0049
Brugia malayi	Receptor family ligand binding region containing protein	0.0047	0.0019	0.002
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.0025	0.0042
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.0025	0.0042
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0052	0.003	1
Brugia malayi	SWIRM domain containing protein	0.0315	0.0623	0.2252
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.0571	0.2058
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0315	0.0623	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0211	0.0387	0.1382
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.4161	0.929	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.0571	0.2097
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0387	0.1424
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0022	0.0034
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0211	0.0387	0.0409
Loa Loa (eye worm)	glutamate receptor	0.0072	0.0075	0.0277
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.0571	0.2097
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0025	0.0041
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0315	0.0623	0.0536
Loa Loa (eye worm)	glutamate receptor	0.0047	0.0019	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0387	0.1424
Brugia malayi	metabotropic glutamate receptor type 2	0.0089	0.0114	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0387	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0052	0.003	0.0362
Loa Loa (eye worm)	TYRA-2 protein	0.0045	0.0013	0.0049
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0211	0.0387	0.1381
Onchocerca volvulus		0.0211	0.0387	0.6134
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0052	0.003	0.0608
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0052	0.003	0.0608
Schistosoma mansoni	BC026374 protein (S09 family)	0.0211	0.0387	0.1381
Loa Loa (eye worm)	hypothetical protein	0.1246	0.2722	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0025	0.0041
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0025	0.0042
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0052	0.003	0.0608
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0025	0.0042
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.0571	0.2059
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Onchocerca volvulus		0.0315	0.0623	1
Loa Loa (eye worm)	carboxylesterase	0.0211	0.0387	0.1424
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0211	0.0387	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0013	0.0049
Loa Loa (eye worm)	acetylcholinesterase 1	0.1246	0.2722	1
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0315	0.0623	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.27 uM	Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR	ChEMBL.	16216508
IC50 (functional)	= 0.27 uM	Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR	ChEMBL.	16216508

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 348153