Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0126 | 0.1328 | 0.2016 |
Brugia malayi | hypothetical protein | 0.0505 | 0.6585 | 1 |
Brugia malayi | hypothetical protein | 0.0126 | 0.1328 | 0.2016 |
Schistosoma mansoni | lipoxygenase | 0.0751 | 1 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0126 | 0.1328 | 0.1328 |
Brugia malayi | Animal haem peroxidase family protein | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0525 | 0.6867 | 0.6387 |
Onchocerca volvulus | Peroxidasin homolog | 0.0505 | 0.6585 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0126 | 0.1328 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Onchocerca volvulus | 0.0505 | 0.6585 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1328 | 0.2016 |
Onchocerca volvulus | Peroxidase homolog | 0.0505 | 0.6585 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1328 | 0.2016 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0126 | 0.1328 | 0.1328 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0126 | 0.1328 | 0.1328 |
Brugia malayi | Peroxidasin | 0.0505 | 0.6585 | 1 |
Schistosoma mansoni | peroxidasin | 0.0505 | 0.6585 | 0.6063 |
Brugia malayi | Blistered cuticle protein 3 | 0.0505 | 0.6585 | 1 |
Onchocerca volvulus | 0.0505 | 0.6585 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0505 | 0.6585 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0505 | 0.6585 | 0.6585 |
Onchocerca volvulus | Peroxidase homolog | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Onchocerca volvulus | 0.0505 | 0.6585 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0505 | 0.6585 | 1 |
Schistosoma mansoni | peroxidasin | 0.0505 | 0.6585 | 0.6063 |
Loa Loa (eye worm) | doublecortin family protein | 0.0126 | 0.1328 | 0.2016 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0505 | 0.6585 | 1 |
Echinococcus multilocularis | RUN | 0.0126 | 0.1328 | 0.1328 |
Onchocerca volvulus | Peroxidasin homolog | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0126 | 0.1328 | 0.1328 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0751 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0505 | 0.6585 | 1 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0126 | 0.1328 | 0.1328 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0126 | 0.1328 | 0.5 |
Brugia malayi | Doublecortin family protein | 0.0126 | 0.1328 | 0.2016 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Echinococcus granulosus | RUN | 0.0126 | 0.1328 | 0.1328 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.02 | 0.236 | 0.1191 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0126 | 0.1328 | 0.1328 |
Onchocerca volvulus | Dual oxidase homolog | 0.0505 | 0.6585 | 1 |
Echinococcus granulosus | peroxidasin | 0.0505 | 0.6585 | 0.6585 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.6585 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0505 | 0.6585 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0505 | 0.6585 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.27 uM | Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR | ChEMBL. | 16216508 |
IC50 (functional) | = 0.27 uM | Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR | ChEMBL. | 16216508 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.