Detailed information for compound 348212

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 605.689 | Formula: C33H35N9O3
  • H donors: 2 H acceptors: 5 LogP: 3.34 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(ccc1NC(=O)c1cc2c(n1C)ccc(c2)C#N)c1nn(c2c1c(N)ncn2)C1CCN(CC1)C1CCOCC1
  • InChi: 1S/C33H35N9O3/c1-40-26-6-3-20(18-34)15-22(26)16-27(40)33(43)38-25-5-4-21(17-28(25)44-2)30-29-31(35)36-19-37-32(29)42(39-30)24-7-11-41(12-8-24)23-9-13-45-14-10-23/h3-6,15-17,19,23-24H,7-14H2,1-2H3,(H,38,43)(H2,35,36,37)
  • InChiKey: BXDOISZIOCCOSD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi uridine phosphorylase family protein 0.0246 0.2032 0.2032
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0114 0.0913 1
Brugia malayi Sex muscle abnormal protein 5 0.0009 0.0027 0.0027
Brugia malayi glutathione reductase 0.0329 0.2726 0.2726
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0114 0.0913 0.0721
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0246 0.2032 0.7244
Mycobacterium tuberculosis Conserved hypothetical protein 0.0246 0.2032 0.1864
Trichomonas vaginalis mercuric reductase, putative 0.0114 0.0913 0.0721
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.003 0.0206 0.0206
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0114 0.0913 0.0721
Echinococcus multilocularis purine nucleoside phosphorylase 0.119 1 1
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.119 1 1
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0246 0.2032 0.7244
Brugia malayi Thioredoxin reductase 0.0329 0.2726 0.2726
Trypanosoma brucei trypanothione reductase 0.0329 0.2726 1
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0027 0.0027
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.003 0.0206 0.0206
Entamoeba histolytica glutamate synthase beta subunit, putative 0.003 0.0206 0.1014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0114 0.0913 0.0721
Plasmodium falciparum glutathione reductase 0.0114 0.0913 0.2803
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0114 0.0913 0.0913
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0037 0.0037
Schistosoma mansoni uridine phosphorylase 0.0246 0.2032 0.2032
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0114 0.0913 0.2803
Treponema pallidum pfs protein (pfs) 0.0246 0.2032 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.003 0.0206 0.0206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0913 0.2803
Echinococcus multilocularis uridine phosphorylase 1 0.0246 0.2032 0.2032
Plasmodium vivax thioredoxin reductase, putative 0.0329 0.2726 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0037 0.0037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0037 0.0037
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0027 0.0027
Echinococcus granulosus c src tyrosine kinase 0.001 0.0037 0.0037
Echinococcus multilocularis glutamate synthase 0.003 0.0206 0.0206
Schistosoma mansoni sulfide quinone reductase 0.003 0.0206 0.0206
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0037 0.0037
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0037 0.0037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0037 0.0037
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.0246 0.2032 0.1864
Echinococcus granulosus thioredoxin glutathione reductase 0.0329 0.2726 0.2726
Echinococcus granulosus purine nucleoside phosphorylase 0.119 1 1
Trypanosoma brucei uridine phosphorylase 0.0246 0.2032 0.7244
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.0027 0.0027
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.003 0.0206 0.0206
Echinococcus granulosus purine nucleoside phosphorylase 0.119 1 1
Schistosoma mansoni hypothetical protein 0.003 0.0206 0.0206
Schistosoma mansoni tyrosine kinase 0.001 0.0037 0.0037
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0114 0.0913 0.2803
Schistosoma mansoni sulfide quinone reductase 0.003 0.0206 0.0206
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0246 0.2032 0.1864
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0246 0.2032 0.1864
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0037 0.0037
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0009 0.0027 0.0034
Schistosoma mansoni uridine phosphorylase 0.0246 0.2032 0.2032
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0329 0.2726 0.2573
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.0027 0.0027
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0114 0.0913 0.2803
Giardia lamblia UPL-1 0.0246 0.2032 0.1864
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0246 0.2032 0.7244
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0037 0.0037
Entamoeba histolytica glutamate synthase beta subunit, putative 0.003 0.0206 0.1014
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0084 0.0657 0.0657
Leishmania major methylthioadenosine phosphorylase, putative 0.0246 0.2032 0.7244
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0114 0.0913 0.2803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0084 0.0657 0.0657
Loa Loa (eye worm) thioredoxin reductase 0.0329 0.2726 0.3443
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0913 0.2803
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0114 0.0913 0.0721
Echinococcus multilocularis purine nucleoside phosphorylase 0.119 1 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0246 0.2032 1
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.119 1 1
Toxoplasma gondii phosphorylase family protein 0.0246 0.2032 0.7244
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0037 0.0037
Schistosoma mansoni tyrosine kinase 0.001 0.0037 0.0037
Trichomonas vaginalis glutathione reductase, putative 0.0114 0.0913 0.0721
Loa Loa (eye worm) uridine phosphorylase 0.0246 0.2032 0.2566
Trypanosoma cruzi trypanothione reductase, putative 0.0114 0.0913 0.2803
Toxoplasma gondii phosphorylase family protein 0.0246 0.2032 0.7244
Mycobacterium tuberculosis Probable oxidoreductase 0.0114 0.0913 0.0721
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0913 0.2803
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0246 0.2032 1
Echinococcus multilocularis NCK adaptor protein 0.0009 0.0027 0.0027
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0246 0.2032 0.2566
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0246 0.2032 0.7244
Mycobacterium tuberculosis Hypothetical protein 0.0246 0.2032 0.1864
Brugia malayi MTAP 0.0246 0.2032 0.2032
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.003 0.0206 0.0206
Toxoplasma gondii NADPH-glutathione reductase 0.0114 0.0913 0.2803
Plasmodium falciparum thioredoxin reductase 0.0114 0.0913 0.2803
Plasmodium falciparum thioredoxin reductase 0.0329 0.2726 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0037 0.0037
Toxoplasma gondii thioredoxin reductase 0.0329 0.2726 1
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.003 0.0206 0.1014
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.003 0.0206 0.0206
Schistosoma mansoni nck2/grb4 0.0009 0.0027 0.0027
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0246 0.2032 0.1864
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0114 0.0913 0.2803
Echinococcus granulosus methylthioadenosine phosphorylase 0.0246 0.2032 0.2032
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0114 0.0913 0.2803
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0037 0.0037
Toxoplasma gondii Purine nucleoside phosphorylase 0.0246 0.2032 0.7244
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0114 0.0913 0.2803
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0037 0.0037
Schistosoma mansoni methylthioadenosine phosphorylase 0.0246 0.2032 0.2032
Schistosoma mansoni glutamate synthase 0.003 0.0206 0.0206
Loa Loa (eye worm) programmed cell death 8 0.003 0.0206 0.026
Echinococcus granulosus tyrosine protein kinase Lyn 0.001 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0009 0.0027 0.0034
Schistosoma mansoni glutamate synthase 0.003 0.0206 0.0206
Loa Loa (eye worm) glutathione reductase 0.0329 0.2726 0.3443
Echinococcus granulosus purine nucleoside phosphorylase 0.119 1 1
Treponema pallidum uridine phosphorylase (udp) 0.0246 0.2032 1
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.003 0.0206 0.0206
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.0027 0.0027
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0246 0.2032 0.7244
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0943 0.7919 0.7919
Trypanosoma cruzi trypanothione reductase, putative 0.0329 0.2726 1
Echinococcus granulosus purine nucleoside phosphorylase 0.119 1 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0246 0.2032 0.1864
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.119 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0114 0.0913 0.0721
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0037 0.0037
Entamoeba histolytica disulphide oxidoreductase, putative 0.003 0.0206 0.1014
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.2032 0.1864
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0037 0.0037
Echinococcus multilocularis purine nucleoside phosphorylase 0.119 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0037 0.0037
Entamoeba histolytica thioredoxin reductase, putative 0.003 0.0206 0.1014
Echinococcus granulosus purine nucleoside phosphorylase 0.119 1 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.003 0.0206 0.0206
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0246 0.2032 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0114 0.0913 0.0913
Treponema pallidum NADH oxidase 0.0114 0.0913 0.387
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0027 0.0027
Mycobacterium leprae probable uridine phosphorylase 0.0246 0.2032 0.1864
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0114 0.0913 0.0913
Schistosoma mansoni disulfide oxidoreductase 0.003 0.0206 0.0206
Plasmodium vivax glutathione reductase, putative 0.0329 0.2726 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.003 0.0206 0.0206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0913 0.2803
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.003 0.0206 0.0206
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0037 0.0037
Brugia malayi SRC-1 0.001 0.0037 0.0037
Schistosoma mansoni tyrosine kinase 0.001 0.0037 0.0037
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0246 0.2032 1
Echinococcus granulosus NCK adaptor protein 0.0009 0.0027 0.0027
Leishmania major nucleoside phosphorylase-like protein 0.0246 0.2032 0.7244
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0246 0.2032 0.1864
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0246 0.2032 0.1864
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0246 0.2032 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0037 0.0037
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0246 0.2032 0.7244
Plasmodium falciparum glutathione reductase 0.0329 0.2726 1
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.0246 0.2032 0.1864
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0246 0.2032 0.1864
Echinococcus multilocularis purine nucleoside phosphorylase 0.119 1 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0114 0.0913 0.0913
Giardia lamblia NADH oxidase lateral transfer candidate 0.0114 0.0913 0.0721
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.003 0.0206 0.0206
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0114 0.0913 0.2803
Schistosoma mansoni purine nucleoside phosphorylase 0.119 1 1
Mycobacterium ulcerans purine nucleoside phosphorylase 0.119 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0114 0.0913 0.0721
Echinococcus granulosus purine nucleoside phosphorylase 0.119 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0037 0.0037
Echinococcus multilocularis purine nucleoside phosphorylase 0.0943 0.7919 0.7919
Echinococcus multilocularis purine nucleoside phosphorylase 0.0943 0.7919 0.7919
Echinococcus granulosus sulfide:quinone oxidoreductase 0.003 0.0206 0.0206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0913 0.2803
Schistosoma mansoni methylthioadenosine phosphorylase 0.0246 0.2032 0.2032
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0114 0.0913 0.2803
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0246 0.2032 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0246 0.2032 0.1864
Echinococcus granulosus purine nucleoside phosphorylase 0.119 1 1
Onchocerca volvulus 0.003 0.0206 0.0206
Echinococcus granulosus uridine phosphorylase 1 0.0246 0.2032 0.2032
Schistosoma mansoni adapter molecule crk 0.0009 0.0027 0.0027
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.003 0.0206 0.0206
Brugia malayi glutamate synthase 0.003 0.0206 0.0206
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.119 1 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0037 0.0037
Schistosoma mansoni tyrosine kinase 0.001 0.0037 0.0037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0114 0.0913 0.2803
Echinococcus multilocularis purine nucleoside phosphorylase 0.119 1 1
Plasmodium falciparum purine nucleoside phosphorylase 0.0246 0.2032 0.7244
Loa Loa (eye worm) hypothetical protein 0.0943 0.7919 1
Schistosoma mansoni methylthioadenosine phosphorylase 0.0246 0.2032 0.2032
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0114 0.0913 0.2803
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0246 0.2032 0.2032
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0037 0.0037
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0114 0.0913 0.2803
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0246 0.2032 0.1864
Loa Loa (eye worm) hypothetical protein 0.003 0.0206 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0246 0.2032 0.1864
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0114 0.0913 0.2803
Echinococcus granulosus glutamate synthase 0.003 0.0206 0.0206
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.003 0.0206 0.1014
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0246 0.2032 1
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0246 0.2032 0.7244
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0114 0.0913 0.387
Echinococcus granulosus purine nucleoside phosphorylase 0.119 1 1
Chlamydia trachomatis AMP nucleosidase 0.0246 0.2032 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.003 0.0206 0.026
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0037 0.0037
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0114 0.0913 0.0721
Schistosoma mansoni glutamate synthase 0.003 0.0206 0.0206
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0027 0.0027
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.119 1 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0114 0.0913 0.2803
Echinococcus multilocularis purine nucleoside phosphorylase 0.119 1 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.003 0.0206 0.0206
Leishmania major trypanothione reductase 0.0329 0.2726 1
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0246 0.2032 0.1864
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0114 0.0913 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0114 0.0913 0.2803
Entamoeba histolytica hypothetical protein 0.0246 0.2032 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.003 0.0206 0.0206
Echinococcus multilocularis thioredoxin glutathione reductase 0.0329 0.2726 0.2726
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0027 0.0034
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0114 0.0913 0.2803
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0037 0.0037
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.003 0.0206 0.1014
Schistosoma mansoni purine nucleoside phosphorylase 0.119 1 1
Loa Loa (eye worm) SRC-1 0.001 0.0037 0.0047

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) Inhibition of TCR stimulated IL2 production in mice administered orally ChEMBL. 16216497
ED50 (functional) 0 Inhibition of TCR stimulated IL2 production in mice administered orally ChEMBL. 16216497
IC50 (functional) Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole blood ChEMBL. 16216497
IC50 (functional) 0 Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole blood ChEMBL. 16216497
IC50 (binding) = 3.48 uM Inhibitory activity against lck ChEMBL. 16216497
IC50 (binding) = 3.48 uM Inhibitory activity against lck ChEMBL. 16216497
IC50 (binding) = 32.5 uM Inhibitory activity against fyn ChEMBL. 16216497
IC50 (binding) = 32.5 uM Inhibitory activity against fyn ChEMBL. 16216497

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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