Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium-sensing receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma japonicum | Metabotropic glutamate receptor 7 precursor, putative | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Schistosoma mansoni | metabotropic glutamate receptor | Get druggable targets OG5_127276 | All targets in OG5_127276 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 1.2102 | 1 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.1535 | 0.1247 | 0.1247 |
Onchocerca volvulus | 0.1535 | 0.1247 | 0.5 | |
Echinococcus multilocularis | thymidylate synthase | 0.1535 | 0.1247 | 0.1247 |
Brugia malayi | thymidylate synthase | 0.1535 | 0.1247 | 0.1247 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1535 | 0.1247 | 0.0708 |
Echinococcus multilocularis | dihydrofolate reductase | 1.2102 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.6548 | 0.54 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.2102 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.2102 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 1.2102 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 1.2102 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.2102 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.1535 | 0.1247 | 0.1247 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.2102 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1535 | 0.1247 | 0.1121 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6548 | 0.54 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.6548 | 0.54 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.073 | 0.058 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.6548 | 0.54 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6548 | 0.54 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 1.2102 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.6548 | 0.54 | 0.5 |
Brugia malayi | hypothetical protein | 0.073 | 0.058 | 0.058 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.25 uM | Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR | ChEMBL. | 16216508 |
IC50 (functional) | = 0.25 uM | Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR | ChEMBL. | 16216508 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.