Detailed information for compound 348288

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 438.553 | Formula: C27H32F2N2O
  • H donors: 2 H acceptors: 1 LogP: 5.29 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@@H]([C@H]1CCCN1Cc1cccc(c1F)F)CNC(Cc1ccc2c(c1)cccc2)(C)C
  • InChi: 1S/C27H32F2N2O/c1-27(2,16-19-12-13-20-7-3-4-8-21(20)15-19)30-17-25(32)24-11-6-14-31(24)18-22-9-5-10-23(28)26(22)29/h3-5,7-10,12-13,15,24-25,30,32H,6,11,14,16-18H2,1-2H3/t24-,25-/m1/s1
  • InChiKey: OYEWEMKJQXRYAD-JWQCQUIFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium-sensing receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Metabotropic glutamate receptor 7 precursor, putative Get druggable targets OG5_127276 All targets in OG5_127276
Schistosoma japonicum Metabotropic glutamate receptor 7 precursor, putative Get druggable targets OG5_127276 All targets in OG5_127276
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127276 All targets in OG5_127276
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus death domain containing protein 0.0015 0.0018 0.0011
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0295 0.081
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0264 0.0362
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0016 0.0031 0.0024
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0196 0.019
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0089 0.0082
Echinococcus granulosus microtubule associated protein 2 0.069 0.8364 0.8363
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0283 0.0992
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0363 0.1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0072 0.0092
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0359 0.0495
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0391 0.4674 0.467
Brugia malayi hypothetical protein 0.0056 0.0535 0.0742
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0089 0.0082
Loa Loa (eye worm) hypothetical protein 0.004 0.0328 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0089 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3489 0.6079
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0029
Echinococcus multilocularis NMDA receptor 0.0015 0.0028 0.0021
Echinococcus multilocularis serotonin transporter 0.0016 0.0031 0.0024
Schistosoma mansoni regulator of G protein signaling 0.002 0.0089 0.0082
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0024 0.0129 0.0186
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0018 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0295 0.0514
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0089 0.0941 0.0935
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0089 0.0941 0.1314
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0045 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0314 0.0466
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0092 0.0086
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0072 0.0092
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0089 0.0082
Schistosoma mansoni regulator of G protein signaling 0.002 0.0089 0.0082
Brugia malayi nuclear hormone receptor family member odr-7 0.0042 0.0359 0.0495
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0089 0.0941 0.0935
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0326 0.0918
Onchocerca volvulus Putative nachr subunit 0.0019 0.0072 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0627 0.174
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0071 0.0194
Schistosoma mansoni rab6-interacting 0.004 0.0328 0.0322
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0326 0.4849
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0089 0.0936 0.093
Brugia malayi nuclear receptor NHR-88 0.0089 0.0941 0.1314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.3489 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0351 0.0935
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.357 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0042 0.0359 0.0534
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0045 0.0067
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0461 0.0639
Loa Loa (eye worm) hypothetical protein 0.0038 0.0314 0.0466
Schistosoma mansoni lipoxygenase 0.0111 0.121 0.1204
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0089 0.0082
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0054
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0072 0.0065
Leishmania major cathepsin L-like protease 0.0064 0.0627 0.174
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0314 0.0432
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0314 0.2236
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0283 0.0493
Loa Loa (eye worm) glutaminase 0.0273 0.3216 0.4866
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0039 0.0325 0.085
Echinococcus multilocularis expressed protein 0.0038 0.0314 0.0307
Loa Loa (eye worm) hypothetical protein 0.0448 0.537 0.8133
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0314 0.0432
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0045 0.0039
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0031 0.0024
Brugia malayi nuclear receptor RXR 0.0042 0.0359 0.0495
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0283 0.0744
Brugia malayi PAS domain containing protein 0.0049 0.0439 0.0608
Toxoplasma gondii hypothetical protein 0.0016 0.0031 0.0107
Schistosoma mansoni hypothetical protein 0.0015 0.0028 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0089 0.0941 0.1314
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0072 0.0065
Echinococcus multilocularis proliferating cell nuclear antigen 0.0065 0.064 0.0634
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0351 0.0935
Schistosoma mansoni nAChR subunit 0.0019 0.0072 0.0065
Loa Loa (eye worm) hypothetical protein 0.0089 0.0941 0.1418
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0209 0.0307
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0089 0.0082
Echinococcus multilocularis dna polymerase eta 0.0015 0.0019 0.0012
Brugia malayi hypothetical protein 0.002 0.0089 0.0115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0196 0.019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0419
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0031 0.0194
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0042 0.0359 0.0495
Echinococcus multilocularis cysteine protease 0.0017 0.0045 0.0039
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0089 0.0941 0.0935
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0283 0.0776
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0295 0.0289
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0295 0.0514
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0295 0.0514
Schistosoma mansoni coup transcription factor 0.0089 0.0941 0.0935
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0596 0.0589
Loa Loa (eye worm) hypothetical protein 0.0047 0.0421 0.0629
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0016 0.0031 0.0024
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0089 0.0082
Schistosoma mansoni glutaminase 0.0273 0.3216 0.3211
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0371 0.2663
Toxoplasma gondii proliferating cell nuclear antigen PCNA2 0.0035 0.0267 0.1886
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0072 0.0092
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0018 0.0011
Brugia malayi hypothetical protein 0.0047 0.0421 0.0583
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0283 0.0277
Entamoeba histolytica cysteine protease, putative 0.0017 0.0045 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Loa Loa (eye worm) RGS-3 protein 0.002 0.0089 0.0124
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0089 0.0124
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0072 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Schistosoma mansoni nuclear receptor 0.0042 0.0359 0.0352
Schistosoma mansoni follistatin 0.0038 0.0314 0.0307
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.276 0.2755
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0089 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0547 0.6601 1
Schistosoma mansoni hypothetical protein 0.0015 0.0018 0.0011
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0508 0.0705
Loa Loa (eye worm) hypothetical protein 0.0038 0.0314 0.0466
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0031 0.0024
Schistosoma mansoni lipoxygenase 0.004 0.0328 0.0322
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0028 0.0021
Loa Loa (eye worm) hypothetical protein 0.0089 0.0936 0.141
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0072 0.0065
Brugia malayi Cation transporter family protein 0.0019 0.0072 0.0092
Leishmania major cathepsin L-like protease 0.0064 0.0627 0.174
Onchocerca volvulus 0.0042 0.0359 0.0614
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0072 0.0065
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0036
Brugia malayi Doublecortin family protein 0.004 0.0328 0.0452
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0071 0.0097
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0089 0.0941 0.0935
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0295 0.0289
Onchocerca volvulus Putative organic anion transporter 0.0056 0.0535 0.0921
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0043 0.0036
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0038 0.0304 0.0297
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0124
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0283 0.0992
Loa Loa (eye worm) hypothetical protein 0.0056 0.0535 0.0801
Schistosoma mansoni metabotropic glutamate receptor 0.0208 0.2407 0.2402
Schistosoma mansoni nAChR subunit 0.0019 0.0072 0.0065
Brugia malayi Glutamate receptor 1 precursor 0.0015 0.0028 0.003
Schistosoma mansoni regulator of G protein signaling 0.002 0.0089 0.0082
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0072 0.0092
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0283 0.0389
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.0028 0.0021
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0124
Echinococcus granulosus metabotropic glutamate receptor 5 0.0038 0.0304 0.0297
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1018 0.1012
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0283 0.0493
Echinococcus granulosus thyroid hormone receptor alpha 0.0042 0.0359 0.0352
Brugia malayi hypothetical protein 0.004 0.0328 0.0452
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0039 0.0325 0.1148
Brugia malayi orphan nuclear receptor NR2E1 0.0042 0.0359 0.0495
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0269 0.0703
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0089 0.0082
Loa Loa (eye worm) hypothetical protein 0.0025 0.0149 0.0217
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0044
Brugia malayi hypothetical protein 0.0448 0.537 0.7538
Loa Loa (eye worm) hypothetical protein 0.0089 0.0941 0.1418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Schistosoma mansoni hypothetical protein 0.0083 0.0861 0.0855
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0072 0.0092
Brugia malayi sodium-independent organic anion transporter family protein 0.0056 0.0535 0.0742
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.1108 0.1102
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0328 0.0322
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1018 0.1764
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0045 0.0108
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0314 0.2236
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0045 0.024
Schistosoma mansoni loxhd1 0.004 0.0328 0.0322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0283 0.0493
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0072 0.0065
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0071 0.0123
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0351 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0089 0.0154
Leishmania major DNA polymerase eta, putative 0.0015 0.0019 0.0035
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.5663 0.566
Loa Loa (eye worm) hypothetical protein 0.0025 0.0149 0.0217
Leishmania major proliferative cell nuclear antigen (PCNA), putative 0.0065 0.064 0.1779
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0045 0.0067
Onchocerca volvulus 0.0017 0.0045 0.0067
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0072 0.0065
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0071 0.018
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0359 0.0352
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0089 0.0941 0.0935
Schistosoma mansoni hypothetical protein 0.0391 0.4674 0.467
Plasmodium vivax proliferating cell nuclear antigen, putative 0.0035 0.0267 0.4001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0196 0.019
Echinococcus granulosus lamin dm0 0.0054 0.0508 0.0502
Onchocerca volvulus 0.0036 0.0283 0.0482
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.0028 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Brugia malayi hypothetical protein 0.0042 0.0359 0.0495
Schistosoma mansoni lamin 0.0054 0.0508 0.0502
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0072 0.0065
Plasmodium falciparum proliferating cell nuclear antigen 1 0.0065 0.064 1
Brugia malayi nuclear hormone receptor 0.0089 0.0941 0.1314
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0035 0.0029
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0072 0.0065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0089 0.0941 0.0935
Loa Loa (eye worm) hypothetical protein 0.0103 0.1108 0.167
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0122 0.1347 0.1341
Schistosoma mansoni nAChR subunit 0.0019 0.0072 0.0065
Echinococcus multilocularis lamin 0.0054 0.0508 0.0502
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0031 0.0107
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0196 0.019
Schistosoma mansoni hypothetical protein 0.004 0.0328 0.0322
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0351 0.0892
Brugia malayi hypothetical protein 0.0056 0.0535 0.0742
Brugia malayi steroid hormone receptor 0.0089 0.0941 0.1314
Plasmodium vivax SET domain protein, putative 0.0061 0.0596 0.9278
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0072 0.0092
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.0028 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0072 0.0099
Loa Loa (eye worm) ctsf protein 0.0017 0.0045 0.0059
Loa Loa (eye worm) cysteine protease 0.0017 0.0045 0.0059
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.357 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1018 0.1774
Echinococcus granulosus geminin 0.0341 0.4048 0.4044
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.1108 0.1102
Trichomonas vaginalis proliferating cell nuclear antigen, putative 0.0065 0.064 0.1116
Toxoplasma gondii hypothetical protein 0.0049 0.044 0.3185
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1604 0.4484
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0558 0.1548
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0421 0.0415
Brugia malayi CXXC zinc finger family protein 0.0058 0.0552 0.0766
Brugia malayi hypothetical protein 0.0047 0.0421 0.0583
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0019 0.0018
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0391 0.4674 0.467
Onchocerca volvulus Putative organic anion transporter 0.0056 0.0535 0.0921
Onchocerca volvulus 0.0017 0.0045 0.0067
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0072 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1018 0.1774
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1018 0.2905
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0084 0.0108
Mycobacterium ulcerans lipase LipD 0.0036 0.0283 0.0676
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0089 0.0936 0.141
Onchocerca volvulus 0.0017 0.0045 0.0067
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0089 0.0941 0.0935
Loa Loa (eye worm) hypothetical protein 0.0089 0.0941 0.1418
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0031 0.0107
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0328 0.0322
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0089 0.0154
Echinococcus granulosus GPCR family 2 0.0016 0.0035 0.0029
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0359 0.0614
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0071 0.018
Mycobacterium ulcerans hypothetical protein 0.0159 0.1804 0.5511
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0089 0.0941 0.1418
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0351 0.0935
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1018 0.1534
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.1264 0.1258
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0018 0.0016
Schistosoma mansoni ATP-binding cassette transporter 0.0015 0.0028 0.0021
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1621 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3489 0.6079
Trypanosoma brucei proliferative cell nuclear antigen (PCNA), putative 0.0065 0.064 0.175
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0072 0.0065
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0371 0.0646
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0045 0.0059
Brugia malayi proliferating cell nuclear antigen (PCNA) 0.0065 0.064 0.0891
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0596 0.0589
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0019 0.0012
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0054
Echinococcus multilocularis cpg binding protein 0.0061 0.0593 0.0586
Brugia malayi hypothetical protein 0.002 0.0089 0.0115
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3489 0.6079
Leishmania major cathepsin L-like protease 0.0017 0.0045 0.0108
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0019 0.0012
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0115 0.1264 0.4676
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0092 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0547 0.6601 0.9269
Leishmania major hypothetical protein, conserved 0.0036 0.0283 0.0776
Brugia malayi nuclear receptor RXR 0.0047 0.0421 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0089 0.0941 0.1314
Schistosoma mansoni nuclear hormone receptor 0.0089 0.0941 0.0935
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0461 0.0639
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0295 0.081
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0072 0.0065
Echinococcus granulosus lamin 0.0054 0.0508 0.0502
Onchocerca volvulus 0.004 0.0328 0.0561
Loa Loa (eye worm) steroid hormone receptor 0.0089 0.0941 0.1418
Echinococcus multilocularis nmda type glutamate receptor 0.0055 0.0514 0.0508
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Schistosoma mansoni nAChR subunit 0.0019 0.0072 0.0065
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0072 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0089 0.0941 0.1314
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0031 0.0024
Plasmodium vivax amine transporter, putative 0.0016 0.0031 0.0194
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0419
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0071 0.0116
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0351 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0089 0.0941 0.1314
Echinococcus granulosus bloom syndrome protein 0.0022 0.0105 0.0098
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0072 0.0099
Echinococcus multilocularis musashi 0.0054 0.0508 0.0502
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.1264 0.1258
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0035 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Schistosoma mansoni netrin receptor unc5 0.0015 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0079
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0018 0.0011
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0371 0.5662
Schistosoma mansoni hypothetical protein 0.0034 0.0264 0.0257
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0045 0.0039
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0028 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0079
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0089 0.0082
Loa Loa (eye worm) glutamate receptor 1 0.0015 0.0028 0.0033
Mycobacterium tuberculosis Conserved protein 0.0036 0.0283 0.0992
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0295 0.0406
Chlamydia trachomatis glutamine binding protein 0.0039 0.0325 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0031 0.0036
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0036
Brugia malayi follicle stimulating hormone receptor 0.0239 0.279 0.3912
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0016 0.0031 0.0034
Echinococcus multilocularis RUN 0.004 0.0328 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0351 0.0935
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0034 0.0028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.279 0.4221
Brugia malayi Uncoordinated protein 44 0.0015 0.0018 0.0016
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0083 0.0861 0.0855
Leishmania major cathepsin L-like protease 0.0017 0.0045 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0045 0.0074
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0072 0.0065
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0283 0.0676
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0031 0.0024
Echinococcus granulosus nuclear receptor nhr 48 0.0042 0.0359 0.0352
Echinococcus granulosus axis inhibition protein axin 0.002 0.0089 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0089 0.0941 0.1418
Entamoeba histolytica hypothetical protein 0.0036 0.0283 0.0793
Onchocerca volvulus 0.0089 0.0936 0.1622
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0314 0.2236
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0089 0.0941 0.1314
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0031 0.0024
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0019 0.0035
Onchocerca volvulus 0.0019 0.0072 0.0114
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0043 0.0036
Schistosoma mansoni nAChR subunit 0.0019 0.0072 0.0065
Trichomonas vaginalis proliferating cell nuclear antigen, putative 0.0065 0.064 0.1116
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0049 0.0042
Echinococcus granulosus glutamate NMDA receptor subunit 0.0015 0.0028 0.0021
Schistosoma mansoni nAChR subunit 0.0019 0.0072 0.0065
Onchocerca volvulus 0.0056 0.0535 0.0921
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0434 0.0601
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0359 0.0495
Schistosoma mansoni proliferating cell nuclear antigen 0.0065 0.064 0.0634
Brugia malayi Pre-SET motif family protein 0.042 0.5024 0.7053
Loa Loa (eye worm) agrin synaptic family protein 0.0038 0.0314 0.0466
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0627 0.174
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0596 0.0589
Brugia malayi Steroid receptor seven-up type 2 0.0089 0.0941 0.1314
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0461 0.0689
Schistosoma mansoni hypothetical protein 0.0083 0.0861 0.0855
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0054
Schistosoma mansoni rab6-interacting 0.004 0.0328 0.0322
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0039 0.0325 0.0807
Loa Loa (eye worm) hypothetical protein 0.0056 0.0535 0.0801
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0419
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0197 0.0268
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0108 0.1168 0.1761
Echinococcus multilocularis thyroid hormone receptor alpha 0.0481 0.5777 0.5774
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0028 0.0021
Brugia malayi sodium-independent organic anion transporter family protein 0.0089 0.0936 0.1307
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Echinococcus multilocularis Ankyrin 0.0015 0.0019 0.0013
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0089 0.0115
Brugia malayi Death domain containing protein 0.0015 0.0018 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.357 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0089 0.0082
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0328 0.0322
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0089 0.0115
Onchocerca volvulus 0.0054 0.0508 0.0875
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0045 0.0111
Schistosoma mansoni nAChR subunit 0.0019 0.0072 0.0065
Onchocerca volvulus 0.0036 0.0283 0.0482
Onchocerca volvulus 0.0056 0.0535 0.0921
Schistosoma mansoni intermediate filament proteins 0.0054 0.0508 0.0502
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.1264 0.3793
Echinococcus granulosus proliferating cell nuclear antigen 0.0065 0.064 0.0634
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0045 0.0039
Echinococcus granulosus Solute carrier organic anion transporter family 0.0056 0.0535 0.0529
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0089 0.0082
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0028 0.0021
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0102 0.031
Schistosoma mansoni single-minded 0.0049 0.0439 0.0433
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0045 0.0111
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0031 0.0024
Plasmodium vivax vivapain-2 0.0017 0.0045 0.0429
Leishmania major cathepsin L-like protease 0.0017 0.0045 0.0108
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0071 0.0123
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0283 0.0277
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0508 0.0761
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0371 0.2663
Schistosoma mansoni proliferating cell nuclear antigen 0.0065 0.064 0.0634
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0351 0.0967
Brugia malayi PXA domain containing protein 0.002 0.0089 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Onchocerca volvulus 0.0016 0.0031 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0089 0.0941 0.1314
Brugia malayi ecdysteroid receptor 0.0089 0.0941 0.1314
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0359 0.0352
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0197 0.0289
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0019
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0031 0.0034
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0018 0.0011
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0508 0.0761
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0089 0.0941 0.0935
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0227 0.0333
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0019 0.0019
Loa Loa (eye worm) histone methyltransferase 0.002 0.0086 0.0121
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0089 0.0082
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0283 0.0992
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0072 0.0092
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0283 0.0992
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0596 0.0589
Brugia malayi beta-lactamase 0.0036 0.0283 0.0389
Onchocerca volvulus 0.0019 0.0072 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3489 0.6079
Toxoplasma gondii proliferating cell nuclear antigen PCNA1 0.0065 0.064 0.469
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0227 0.0584
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0351 0.0612
Loa Loa (eye worm) hypothetical protein 0.0103 0.1108 0.167
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0045 0.0039
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1018 0.1774
Plasmodium vivax proliferating cell nuclear antigen, putative 0.0065 0.064 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0045 0.024
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0072 0.0065
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0072 0.0065
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0043 0.0036
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0019 0.0013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.042 0.5024 0.7609
Echinococcus multilocularis ecdysone induced protein 78C 0.0089 0.0941 0.0935
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0351 0.0892
Mycobacterium ulcerans hypothetical protein 0.011 0.1194 0.3573
Loa Loa (eye worm) hypothetical protein 0.0047 0.0421 0.0629
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0283 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0089 0.0941 0.1314
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0092 0.013
Loa Loa (eye worm) hypothetical protein 0.0047 0.0421 0.0629
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0083 0.0861 0.0855
Brugia malayi hypothetical protein 0.0036 0.0283 0.0388
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0067
Entamoeba histolytica hypothetical protein 0.0036 0.0283 0.0793
Loa Loa (eye worm) glutaminase 2 0.0273 0.3216 0.4866
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0089 0.0082
Onchocerca volvulus 0.0048 0.0434 0.0746
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0017
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0089 0.0941 0.0935
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0328 0.0322
Schistosoma mansoni cpg binding protein 0.0061 0.0593 0.0586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0089 0.0941 0.1418
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0024 0.0129 0.0186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0072 0.0065
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0031 0.0034
Loa Loa (eye worm) hypothetical protein 0.0089 0.0941 0.1418
Brugia malayi Cytochrome P450 family protein 0.003 0.0209 0.0285
Onchocerca volvulus 0.0019 0.0072 0.0114
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0072 0.0065
Schistosoma mansoni hypothetical protein 0.0341 0.4048 0.4044
Echinococcus multilocularis microtubule associated protein 2 0.069 0.8364 0.8363
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.3489 1
Schistosoma mansoni RAR-like nuclear receptor 0.0089 0.0941 0.0935
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0162 0.0155
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0089 0.0941 0.0935
Onchocerca volvulus 0.0038 0.0314 0.0536
Onchocerca volvulus Putative organic anion transporter 0.0056 0.0535 0.0921
Echinococcus granulosus single minded 2 0.0036 0.0283 0.0277
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0054
Brugia malayi ecdysone receptor 0.0042 0.0359 0.0495
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0083 0.0861 0.0855
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0031 0.0036
Brugia malayi hypothetical protein 0.0236 0.276 0.387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0596 0.0589
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0089 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Schistosoma mansoni agrin 0.0038 0.0314 0.0307
Onchocerca volvulus 0.0036 0.0283 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0045 0.0079
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1018 0.1774
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0419
Entamoeba histolytica hypothetical protein 0.002 0.0089 0.0236
Mycobacterium ulcerans hypothetical protein 0.0036 0.0283 0.0676
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0552 0.0827
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0283 0.0776
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0283 0.0277
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0018 0.0011
Schistosoma mansoni glutamate receptor NMDA 0.0029 0.0196 0.019
Schistosoma mansoni cpg binding protein 0.0058 0.0552 0.0546
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0089 0.0124
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0071 0.0658
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0371 0.0364
Mycobacterium ulcerans glutaminase 0.0273 0.3216 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0535 0.0801
Leishmania major DNA polymerase kappa, putative 0.0021 0.0102 0.0266
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0071 0.009
Brugia malayi Pre-SET motif family protein 0.0061 0.0596 0.0828
Leishmania major cathepsin L-like protease 0.0017 0.0045 0.0108
Schistosoma mansoni ap endonuclease 0.0019 0.0071 0.0064
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0122 0.1347 0.3762
Onchocerca volvulus 0.0017 0.0045 0.0067
Entamoeba histolytica hypothetical protein 0.002 0.0089 0.0236
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.1262 0.936
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0596 0.0589
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0351 0.0967
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3489 0.6079
Brugia malayi hypothetical protein 0.0163 0.1855 0.2597
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0351 0.0935
Schistosoma mansoni hypothetical protein 0.0083 0.0861 0.0855
Toxoplasma gondii hypothetical protein 0.0016 0.0031 0.0107
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0072 0.0065
Entamoeba histolytica proliferating cell nuclear antigen, putative 0.0065 0.064 0.182
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0029 0.0196 0.019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1347 0.4058
Brugia malayi intermediate filament protein 0.0054 0.0508 0.0705
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0351 0.0935
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0478 0.1322
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0015 0.0028 0.0021
Echinococcus granulosus glutamate receptor 2 0.0029 0.0196 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1018 0.1774
Loa Loa (eye worm) hypothetical protein 0.0026 0.0162 0.0235
Echinococcus granulosus dna polymerase kappa 0.0042 0.0351 0.0345
Onchocerca volvulus 0.0016 0.0031 0.0042
Echinococcus multilocularis lamin dm0 0.0054 0.0508 0.0502
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0295 0.0289
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0359 0.0352
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0283 0.0276
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0627 0.174
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0363 0.1
Toxoplasma gondii ABC1 family protein 0.0036 0.0283 0.2005
Schistosoma mansoni axis inhibition protein axin 0.002 0.0089 0.0082
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1621 0.4931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0028 0.0021
Onchocerca volvulus 0.0058 0.0552 0.0951
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0031 0.0024
Onchocerca volvulus 0.0054 0.0508 0.0875
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.268 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0079
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0314 0.0466
Loa Loa (eye worm) serotonin transporter b 0.0016 0.0031 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0045 0.0079
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0162 0.0155
Echinococcus granulosus agrin 0.0038 0.0314 0.0307
Loa Loa (eye worm) hypothetical protein 0.0056 0.0535 0.0801
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.1264 0.1767
Echinococcus multilocularis follistatin 0.0038 0.0314 0.0307
Echinococcus granulosus nuclear factor of activated T cells 5 0.0074 0.0758 0.0752
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0071 0.0839
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0359 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0089 0.0941 0.1314
Toxoplasma gondii aldehyde dehydrogenase 0.0122 0.1347 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0089 0.0941 0.0935
Echinococcus granulosus cpg binding protein 0.0061 0.0593 0.0586
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.0129 0.0172
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0072 0.0099
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0019 0.0012
Brugia malayi Metabotropic glutamate receptor precursor. 0.0024 0.0129 0.0172
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0042 0.0359 0.0352
Brugia malayi Nuclear hormone receptor-like 1 0.0547 0.6601 0.9269
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.0028 0.0021
Onchocerca volvulus Protein ultraspiracle homolog 0.0089 0.0941 0.163
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0092 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3489 0.6079
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0089 0.0941 0.1314
Schistosoma mansoni retinoic acid receptor RXR 0.0089 0.0941 0.0935
Brugia malayi prostaglandin transporter 0.0056 0.0535 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0351 0.0935
Brugia malayi secreted modular calcium-binding protein 1 0.0038 0.0314 0.0432
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.1264 0.3793
Loa Loa (eye worm) doublecortin family protein 0.004 0.0328 0.0488
Onchocerca volvulus 0.0478 0.574 1
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0105 0.0183
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0024 0.0135 0.0129
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0089 0.0941 0.1314
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0045 0.024
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0036
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0083 0.0861 0.1201
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0042 0.0359 0.0352
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1347 0.4058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0035 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0035 0.0029
Onchocerca volvulus 0.0061 0.0596 0.1027
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0359 0.0614
Schistosoma mansoni survival motor neuron protein 0.0048 0.0434 0.0428
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0089 0.0154
Loa Loa (eye worm) norepinephrine transporter 0.0016 0.0031 0.0036
Echinococcus granulosus expressed protein 0.0394 0.4712 0.4708
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0089 0.0154
Brugia malayi PXA domain containing protein 0.002 0.0089 0.0115
Loa Loa (eye worm) fibroinase 0.0017 0.0045 0.0059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0036
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0031 0.0034
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0283 0.0676
Loa Loa (eye worm) hypothetical protein 0.0083 0.0861 0.1296
Schistosoma mansoni sodium-dependent amino acid transporter 0.0016 0.0031 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0596 0.4353
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1018 0.2839
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3489 0.6079
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0072 0.0099
Onchocerca volvulus Bile acid receptor homolog 0.0089 0.0941 0.163
Loa Loa (eye worm) hypothetical protein 0.004 0.0328 0.0488
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0045 0.0054
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0122 0.1347 0.4989
Loa Loa (eye worm) glutamate receptor 0.0024 0.0135 0.0195
Schistosoma mansoni kinase 0.0049 0.0438 0.0432
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0035 0.0044
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0283 0.0493
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0079
Schistosoma mansoni steroid hormone receptor ad4bp 0.0089 0.0941 0.0935
Brugia malayi nuclear hormone receptor family member nhr-6 0.0042 0.0359 0.0495
Trypanosoma brucei unspecified product 0.0035 0.0269 0.0703
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0083 0.0861 0.0855
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0283 0.4255
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0089 0.0941 0.1418
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0283 0.0992
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1648 0.1643
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0074 0.0758 0.0752
Loa Loa (eye worm) hypothetical protein 0.0017 0.0045 0.0059
Schistosoma mansoni cpg binding protein 0.0061 0.0593 0.0586
Loa Loa (eye worm) hypothetical protein 0.0089 0.0941 0.1418
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0314 0.0432
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0039 0.0325 1
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0627 0.174
Echinococcus multilocularis expressed protein 0.0394 0.4712 0.4708
Brugia malayi conserved hypotetical protein 0.0042 0.0359 0.0495
Trypanosoma brucei polo-like protein kinase 0.0095 0.1018 0.2813
Brugia malayi beta-lactamase family protein 0.0036 0.0283 0.0389
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0089 0.0115
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0072 0.0092
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0019 0.0036
Echinococcus multilocularis geminin 0.0341 0.4048 0.4044
Onchocerca volvulus 0.004 0.0328 0.0561
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0089 0.0941 0.0935
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0103 0.1108 0.1102
Onchocerca volvulus 0.0036 0.0283 0.0482
Onchocerca volvulus 0.0042 0.0359 0.0614
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.0028 0.0021
Onchocerca volvulus 0.0016 0.0031 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0089 0.0941 0.1314
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0089 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0351 0.0935
Brugia malayi nuclear hormone receptor 0.0042 0.0359 0.0495
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1648 0.1643
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1018 0.1012
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0072 0.0065
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0103 0.1108 0.1102
Loa Loa (eye worm) glutamate receptor 0.0024 0.0129 0.0186
Schistosoma mansoni hypothetical protein 0.0341 0.4048 0.4044
Echinococcus multilocularis nuclear receptor nhr 48 0.0042 0.0359 0.0352
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0039 0.0325 0.085
Loa Loa (eye worm) hypothetical protein 0.0056 0.0535 0.0801
Loa Loa (eye worm) RecQ helicase 0.0022 0.0105 0.0149
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0072 0.0099
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.0186
Loa Loa (eye worm) proliferating cell nuclear antigen 0.0065 0.064 0.0961
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0031 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0079
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0045 0.0108
Schistosoma mansoni hypothetical protein 0.0048 0.0434 0.0428
Schistosoma mansoni lamin 0.0054 0.0508 0.0502
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0089 0.0941 0.1418
Toxoplasma gondii exonuclease III APE 0.0019 0.0071 0.0408
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0072 0.0687
Schistosoma mansoni lozenge 0.0056 0.0532 0.0526
Brugia malayi photoreceptor-specific nuclear receptor 0.0089 0.0941 0.1314
Loa Loa (eye worm) runx1 0.0056 0.0532 0.0797
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0089 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Schistosoma mansoni hypothetical protein 0.0052 0.0484 0.0478
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0283 0.0276
Echinococcus multilocularis FTZ F1 alpha 0.0089 0.0941 0.0935
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1018 0.2839
Schistosoma mansoni hypothetical protein 0.0822 1 1
Schistosoma mansoni zinc finger protein 0.0042 0.0359 0.0352
Mycobacterium ulcerans beta-lactamase 0.0036 0.0283 0.0676
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0072 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Echinococcus granulosus serotonin transporter 0.0016 0.0031 0.0024
Loa Loa (eye worm) hypothetical protein 0.0054 0.0508 0.0761
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.0028 0.0021
Echinococcus granulosus follistatin 0.0038 0.0314 0.0307
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0089 0.0941 0.0935
Onchocerca volvulus 0.0448 0.537 0.9354
Brugia malayi SPARC precursor 0.0038 0.0314 0.0432
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0089 0.0941 0.0935
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0072 0.0092
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1621 0.6021
Echinococcus multilocularis nAChR subunit 0.0019 0.0072 0.0065
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0086 0.008
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0328 0.4979
Brugia malayi hypothetical protein 0.0016 0.0031 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0481 0.5777 0.5774
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Trichomonas vaginalis set domain proteins, putative 0.0478 0.5739 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0071 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0089 0.0941 0.1418
Brugia malayi Nuclear hormone receptor-like 1 0.0589 0.7121 1
Loa Loa (eye worm) acetyltransferase 0.0146 0.1648 0.249
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Loa Loa (eye worm) hypothetical protein 0.0089 0.0941 0.1418
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0071 0.0184
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0071 0.0064
Brugia malayi glutaminase DH11.1 0.0273 0.3216 0.451
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0072 0.0065
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0115 0.1264 0.1258
Echinococcus granulosus nAChR subunit 0.0019 0.0072 0.0065
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0105 0.0183
Echinococcus granulosus Ankyrin 0.0015 0.0019 0.0013
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0045 0.0067
Loa Loa (eye worm) DR-78 0.0042 0.0359 0.0534
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0086 0.008
Brugia malayi hypothetical protein 0.004 0.0328 0.0452
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0089 0.0941 0.0935
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0102 0.0266
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0072 0.0092
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0283 0.0276
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0083 0.0861 0.0855
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Loa Loa (eye worm) hypothetical protein 0.0034 0.0264 0.039
Plasmodium vivax vivapain-2 0.0017 0.0045 0.0429
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0031 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1018 0.1774
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0124
Loa Loa (eye worm) hypothetical protein 0.0061 0.0596 0.0893
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1598 0.1592
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.276 0.2755
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0031 0.0034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.1379 0.1373
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0071 0.0064
Toxoplasma gondii cathepsin CPL 0.0017 0.0045 0.0217
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0031 0.0024
Loa Loa (eye worm) glutamate receptor 2 0.0015 0.0028 0.0033
Schistosoma mansoni organic anion transporter 0.0056 0.0535 0.0529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0089 0.0941 0.1418
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0283 0.0992
Echinococcus multilocularis GPCR, family 2 0.0016 0.0035 0.0029
Brugia malayi hypothetical protein 0.0042 0.0359 0.0495
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0196 0.019
Schistosoma mansoni nuclear receptor 0.0042 0.0359 0.0352
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0115 0.1264 0.3528
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0314 0.0432
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0072 0.0065
Echinococcus granulosus FTZ F1 alpha 0.0089 0.0941 0.0935
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0031 0.0024
Toxoplasma gondii protease inhibitor PI2 0.0038 0.0314 0.2236
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0458 0.1266
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0314 0.2236
Schistosoma mansoni microtubule-associated protein tau 0.069 0.8364 0.8363
Echinococcus granulosus ecdysone induced protein 78C 0.0089 0.0941 0.0935
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0036
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0072 0.0065
Loa Loa (eye worm) beta-lactamase 0.0036 0.0283 0.0419
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1804 0.6706
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0363 0.0969
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0043 0.0036
Brugia malayi nuclear receptor NHR-88 0.0042 0.0359 0.0495
Schistosoma mansoni ap endonuclease 0.0019 0.0071 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0359 0.0352
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0072 0.0065
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0016 0.0031 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0283 0.0277
Loa Loa (eye worm) hypothetical protein 0.0542 0.6539 0.9905
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0092 0.0121
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0089 0.0941 0.0935
Schistosoma mansoni polycystin 1-related 0.004 0.0328 0.0322
Schistosoma mansoni regulator of G protein signaling 0.002 0.0089 0.0082
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0089 0.0082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0359 0.0352
Loa Loa (eye worm) hypothetical protein 0.0056 0.0535 0.0801
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0045 0.0039
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0054
Brugia malayi Cation transporter family protein 0.0019 0.0072 0.0092
Loa Loa (eye worm) hypothetical protein 0.0089 0.0941 0.1418
Trypanosoma cruzi MFS transporter, putative 0.0056 0.0535 0.1482
Giardia lamblia Kinase, PLK 0.0095 0.1018 0.2772
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0029 0.0196 0.019
Schistosoma mansoni apoptosis regulator bax 0.0083 0.0861 0.0855
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0111 0.121 0.1204
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0419
Mycobacterium tuberculosis Conserved protein 0.0036 0.0283 0.0992
Onchocerca volvulus 0.0017 0.0045 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0079
Loa Loa (eye worm) apoptosis regulator protein 0.0083 0.0861 0.1296
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0124
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0045 0.0059
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0103 0.1108 0.1102
Echinococcus granulosus axis inhibition protein axin 0.002 0.0089 0.0082
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0553 0.0546
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1347 0.1341
Brugia malayi Cation transporter family protein 0.0019 0.0072 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1018 0.1774
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0295 0.0289
Toxoplasma gondii transporter, major facilitator family protein 0.0056 0.0535 0.3896
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1604 0.4464
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0295 0.081
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0042 0.0359 0.0352
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0072 0.0099
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0036
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0031 0.0024
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.0028 0.0021
Giardia lamblia DINP protein human, muc B family 0.0021 0.0102 0.009
Trichomonas vaginalis glutaminase, putative 0.0273 0.3216 0.5603
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0089 0.0941 0.0935
Echinococcus granulosus RUN 0.004 0.0328 0.0322
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0351 0.0935
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0295 0.0289
Schistosoma mansoni nuclear receptor nhr-48 0.0042 0.0359 0.0352
Brugia malayi polk-prov protein 0.0031 0.0227 0.0309
Mycobacterium tuberculosis Conserved protein 0.0036 0.0283 0.0992
Loa Loa (eye worm) hypothetical protein 0.0042 0.0359 0.0534
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0071 0.0145
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0042 0.0359 0.0534
Echinococcus multilocularis dnaJ subfamily B 0.0822 1 1
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0018 0.002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0089 0.0941 0.163
Mycobacterium ulcerans aldehyde dehydrogenase 0.0122 0.1347 0.4058
Brugia malayi metabotropic glutamate receptor type 2 0.0038 0.0304 0.0418
Onchocerca volvulus 0.0017 0.0045 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3489 0.6079
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0351 0.0967
Loa Loa (eye worm) hypothetical protein 0.0163 0.1855 0.2802
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0072 0.0065
Onchocerca volvulus 0.0019 0.0072 0.0114
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0283 0.0676
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0092 0.0086
Onchocerca volvulus 0.0019 0.0072 0.0114
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0029
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0351 0.0935
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.5663 0.566
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0092 0.013
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0422 0.0736
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1604 0.4484
Schistosoma mansoni hypothetical protein 0.0036 0.0283 0.0276
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0072 0.0065
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0071 0.018
Brugia malayi Cathepsin L-like precursor 0.0017 0.0045 0.0054
Loa Loa (eye worm) hypothetical protein 0.0047 0.0421 0.0629
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0019 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0283 0.0493
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0072 0.0092
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0045 0.0039
Brugia malayi tailless protein 0.0042 0.0359 0.0495
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0295 0.0657
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0359 0.0352
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0072 0.0099
Trypanosoma cruzi proliferative cell nuclear antigen (PCNA), putative 0.0065 0.064 0.1779
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0295 0.0289
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0089 0.0082
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0359 0.0352
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0089 0.0082
Plasmodium falciparum proliferating cell nuclear antigen 2 0.0035 0.0267 0.3883
Echinococcus granulosus nmda type glutamate receptor 0.0055 0.0514 0.0508
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0072 0.0065
Loa Loa (eye worm) hypothetical protein 0.0448 0.537 0.8133
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0089 0.0082
Entamoeba histolytica hypothetical protein 0.002 0.0089 0.0236
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1018 0.1012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0295 0.0438
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0035 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0089 0.0941 0.0935
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0072 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.1698 0.2566
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0036
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0351 0.0612
Echinococcus multilocularis Protein lozenge 0.0056 0.0532 0.0526
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0439 0.0433
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1648 0.2308
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0295 0.0829
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0122 0.1347 0.1341
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0295 0.0778
Onchocerca volvulus 0.0016 0.0031 0.0042
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0056 0.0535 0.0529
Loa Loa (eye worm) hypothetical protein 0.0047 0.0421 0.0629
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0328 0.0322
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0124
Echinococcus granulosus dna polymerase eta 0.0015 0.0019 0.0012
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0031 0.0024
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0295 0.0289
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0089 0.0936 0.093
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1018 0.2839
Brugia malayi sodium-independent organic anion transporter family protein 0.0089 0.0936 0.1307
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0072 0.0092
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0363 0.1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0328 0.0322
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0072 0.0065
Onchocerca volvulus 0.0089 0.0936 0.1622
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0045 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0283 0.0419
Schistosoma mansoni axis inhibition protein axin 0.002 0.0089 0.0082
Onchocerca volvulus 0.0019 0.0072 0.0114
Loa Loa (eye worm) hypothetical protein 0.0236 0.276 0.4175
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0283 0.0389
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0031 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Trypanosoma cruzi proliferative cell nuclear antigen (PCNA), putative 0.0065 0.064 0.1779
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0283 0.0992
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0045 0.0079
Loa Loa (eye worm) hypothetical protein 0.0089 0.0941 0.1418
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.3489 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0099
Echinococcus granulosus intermediate filament protein 0.0054 0.0508 0.0502
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0029 0.0196 0.019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0304 0.0451
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0326 0.0748
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0072 0.0065
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0089 0.0082
Entamoeba histolytica hypothetical protein 0.0036 0.0283 0.0793
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1018 0.1422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0045 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0036
Loa Loa (eye worm) hypothetical protein 0.005 0.0461 0.0689
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0072 0.0065
Brugia malayi nuclear receptor NHR-67 0.0042 0.0359 0.0495
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0055 0.0514 0.0508
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0371 0.0646
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0047 0.0421 0.0415
Loa Loa (eye worm) hypothetical protein 0.0038 0.0314 0.0466
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.357 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0019 0.0012
Echinococcus granulosus cathepsin l1 0.0017 0.0045 0.0039
Giardia lamblia PcnA 0.0065 0.064 0.1667
Loa Loa (eye worm) hypothetical protein 0.0053 0.0496 0.0742
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0072 0.0065
Schistosoma mansoni regulator of G protein signaling 0.002 0.0089 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0422 0.0736
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.0028 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0089 0.0154
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0072 0.0092
Onchocerca volvulus 0.0056 0.0535 0.0921
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0072 0.0092
Schistosoma mansoni aldehyde dehydrogenase 0.0122 0.1347 0.1341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0042 0.0359 0.0352
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0092 0.0086
Leishmania major cathepsin L-like protease 0.0017 0.0045 0.0108
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0105 0.0138
Leishmania major cathepsin L-like protease 0.0064 0.0627 0.174
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0124
Onchocerca volvulus 0.0017 0.0045 0.0067
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0596 0.0589
Entamoeba histolytica hypothetical protein 0.0036 0.0283 0.0793
Trichomonas vaginalis esterase, putative 0.0036 0.0283 0.0493
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0047 0.0421 0.0415
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0295 0.0289
Brugia malayi beta-lactamase family protein 0.0036 0.0283 0.0389
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.5663 0.566
Schistosoma mansoni thyroid hormone receptor 0.0481 0.5777 0.5774
Onchocerca volvulus 0.0089 0.0941 0.163
Brugia malayi Protein kinase domain containing protein 0.0015 0.0022 0.0021
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0047 0.0421 0.0415
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0045 0.0039
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0351 0.0345
Brugia malayi Glutamate receptor 2 precursor 0.0015 0.0028 0.003
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0031 0.0107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0072 0.0092
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0328 0.488
Loa Loa (eye worm) solute carrier family 6 member 4 0.0016 0.0031 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0102 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0089 0.0941 0.1314
Echinococcus multilocularis cysteine protease 0.0017 0.0045 0.0039
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0042 0.0359 0.0352
Loa Loa (eye worm) hypothetical protein 0.0036 0.0283 0.0419
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.3489 1
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0105 0.0098
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0029
Echinococcus granulosus neuropeptide s receptor 0.0471 0.5663 0.566
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0028 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0089 0.0941 0.0935
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0072 0.0092
Echinococcus multilocularis agrin 0.0038 0.0314 0.0307
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0072 0.0065
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0089 0.0115
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0111 0.121 0.1204
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0045 0.0074
Schistosoma mansoni DNA polymerase eta 0.0015 0.0019 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0227 0.0584
Loa Loa (eye worm) nuclear hormone receptor 0.0042 0.0359 0.0534
Schistosoma mansoni organic anion transporter 0.0089 0.0936 0.093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0627 0.1711
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0029 0.0196 0.019
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0043 0.0036
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0035 0.004
Brugia malayi hypoxia-induced factor 1 0.0151 0.1698 0.2378

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.36 uM Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR ChEMBL. 16216508
IC50 (functional) = 0.36 uM Inhibition of intracellular calcium release in human TT cells containing calcium-sensing receptor by FLIPR ChEMBL. 16216508

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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