Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.219 | 0.2089 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.219 | 0.2089 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.3105 | 1 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0025 | 0.1185 | 0.3553 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3105 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0025 | 0.1185 | 0.3553 |
Plasmodium falciparum | exonuclease I, putative | 0.0005 | 0.0128 | 0.1076 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.3105 | 1 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0005 | 0.0128 | 0.1076 |
Plasmodium vivax | exonuclease I, putative | 0.0005 | 0.0128 | 0.1076 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.219 | 0.2089 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.3105 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.219 | 0.2089 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.3105 | 1 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0025 | 0.1185 | 0.3553 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.3105 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.3105 | 0.3016 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0005 | 0.0128 | 0.1076 |
Plasmodium falciparum | flap endonuclease 1 | 0.0025 | 0.1185 | 1 |
Entamoeba histolytica | Flap nuclease, putative | 0.0025 | 0.1185 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.3105 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.219 | 0.6927 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0025 | 0.1185 | 0.1071 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.1185 | 0.3553 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.3105 | 1 |
Echinococcus multilocularis | geminin | 0.0192 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3105 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.219 | 0.2089 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.3105 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.219 | 0.2089 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.3105 | 0.3016 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.3105 | 0.3016 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0025 | 0.1185 | 0.3553 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.1058 | 0.0942 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.219 | 0.6927 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0025 | 0.1185 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.3105 | 0.3016 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.219 | 0.2089 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.1185 | 0.3553 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.3105 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.1185 | 0.3553 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.3105 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.0025 | 0.1185 | 0.1071 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.3105 | 1 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0025 | 0.1185 | 0.3553 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.3105 | 0.3016 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.3105 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3105 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.3105 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.