Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0064 | 0.3322 | 0.3322 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3322 | 0.889 |
Brugia malayi | Inositol-1 | 0.0037 | 0.1344 | 0.1344 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.1344 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.1344 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3322 | 0.889 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0067 | 0.3569 | 0.3569 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.3569 | 0.2571 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.3322 | 0.3322 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0067 | 0.3569 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.1344 | 0.1344 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.1344 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1344 | 0.1344 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.1344 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.3569 | 0.3569 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.3322 | 0.2285 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.1047 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1344 | 0.1344 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.1047 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.3322 | 0.3322 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3322 | 0.889 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.3569 | 0.3569 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3322 | 0.889 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3322 | 0.889 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.3569 | 0.3569 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.3322 | 0.2285 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0039 | 0.1441 | 0.0113 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1344 | 0.1344 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.1344 | 0.1344 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0067 | 0.3569 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.1344 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0067 | 0.3569 | 0.3569 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0039 | 0.1441 | 0.0113 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0067 | 0.3569 | 0.3569 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.3322 | 0.3322 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.3322 | 0.3322 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.3322 | 0.3322 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0067 | 0.3569 | 0.2571 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.1344 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 0.28 uM.hr/mg.kg | Area under the curve in rhesus monkey, po | ChEMBL. | 16242322 |
AUC (ADMET) | = 0.99 uM.hr/mg.kg | Area under the curve in dog, po | ChEMBL. | 16242322 |
AUC (ADMET) | = 1.02 uM.hr/mg.kg | Area under the curve in rat, po | ChEMBL. | 16242322 |
Cp (ADMET) | = 14 mL/min.kg | Plasma clearance in rat | ChEMBL. | 16242322 |
Cp (ADMET) | = 26.75 mL/min.kg | Plasma clearance in dog | ChEMBL. | 16242322 |
Cp (ADMET) | = 52.85 mL/min.kg | Plasma clearance in rhesus monkey | ChEMBL. | 16242322 |
F (ADMET) | = 47.7 % | Oral bioavailability in rat | ChEMBL. | 16242322 |
F (ADMET) | = 49 % | Oral bioavailability in rhesus monkey | ChEMBL. | 16242322 |
F (ADMET) | = 83 % | Oral bioavailability in dog | ChEMBL. | 16242322 |
IC50 (functional) | = 0.27 nM | Inhibition of TNF alpha release in THP1 cells | ChEMBL. | 16242322 |
IC50 (functional) | = 0.27 nM | Inhibition of TNF alpha release in THP1 cells | ChEMBL. | 16242322 |
IC50 (binding) | = 0.31 nM | Inhibition of P38 alpha MAPK | ChEMBL. | 16242322 |
IC50 (binding) | = 0.31 nM | Inhibition of P38 alpha MAPK | ChEMBL. | 16242322 |
IC50 (functional) | = 2.6 nM | Inhibition of LPS stimulated TNF alpha release in whole blood | ChEMBL. | 16242322 |
IC50 (functional) | = 2.6 nM | Inhibition of LPS stimulated TNF alpha release in whole blood | ChEMBL. | 16242322 |
T1/2 (ADMET) | = 3.5 hr | Half life in rat, iv | ChEMBL. | 16242322 |
T1/2 (ADMET) | = 5.59 hr | Half life in dog, iv | ChEMBL. | 16242322 |
T1/2 (ADMET) | = 13.6 hr | Half life in rhesus monkey, iv | ChEMBL. | 16242322 |
Vdss (ADMET) | = 3.84 L/kg | Volume of distribution in rat | ChEMBL. | 16242322 |
Vdss (ADMET) | = 23.8 L/kg | Volume of distribution in dog | ChEMBL. | 16242322 |
Vdss (ADMET) | = 52.8 L/kg | Volume of distribution in rhesus monkey | ChEMBL. | 16242322 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.