Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Inositol-1 | 0.004 | 0.3343 | 0.3343 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.9519 | 0.9519 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.3343 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.9519 | 0.9519 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.9519 | 0.9519 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.3343 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.3343 | 0.3343 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.9519 | 0.9519 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.9519 | 0.9519 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 1 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 1 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 1 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0071 | 1 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.2456 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0071 | 1 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0071 | 1 | 1 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.9519 | 0.9519 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.2456 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.3634 | 0.3634 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.9519 | 0.9519 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.3634 | 0.3634 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.3343 | 0.3343 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.3343 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.3343 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0071 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.9519 | 0.9519 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.3343 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.3343 | 0.3343 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.9519 | 0.9519 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.9519 | 0.9519 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.3343 | 0.3343 |
Brugia malayi | RNA binding protein | 0.0069 | 0.9519 | 0.9519 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0024 | 0 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.9519 | 0.9519 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.3343 | 0.3343 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.3343 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.9519 | 0.9519 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0024 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against gram positive Bacillus sphaericus(MTCC 11) | ChEMBL. | 16213726 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against gram positive Staphylococcus aureus(MTCC 96) | ChEMBL. | 16213726 |
MIC (functional) | = 12.5 ug ml-1 | Antibacterial activity against gram negative Chromobacterium violaceum(MTCC 2656) | ChEMBL. | 16213726 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against gram positive Bacillus subtilis MTCC 441 | ChEMBL. | 16213726 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against gram negative Klebsiella aerogenes(MTCC 39) | ChEMBL. | 16213726 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.