Detailed information for compound 348838

Basic information

Technical information
  • TDR Targets ID: 348838
  • Name: 4-[(E)-1-(3,4-dimethoxyphenyl)-3-[(2S)-2-meth ylpiperidin-1-yl]prop-1-en-2-yl]phenol
  • MW: 367.481 | Formula: C23H29NO3
  • H donors: 1 H acceptors: 1 LogP: 5.15 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)/C=C(\c1ccc(cc1)O)/CN1CCCC[C@@H]1C
  • InChi: 1S/C23H29NO3/c1-17-6-4-5-13-24(17)16-20(19-8-10-21(25)11-9-19)14-18-7-12-22(26-2)23(15-18)27-3/h7-12,14-15,17,25H,4-6,13,16H2,1-3H3/b20-14-/t17-/m0/s1
  • InChiKey: QTJQUKYSKDRPQH-PNWWAVQQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(E)-2-(3,4-dimethoxyphenyl)-1-[[(2S)-2-methyl-1-piperidyl]methyl]vinyl]phenol
  • 4-[(E)-2-(3,4-dimethoxyphenyl)-1-[[(2S)-2-methyl-1-piperidinyl]methyl]vinyl]phenol
  • 4-[(E)-2-(3,4-dimethoxyphenyl)-1-[[(2S)-2-methylpiperidino]methyl]vinyl]phenol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0056 0.0368 0.04
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0368 0.0368
Echinococcus granulosus expressed conserved protein 0.0091 0.0707 0.0707
Toxoplasma gondii FATC domain-containing protein 0.0035 0.0158 0.0505
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0035 0.0158 0.021
Schistosoma mansoni nuclear hormone receptor 0.0056 0.0368 0.0368
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0117 0.0117
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.264 0.3527
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0035 0.0158 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Plasmodium vivax serine--tRNA ligase, putative 0.0038 0.0184 0.0589
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0035 0.0158 0.0158
Brugia malayi CXXC zinc finger family protein 0.0031 0.0113 0.0151
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.077 0.247
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0131 0.1103 0.1103
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0057 0.0371 0.0496
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.1902 0.2068
Plasmodium vivax hypothetical protein 0.0035 0.0158 0.0505
Brugia malayi AMP-binding enzyme family protein 0.0097 0.077 0.1029
Schistosoma mansoni intermediate filament proteins 0.0029 0.0095 0.0095
Schistosoma mansoni lamin 0.0029 0.0095 0.0095
Brugia malayi nuclear receptor RXR 0.0027 0.0074 0.0099
Plasmodium falciparum threonine--tRNA ligase 0.0094 0.0743 0.2382
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.077 0.2272
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0074 0.0099
Mycobacterium ulcerans seryl-tRNA synthetase 0.0038 0.0184 0.0542
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0335 0.3119 0.4166
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0076 0.0244
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0035 0.0158 0.0158
Wolbachia endosymbiont of Brugia malayi seryl-tRNA synthetase 0.0038 0.0184 0.0542
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0094 0.0743 0.0993
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0116 0.0962 0.1765
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0095 0.0103
Brugia malayi tailless protein 0.0027 0.0074 0.0099
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0056 0.0368 0.0368
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0158 0.0171
Trypanosoma cruzi histidyl-tRNA synthetase 0.0057 0.0371 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0074 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0093 0.0275
Leishmania major phosphatidylinositol kinase, putative 0.0035 0.0158 0.0505
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0335 0.3119 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0074 0.0081
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0054 0.0173
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0035 0.0158 0.0505
Brugia malayi conserved hypotetical protein 0.0027 0.0074 0.0099
Echinococcus granulosus ecdysone induced protein 78C 0.0056 0.0368 0.0368
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0093 0.0275
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0035 0.0158 0.0158
Echinococcus granulosus cpg binding protein 0.0032 0.013 0.013
Plasmodium vivax SET domain protein, putative 0.0031 0.0117 0.0376
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0093 0.0275
Plasmodium vivax glycine--tRNA ligase, putative 0.0094 0.0743 0.2382
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0035 0.0158 0.0505
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0171
Echinococcus granulosus histidyl tRNA synthetase 0.0057 0.0371 0.0371
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0094 0.0743 0.0993
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0056 0.0368 0.0368
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0057 0.0371 0.0496
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0154 0.1333 0.1781
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0035 0.0158 0.0505
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0117 0.0117
Schistosoma mansoni hypothetical protein 0.0029 0.0095 0.0095
Echinococcus granulosus serine protein kinase ATM 0.0035 0.0158 0.0158
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0093 0.0124
Giardia lamblia Phosphatidylinositol 4-kinase 0.0035 0.0158 0.0289
Brugia malayi Metabotropic glutamate receptor precursor. 0.0177 0.156 0.2084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0462 0.0462
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0528 0.1074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0093 0.0275
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0035 0.0158 0.021
Echinococcus multilocularis 0.0035 0.0158 0.0158
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0221 0.024
Brugia malayi Bm-MIF-1, identical 0.0331 0.3085 0.4122
Chlamydia trachomatis threonine--tRNA ligase 0.0094 0.0743 0.1744
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.04 0.1178
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0221 0.0221
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1193 0.3637
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0056 0.0368 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0142 0.0189
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0094 0.0743 0.0743
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1031 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0083
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0528 0.1693
Schistosoma mansoni hypothetical protein 0.004 0.0206 0.0206
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0158 0.0171
Mycobacterium ulcerans hypothetical protein 0.0097 0.077 0.2272
Onchocerca volvulus 0.0037 0.0181 0.0503
Loa Loa (eye worm) seryl-tRNA synthetase 0.0038 0.0184 0.02
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0094 0.0743 0.0743
Loa Loa (eye worm) hypothetical protein 0.0056 0.0368 0.04
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0093 0.0124
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0093 0.0101
Schistosoma mansoni hypothetical protein 0.0122 0.1016 0.1016
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0093 0.0275
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0154 0.1333 0.1333
Echinococcus granulosus FTZ F1 alpha 0.0056 0.0368 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0131 0.1103 0.1474
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0035 0.0158 0.0505
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.031 0.031
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0056 0.0368 0.0492
Brugia malayi ecdysone receptor 0.0027 0.0074 0.0099
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.04 0.0534
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0035 0.0158 0.021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.036 0.337 0.4503
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0368 0.0492
Echinococcus multilocularis Zinc finger, PHD finger 0.0154 0.1333 0.1333
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0154 0.1333 0.1781
Entamoeba histolytica hypothetical protein 0.0035 0.0158 0.021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0056 0.0368 0.04
Brugia malayi hypothetical protein 0.0169 0.1484 0.1983
Schistosoma mansoni prolyl-tRNA synthetase 0.0306 0.2831 0.2831
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0056 0.0368 0.0368
Echinococcus granulosus GPCR family 3 C terminal 0.0029 0.0095 0.0095
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0056 0.0368 0.0368
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0045 0.026 0.0283
Brugia malayi glycyl-tRNA synthetase 0.0094 0.0743 0.0993
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0141 0.1208 0.1314
Giardia lamblia Prolyl-tRNA synthetase 0.0094 0.0743 0.1364
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.077 0.247
Loa Loa (eye worm) hypothetical protein 0.0033 0.0142 0.0154
Loa Loa (eye worm) hypothetical protein 0.0056 0.0368 0.04
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.077 0.2238
Schistosoma mansoni cpg binding protein 0.0032 0.013 0.013
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0035 0.0158 0.0158
Schistosoma mansoni coup transcription factor 0.0056 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0051 0.0318 0.0346
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0093 0.0124
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0074 0.0099
Echinococcus multilocularis muscleblind protein 1 0.0146 0.1257 0.1257
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0779 0.0779
Loa Loa (eye worm) hypothetical protein 0.0041 0.0221 0.024
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0094 0.0743 0.2191
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0093 0.0275
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0097 0.077 0.2272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Echinococcus multilocularis GPCR, family 3, C terminal 0.0029 0.0095 0.0095
Mycobacterium tuberculosis Probable prolyl-tRNA synthetase ProS (proline--tRNA ligase) (PRORS) (global RNA synthesis factor) (proline translase) 0.0268 0.2459 0.7885
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0035 0.0158 0.0505
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.2293 0.2293
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1193 0.3827
Schistosoma mansoni dihydroorotate dehydrogenase 0.0335 0.3119 0.3119
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0094 0.0743 0.0993
Plasmodium vivax proline--tRNA ligase, putative 0.0306 0.2831 0.9077
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0035 0.0158 0.0158
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0093 0.0275
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0331 0.3085 0.9893
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0093 0.0124
Brugia malayi hypothetical protein 0.0027 0.0074 0.0099
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.077 0.1029
Plasmodium falciparum serine--tRNA ligase, putative 0.0038 0.0184 0.0589
Loa Loa (eye worm) hypothetical protein 0.0218 0.1964 0.2135
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.077 0.247
Trypanosoma brucei seryl-tRNA synthetase 0.0038 0.0184 0.0589
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0035 0.0158 0.0158
Entamoeba histolytica seryl-tRNA synthetase, putative 0.0038 0.0184 0.0245
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0094 0.0743 0.0993
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0117 0.0117
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0029 0.0095 0.0128
Brugia malayi nuclear hormone receptor 0.0027 0.0074 0.0099
Echinococcus granulosus metabotropic glutamate receptor 2 0.0148 0.1276 0.1276
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0093 0.0093
Echinococcus granulosus seryl tRNA synthetase mitochondrial 0.0038 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0056 0.0368 0.04
Echinococcus multilocularis histidyl tRNA synthetase 0.0057 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.0127
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0115
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0335 0.3119 0.4166
Brugia malayi Met-10+ like-protein 0.0268 0.2459 0.3285
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0094 0.0743 0.2382
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0056 0.0368 0.0368
Brugia malayi nuclear receptor NHR-67 0.0027 0.0074 0.0099
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0093 0.0299
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0652 0.6252 0.8353
Onchocerca volvulus Bile acid receptor homolog 0.0056 0.0368 0.1389
Plasmodium falciparum dihydroorotate dehydrogenase 0.0335 0.3119 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0076 0.0244
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0094 0.0743 0.2148
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0528 0.1693
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0035 0.0158 0.021
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0076 0.0244
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0154 0.1333 0.4275
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0035 0.0158 0.0505
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0057 0.0371 0.0496
Giardia lamblia Macrophage migration inhibitory factor 0.0331 0.3085 0.5663
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0331 0.3085 0.3355
Brugia malayi Receptor family ligand binding region containing protein 0.0045 0.026 0.0347
Loa Loa (eye worm) hypothetical protein 0.0056 0.0368 0.04
Onchocerca volvulus 0.0028 0.0093 0.009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0158 0.021
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0777 0.7485 1
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0094 0.0743 0.2191
Entamoeba histolytica seryl-tRNA synthetase, putative 0.0038 0.0184 0.0245
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0115
Echinococcus multilocularis Seryl tRNA Synthetase 0.0038 0.0184 0.0184
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0148 0.1276 0.1276
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0368 0.0368
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0035 0.0158 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0056 0.0368 0.0492
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0093 0.0275
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0074 0.0081
Schistosoma mansoni patched 1 0.0041 0.0221 0.0221
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0097 0.077 0.2272
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0695 0.6681 0.8926
Leishmania major phosphatidylinositol 3-kinase, putative 0.0154 0.1333 0.4275
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0035 0.0158 0.0505
Onchocerca volvulus 0.0035 0.0158 0.0394
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.02 0.1792 0.2393
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0131 0.1103 0.1474
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0056 0.0368 0.0492
Mycobacterium tuberculosis Conserved hypothetical protein 0.0035 0.0158 0.0505
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0093 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0158 0.021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0394 0.1262
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0117 0.0117
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0131 0.1103 0.1474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0368 0.0492
Brugia malayi PAS domain containing protein 0.005 0.031 0.0414
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0093 0.0299
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0368 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0035 0.0158 0.021
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0035 0.0158 0.021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.264 0.3527
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.2293 0.2293
Entamoeba histolytica hypothetical protein 0.0695 0.6681 0.8926
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0362 0.339 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0035 0.0158 0.0158
Brugia malayi Pre-SET motif family protein 0.0031 0.0117 0.0157
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0093 0.0124
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.04 0.1281
Leishmania major dihydroorotate dehydrogenase 0.0335 0.3119 1
Brugia malayi Steroid receptor seven-up type 2 0.0056 0.0368 0.0492
Brugia malayi Muscleblind-like protein 0.0146 0.1257 0.168
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0777 0.7485 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0158 0.021
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0056 0.0368 0.0368
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0035 0.0158 0.021
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0093 0.0124
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0158 0.0213
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0158 0.0171
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0335 0.3119 0.4166
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0074 0.0074
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0035 0.0158 0.0505
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0158 0.0171
Echinococcus multilocularis ecdysone induced protein 78C 0.0056 0.0368 0.0368
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0035 0.0158 0.0505
Brugia malayi nuclear receptor NHR-88 0.0056 0.0368 0.0492
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0093 0.0299
Chlamydia trachomatis proline--tRNA ligase 0.0362 0.339 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0313 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0093 0.0299
Loa Loa (eye worm) hypothetical protein 0.0028 0.009 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.1016 0.1016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Loa Loa (eye worm) phosphatidylinositol 3 0.02 0.1792 0.1948
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.008 0.0087
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0777 0.7485 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0035 0.0158 0.0158
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0106 0.0106
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0035 0.0158 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Schistosoma mansoni nuclear receptor 0.0027 0.0074 0.0074
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0261 0.2387 0.2596
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1173 0.1173
Leishmania major phosphatidylinositol 3-kinase, putative 0.0035 0.0158 0.0505
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0093 0.0124
Loa Loa (eye worm) hypothetical protein 0.0072 0.0528 0.0574
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0093 0.0124
Loa Loa (eye worm) hypothetical protein 0.036 0.337 0.3665
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0035 0.0158 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0331 0.3085 0.4122
Echinococcus granulosus prolyl tRNA synthetase mitochondrial 0.0306 0.2831 0.2831
Loa Loa (eye worm) hypothetical protein 0.0056 0.0368 0.04
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0056 0.0368 0.04
Echinococcus multilocularis lamin 0.0029 0.0095 0.0095
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0074 0.0074
Echinococcus multilocularis FTZ F1 alpha 0.0056 0.0368 0.0368
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0093 0.0299
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0093 0.0275
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0035 0.0158 0.0505
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0035 0.0158 0.021
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0115
Brugia malayi hypothetical protein 0.0027 0.0074 0.0099
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0056 0.0368 0.1389
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0093 0.0299
Leishmania major macrophage migration inhibitory factor-like protein 0.0331 0.3085 0.9893
Echinococcus multilocularis tumor protein p63 0.035 0.3274 0.3274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0094 0.0743 0.0993
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0035 0.0158 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0056 0.0368 0.0492
Loa Loa (eye worm) hypothetical protein 0.0251 0.2293 0.2494
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.036 0.0391
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0777 0.7485 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0158 0.021
Brugia malayi hypothetical protein 0.003 0.0106 0.0141
Schistosoma mansoni nuclear receptor 0.0027 0.0074 0.0074
Schistosoma mansoni seryl-tRNA synthetase 0.0038 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0033 0.0142 0.0142
Entamoeba histolytica acyl-coA synthetase, putative 0.0097 0.077 0.1029
Loa Loa (eye worm) hypothetical protein 0.0072 0.0528 0.0574
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0097 0.077 0.247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.016 0.1395 0.1864
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Loa Loa (eye worm) hypothetical protein 0.0097 0.077 0.0838
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1173 0.1173
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0764 0.1021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Loa Loa (eye worm) hypothetical protein 0.0096 0.0764 0.0831
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.04 0.04
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0093 0.0275
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0095 0.0103
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0255 0.2327 0.3108
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0093 0.0275
Toxoplasma gondii glycyl-tRNA synthetase 0.0094 0.0743 0.2382
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0368 0.0368
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0094 0.0743 0.2382
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0076 0.0102
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0035 0.0158 0.0158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0368 0.0492
Plasmodium falciparum proline--tRNA ligase, putative 0.0306 0.2831 0.9077
Loa Loa (eye worm) hypothetical protein 0.0097 0.077 0.0838
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0056 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0171
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0094 0.0743 0.2382
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0035 0.0158 0.0158
Brugia malayi ecdysteroid receptor 0.0056 0.0368 0.0492
Onchocerca volvulus 0.0032 0.0133 0.0277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.264 0.3527
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0093 0.0299
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0777 0.7485 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0093 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0074 0.0074
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0331 0.3085 0.4122
Brugia malayi hypoxia-induced factor 1 0.0156 0.1354 0.1809
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0093 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Brugia malayi hypothetical protein 0.0027 0.0076 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Onchocerca volvulus 0.0031 0.0117 0.0203
Echinococcus granulosus lamin dm0 0.0029 0.0095 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0489 0.1567
Loa Loa (eye worm) hypothetical protein 0.0362 0.339 0.3687
Brugia malayi AMP-binding enzyme family protein 0.0097 0.077 0.1029
Schistosoma mansoni cpg binding protein 0.0031 0.0113 0.0113
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0318 0.0318
Onchocerca volvulus 0.0031 0.0113 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.264 0.3527
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0335 0.3119 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0093 0.0124
Loa Loa (eye worm) steroid hormone receptor 0.0056 0.0368 0.04
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0056 0.0368 0.0368
Toxoplasma gondii seryl-tRNA synthetase, cytoplasmic, putative 0.0038 0.0184 0.0589
Brugia malayi Cytochrome P450 family protein 0.0027 0.008 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0057 0.0371 0.119
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0235 0.2137 0.2855
Leishmania major phosphatidylinositol 4-kinase, putative 0.0035 0.0158 0.0505
Schistosoma mansoni thyroid hormone receptor 0.0178 0.1573 0.1573
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0035 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.0171
Schistosoma mansoni histidyl-tRNA synthetase 0.0057 0.0371 0.0371
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0093 0.0275
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0158 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0235 0.2137 0.2855
Schistosoma mansoni zinc finger protein 0.0027 0.0074 0.0074
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0742 0.7139 0.9538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0764 0.0764
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0056 0.0368 0.04
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0117 0.0117
Giardia lamblia Glycyl-tRNA synthetase 0.0094 0.0743 0.1364
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Onchocerca volvulus 0.0051 0.0318 0.1155
Loa Loa (eye worm) hypothetical protein 0.0072 0.0528 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0368 0.0492
Echinococcus granulosus tumor protein p63 0.035 0.3274 0.3274
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0074 0.0074
Brugia malayi intermediate filament protein 0.0029 0.0095 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.264 0.3527
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0362 0.339 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0158 0.021
Loa Loa (eye worm) oxidoreductase 0.0028 0.0093 0.0101
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0035 0.0158 0.0505
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0158 0.0171
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0093 0.0299
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0093 0.0275
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.057 0.5448 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0743 0.0808
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0764 0.1021
Loa Loa (eye worm) Sars1 protein 0.0038 0.0184 0.02
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0035 0.0158 0.0158
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0094 0.0743 0.0743
Echinococcus multilocularis musashi 0.0029 0.0095 0.0095
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.264 0.3527
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0368 0.0368
Onchocerca volvulus 0.0029 0.0095 0.0097
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0074 0.0099
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0094 0.0743 0.2191
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0154 0.1333 0.1781
Loa Loa (eye worm) hypothetical protein 0.0094 0.0743 0.0808
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.7659 0.7659
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0093 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0368 0.0492
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0093 0.0124
Plasmodium falciparum macrophage migration inhibitory factor 0.0331 0.3085 0.9893
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0094 0.0743 0.0808
Schistosoma mansoni hypothetical protein 0.018 0.159 0.159
Loa Loa (eye worm) phosphatidylinositol 3 0.095 0.9196 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0131 0.1103 0.1103
Echinococcus granulosus muscleblind protein 0.0146 0.1257 0.1257
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0094 0.0743 0.2382
Loa Loa (eye worm) phosphatidylinositol 3 0.0035 0.0158 0.0171
Onchocerca volvulus 0.0028 0.0093 0.009
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0146 0.1257 0.1367
Schistosoma mansoni RAR-like nuclear receptor 0.0056 0.0368 0.0368
Schistosoma mansoni retinoic acid receptor RXR 0.0056 0.0368 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0117 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Leishmania major hypothetical protein, conserved 0.0027 0.0076 0.0244
Loa Loa (eye worm) hypothetical protein 0.0029 0.0095 0.0103
Schistosoma mansoni single-minded 0.005 0.031 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.264 0.3527
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0154 0.1333 0.4275
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0035 0.0158 0.0505
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0335 0.3119 1
Entamoeba histolytica hypothetical protein 0.0035 0.0158 0.021
Brugia malayi nuclear receptor RXR 0.003 0.0106 0.0141
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0097 0.077 0.1029
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0057 0.0371 0.0496
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0074 0.0074
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0154 0.1333 0.1781
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0131 0.1103 0.1474
Brugia malayi Pre-SET motif family protein 0.0212 0.1902 0.2541
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0074 0.0074
Echinococcus multilocularis expressed conserved protein 0.0091 0.0707 0.0707
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0335 0.3119 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0158 0.0505
Schistosoma mansoni metabotropic glutamate receptor 0.0086 0.0664 0.0664
Brugia malayi metabotropic glutamate receptor type 2 0.0086 0.0664 0.0887
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0131 0.1103 0.1103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0158 0.021
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0093 0.0299
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0074 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Schistosoma mansoni threonyl-tRNA synthetase 0.0038 0.0184 0.0184
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0094 0.0743 0.0993
Plasmodium vivax histidine--tRNA ligase, putative 0.0057 0.0371 0.119
Plasmodium vivax serine--tRNA ligase, putative 0.0038 0.0184 0.0589
Loa Loa (eye worm) hypothetical protein 0.0049 0.0294 0.032
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0131 0.1103 0.1474
Brugia malayi Zinc finger, C2H2 type family protein 0.0131 0.1103 0.1474
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0154 0.1333 0.1333
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0141 0.1208 0.1314
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0154 0.1333 0.1333
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0074 0.0099
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0035 0.0158 0.021
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0097 0.077 0.2272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0777 0.7485 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0074 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0489 0.1567
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0057 0.0371 0.0496
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0035 0.0158 0.021
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0181 0.0181
Onchocerca volvulus 0.0051 0.0318 0.1152
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0093 0.0299
Brugia malayi Nuclear hormone receptor-like 1 0.0261 0.2387 0.3189
Schistosoma mansoni seryl-tRNA synthetase 0.0038 0.0184 0.0184
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0035 0.0158 0.0158
Schistosoma mansoni survival motor neuron protein 0.0051 0.0318 0.0318
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0093 0.0275
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0218 0.1964 0.1964
Leishmania major glycyl tRNA synthetase, putative 0.0057 0.0371 0.119
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0074 0.0074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.264 0.3527
Loa Loa (eye worm) hypothetical protein 0.0257 0.2356 0.2562
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0057 0.0371 0.1094
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0181 0.0241
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0094 0.0743 0.0993
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0093 0.0124
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0115
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0335 0.3119 0.9199
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0035 0.0158 0.0505
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0056 0.0368 0.0368
Plasmodium falciparum serine--tRNA ligase, putative 0.0038 0.0184 0.0589
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0158 0.0505
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0035 0.0158 0.0158
Entamoeba histolytica protein kinase rad3, putative 0.0035 0.0158 0.021
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0035 0.0158 0.021
Schistosoma mansoni hypothetical protein 0.004 0.0206 0.0206
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0335 0.3119 1
Giardia lamblia Hypothetical protein 0.0035 0.0158 0.0289
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0154 0.1333 0.4275
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0057 0.0371 0.1094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Onchocerca volvulus Poor gastrulation protein homolog 0.0029 0.0095 0.0101
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.264 0.3527
Loa Loa (eye worm) hypothetical protein 0.0416 0.3927 0.427
Loa Loa (eye worm) hypothetical protein 0.0028 0.0093 0.0101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0097 0.077 0.247
Schistosoma mansoni hypothetical protein 0.004 0.0206 0.0206
Schistosoma mansoni lamin 0.0029 0.0095 0.0095
Onchocerca volvulus 0.0035 0.0158 0.0394
Leishmania major threonyl-tRNA synthetase, putative 0.0094 0.0743 0.2382
Echinococcus multilocularis prolyl tRNA synthetase, mitochondrial 0.0306 0.2831 0.2831
Brugia malayi seryl-tRNA synthetase, mitochondrial precursor, putative 0.0038 0.0184 0.0245
Echinococcus granulosus single minded 2 0.0037 0.0181 0.0181
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0093 0.0124
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0093 0.0275
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0076 0.0102
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0201 0.1799 0.1799
Loa Loa (eye worm) hypothetical protein 0.003 0.0106 0.0115
Echinococcus granulosus lamin 0.0029 0.0095 0.0095
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0154 0.1333 0.1781
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0489 0.1567
Plasmodium falciparum proline--tRNA ligase 0.0094 0.0743 0.2382
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0074 0.0074
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1193 0.352
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0035 0.0158 0.0158
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0069 0.0489 0.1567
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0035 0.0158 0.0505
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0528 0.1693
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0335 0.3119 0.4166
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0038 0.0184 0.0245
Onchocerca volvulus Protein ultraspiracle homolog 0.0056 0.0368 0.1389
Schistosoma mansoni cpg binding protein 0.0032 0.013 0.013
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0093 0.0299
Trypanosoma brucei histidyl-tRNA synthetase 0.0057 0.0371 0.119
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0154 0.1333 0.1333
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0154 0.1333 0.1781
Schistosoma mansoni hypothetical protein 0.004 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0035 0.0158 0.0158
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0029 0.0095 0.0101
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0113 0.0123
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0076 0.0244
Loa Loa (eye worm) glutamate receptor 0.007 0.0499 0.0543
Schistosoma mansoni histidyl-tRNA synthetase 0.0057 0.0371 0.0371
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0235 0.2137 0.2855
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0106 0.0106
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0094 0.0743 0.0993
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0057 0.0371 0.0403
Treponema pallidum threonyl-tRNA synthetase 0.0094 0.0743 0.2191
Schistosoma mansoni metabotropic glutamate receptor 0.0148 0.1276 0.1276
Loa Loa (eye worm) phosphatidylinositol kinase 0.0035 0.0158 0.0171
Brugia malayi Sars1 protein 0.0038 0.0184 0.0245
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0154 0.1333 0.1333
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0294 0.032
Brugia malayi nuclear receptor NHR-88 0.0027 0.0074 0.0099
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0235 0.2137 0.6853
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0045 0.026 0.0283
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0154 0.1333 0.145
Echinococcus granulosus metabotropic glutamate receptor 5 0.0218 0.1964 0.1964
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0235 0.2137 0.2855
Brugia malayi hypothetical protein 0.0251 0.2293 0.3063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.077 0.1029
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.1016 0.1016
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0093 0.0275
Echinococcus multilocularis seryl tRNA synthetase, mitochondrial 0.0038 0.0184 0.0184
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0093 0.0299
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0094 0.0743 0.0993
Echinococcus multilocularis serine protein kinase ATM 0.0035 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0072 0.0528 0.0574
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.04 0.1281
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0158 0.0505
Leishmania major hypothetical protein, unknown function 0.0035 0.0158 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0056 0.0368 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0074 0.0074
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.264 0.7787
Trypanosoma cruzi seryl-tRNA synthetase 0.0038 0.0184 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Onchocerca volvulus 0.0028 0.0093 0.009
Schistosoma mansoni thyroid hormone receptor 0.0178 0.1573 0.1573
Loa Loa (eye worm) hypothetical protein 0.0056 0.0368 0.04
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0235 0.2137 0.2137
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0094 0.0743 0.2148
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0093 0.0275
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0035 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0072 0.0528 0.0574
Loa Loa (eye worm) hypothetical protein 0.0028 0.0093 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0056 0.0368 0.04
Echinococcus multilocularis muscleblind protein 0.0146 0.1257 0.1257
Echinococcus multilocularis geminin 0.018 0.159 0.159
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0035 0.0158 0.0158
Trichomonas vaginalis set domain proteins, putative 0.0241 0.219 0.2925
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0074 0.0081
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0235 0.2137 0.2855
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1031 1 1
Echinococcus granulosus Seryl tRNA Synthetase 0.0038 0.0184 0.0184
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0279 0.2566 0.3428
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0131 0.1103 0.1474
Leishmania major seryl-tRNA synthetase, putative 0.0038 0.0184 0.0589
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0035 0.0158 0.0505
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0056 0.0368 0.0368
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0331 0.3085 0.4122
Brugia malayi Nuclear hormone receptor-like 1 0.0261 0.2387 0.3189
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0335 0.3119 0.4166
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0094 0.0743 0.0743
Schistosoma mansoni glycyl-tRNA synthetase 0.0094 0.0743 0.0743
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0094 0.0743 0.2382
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0056 0.0368 0.0368
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0035 0.0158 0.021
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0094 0.0743 0.0993
Brugia malayi hypothetical protein 0.003 0.0106 0.0141
Schistosoma mansoni threonyl-tRNA synthetase 0.0057 0.0371 0.0371
Toxoplasma gondii tRNA ligase class II core domain (G, H, P, S and T) domain-containing protein 0.0038 0.0184 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0056 0.0368 0.0368
Plasmodium falciparum glycine--tRNA ligase 0.0057 0.0371 0.119
Schistosoma mansoni hypothetical protein 0.0035 0.0158 0.0158
Echinococcus granulosus Threonyl tRNA synthetase C 0.0094 0.0743 0.0743
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0158 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0368 0.0492
Brugia malayi CHE-14 protein 0.0041 0.0221 0.0295
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0074 0.0074
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0093 0.0101
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0764 0.0764
Trichomonas vaginalis seryl-tRNA synthetase, putative 0.0038 0.0184 0.0245
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.036 0.337 0.337
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0158 0.021
Echinococcus granulosus glycyl tRNA synthetase 0.0094 0.0743 0.0743
Leishmania major histidyl-tRNA synthetase, putative 0.0057 0.0371 0.119
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0076 0.0244
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0093 0.0299
Loa Loa (eye worm) hypothetical protein 0.0097 0.077 0.0838
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0094 0.0743 0.2382
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.04 0.04
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0158 0.021
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0235 0.2137 0.2855
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0093 0.0093
Onchocerca volvulus 0.0029 0.0095 0.0097
Leishmania major hypothetical protein, conserved 0.0035 0.0158 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Entamoeba histolytica hypothetical protein 0.0035 0.0158 0.021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0294 0.0393
Treponema pallidum seryl-tRNA synthetase 0.0038 0.0184 0.0542
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.036 0.337 0.337
Brugia malayi steroid hormone receptor 0.0056 0.0368 0.0492
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0093 0.0299
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0094 0.0743 0.0993
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0093 0.0299
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0528 0.1557
Loa Loa (eye worm) hypothetical protein 0.0169 0.1484 0.1614
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0074 0.0099
Giardia lamblia Seryl-tRNA synthetase 0.0038 0.0184 0.0337
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0158 0.021
Onchocerca volvulus 0.0097 0.077 0.329
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0035 0.0158 0.021
Chlamydia trachomatis histidine--tRNA ligase 0.0057 0.0371 0.0584
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0035 0.0158 0.0158
Echinococcus multilocularis lamin dm0 0.0029 0.0095 0.0095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0074 0.0074
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0154 0.1333 0.1781
Echinococcus multilocularis glycyl tRNA synthetase 0.0094 0.0743 0.0743
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0035 0.0158 0.0505
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.264 0.4846
Loa Loa (eye worm) hypothetical protein 0.0056 0.0368 0.04
Leishmania major macrophage migration inhibitory factor-like protein 0.0331 0.3085 0.9893
Brugia malayi Nuclear hormone receptor-like 1 0.0287 0.2649 0.354
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0331 0.3085 0.9893
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0056 0.0368 0.0492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0095 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0056 0.0368 0.04
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0074 0.0074
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0093 0.0093
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0362 0.339 0.4529
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0056 0.0368 0.0368
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0094 0.0743 0.2382
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0221 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.077 0.2272
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0131 0.1103 0.1474
Echinococcus multilocularis cpg binding protein 0.0032 0.013 0.013
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0335 0.3119 0.9199
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0094 0.0743 0.0808
Brugia malayi nuclear hormone receptor 0.0056 0.0368 0.0492
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.077 0.2272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.264 0.3527
Loa Loa (eye worm) hypothetical protein 0.0056 0.0368 0.04
Plasmodium vivax proline--tRNA ligase, putative 0.0094 0.0743 0.2382
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0131 0.1103 0.1474
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0093 0.0299
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0154 0.1333 0.4275
Onchocerca volvulus 0.0241 0.219 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.04 0.1178
Echinococcus granulosus intermediate filament protein 0.0029 0.0095 0.0095
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0035 0.0158 0.021
Entamoeba histolytica hypothetical protein 0.0035 0.0158 0.021
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0094 0.0743 0.0993
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.04 0.04
Brugia malayi photoreceptor-specific nuclear receptor 0.0056 0.0368 0.0492
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0777 0.7485 1
Plasmodium vivax threonine--tRNA ligase, putative 0.0094 0.0743 0.2382
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0035 0.0158 0.0158
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0652 0.6252 0.8353
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0035 0.0158 0.0505
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0154 0.1333 0.4275
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0056 0.0368 0.0368
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0154 0.1333 0.4275
Echinococcus multilocularis protein dispatched 1 0.0047 0.0278 0.0278
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0093 0.0124
Loa Loa (eye worm) DR-78 0.0027 0.0074 0.0081
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0094 0.0743 0.2382
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0318 0.0425
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.077 0.2238
Toxoplasma gondii anticodon binding domain-containing protein 0.0057 0.0371 0.119
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.01 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0158 0.021
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.0074 0.0074
Giardia lamblia Threonyl-tRNA synthetase 0.0094 0.0743 0.1364
Schistosoma mansoni hypothetical protein 0.018 0.159 0.159
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0181 0.0533
Echinococcus multilocularis thyroid hormone receptor alpha 0.0178 0.1573 0.1573
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0146 0.1257 0.1367
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.1354 0.1473
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0074 0.0099
Loa Loa (eye worm) glutamate receptor 0.0177 0.156 0.1696
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0117 0.0117
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0294 0.0393
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0035 0.0158 0.0505
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0131 0.1103 0.1103
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0117 0.0117
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0097 0.077 0.2272
Treponema pallidum glycyl-tRNA synthetase 0.0057 0.0371 0.1094
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0235 0.2137 0.2855
Loa Loa (eye worm) hypothetical protein 0.0045 0.026 0.0283
Echinococcus multilocularis protein patched 0.0041 0.0221 0.0221
Echinococcus granulosus geminin 0.018 0.159 0.159
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0074 0.0074
Plasmodium falciparum histidine--tRNA ligase, putative 0.0057 0.0371 0.119
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0093 0.0299
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0106 0.0106
Onchocerca volvulus 0.0056 0.0368 0.1389
Schistosoma mansoni hypothetical protein 0.0051 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0027 0.0074 0.0081
Trichomonas vaginalis seryl-tRNA synthetase, putative 0.0038 0.0184 0.0245
Schistosoma mansoni steroid hormone receptor ad4bp 0.0056 0.0368 0.0368
Toxoplasma gondii serine--tRNA ligase 0.0038 0.0184 0.0589
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0106 0.0106
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0094 0.0743 0.0743
Leishmania major phosphatidylinositol kinase related protein, putative 0.0035 0.0158 0.0505
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0154 0.1333 0.1781
Giardia lamblia GTOR 0.0035 0.0158 0.0289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0056 0.0368 0.04
Treponema pallidum prolyl-tRNA synthetase 0.0362 0.339 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0 Cytotoxicity against human breast carcinoma, MCF7 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human erythroleukemia TF1 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human breast carcinoma, BT20 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against rat prostate carcinoma, MatLyLu cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human osteosarcoma, ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human epidermoid carcinoma, A431 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human melanoma, A375 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human lung carcinoma, A549 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human colon carcinoma, HCT15 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human bladder carcinoma, HT1376 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human ovarian teratocarcinoma, PA1 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human hepatoma, HEPG2 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against HEK293 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human fibroblast, BUD8 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human Burkitt lymphoma, RAMOS cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human Burkitt lymphoma, DAUDI cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human uterine sarcoma, MES-SA cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human uterine sarcoma, MES-SA-Dx5 cells derived from MES-SA ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against murine cytotoxic T cells, CTLL2 ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human erythroleukemia TF1 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human breast carcinoma, BT20 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human osteosarcoma, ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human epidermoid carcinoma, A431 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human melanoma, A375 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human lung carcinoma, A549 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human colon carcinoma, HCT15 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human bladder carcinoma, HT1376 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human ovarian teratocarcinoma, PA1 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human hepatoma, HEPG2 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against HEK293 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human fibroblast, BUD8 cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human Burkitt lymphoma, RAMOS cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human Burkitt lymphoma, DAUDI cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human uterine sarcoma, MES-SA cells ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against human uterine sarcoma, MES-SA-Dx5 cells derived from MES-SA ChEMBL. 16236503
IC50 (functional) > 20 uM Cytotoxicity against murine cytotoxic T cells, CTLL2 ChEMBL. 16236503
Inhibition (functional) = 31 % Inhibition of blood vessel growth in rat aorta at 0.1 ug/mL ChEMBL. 16236503
Inhibition (functional) = 42 % Inhibition of blood vessel growth in rat aorta at 10 ug/mL ChEMBL. 16236503
Inhibition (functional) = 53 % Inhibition of blood vessel growth in rat aorta at 1 ug/mL ChEMBL. 16236503
Inhibition (functional) = 100 % Inhibition of blood vessel growth in rat aorta at 100 ug/mL ChEMBL. 16236503

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.