Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 20 nM | Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortex | ChEMBL. | 16236497 |
Ki (binding) | = 20 nM | Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortex | ChEMBL. | 16236497 |
Ki (binding) | = 59.8 nM | Displacement of [3H]GBR-12935 from DAT in rat rat frontoparietal cerebral cortex | ChEMBL. | 16236497 |
Ki (binding) | = 59.8 nM | Displacement of [3H]GBR-12935 from DAT in rat rat frontoparietal cerebral cortex | ChEMBL. | 16236497 |
Ki (binding) | > 30000 nM | Displacement of [3H]nisoxetine from NET in rat caudate-putamen | ChEMBL. | 16236497 |
Ki (binding) | > 30000 nM | Displacement of [3H]nisoxetine from NET in rat caudate-putamen | ChEMBL. | 16236497 |
Ratio Ki (binding) | = 3 | Selectivity for SERT over DAT | ChEMBL. | 16236497 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.