Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | dihydrofolate reductase family protein | 0.0336 | 0.0574 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0336 | 0.0574 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0653 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0336 | 0.0574 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0653 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0653 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0653 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0336 | 0.0574 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0336 | 0.0574 | 1 |
Onchocerca volvulus | 0.0317 | 0 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.0336 | 0.0574 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0336 | 0.0574 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0336 | 0.0574 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0336 | 0.0574 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0653 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0336 | 0.0574 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Inhibition of TXB2 production in Sprague-Dawley rat whole blood | ChEMBL. | 16392799 |
IC50 (binding) | = 22 uM | Inhibition of cytosolic phospholipase A2alpha in GLU micelle assay | ChEMBL. | 16392799 |
IC50 (binding) | = 22 uM | Inhibition of cytosolic phospholipase A2alpha in GLU micelle assay | ChEMBL. | 16392799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.