Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Homo sapiens | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3363 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1584 | 0.4307 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1584 | 0.4307 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3363 | 1 | 1 |
Onchocerca volvulus | 0.0238 | 0 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3363 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1584 | 0.4307 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.3363 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3363 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1584 | 0.4307 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1584 | 0.4307 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1584 | 0.4307 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0634 | 0.1266 | 0.1266 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3363 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.3363 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3363 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.3363 | 1 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 0.1266 | 0.1266 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 40 nM | Displacement of [3H]U69593 from cloned human kappa opioid receptor | ChEMBL. | 16236510 |
Ki (binding) | = 40 nM | Displacement of [3H]U69593 from cloned human kappa opioid receptor | ChEMBL. | 16236510 |
Ki (binding) | = 138 nM | Displacement of [3H]DPDPE from cloned human delta opioid receptor | ChEMBL. | 16236510 |
Ki (binding) | = 138 nM | Displacement of [3H]DPDPE from cloned human delta opioid receptor | ChEMBL. | 16236510 |
Ki (binding) | = 235 nM | Displacement of [3H]DAMGO from cloned human mu opioid receptor | ChEMBL. | 16236510 |
Ki (binding) | = 235 nM | Displacement of [3H]DAMGO from cloned human mu opioid receptor | ChEMBL. | 16236510 |
Ratio Ki (binding) | = 0.29 | Selectivity for cloned human kappa opioid receptor over delta opioid receptor | ChEMBL. | 16236510 |
Ratio Ki (binding) | = 1.7 | Selectivity for cloned human mu opioid receptor over delta opioid receptor | ChEMBL. | 16236510 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.