Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0436 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0162 | 0.3092 | 0.3092 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0074 | 0.0864 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0074 | 0.0864 | 0.5 |
Onchocerca volvulus | 0.0162 | 0.3092 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0074 | 0.0864 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0074 | 0.0864 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0074 | 0.0864 | 0.0864 |
Onchocerca volvulus | 0.0074 | 0.0864 | 0.2794 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3092 | 0.3092 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Onchocerca volvulus | 0.0074 | 0.0864 | 0.2794 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0864 | 0.0864 |
Echinococcus granulosus | acetylcholinesterase | 0.0436 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0074 | 0.0864 | 0.0864 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0074 | 0.0864 | 0.0864 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0864 | 0.0864 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0162 | 0.3092 | 0.3092 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0162 | 0.3092 | 0.3092 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0074 | 0.0864 | 0.0864 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0074 | 0.0864 | 0.0864 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0864 | 0.0864 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0162 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | carboxylesterase | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | carboxylesterase | 0.0436 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0436 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0436 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0162 | 0.3092 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Onchocerca volvulus | 0.0074 | 0.0864 | 0.2794 | |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3092 | 0.3092 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0074 | 0.0864 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0074 | 0.0864 | 0.0864 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0074 | 0.0864 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0162 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0162 | 0.3092 | 0.3092 |
Echinococcus multilocularis | serotonin transporter | 0.0162 | 0.3092 | 0.3092 |
Onchocerca volvulus | 0.0074 | 0.0864 | 0.2794 | |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Brugia malayi | Carboxylesterase family protein | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 1 | 1 |
Onchocerca volvulus | 0.0074 | 0.0864 | 0.2794 | |
Echinococcus granulosus | serotonin transporter | 0.0162 | 0.3092 | 0.3092 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0864 | 0.0864 |
Echinococcus multilocularis | neuroligin | 0.0074 | 0.0864 | 0.0864 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Echinococcus multilocularis | acetylcholinesterase | 0.0436 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0074 | 0.0864 | 0.0864 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3092 | 0.3092 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 27 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 27 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 44 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 44 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 81 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 81 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Ki (binding) | = 7.85 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Log Ki (binding) | = 7.85 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.