Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0153 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0153 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0153 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 | |
Inhibition (binding) | Displacement of [3H]NECA from recombinant human adenosine A3 receptor expressed in HeLa cells at 1uM | ChEMBL. | 16392813 | |
Inhibition (binding) | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 | |
Inhibition (binding) | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 | |
Inhibition (binding) | 0 | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | 0 | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | 0 | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | 0 | Displacement of [3H]NECA from recombinant human adenosine A3 receptor expressed in HeLa cells at 1uM | ChEMBL. | 16392813 |
Log Ki (binding) | 0 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Log Ki (binding) | 0 | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 |
Log Ki (binding) | 0 | Binding affinity to recombinant human adenosine A1 receptor | ChEMBL. | 16392813 |
Log Ki (binding) | 0 | Binding affinity to recombinant human adenosine A3 receptor | ChEMBL. | 16392813 |
Log Ki (binding) | 0 | Binding affinity to rat adenosine A2A receptor | ChEMBL. | 16392813 |
Log Ki (binding) | 0 | Binding affinity to rat adenosine A1 receptor | ChEMBL. | 16392813 |
pA2 (functional) | Antagonist potency at cloned recombinant human adenosine A2A receptor transfected in CHO cells by cAMP assay | ChEMBL. | 16392813 | |
pA2 (functional) | Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay | ChEMBL. | 16392813 | |
pA2 (functional) | Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle | ChEMBL. | 16392813 | |
pA2 (functional) | Antagonist potency against adenosine A2A receptor of Sprague-Dawley rat aortic smooth muscle | ChEMBL. | 16392813 | |
pA2 (functional) | 0 | Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay | ChEMBL. | 16392813 |
pA2 (functional) | 0 | Antagonist potency at cloned recombinant human adenosine A2A receptor transfected in CHO cells by cAMP assay | ChEMBL. | 16392813 |
pA2 (functional) | 0 | Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle | ChEMBL. | 16392813 |
pA2 (functional) | 0 | Antagonist potency against adenosine A2A receptor of Sprague-Dawley rat aortic smooth muscle | ChEMBL. | 16392813 |
pKi (binding) | Binding affinity to recombinant human adenosine A1 receptor | ChEMBL. | 16392813 | |
pKi (binding) | Binding affinity to rat adenosine A2A receptor | ChEMBL. | 16392813 | |
pKi (binding) | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 | |
pKi (binding) | Binding affinity to recombinant human adenosine A3 receptor | ChEMBL. | 16392813 | |
pKi (binding) | Binding affinity to rat adenosine A1 receptor | ChEMBL. | 16392813 | |
pKi (binding) | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 | |
Ratio Ki (binding) | Selectivity for human adenosine A2B over human adenosine A2A receptor | ChEMBL. | 16392813 | |
Ratio Ki (binding) | 0 | Selectivity for human adenosine A2B over human adenosine A2A receptor | ChEMBL. | 16392813 |
Ratio Ki (binding) | 0 | Selectivity for human adenosine A2B over human adenosine A3 receptor | ChEMBL. | 16392813 |
Ratio Ki (binding) | 0 | Selectivity for human adenosine A2B over human adenosine A1 receptor | ChEMBL. | 16392813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.