Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0513 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0513 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0513 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0513 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0513 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0513 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0513 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0513 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0513 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0513 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0513 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 57 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 57 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 93 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 93 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 96 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 96 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Ki (binding) | = 7.81 | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 |
Ki (binding) | = 8.33 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Log Ki (binding) | = 7.81 | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 |
Log Ki (binding) | = 8.33 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Ratio Ki (binding) | = 3.3 | Selectivity for human adenosine A2B over human adenosine A2A receptor | ChEMBL. | 16392813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.