Detailed information for compound 349108

Basic information

Technical information
  • TDR Targets ID: 349108
  • Name: 5-(1,3-benzodioxol-5-yl)-N-[4-[2-(4-methylpip erazin-1-yl)ethyl]phenyl]-2-oxo-1H-pyridine-3 -carboxamide
  • MW: 460.525 | Formula: C26H28N4O4
  • H donors: 2 H acceptors: 3 LogP: 3.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)CCc1ccc(cc1)NC(=O)c1cc(cnc1O)c1ccc2c(c1)OCO2
  • InChi: 1S/C26H28N4O4/c1-29-10-12-30(13-11-29)9-8-18-2-5-21(6-3-18)28-26(32)22-14-20(16-27-25(22)31)19-4-7-23-24(15-19)34-17-33-23/h2-7,14-16H,8-13,17H2,1H3,(H,27,31)(H,28,32)
  • InChiKey: JNAZGEGXKHNDBG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(1,3-benzodioxol-5-yl)-N-[4-[2-(4-methyl-1-piperazinyl)ethyl]phenyl]-2-oxo-1H-pyridine-3-carboxamide
  • 5-(1,3-benzodioxol-5-yl)-2-keto-N-[4-[2-(4-methylpiperazino)ethyl]phenyl]-1H-pyridine-3-carboxamide
  • 5-(1,3-benzodioxol-5-yl)-2-keto-N-[4-[2-(4-methylpiperazin-1-yl)ethyl]phenyl]-1H-pyridine-3-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase References
Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) Starlite/ChEMBL References
Homo sapiens breakpoint cluster region Starlite/ChEMBL References
Homo sapiens insulin-like growth factor 1 receptor Starlite/ChEMBL References
Homo sapiens insulin receptor Starlite/ChEMBL References
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL References
Homo sapiens anaplastic lymphoma receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132231 All targets in OG5_132231
Echinococcus granulosus insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) TK/ALK protein kinase Get druggable targets OG5_132231 All targets in OG5_132231
Schistosoma japonicum ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum ko:K04527 insulin receptor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis active breakpoint cluster region Get druggable targets OG5_131841 All targets in OG5_131841
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Loa Loa (eye worm) TK/INSR protein kinase Get druggable targets OG5_129857 All targets in OG5_129857
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum IPR008957,Fibronectin, type III-like fold,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_132231 All targets in OG5_132231
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus active breakpoint cluster region Get druggable targets OG5_131841 All targets in OG5_131841
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0103 0.1377 0.1377
Schistosoma mansoni tyrosine kinase 0.0322 0.5216 0.5216
Loa Loa (eye worm) hypothetical protein 0.0101 0.1326 0.1326
Echinococcus multilocularis Cyclin L1 0.0029 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0101 0.1326 0.1326
Schistosoma mansoni cyclins 0.012 0.1665 0.1665
Echinococcus multilocularis protein kinase shaggy 0.0103 0.1377 0.1377
Leishmania major casein kinase II, putative 0.0075 0.0878 0.2503
Echinococcus multilocularis unc 13 (munc13) 0.0032 0.0121 0.0121
Schistosoma mansoni protein kinase 0.0075 0.0878 0.0878
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.007 0.007
Echinococcus granulosus cyclins 0.0029 0.007 0.007
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0086 0.1076 0.1076
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.1942 0.1942
Echinococcus granulosus dual specificity mitogen activated protein 0.0161 0.2389 0.2389
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.007 0.0798 0.0798
Brugia malayi Protein kinase c protein 2 0.0119 0.1648 0.1648
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1205 0.1205
Trypanosoma brucei mitotic cyclin 6 0.0213 0.3299 1
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0046 0.0367 0.0367
Echinococcus granulosus cyclin dependent kinase 0.0094 0.1205 0.1205
Echinococcus granulosus casein kinase I alpha 0.0046 0.0367 0.0367
Echinococcus granulosus tyrosine protein kinase ABL1 0.0261 0.4147 0.4147
Loa Loa (eye worm) cyclin domain-containing protein 0.0265 0.4213 0.4213
Trichomonas vaginalis cyclin B, putative 0.012 0.1665 0.5048
Schistosoma mansoni tyrosine kinase 0.0141 0.2041 0.2041
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0101 0.1326 0.1326
Trichomonas vaginalis CK1 family protein kinase 0.0046 0.0367 0.1112
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0878 0.2662
Plasmodium falciparum protein kinase 7 0.0302 0.4853 1
Trichomonas vaginalis cyclin B3, putative 0.012 0.1665 0.5048
Echinococcus granulosus cyclins 0.012 0.1665 0.1665
Trypanosoma brucei cdc2-related kinase 1 0.0094 0.1205 0.3651
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.1543 0.4676
Plasmodium falciparum NIMA related kinase 1 0.0111 0.1507 0.3004
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0103 0.1377 0.4046
Trichomonas vaginalis STE family protein kinase 0.0111 0.1507 0.4568
Trichomonas vaginalis cyclins, putative 0.0213 0.3299 1
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0046 0.0367 0.0919
Entamoeba histolytica cyclin family protein 0.012 0.1665 0.5048
Brugia malayi cyclin fold protein 1 variant b 0.0029 0.007 0.007
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0029 0.007 0.007
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0104 0.1386 0.1386
Entamoeba histolytica diacylglycerol kinase, putative 0.0028 0.005 0.0151
Entamoeba histolytica casein kinase, putative 0.0075 0.0878 0.2662
Echinococcus granulosus cyclin y 0.0029 0.007 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.1543 0.4676
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0878 0.2662
Echinococcus granulosus cyclin 0.0029 0.007 0.007
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.1205 0.3651
Echinococcus multilocularis RNA directed DNA polymerase 0.0079 0.0947 0.0947
Trichomonas vaginalis cyclins, putative 0.0213 0.3299 1
Brugia malayi Pleckstrin Homology Domain 0.0028 0.005 0.005
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0028 0.005 0.005
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0031 0.0115 0.0115
Trypanosoma brucei cyclin 3 0.0029 0.007 0.0213
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0029 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0034 0.0159 0.0159
Brugia malayi Protein kinase domain containing protein 0.0354 0.5775 0.5775
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1377 0.4173
Schistosoma mansoni cyclin l 0.0029 0.007 0.007
Echinococcus granulosus cyclin B3 1 0.012 0.1665 0.1665
Toxoplasma gondii hypothetical protein 0.0091 0.1158 0.2386
Brugia malayi Carboxylesterase family protein 0.0101 0.1326 0.1326
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.007 0.007
Brugia malayi Cyclin C 0.0029 0.007 0.007
Schistosoma mansoni tyrosine kinase 0.0141 0.2041 0.2041
Trypanosoma brucei cyclin 9 0.0029 0.007 0.0213
Echinococcus multilocularis cyclins 0.012 0.1665 0.1665
Schistosoma mansoni serine/threonine protein kinase 0.0354 0.5775 0.5775
Giardia lamblia Kinase, CMGC CDK 0.0094 0.1205 0.3513
Onchocerca volvulus 0.0038 0.0224 0.0534
Echinococcus granulosus insulin receptor 0.0322 0.5216 0.5216
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Brugia malayi hypothetical protein 0.0034 0.0159 0.0159
Echinococcus multilocularis protein kinase c eta type 0.0028 0.005 0.005
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.007 0.007
Brugia malayi Cyclin, N-terminal domain containing protein 0.0213 0.3299 0.3299
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Trichomonas vaginalis cyclin B3, putative 0.0029 0.007 0.0213
Trypanosoma cruzi casein kinase, putative 0.0046 0.0367 0.0919
Echinococcus granulosus protein kinase C gamma type 0.0108 0.1455 0.1455
Plasmodium falciparum cyclin 0.012 0.1665 0.3335
Schistosoma mansoni BC026374 protein (S09 family) 0.0101 0.1326 0.1326
Brugia malayi protein kinase C3,putative 0.0036 0.0193 0.0193
Echinococcus granulosus twitchin 0.0027 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0034 0.0159 0.0159
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0113 0.1543 0.456
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.1205 0.3651
Echinococcus granulosus casein kinase I alpha 0.0046 0.0367 0.0367
Echinococcus multilocularis Rac GTPase activating protein 1 0.0028 0.0051 0.0051
Schistosoma mansoni diacylglycerol kinase theta 0.0028 0.005 0.005
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.1543 0.4676
Echinococcus multilocularis casein kinase I delta 0.0046 0.0367 0.0367
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0215 0.3326 0.3326
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0367 0.0367
Echinococcus granulosus unc 13 munc13 0.0032 0.0121 0.0121
Trichomonas vaginalis cyclin B, putative 0.0029 0.007 0.0213
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0101 0.1326 0.5
Brugia malayi Carboxylesterase family protein 0.0595 1 1
Schistosoma mansoni cyclin B 0.0213 0.3299 0.3299
Echinococcus multilocularis cyclin y 0.0029 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Echinococcus multilocularis acetylcholinesterase 0.0595 1 1
Echinococcus granulosus protein kinase c eta type 0.0028 0.005 0.005
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0036 0.0193 0.0193
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0091 0.1161 0.1161
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.007 0.007
Schistosoma mansoni protein kinase 0.0215 0.3326 0.3326
Echinococcus granulosus MAM 0.0034 0.0159 0.0159
Toxoplasma gondii protein kinase, putative 0.0302 0.4853 1
Schistosoma mansoni rac gtpase activating protein 0.0028 0.0051 0.0051
Echinococcus multilocularis cyclin B3 1 0.012 0.1665 0.1665
Loa Loa (eye worm) RasGEF domain-containing protein 0.0028 0.005 0.005
Giardia lamblia Kinase, NEK 0.0111 0.1507 0.445
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.007 0.007
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.007 0.007
Giardia lamblia Kinase, NEK 0.0111 0.1507 0.445
Echinococcus multilocularis mitogen activated protein kinase 3 0.0113 0.1543 0.1543
Echinococcus granulosus cyclin t1 0.0029 0.007 0.007
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0036 0.0193 0.0193
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.1205 0.3513
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0261 0.4145 0.4145
Echinococcus granulosus cyclin dependent kinase 5 0.0094 0.1205 0.1205
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0256 0.4054 0.4054
Echinococcus multilocularis cyclin b3 0.012 0.1665 0.1665
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0038 0.0224 0.0475
Entamoeba histolytica hypothetical protein 0.0029 0.007 0.0213
Echinococcus granulosus cyclin dependent kinase 1 0.0094 0.1205 0.1205
Loa Loa (eye worm) cyclin C 0.0029 0.007 0.007
Echinococcus multilocularis cyclin 0.0029 0.007 0.007
Schistosoma mansoni atypical protein kinase C 0.0053 0.0487 0.0487
Entamoeba histolytica hypothetical protein 0.0028 0.005 0.0151
Schistosoma mansoni tyrosine kinase 0.015 0.2194 0.2194
Schistosoma mansoni tyrosine kinase 0.015 0.2194 0.2194
Plasmodium falciparum casein kinase 1 0.0046 0.0367 0.062
Plasmodium falciparum glycogen synthase kinase 3 0.0103 0.1377 0.2732
Schistosoma mansoni tyrosine kinase 0.0322 0.5216 0.5216
Echinococcus granulosus cyclin k 0.0029 0.007 0.007
Toxoplasma gondii casein kinase I 0.0046 0.0367 0.0756
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0045 0.0045
Echinococcus multilocularis para nitrobenzyl esterase 0.0101 0.1326 0.1326
Schistosoma mansoni protein kinase 0.0215 0.3326 0.3326
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0113 0.1543 0.456
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.1543 0.1543
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0029 0.007 0.0145
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0094 0.1205 0.3513
Trypanosoma cruzi casein kinase, putative 0.0046 0.0367 0.0919
Brugia malayi Protein kinase domain containing protein 0.0293 0.4697 0.4697
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0103 0.1377 0.2837
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0103 0.1377 0.1377
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0878 0.2662
Onchocerca volvulus 0.0034 0.0159 0.0337
Onchocerca volvulus 0.0101 0.1326 0.3929
Echinococcus multilocularis carboxylesterase 5A 0.0595 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0113 0.1543 0.1543
Plasmodium vivax glycogen synthase kinase 3, putative 0.0103 0.1377 0.9093
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0256 0.4054 0.4054
Brugia malayi Ras association domain family 1 isoform A 0.0028 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.007 0.0213
Giardia lamblia Hypothetical protein 0.012 0.1665 0.494
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.1205 0.3651
Echinococcus multilocularis cyclin B 0.0213 0.3299 0.3299
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0027 0.0045 0.0045
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.1205 0.1205
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.1205 0.3513
Trypanosoma cruzi casein kinase II, putative 0.0075 0.0878 0.2503
Entamoeba histolytica casein kinase 1, putative 0.0046 0.0367 0.1112
Echinococcus granulosus cyclin B 0.0213 0.3299 0.3299
Echinococcus multilocularis epidermal growth factor receptor 0.015 0.2194 0.2194
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0101 0.1326 0.1326
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0086 0.1077 0.1077
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0075 0.0878 0.5624
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0046 0.0367 0.0367
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0878 0.2662
Echinococcus multilocularis casein kinase I alpha 0.0046 0.0367 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0193 0.0193
Mycobacterium ulcerans carboxylesterase, LipT 0.0101 0.1326 0.5
Echinococcus granulosus cyclin b3 0.012 0.1665 0.1665
Echinococcus multilocularis cyclins 0.012 0.1665 0.1665
Schistosoma mansoni cyclin G 0.0029 0.007 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0878 0.2662
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0113 0.1543 0.456
Trypanosoma cruzi cdc2-related kinase 3 0.0094 0.1205 0.3513
Onchocerca volvulus Cyclin L homolog 0.0029 0.007 0.0063
Echinococcus granulosus Protein kinase C brain isozyme 0.0136 0.1942 0.1942
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0231 0.3618 0.3618
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0101 0.1326 0.1326
Loa Loa (eye worm) hypothetical protein 0.0101 0.1326 0.1326
Entamoeba histolytica cyclin family protein 0.012 0.1665 0.5048
Toxoplasma gondii cyclin 4, putative 0.0029 0.007 0.0145
Echinococcus multilocularis casein kinase I alpha 0.0046 0.0367 0.0367
Giardia lamblia G2/mitotic-specific cyclin B 0.0213 0.3299 1
Loa Loa (eye worm) carboxylesterase 0.0101 0.1326 0.1326
Brugia malayi RhoGAP domain containing protein 0.0031 0.0115 0.0115
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0103 0.1377 0.4046
Trypanosoma brucei protein kinase, putative 0.0103 0.1377 0.4173
Trichomonas vaginalis cyclins, putative 0.0029 0.007 0.0213
Echinococcus granulosus cyclins 0.012 0.1665 0.1665
Echinococcus multilocularis casein kinase ii subunit alpha 0.0075 0.0878 0.0878
Loa Loa (eye worm) hypothetical protein 0.0101 0.1326 0.1326
Echinococcus multilocularis BC026374 protein (S09 family) 0.0101 0.1326 0.1326
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0322 0.5216 0.5216
Trichomonas vaginalis cyclins, putative 0.0029 0.007 0.0213
Leishmania major casein kinase, putative 0.0046 0.0367 0.0919
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0036 0.0193 0.0193
Onchocerca volvulus 0.0101 0.1326 0.3929
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0113 0.1543 0.456
Echinococcus multilocularis cyclin dependent kinase 0.0094 0.1205 0.1205
Echinococcus multilocularis cyclin dependent kinase 1 0.0094 0.1205 0.1205
Trypanosoma brucei casein kinase I, isoform 2 0.0046 0.0367 0.1112
Echinococcus multilocularis raf serine:threonine protein kinase 0.0468 0.7769 0.7769
Echinococcus multilocularis cyclin k 0.0029 0.007 0.007
Trichomonas vaginalis cyclins, putative 0.012 0.1665 0.5048
Schistosoma mansoni hypothetical protein 0.0029 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.007 0.0213
Loa Loa (eye worm) hypothetical protein 0.0085 0.1061 0.1061
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.015 0.2194 0.2194
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0878 0.2662
Toxoplasma gondii cyclin dependent kinase binding protein 0.0029 0.007 0.0145
Loa Loa (eye worm) TK/ABL protein kinase 0.0261 0.4147 0.4147
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0558 0.0558
Schistosoma mansoni neuroligin 3 (S09 family) 0.0101 0.1326 0.1326
Onchocerca volvulus 0.0101 0.1326 0.3929
Loa Loa (eye worm) TK/EGFR protein kinase 0.015 0.2194 0.2194
Trypanosoma cruzi cyclin 6, putative 0.0213 0.3299 1
Loa Loa (eye worm) hypothetical protein 0.025 0.3946 0.3946
Brugia malayi Carboxylesterase family protein 0.0101 0.1326 0.1326
Entamoeba histolytica casein kinase, putative 0.0046 0.0367 0.1112
Loa Loa (eye worm) cyclin domain-containing protein 0.0231 0.3618 0.3618
Trichomonas vaginalis CMGC family protein kinase 0.0094 0.1205 0.3651
Plasmodium falciparum protein kinase 5 0.0094 0.1205 0.2372
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0028 0.0051 0.0051
Entamoeba histolytica protein kinase domain containing protein 0.0075 0.0878 0.2662
Brugia malayi hypothetical protein 0.0029 0.007 0.007
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0161 0.2389 0.7182
Echinococcus granulosus casein kinase I delta 0.0046 0.0367 0.0367
Echinococcus granulosus Diacylglycerol kinase theta 0.0028 0.005 0.005
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0595 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0113 0.1543 0.456
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0113 0.1543 0.4676
Echinococcus granulosus protein kinase c iota type 0.0053 0.0487 0.0487
Entamoeba histolytica cyclin, putative 0.012 0.1665 0.5048
Echinococcus multilocularis serine threonine protein kinase 0.0108 0.1455 0.1455
Trypanosoma brucei Casein kinase II 0.0075 0.0878 0.2662
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0029 0.007 0.007
Echinococcus granulosus cyclins 0.012 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0062 0.0655 0.0655
Echinococcus granulosus epidermal growth factor receptor 0.015 0.2194 0.2194
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0036 0.0193 0.0193
Plasmodium vivax casein kinase 1, putative 0.0046 0.0367 0.2065
Brugia malayi cell division control protein 2 homolog 0.0094 0.1205 0.1205
Onchocerca volvulus Protein CNPPD1 homolog 0.0029 0.007 0.0063
Echinococcus multilocularis cyclin A3 4 0.0029 0.007 0.007
Entamoeba histolytica cyclin, putative 0.0213 0.3299 1
Echinococcus multilocularis cyclin G2 0.0029 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0028 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Trichomonas vaginalis cyclin B3, putative 0.0029 0.007 0.0213
Echinococcus granulosus mitogen activated protein kinase 3 0.0113 0.1543 0.1543
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0213 0.3299 1
Schistosoma mansoni Cyclin fold protein 0.0029 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0595 1 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0322 0.5216 0.5216
Entamoeba histolytica cyclin, domain containing protein 0.0029 0.007 0.0213
Echinococcus multilocularis mitogen activated protein kinase 0.0113 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.007
Echinococcus granulosus carboxylesterase 5A 0.0595 1 1
Leishmania major cyclin 0.0213 0.3299 1
Echinococcus granulosus protein kinase shaggy 0.0103 0.1377 0.1377
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0215 0.3326 0.3326
Schistosoma mansoni serine/threonine protein kinase 0.0468 0.7769 0.7769
Entamoeba histolytica protein kinase domain containing protein 0.0103 0.1377 0.4173
Echinococcus granulosus G1:S specific cyclin D1 0.0029 0.007 0.007
Echinococcus multilocularis epidermal growth factor receptor 0.015 0.2194 0.2194
Trypanosoma brucei protein kinase, putative 0.0113 0.1543 0.4676
Echinococcus granulosus Cyclin L1 0.0029 0.007 0.007
Onchocerca volvulus 0.0101 0.1326 0.3929
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0029 0.007 0.007
Echinococcus granulosus cyclins 0.012 0.1665 0.1665
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0094 0.1205 0.1205
Loa Loa (eye worm) hypothetical protein 0.0206 0.3183 0.3183
Loa Loa (eye worm) hypothetical protein 0.0213 0.3299 0.3299
Brugia malayi Protein kinase domain containing protein 0.0181 0.2739 0.2739
Trichomonas vaginalis AGC family protein kinase 0.0111 0.1507 0.4568
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0086 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Schistosoma mansoni protein kinase C 0.0032 0.0121 0.0121
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0029 0.007 0.007
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.007 0.007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0113 0.1543 0.456
Echinococcus multilocularis protein kinase c iota type 0.0053 0.0487 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.007 0.0213
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0111 0.1507 1
Loa Loa (eye worm) hypothetical protein 0.0595 1 1
Schistosoma mansoni unc-13 (munc13) 0.0032 0.0121 0.0121
Echinococcus multilocularis dual specificity mitogen activated protein 0.0161 0.2389 0.2389
Echinococcus multilocularis tyrosine protein kinase Abl 0.0111 0.1512 0.1512
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.007 0.007
Loa Loa (eye worm) cyclin domain-containing protein 0.0029 0.007 0.007
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.1205 0.1205
Brugia malayi Protein kinase domain containing protein 0.0322 0.5216 0.5216
Schistosoma mansoni hypothetical protein 0.0034 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0101 0.1326 0.1326
Trypanosoma cruzi cdc2-related kinase 1 0.0094 0.1205 0.3513
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0029 0.007 0.0145
Brugia malayi Cyclin, N-terminal domain containing protein 0.0265 0.4213 0.4213
Brugia malayi Tyrosine-protein kinase abl-1 0.0111 0.1512 0.1512
Echinococcus multilocularis active breakpoint cluster region 0.0124 0.1741 0.1741
Echinococcus granulosus cyclin G2 0.0029 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.1942 0.1942
Echinococcus multilocularis 0.0041 0.0287 0.0287
Echinococcus multilocularis MAM 0.0034 0.0159 0.0159
Trypanosoma cruzi CYC2-like cyclin, putative 0.0213 0.3299 1
Trichomonas vaginalis cyclin D, putative 0.012 0.1665 0.5048
Loa Loa (eye worm) hypothetical protein 0.0079 0.0947 0.0947
Trichomonas vaginalis cyclins, putative 0.0122 0.1704 0.5166
Schistosoma mansoni tyrosine kinase 0.0141 0.2041 0.2041
Loa Loa (eye worm) TK/ALK protein kinase 0.0293 0.4696 0.4696
Entamoeba histolytica cyclin, domain containing protein 0.0029 0.007 0.0213
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0029 0.007 0.007
Onchocerca volvulus 0.0046 0.0367 0.0976
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0101 0.1326 0.1326
Trichomonas vaginalis cyclin D, putative 0.012 0.1665 0.5048
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0079 0.0947 0.0947
Schistosoma mansoni acetylcholinesterase 0.0101 0.1326 0.1326
Giardia lamblia Kinase, CMGC CK2 0.0075 0.0878 0.2503
Entamoeba histolytica protein kinase domain containing protein 0.0103 0.1377 0.4173
Entamoeba histolytica protein kinase, putative 0.0086 0.1077 0.3263
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.0798 0.2254
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0101 0.1326 0.1326
Loa Loa (eye worm) carboxylesterase 0.0101 0.1326 0.1326
Brugia malayi protein kinase C II. 0.0057 0.0558 0.0558
Loa Loa (eye worm) carboxylesterase 0.0595 1 1
Brugia malayi hypothetical protein 0.0123 0.1713 0.1713
Giardia lamblia Kinase, CMGC GSK 0.0103 0.1377 0.4046
Schistosoma mansoni vav2 0.0031 0.0115 0.0115
Schistosoma mansoni cyclin k 0.0029 0.007 0.007
Loa Loa (eye worm) acetylcholinesterase 1 0.0595 1 1
Brugia malayi Protein kinase domain containing protein 0.0094 0.1205 0.1205
Brugia malayi Cyclin, N-terminal domain containing protein 0.0231 0.3618 0.3618
Echinococcus multilocularis cyclins 0.012 0.1665 0.1665
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.1543 0.4676
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0086 0.1076 0.1076
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0103 0.1377 0.1377
Echinococcus granulosus raf serine:threonine protein kinase 0.0468 0.7769 0.7769
Schistosoma mansoni tyrosine kinase 0.015 0.2194 0.2194
Brugia malayi Cyclin, N-terminal domain containing protein 0.0029 0.007 0.007
Echinococcus granulosus cyclins 0.012 0.1665 0.1665
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0036 0.0193 0.0193
Loa Loa (eye worm) CYL-1 protein 0.0029 0.007 0.007
Echinococcus multilocularis N chimaerin 0.0031 0.0115 0.0115
Giardia lamblia Kinase, STE STE20 0.0161 0.2389 0.7182
Brugia malayi hypothetical protein 0.0029 0.007 0.007
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0094 0.1205 0.1205
Brugia malayi Carboxylesterase family protein 0.0101 0.1326 0.1326
Loa Loa (eye worm) TK/INSR protein kinase 0.0322 0.5216 0.5216
Trypanosoma cruzi casein kinase, putative 0.0046 0.0367 0.0919
Entamoeba histolytica cell division protein kinase 2, putative 0.0094 0.1205 0.3651
Loa Loa (eye worm) hypothetical protein 0.0123 0.1713 0.1713
Schistosoma mansoni cyclin B3 0.0231 0.3618 0.3618
Mycobacterium tuberculosis Carboxylesterase LipT 0.0101 0.1326 0.5
Schistosoma mansoni cyclin G2 0.0029 0.007 0.007
Echinococcus granulosus para nitrobenzyl esterase 0.0101 0.1326 0.1326
Echinococcus granulosus mitogen activated protein kinase 0.0113 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0172 0.2586 0.2586
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0046 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0107 0.1434 0.1434
Brugia malayi Cyclin, N-terminal domain containing protein 0.0213 0.3299 0.3299
Echinococcus granulosus Rac GTPase activating protein 1 0.0028 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0034 0.0159 0.0159
Schistosoma mansoni gliotactin 0.0101 0.1326 0.1326
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.226 0.226
Plasmodium vivax protein kinase Crk2 0.0094 0.1205 0.7894
Loa Loa (eye worm) hypothetical protein 0.0256 0.4054 0.4054
Brugia malayi Protein kinase domain containing protein 0.0036 0.0193 0.0193
Trichomonas vaginalis cyclin B, putative 0.0213 0.3299 1
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1205 0.1205
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0161 0.2389 0.7242
Brugia malayi hypothetical protein 0.0101 0.1326 0.1326
Echinococcus multilocularis neuroligin 0.0101 0.1326 0.1326
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0161 0.2389 0.2389
Toxoplasma gondii CMGC kinase, CK2 family 0.0075 0.0878 0.181
Echinococcus multilocularis cyclin y 0.0029 0.007 0.007
Echinococcus multilocularis G1:S specific cyclin D1 0.0029 0.007 0.007
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0031 0.0115 0.0115
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.0798 0.2254
Trypanosoma cruzi casein kinase, putative 0.0046 0.0367 0.0919
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0057 0.0558 0.0558
Giardia lamblia Cyclin A 0.012 0.1665 0.494
Brugia malayi diacylglycerol kinase 0.0028 0.005 0.005
Echinococcus granulosus cyclin y 0.0029 0.007 0.007
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0094 0.1205 0.3513
Brugia malayi C1-like domain containing protein 0.0036 0.0193 0.0193
Onchocerca volvulus 0.0213 0.3299 1
Echinococcus multilocularis protein kinase c epsilon type 0.0057 0.0558 0.0558
Trichomonas vaginalis cyclin B, putative 0.0213 0.3299 1
Brugia malayi RhoGAP domain containing protein 0.0028 0.0051 0.0051
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0094 0.1205 0.1205
Schistosoma mansoni protein kinase 0.0161 0.2389 0.2389
Echinococcus granulosus RNA directed DNA polymerase 0.0079 0.0947 0.0947
Entamoeba histolytica cyclin C, putative 0.0029 0.007 0.0213
Brugia malayi diacylglycerol kinase 0.0028 0.005 0.005
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0031 0.0115 0.0115
Trichomonas vaginalis spcc417.12 protein, putative 0.0101 0.1326 0.402
Giardia lamblia Kinase, CMGC GSK 0.0103 0.1377 0.4046
Giardia lamblia Kinase, CMGC MAPK 0.0113 0.1543 0.456
Trichomonas vaginalis STE family protein kinase 0.0161 0.2389 0.7242
Loa Loa (eye worm) hypothetical protein 0.0101 0.1326 0.1326
Echinococcus granulosus protein kinase c epsilon type 0.0057 0.0558 0.0558
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0115 0.0115
Echinococcus multilocularis cyclin dependent kinase 5 0.0094 0.1205 0.1205
Trichomonas vaginalis STE family protein kinase 0.0161 0.2389 0.7242
Echinococcus multilocularis casein kinase i 0.0046 0.0367 0.0367
Echinococcus granulosus casein kinase ii subunit alpha 0.0075 0.0878 0.0878
Giardia lamblia Kinase, CMGC CDK 0.0094 0.1205 0.3513
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0094 0.1205 0.2482
Schistosoma mansoni protein kinase 0.0046 0.0367 0.0367
Echinococcus multilocularis Diacylglycerol kinase theta 0.0028 0.005 0.005
Brugia malayi casein kinase I 0.0046 0.0367 0.0367
Schistosoma mansoni cyclin d 0.0029 0.007 0.007
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0354 0.5775 0.5775
Echinococcus multilocularis acetylcholinesterase 0.0595 1 1
Entamoeba histolytica protein kinase, putative 0.0103 0.1377 0.4173
Echinococcus granulosus cyclin G2 0.0029 0.007 0.007
Echinococcus multilocularis cyclins 0.012 0.1665 0.1665
Loa Loa (eye worm) raf kinase 0.0459 0.7616 0.7616
Brugia malayi MAP kinase sur-1 0.0113 0.1543 0.1543
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0032 0.0121 0.0121
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0256 0.4054 0.4054
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0113 0.1543 0.3179
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0101 0.1326 0.5
Trypanosoma cruzi cyclin, putative 0.0213 0.3299 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0028 0.005 0.0151
Echinococcus granulosus epidermal growth factor receptor 0.015 0.2194 0.2194
Echinococcus multilocularis cyclin t1 0.0029 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Echinococcus multilocularis casein kinase I alpha 0.0046 0.0367 0.0367
Trypanosoma cruzi cyclin, putative 0.0213 0.3299 1
Schistosoma mansoni diacylglycerol kinase theta 0.0028 0.005 0.005
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0161 0.2389 0.7182
Plasmodium falciparum casein kinase 2, alpha subunit 0.0075 0.0878 0.169
Toxoplasma gondii hypothetical protein 0.0029 0.007 0.0145
Echinococcus multilocularis casein kinase I delta 0.0046 0.0367 0.0367
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1377 0.4173
Echinococcus granulosus active breakpoint cluster region 0.0124 0.1741 0.1741
Echinococcus multilocularis cyclins 0.012 0.1665 0.1665
Brugia malayi RhoGEF domain containing protein 0.0028 0.0051 0.0051
Echinococcus granulosus neuroligin 0.0101 0.1326 0.1326
Trichomonas vaginalis cyclins, putative 0.0213 0.3299 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1326 0.1326
Schistosoma mansoni protein kinase C mu 0.0036 0.0193 0.0193
Trypanosoma brucei mitotic cyclin 0.0029 0.007 0.0213
Onchocerca volvulus 0.0101 0.1326 0.3929
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0111 0.1507 0.3106
Schistosoma mansoni tyrosine kinase 0.0258 0.4083 0.4083
Trichomonas vaginalis cyclin B, putative 0.0029 0.007 0.0213
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.007 0.0213
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0075 0.0878 0.0878
Trichomonas vaginalis CK1 family protein kinase 0.0046 0.0367 0.1112
Loa Loa (eye worm) hypothetical protein 0.0034 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0123 0.1713 0.1713
Brugia malayi casein kinase 1, delta 0.0046 0.0367 0.0367
Trichomonas vaginalis cyclin D, putative 0.0029 0.007 0.0213
Echinococcus granulosus casein kinase I delta 0.0046 0.0367 0.0367
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0261 0.4147 0.4147
Plasmodium vivax unspecified product 0.0075 0.0878 0.5624
Onchocerca volvulus Cyclin L homolog 0.0029 0.007 0.0063
Echinococcus multilocularis cyclin G2 0.0029 0.007 0.007
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0029 0.007 0.0213
Trypanosoma cruzi casein kinase, putative 0.0046 0.0367 0.0919
Echinococcus granulosus myotubularin protein 13 0.0028 0.005 0.005
Echinococcus multilocularis myotubularin protein 13 0.0028 0.005 0.005
Schistosoma mansoni unc-13 (munc13) 0.0032 0.0121 0.0121
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0103 0.1377 0.1377
Trichomonas vaginalis STE family protein kinase 0.0161 0.2389 0.7242
Trichomonas vaginalis cyclin A, putative 0.0029 0.007 0.0213
Echinococcus granulosus acetylcholinesterase 0.0595 1 1
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0231 0.3618 0.3618
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0193 0.0193
Trichomonas vaginalis cyclin B, putative 0.0213 0.3299 1
Echinococcus granulosus casein kinase i 0.0046 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0213 0.3299 0.3299
Trichomonas vaginalis CK1 family protein kinase 0.0046 0.0367 0.1112
Brugia malayi Raf kinase 0.044 0.7282 0.7282
Echinococcus granulosus casein kinase I alpha 0.0046 0.0367 0.0367
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0032 0.0121 0.0121
Schistosoma mansoni protein kinase C mu 0.0028 0.005 0.005
Brugia malayi Casein kinase II, alpha chain 0.0075 0.0878 0.0878
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0031 0.0115 0.0115
Brugia malayi Carboxylesterase family protein 0.0101 0.1326 0.1326
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Onchocerca volvulus 0.0032 0.0121 0.0217
Brugia malayi intracellular kinase 0.0103 0.1377 0.1377
Echinococcus multilocularis insulin receptor 0.0322 0.5216 0.5216
Trichomonas vaginalis conserved hypothetical protein 0.012 0.1665 0.5048
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.0878 0.2662
Echinococcus granulosus N chimaerin 0.0031 0.0115 0.0115
Trichomonas vaginalis cyclin A, putative 0.0213 0.3299 1
Onchocerca volvulus 0.0034 0.0159 0.0337
Trichomonas vaginalis cyclins, putative 0.0213 0.3299 1
Giardia lamblia Kinase, CK1 Casein kinase 0.0046 0.0367 0.0919
Echinococcus granulosus acetylcholinesterase 0.0595 1 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0031 0.0115 0.0115
Onchocerca volvulus 0.0103 0.1377 0.4084
Schistosoma mansoni g1/s-specific cyclin C 0.0029 0.007 0.007
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0103 0.1377 0.1377
Loa Loa (eye worm) hypothetical protein 0.0093 0.1197 0.1197
Schistosoma mansoni hypothetical protein 0.0029 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.1077 0.1077
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0101 0.1326 0.402
Echinococcus multilocularis cyclins 0.012 0.1665 0.1665
Echinococcus granulosus BC026374 protein S09 family 0.0101 0.1326 0.1326
Brugia malayi Furin-like cysteine rich region family protein 0.015 0.2194 0.2194
Trypanosoma brucei cdc2-related kinase 3 0.0094 0.1205 0.3651
Onchocerca volvulus 0.0029 0.007 0.0063
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0161 0.2389 0.2389
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0136 0.1942 0.1942
Toxoplasma gondii diacylglycerol kinase, putative 0.0028 0.005 0.0103
Echinococcus multilocularis cyclins 0.012 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.005
Trichomonas vaginalis cyclin B, putative 0.0213 0.3299 1
Entamoeba histolytica protein kinase, putative 0.0086 0.1077 0.3263
Echinococcus granulosus cyclin A3 4 0.0029 0.007 0.007
Brugia malayi Neuronal symmetry protein 1 0.0215 0.3326 0.3326
Giardia lamblia Kinase, NEK 0.0111 0.1507 0.445

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.4 uM Inhibitory activity against ALK ChEMBL. 16451066
IC50 (binding) = 0.4 uM Inhibitory activity against ALK ChEMBL. 16451066
IC50 (binding) = 3.6 uM Inhibitory activity aginst IRK ChEMBL. 16451066
IC50 (binding) = 3.6 uM Inhibitory activity aginst IRK ChEMBL. 16451066
IC50 (binding) = 4 uM Inhibitory activity aginst Flt3 ChEMBL. 16451066
IC50 (binding) = 4 uM Inhibitory activity aginst Flt3 ChEMBL. 16451066
IC50 (functional) = 4.7 uM Antiproliferative activity against human T-cell leukemia Jurkat cell line ChEMBL. 16451066
IC50 (functional) = 4.7 uM Antiproliferative activity against human T-cell leukemia Jurkat cell line ChEMBL. 16451066
IC50 (binding) = 7 uM Inhibitory activity aginst IGF1R ChEMBL. 16451066
IC50 (binding) = 7 uM Inhibitory activity aginst IGF1R ChEMBL. 16451066
IC50 (functional) = 7.5 uM Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell line ChEMBL. 16451066
IC50 (functional) = 7.5 uM Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell line ChEMBL. 16451066
IC50 (functional) = 9.5 uM Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell line ChEMBL. 16451066
IC50 (functional) = 9.5 uM Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell line ChEMBL. 16451066
IC50 (functional) = 17.4 uM Antiproliferative activity against murine BaF3 cell line expressing NPM-ALK ChEMBL. 16451066
IC50 (functional) = 17.4 uM Antiproliferative activity against murine BaF3 cell line expressing NPM-ALK ChEMBL. 16451066
IC50 (functional) = 18 uM Antiproliferative activity against parental interleukin-3-dependent BaF3 cell line ChEMBL. 16451066
IC50 (functional) = 18 uM Antiproliferative activity against parental interleukin-3-dependent BaF3 cell line ChEMBL. 16451066
IC50 (binding) > 20 uM Inhibitory activity aginst Abl ChEMBL. 16451066
IC50 (binding) > 20 uM Inhibitory activity against Src ChEMBL. 16451066
IC50 (binding) > 20 uM Inhibitory activity aginst Abl ChEMBL. 16451066
IC50 (binding) > 20 uM Inhibitory activity against Src ChEMBL. 16451066
Ki (binding) = 0.2 uM Inhibitory activity against ALK ChEMBL. 16451066
Ki (binding) = 0.2 uM Inhibitory activity against ALK ChEMBL. 16451066
Ki (binding) > 20 uM Inhibitory activity aginst IRK ChEMBL. 16451066
Ki (binding) > 20 uM Inhibitory activity aginst IRK ChEMBL. 16451066

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 16451066
Homo sapiens ChEMBL23 16451066

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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