Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0864 | 0.0864 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Echinococcus granulosus | carboxylesterase 5A | 0.0436 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0162 | 0.3092 | 0.3092 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0074 | 0.0864 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0436 | 1 | 1 |
Onchocerca volvulus | 0.0074 | 0.0864 | 0.2794 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0162 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Onchocerca volvulus | 0.0162 | 0.3092 | 1 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0074 | 0.0864 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3092 | 0.3092 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0162 | 0.3092 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0074 | 0.0864 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.0864 | 0.2794 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Echinococcus granulosus | neuroligin | 0.0074 | 0.0864 | 0.0864 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0074 | 0.0864 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0864 | 0.0864 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0162 | 0.3092 | 0.3092 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | serotonin transporter b | 0.0162 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Echinococcus granulosus | acetylcholinesterase | 0.0436 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Onchocerca volvulus | 0.0074 | 0.0864 | 0.2794 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Onchocerca volvulus | 0.0074 | 0.0864 | 0.2794 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0162 | 0.3092 | 0.3092 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0162 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Echinococcus granulosus | serotonin transporter | 0.0162 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 1 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Echinococcus multilocularis | acetylcholinesterase | 0.0436 | 1 | 1 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0074 | 0.0864 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0074 | 0.0864 | 0.0864 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0074 | 0.0864 | 0.0864 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.0864 | 0.0864 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0864 | 0.0864 |
Echinococcus multilocularis | neuroligin | 0.0074 | 0.0864 | 0.0864 |
Echinococcus granulosus | acetylcholinesterase | 0.0436 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | carboxylesterase | 0.0074 | 0.0864 | 0.0864 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0074 | 0.0864 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | carboxylesterase | 0.0074 | 0.0864 | 0.0864 |
Schistosoma mansoni | acetylcholinesterase | 0.0074 | 0.0864 | 0.0864 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0162 | 0.3092 | 0.3092 |
Loa Loa (eye worm) | carboxylesterase | 0.0436 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0074 | 0.0864 | 0.0864 |
Onchocerca volvulus | 0.0074 | 0.0864 | 0.2794 | |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.0864 | 0.0864 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 36 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 36 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 40 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 40 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 80 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 80 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Ki (binding) | = 7.16 | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 |
Ki (binding) | = 7.79 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Log Ki (binding) | = 7.16 | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 |
Log Ki (binding) | = 7.79 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Ratio Ki (binding) | = 4.3 | Selectivity for human adenosine A2B over human adenosine A2A receptor | ChEMBL. | 16392813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.