Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0327 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0327 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0327 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0327 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0327 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0327 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.008 nM | Inhibition of human AChE | ChEMBL. | 16420031 |
IC50 (binding) | = 0.008 nM | Inhibition of human AChE | ChEMBL. | 16420031 |
IC50 (binding) | = 2 nM | Inhibition of AchE from bovine erythrocytes | ChEMBL. | 16420031 |
IC50 (binding) | = 2 nM | Inhibition of AchE from bovine erythrocytes | ChEMBL. | 16420031 |
IC50 (binding) | = 7.8 nM | Inhibition of human BuChE | ChEMBL. | 16420031 |
IC50 (binding) | = 7.8 nM | Inhibition of human BuChE | ChEMBL. | 16420031 |
IC50 (binding) | = 85 nM | Inhibition of BuChE from horse serum | ChEMBL. | 16420031 |
IC50 (binding) | = 85 nM | Inhibition of BuChE from horse serum | ChEMBL. | 16420031 |
IC50 (binding) | = 8 pM | Inhibition of human AchE | ChEMBL. | 18181565 |
IC50 (binding) | = 8 pM | Inhibition of human AchE | ChEMBL. | 18181565 |
Ratio IC50 (binding) | = 975 | Selectivity for human AChE over human BuChE | ChEMBL. | 16420031 |
Selectivity ratio (binding) | = 1000 | Selectivity for human Ach over human BuCh | ChEMBL. | 18181565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.