Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | CHE-14 protein | 0.0689 | 0.3784 | 0.3784 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1673 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0785 | 0.4391 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1673 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1673 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0689 | 0.3784 | 0.8618 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0689 | 0.3784 | 0.3784 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1673 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0689 | 0.3784 | 0.3784 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0785 | 0.4391 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0689 | 0.3784 | 0.3784 |
Loa Loa (eye worm) | hypothetical protein | 0.0689 | 0.3784 | 0.3784 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0785 | 0.4391 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0689 | 0.3784 | 0.3784 |
Schistosoma mansoni | patched 1 | 0.0689 | 0.3784 | 0.3784 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1673 | 1 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0689 | 0.3784 | 0.3784 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1673 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1673 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1673 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0689 | 0.3784 | 0.3784 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0689 | 0.3784 | 0.3784 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1673 | 1 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0689 | 0.3784 | 0.3784 |
Echinococcus multilocularis | protein patched | 0.0689 | 0.3784 | 0.3784 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0785 | 0.4391 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 26 nM | Inhibition of basal ERK phosphorylation in Malme-3M cells | ChEMBL. | 16420026 |
Activity (functional) | = 26 nM | Inhibition of basal ERK phosphorylation in Malme-3M cells | ChEMBL. | 16420026 |
Activity (functional) | = 165 nM | Inhibition of cellular viability of Malme-3M cells | ChEMBL. | 16420026 |
Activity (functional) | = 165 nM | Inhibition of cellular viability of Malme-3M cells | ChEMBL. | 16420026 |
IC50 (binding) | = 39 nM | Inhibitory activity aginst MEK1 | ChEMBL. | 16420026 |
IC50 (binding) | = 39 nM | Inhibitory activity aginst MEK1 | ChEMBL. | 16420026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.