Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | adenosine kinase, putative | adenosine kinase | 345 aa | 337 aa | 35.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0255 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0255 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0255 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0135 | 0.1071 | 0.1071 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0255 | 1 | 1 |
Onchocerca volvulus | 0.0255 | 1 | 1 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0255 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0255 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0255 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0135 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1071 | 0.1071 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0255 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0255 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0255 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0255 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0135 | 0.1071 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0135 | 0.1071 | 0.1071 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0255 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0255 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0135 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0255 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0135 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0255 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0255 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0255 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0255 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0255 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1071 | 0.1071 |
Brugia malayi | nuclear receptor NHR-88 | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0135 | 0.1071 | 0.1071 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0255 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0255 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0135 | 0.1071 | 0.1071 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0255 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0255 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0255 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0255 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0255 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0135 | 0.1071 | 0.1071 |
Echinococcus granulosus | FTZ F1 alpha | 0.0255 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1071 | 0.1071 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0255 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0255 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0255 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0255 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0135 | 0.1071 | 0.1071 |
Brugia malayi | nuclear hormone receptor | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0255 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0255 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0255 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0255 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0255 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0255 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.145 uM | Inhibitory activity against recombinant human adenosine kinase | ChEMBL. | 16302820 |
IC50 (binding) | = 0.145 uM | Inhibitory activity against recombinant human adenosine kinase | ChEMBL. | 16302820 |
Inhibition (functional) | = 22 % | Inhibition of the licking and biting response at 20 mg/kg, po in rat by formalin paw antinociceptive assay | ChEMBL. | 16302820 |
Solubility | > 1000 ug ml-1 | Solubility in water at pH 7.4 | ChEMBL. | 16302820 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.