Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 5 | 260 aa | 307 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.0456 | 0.9923 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0456 | 0.9923 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0456 | 0.9923 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0458 | 1 | 0.5 |
Onchocerca volvulus | 0.0227 | 0.3396 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0458 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0456 | 0.9923 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0456 | 0.9923 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0458 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0456 | 0.9923 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0456 | 0.9923 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0456 | 0.9923 | 1 |
Brugia malayi | thymidylate synthase | 0.0227 | 0.3396 | 0.3423 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0456 | 0.9923 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0108 | 0 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0456 | 0.9923 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0458 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0458 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0227 | 0.3396 | 0.3423 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 | Inhibitory activity against GSK3 from porcine brain | ChEMBL. | 16420063 |
IC50 (functional) | 0 | Relative resistance index (IC50-CEMC2/IC50 CEM) | ChEMBL. | 16420063 |
IC50 (binding) | > 10 uM | Inhibitory activity against CDK1/Cyclin B from from starfish oocytes | ChEMBL. | 16420063 |
IC50 (binding) | > 10 uM | Inhibitory activity against CDK5/p25 | ChEMBL. | 16420063 |
IC50 (binding) | > 10 uM | Inhibitory activity against CDK5/p25 | ChEMBL. | 16420063 |
IC50 (functional) | > 100 uM | Cytotoxicity against camptothecin-resistant human leukemic CEMC2 cell line | ChEMBL. | 16420063 |
IC50 (functional) | > 100 uM | Cytotoxicity against human leukemic CEM cell line | ChEMBL. | 16420063 |
IC50 (functional) | > 100 uM | Cytotoxicity against camptothecin-resistant human leukemic CEMC2 cell line | ChEMBL. | 16420063 |
IC50 (functional) | > 100 uM | Cytotoxicity against human leukemic CEM cell line | ChEMBL. | 16420063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.