Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.4804 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.2842 | 0.2842 |
Onchocerca volvulus | 0.0027 | 0.2842 | 0.5 | |
Echinococcus multilocularis | lamin | 0.0027 | 0.2842 | 0.2772 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.4804 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.2842 | 0.2772 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.4804 | 0.274 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.4804 | 0.4804 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.2842 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2745 | 0.2745 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 1 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.4804 | 0.4753 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.2842 | 0.2842 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.2842 | 0.2561 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.4804 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.2842 | 0.2561 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.4042 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.4042 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.4804 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 0.2842 | 0.2772 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.4804 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.4804 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0379 | 0.0379 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.2842 | 0.2772 |
Brugia malayi | Inositol-1 | 0.0037 | 0.4804 | 0.4599 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.4804 | 0.274 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.2842 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2842 | 0.2842 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.4804 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.4804 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.4804 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.2842 | 0.5 | |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.4804 | 0.4753 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.4804 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.4804 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2.9 % | Maximal agonistic effect at human adenosine A3 receptor in CHO cells at 10 uM by inhibition of forskolin-stimulated cAMP prodution | ChEMBL. | 16392812 |
Activity (functional) | = 2.9 % | Maximal agonistic effect at human adenosine A3 receptor in CHO cells at 10 uM by inhibition of forskolin-stimulated cAMP prodution | ChEMBL. | 16392812 |
Inhibition (binding) | = 28 % | Inhibition of [3H]R-PIA binding to human adenosine A1 receptor transfected in CHO cells at 10 uM | ChEMBL. | 16392812 |
Inhibition (binding) | = 28 % | Inhibition of [3H]R-PIA binding to human adenosine A1 receptor transfected in CHO cells at 10 uM | ChEMBL. | 16392812 |
Inhibition (binding) | = 34 % | Inhibition of [3H]CGS21680 binding to human adenosine A2A receptor transfected in HEK293 cells at 10 uM | ChEMBL. | 16392812 |
Inhibition (binding) | = 34 % | Inhibition of [3H]CGS21680 binding to human adenosine A2A receptor transfected in HEK293 cells at 10 uM | ChEMBL. | 16392812 |
Ki (binding) | = 2700 nM | Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cells | ChEMBL. | 16392812 |
Ki (binding) | = 2700 nM | Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cells | ChEMBL. | 16392812 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.